EKS-RAN-00284

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00284

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	448.6	1.6E-134	150	470	321

Status

Reviewed

Ensembl Protein

ENSRNOP00000042446

UniProt Accession

Q63470;

Protein Name

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Protein Synonyms/Alias

Dual specificity YAK1-related kinase; Protein kinase minibrain homolog; MNBH; RP86;

Gene Name

Dyrk1a

Gene Synonyms/Alias

Dyrk1a; Dyrk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000001662	ENSRNOP00000042446	ENSRNOT00000050342

Organism

Rattus norvegicus

Functional Description

May play a role in a signaling pathway regulatingnuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.

Protein Length

754

Protein Sequence
(FASTA)

MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AAQMPHSHQY SDRRQPNISD QQVSALSYSD 60

QIQQPLTNQR RMPQTFRDPA TAPLRKLSVD LIKTYKHINE VYYAKKKRRH QQGQGDDSSH 120

KKERKVYNDG YDDDNYDYIV KNGEKWMDRY EIDSLIGKGS FGQVVKAYDR VEQEWVAIKI 180

IKNKKAFLNQ AQIEVRLLEL MNKHDTEMKY YIVHLKRHFM FRNHLCLVFE MLSYNLYDLL 240

RNTNFRGVSL NLTRKFAQQM CTALLFLATP ELSIIHCDLK PENILLCNPK RSAIKIVDFG 300

SSCQLGQRIY QYIQSRFYRS PEVLLGMPYD LAIDMWSLGC ILVEMHTGEP LFSGANEVDQ 360

MNKIVEVLGI PPAHILDQAP KARKFFEKLP DGTWSLKKTK DGKREYKPPG TRKLHNILGV 420

ETGGPGGRRA GESGHTVADY LKFKDLILRM LDYDPKTRIQ PYYALQHSFF KKTADEGTNT 480

SNSVSTSPAM EQSQSSGTTS STSSSSGGSS GTSNSGRARS DPTHQHRHSG GHFAAAVQAM 540

DCETHSPQVR QQFPAPLGWS GTEAPTQVTV ETHPVQETTF HVAPQQNALH HHHGNSSHHH 600

HHHHHHHHHH GQQALGNRTR PRVYNSPTNS SSTQDSMEVG HSHHSMTSLS SSTTSSSTSS 660

SSTGNQGNQA YQNRPVAANT LDFGQNGAMD VNLTVYSNPR QETGIAGHPT YQFSANTGPA 720

HYMTEGHLTM RQGADREESP MTGVCVQQSP VASS 754

Nucleotide Sequence
(FASTA)

ATGCATACAG GAGGAGAGAC TTCAGCATGC AAACCTTCAT CTGTCCGGCT CGCACCGTCA 60

TTCTCATTCC ATGCTGCTGG CCTTCAGATG GCTGCACAGA TGCCCCATTC ACATCAGTAC 120

AGTGACCGTC GCCAGCCAAA CATAAGTGAC CAGCAGGTTT CTGCCTTATC ATATTCTGAC 180

CAGATTCAGC AACCTCTAAC TAACCAGAGG CGGATGCCCC AAACCTTCCG TGATCCAGCA 240

ACTGCTCCTC TGAGAAAACT CTCTGTGGAC TTGATCAAAA CATACAAGCA TATTAATGAG 300

GTTTACTATG CAAAAAAGAA GCGAAGACAC CAACAGGGCC AGGGGGACGA TTCTAGTCAT 360

AAGAAGGAGC GGAAGGTTTA CAACGATGGT TACGATGACG ATAACTATGA TTACATTGTA 420

AAAAACGGAG AAAAGTGGAT GGACCGTTAT GAAATCGACT CCTTAATAGG CAAAGGTTCA 480

TTTGGACAGG TTGTGAAAGC ATATGACAGA GTGGAACAAG AATGGGTCGC CATTAAAATC 540

ATCAAGAACA AGAAGGCGTT TCTGAATCAA GCGCAGATAG AAGTGCGGCT GCTTGAGCTC 600

ATGAACAAAC ATGACACTGA GATGAAGTAC TACATAGTGC ATTTGAAACG CCACTTTATG 660

TTTCGGAACC ATCTCTGTCT AGTGTTTGAA ATGCTGTCCT ATAATCTCTA TGATTTGTTG 720

AGGAACACCA ACTTCCGAGG GGTCTCTTTG AACCTGACAC GAAAGTTTGC ACAACAGATG 780

TGCACAGCAT TGCTTTTCCT TGCGACTCCA GAACTTAGTA TCATTCACTG TGACTTAAAG 840

CCGGAGAACA TCCTTCTGTG TAACCCCAAA CGAAGTGCAA TCAAGATTGT TGACTTTGGC 900

AGCTCTTGTC AGTTGGGGCA GAGGATATAC CAGTATATTC AGAGTCGCTT CTATCGGTCT 960

CCAGAGGTGC TACTGGGAAT GCCTTATGAC CTTGCTATCG ACATGTGGTC CCTTGGATGT 1020

ATCTTGGTTG AAATGCACAC TGGAGAGCCT CTGTTCAGTG GTGCCAATGA GGTGGATCAG 1080

ATGAATAAAA TAGTGGAAGT CTTGGGCATC CCACCTGCTC ATATTCTTGA CCAAGCACCG 1140

AAAGCAAGAA AGTTCTTTGA GAAGTTGCCT GATGGCACTT GGAGCTTAAA GAAGACCAAA 1200

GATGGAAAAC GGGAGTACAA ACCACCAGGA ACCCGTAAAC TTCATAATAT TCTTGGAGTG 1260

GAAACAGGAG GACCTGGCGG GCGGCGTGCT GGGGAGTCAG GTCACACTGT AGCTGACTAC 1320

TTGAAGTTCA AAGACCTCAT TTTAAGGATG CTTGATTATG ACCCCAAAAC TCGGATTCAA 1380

CCTTATTATG CCCTGCAGCA CAGTTTTTTC AAGAAAACAG CTGATGAAGG TACAAACACA 1440

AGCAACAGTG TGTCCACCAG CCCTGCCATG GAGCAGTCCC AGTCTTCAGG CACCACCTCC 1500

AGCACCTCCT CCAGCTCAGG TGGATCCTCG GGAACGAGCA ACAGTGGGAG AGCCAGGTCG 1560

GATCCGACGC ACCAGCATCG GCACAGTGGC GGGCACTTCG CTGCTGCTGT CCAGGCCATG 1620

GACTGTGAGA CACATAGTCC CCAGGTGCGC CAGCAGTTTC CGGCTCCTCT GGGCTGGTCA 1680

GGCACTGAAG CTCCTACACA AGTCACTGTT GAAACTCATC CTGTTCAAGA AACAACCTTT 1740

CATGTAGCCC CTCAGCAGAA TGCATTGCAT CATCACCATG GAAACAGTTC CCATCATCAC 1800

CACCACCACC ATCACCACCA CCACCACCAT GGACAGCAAG CCTTGGGTAA CCGGACCAGG 1860

CCAAGGGTCT ACAATTCTCC AACAAATAGC TCCTCTACCC AGGATTCTAT GGAGGTTGGC 1920

CACAGTCACC ACTCCATGAC ATCCCTGTCT TCCTCAACAA CTTCTTCCTC GACATCTTCC 1980

TCCTCTACTG GTAATCAAGG CAATCAGGCC TATCAGAACC GCCCAGTGGC TGCTAACACC 2040

TTGGACTTTG GACAGAATGG AGCTATGGAC GTTAATTTGA CCGTCTACTC CAATCCCCGC 2100

CAAGAGACTG GCATAGCTGG ACATCCAACA TACCAATTTT CTGCTAATAC AGGTCCTGCA 2160

CATTACATGA CTGAAGGACA TCTGACGATG AGGCAAGGGG CTGATAGAGA AGAGTCTCCC 2220

ATGACAGGAG TTTGTGTGCA ACAGAGTCCT GTAGCTAGCT CGTGA 2265

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye++++igkGsfgqVvka+d+ ++e+vaikiiknkk+f++qaq+Ev++Le +nk+d+e+k

Q: 150   YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK  209

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119

         y++v+l+++f+frnhlclvfe+ls+nLy+ll++++f+g+sl+l+rk+aqq+++aL +L+

Q: 210   YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAt  269

         **********************************************************99

S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++

Q: 270   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMP  328

         99*************************************.********************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238

         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq+++ivevlg+pp+++l++a ka+kff+k

Q: 329   YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEK  388

         ************************************************************

S: 239   keapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.f  288

           + ++ lk++          ++rk +++l+v++ +     p+ +++ge+ ++++d+l f

Q: 389   LPDGTWSLKKTkdgkreykpPGTRKLHNILGVETGG-----PGGRRAGESGHTVADYLkF  443

         ********9997777777777777777777777776.....99*****************

S: 289   kdllkrmleldpakRitpkealkhpfv  315

         kdl+ rml++dp++Ri+p++al+h+f+

Q: 444   KDLILRMLDYDPKTRIQPYYALQHSFF  470

         **************************7

Domain Sequence
(FASTA)

YEIDSLIGKG SFGQVVKAYD RVEQEWVAIK IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK 60

YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT 120

PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY 180

DLAIDMWSLG CILVEMHTGE PLFSGANEVD QMNKIVEVLG IPPAHILDQA PKARKFFEKL 240

PDGTWSLKKT KDGKREYKPP GTRKLHNILG VETGGPGGRR AGESGHTVAD YLKFKDLILR 300

MLDYDPKTRI QPYYALQHSF F 321

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016607	; C:nuclear speck
GO:0030529	; C:ribonucleoprotein complex
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0043621	; F:protein self-association
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0043518	; P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0007399	; P:nervous system development
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0090312	; P:positive regulation of protein deacetylation
GO:0046777	; P:protein autophosphorylation
GO:0030100	; P:regulation of endocytosis

KEGG

rno:25255

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013