EKS-RAN-00395

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00395

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	318.4	4.4E-95	17	260	244

Status

Unreviewed

Ensembl Protein

ENSRNOP00000002068

UniProt Accession

D4AE18;

Protein Name

Protein Synonyms/Alias

Protein Zak;

Gene Name

Zak

Gene Synonyms/Alias

Zak;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000001515	ENSRNOP00000002068	ENSRNOT00000002068
ENSRNOG00000001515	ENSRNOP00000002067	ENSRNOT00000002067

Organism

Rattus norvegicus

Functional Description

Protein Length

453

Protein Sequence
(FASTA)

MSSLGASFVQ IKFDDLQFFE NCGGGSFGSV YRAKWISQDK EVAVKKLLKI EKEAEILSVL 60

SHRNVIQFYG VILEPPNYGI VTEYASLGSL YDYINSNRSE EMDMEHIMTW ATDVAKGMHY 120

LHMEAPVKVI HRDLKSRNVV IAADGVLKIC DFGASRFHNH TTHMSLVGTF PWMAPEVIQS 180

LPVSETCDTY SYGVVLWEML TREVPFKGLE GLQVAWLVVE KNERLTIPSS CPRSFAELLH 240

QCWEADAKKR PSFKQIISIL ESMSNDTNLP DQCNSFLHNK AEWRCEIEAT LERLKKLERD 300

LSFKEQELKE RERRLKMWEQ KLTEQSNTPL LLPLSARMSE ESYFESKTEE SNSAEMSCQI 360

TAASNGEGHG MNPSLQAMML MGFGDVFSMN KAGAVLHSGM QINMQAKQNS SKTTCKRRGK 420

KVNMALGFSD FDLSEGDDDD DDGEEEKDVD NSD 453

Nucleotide Sequence
(FASTA)

ATGTCGTCTC TCGGTGCCTC CTTTGTGCAA ATTAAATTTG ACGACTTGCA GTTTTTTGAA 60

AACTGCGGTG GAGGAAGTTT CGGGAGTGTT TATCGAGCCA AATGGATATC CCAGGACAAG 120

GAGGTGGCTG TGAAGAAGTT ACTCAAAATA GAGAAAGAGG CAGAAATCCT GAGTGTTCTC 180

AGTCACAGGA ACGTCATCCA GTTTTACGGA GTGATTCTGG AACCTCCCAA CTATGGCATT 240

GTCACAGAAT ATGCATCCCT GGGATCCCTG TATGATTACA TTAACAGCAA CAGGAGCGAG 300

GAAATGGACA TGGAGCACAT CATGACCTGG GCCACCGACG TAGCCAAAGG GATGCACTAC 360

CTGCACATGG AGGCTCCGGT CAAGGTGATC CACAGAGACC TCAAGTCAAG AAACGTTGTC 420

ATTGCTGCTG ACGGAGTGCT GAAGATTTGT GACTTCGGTG CATCGCGGTT CCATAACCAT 480

ACAACACACA TGTCCTTGGT TGGCACTTTC CCATGGATGG CTCCAGAAGT TATCCAGAGT 540

CTCCCTGTGT CTGAAACCTG TGACACATAT TCCTACGGTG TGGTTCTCTG GGAGATGCTA 600

ACAAGGGAGG TCCCCTTTAA AGGTTTGGAA GGATTACAAG TCGCTTGGCT TGTAGTGGAA 660

AAAAACGAGA GATTAACCAT TCCAAGCAGT TGCCCCAGAA GCTTTGCTGA ACTGCTACAC 720

CAGTGTTGGG AGGCTGATGC CAAGAAACGG CCATCGTTCA AGCAAATCAT TTCAATCCTA 780

GAGTCCATGT CAAATGACAC GAATCTTCCT GACCAGTGTA ACTCATTTTT ACATAACAAG 840

GCAGAATGGA GGTGTGAAAT TGAGGCTACC CTTGAGCGGC TGAAGAAGCT AGAGCGCGAT 900

CTCAGCTTTA AAGAGCAGGA GCTCAAAGAA AGGGAGAGAC GCTTGAAGAT GTGGGAGCAG 960

AAACTGACCG AGCAGTCCAA CACCCCGCTT CTCTTGCCTC TCTCTGCAAG AATGTCTGAG 1020

GAGTCTTACT TTGAATCTAA AACAGAGGAA TCAAACAGTG CAGAGATGTC TTGCCAGATC 1080

ACTGCAGCGA GTAACGGGGA GGGCCATGGC ATGAACCCAA GTCTGCAGGC CATGATGCTC 1140

ATGGGCTTTG GGGATGTCTT CTCAATGAAC AAAGCAGGAG CTGTGCTGCA TTCTGGGATG 1200

CAGATAAACA TGCAAGCCAA GCAGAATTCA TCCAAAACCA CATGTAAGAG GAGAGGGAAG 1260

AAAGTCAACA TGGCCTTGGG GTTCAGTGAC TTTGACTTGT CAGAAGGTGA CGATGATGAC 1320

GATGATGGTG AGGAGGAGAA GGACGTGGAT AATAGTGATT GA 1362

Domain Profile

S: 2     eleeligsgafgkvykakwrkke..vavKklreeaeekekleklereakllsklshpnii  59

         ++ e +g g+fg+vy+akw +++  vavKkl +          +e+ea++ls lsh+n+i

Q: 17    QFFENCGGGSFGSVYRAKWISQDkeVAVKKLLK----------IEKEAEILSVLSHRNVI  66

         67799**************665444****9987..........899**************

S: 60    ellGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseap  119

         +++Gv+le+pn+++v+ey++ gsL++++++++++e+d+e++++wa+++A+Gm+YLh eap

Q: 67    QFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMEHIMTWATDVAKGMHYLHMEAP  126

         ************************************************************

S: 120   kkiihrdLksknvLlseekktlkicdFGtarelskstkmsaagtlawmaPEvlkeekvse  179

         +k+ihrdLks+nv++ +++ +lkicdFG +r+++++t+ms  gt+ wmaPEv+++ +vse

Q: 127   VKVIHRDLKSRNVVI-AADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSE  185

         ***************.********************************************

S: 180   ksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwne  239

         ++D +SygvvLWe+ltrevP+k+l+ l++a+ v++k++rl+ipsscp+++++L+++cw++

Q: 186   TCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEA  245

         ************************************************************

S: 240   dpekRpsfseivksl  254

         d++kRpsf++i+++l

Q: 246   DAKKRPSFKQIISIL  260

         ***********9875

Domain Sequence
(FASTA)

QFFENCGGGS FGSVYRAKWI SQDKEVAVKK LLKIEKEAEI LSVLSHRNVI QFYGVILEPP 60

NYGIVTEYAS LGSLYDYINS NRSEEMDMEH IMTWATDVAK GMHYLHMEAP VKVIHRDLKS 120

RNVVIAADGV LKICDFGASR FHNHTTHMSL VGTFPWMAPE VIQSLPVSET CDTYSYGVVL 180

WEMLTREVPF KGLEGLQVAW LVVEKNERLT IPSSCPRSFA ELLHQCWEAD AKKRPSFKQI 240

ISIL 244

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0007257	; P:activation of JUN kinase activity
GO:0007050	; P:cell cycle arrest
GO:0007010	; P:cytoskeleton organization
GO:0000077	; P:DNA damage checkpoint
GO:0043065	; P:positive regulation of apoptotic process
GO:0009314	; P:response to radiation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00454

; SAM; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013