EKS-RAN-00360

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00360

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ack	450.9	1.5E-135	127	385	259

Status

Unreviewed

Ensembl Protein

ENSRNOP00000002411

UniProt Accession

D4ADJ2;

Protein Name

Protein Synonyms/Alias

Activated CDC42 kinase 1;

Gene Name

Tnk2

Gene Synonyms/Alias

Tnk2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000001769	ENSRNOP00000002411	ENSRNOT00000002411

Organism

Rattus norvegicus

Functional Description

Protein Length

1040

Protein Sequence
(FASTA)

MQPEEGTGWL LELLSEVQLQ QYFLRLRDDL NITRLSHFEY VKNEDLEKIG MGRPGQRRLW 60

EAVKRRKAMC KRKSWMSKVF SGKRQEAEFP SHHSQSTFRK PSPTPGGLAG EGTLQSLTCL 120

IGEKDLRLLE KLGDGSFGVV RRGEWDAPAG KTVSVAVKCL KPDVLSQPEA MDDFIREVNA 180

MHSLDHRNLI RLYGVVLTPP MKMVTELAPL GSLLDRLRKH QGHFLLGTLS RYAVQVAEGM 240

GYLESKRFIH RDLAARNLLL ATRDLVKIGD FGLMRALPQN DDHYVMQEHR KVPFAWCAPE 300

SLKTRTFSHA SDTWMFGVTL WEMFTYGQEP WIGLNGSQIL HKIDKEGERL PRPEDCPQDI 360

YNVMVQCWAH KPEDRPTFVA LRDFLLEAQP TDMRALQDFE EPDKLHIQMN DVITVIEGRA 420

ENYWWRGQNT RTLCVGPFPR NVVTSVAGLS AQDISQPLQN SFIHTGHGDS DPRHCWGFPD 480

RIDELYLGNP MDPPDLLSVE LSTSRPTQHL GRMKKPTYDP VSEDPDPLSS DFKRLGLRKP 540

ALPRGLWLAK PSARVPGTKA GRSSGGEVTL IDFGEEPVAP TPRPCAPSLA QLAMDACSLL 600

DKTPPQSPTR ALPRPLHPTP VVDWDARPLP PPPAYDDVAQ DEDDFEVCSI NSTLVSAGLP 660

TGPSQGETNY AFVPEQAQLP PALEDNLFLP PQGGGQPPSS AQTAEIFQAL QQECMRQLQV 720

PTGQLTPSPT PGGDDKPQVP PRVPIPPRPT RPRVGLSPAP LGEEEASRWP GPSSPPRVPP 780

REPLSPQGSR TPSPLVPPGS SPLPHRLSSS PGKTMPTTQS FASDPKYATP QVIQAPGPRA 840

GPCILPIVRD GRKVSSTHYY LLPERPPYLE RYQRFLREAQ SPEEPAALPV PPLLPPPSTP 900

APAAPTATVR PMPQAAPDPK ANFSTNNSNP GAQPPSLRAS ARLPQRGCPG DGQEAARPAD 960

KVQMLQAMVH GVTTEECQAA LRSHSWSIQR AAQYLKVEQL FGLGLRPRVE CHKVLEMFDW 1020

NLEQAGCHLL GSCGPAHHKR 1040

Nucleotide Sequence
(FASTA)

ATGCAGCCGG AGGAGGGAAC AGGCTGGCTG CTGGAGCTGC TGTCTGAGGT GCAGCTACAA 60

CAGTATTTCC TGAGGCTCCG AGATGACCTC AACATTACCC GCCTGTCTCA TTTTGAGTAT 120

GTCAAAAACG AAGACCTGGA AAAGATTGGC ATGGGCCGGC CTGGCCAGAG GCGGCTATGG 180

GAGGCTGTGA AGAGGAGGAA GGCCATGTGC AAACGCAAGT CATGGATGAG CAAGGTGTTC 240

AGTGGAAAGC GGCAGGAGGC TGAGTTCCCT TCCCATCACT CTCAGAGCAC CTTCCGGAAG 300

CCCTCCCCCA CCCCAGGGGG CCTGGCAGGG GAGGGGACCC TGCAGAGCCT CACCTGCCTC 360

ATTGGGGAGA AAGACCTGCG CCTGCTGGAG AAGCTGGGAG ATGGCTCCTT TGGCGTGGTG 420

CGCAGGGGTG AATGGGATGC CCCTGCAGGG AAGACGGTGA GTGTGGCCGT GAAGTGCCTG 480

AAACCTGATG TGCTGAGCCA GCCCGAGGCC ATGGACGACT TCATCCGGGA GGTCAATGCC 540

ATGCATTCGC TAGACCACCG AAACCTCATT CGCTTGTACG GTGTGGTGCT CACACCACCC 600

ATGAAGATGG TGACAGAGCT GGCCCCTCTG GGATCCTTGT TGGACCGGCT ACGTAAACAC 660

CAAGGTCATT TCCTCTTGGG GACGCTGAGT CGCTATGCCG TGCAGGTGGC TGAGGGCATG 720

GGCTACCTGG AGTCCAAGCG CTTCATTCAC CGAGACCTGG CTGCTCGAAA TCTGCTTTTG 780

GCCACCCGTG ACCTGGTCAA GATTGGGGAC TTTGGACTGA TGCGAGCTCT GCCCCAGAAT 840

GATGACCACT ATGTCATGCA AGAACATCGC AAGGTGCCCT TTGCCTGGTG TGCCCCTGAG 900

AGCCTGAAGA CACGGACTTT CTCCCATGCC AGTGACACCT GGATGTTTGG GGTCACACTG 960

TGGGAGATGT TTACGTATGG CCAGGAGCCC TGGATTGGCC TCAATGGCAG CCAGATCCTG 1020

CATAAGATTG ACAAGGAAGG GGAGCGCCTG CCCCGGCCTG AGGACTGCCC CCAAGACATC 1080

TACAATGTCA TGGTCCAGTG CTGGGCCCAC AAGCCAGAGG ACAGACCCAC ATTTGTGGCC 1140

CTTCGGGACT TCCTGCTGGA GGCTCAGCCT ACAGACATGC GGGCCCTTCA GGACTTCGAG 1200

GAGCCGGACA AGCTGCACAT CCAGATGAAC GACGTCATTA CTGTCATTGA GGGAAGGGCT 1260

GAGAACTACT GGTGGCGTGG TCAGAACACA CGGACGCTGT GTGTGGGACC CTTCCCTCGA 1320

AATGTGGTGA CCTCTGTGGC TGGCCTGTCA GCCCAGGACA TCAGCCAGCC TCTACAGAAT 1380

AGCTTCATTC ACACAGGGCA TGGCGACAGT GACCCCCGCC ACTGCTGGGG GTTCCCTGAC 1440

AGGATCGATG AACTGTACCT GGGAAACCCC ATGGACCCCC CTGACCTGCT GAGTGTGGAA 1500

CTGAGCACCT CGCGACCCAC CCAGCATTTA GGACGGATGA AAAAGCCAAC ATATGACCCT 1560

GTGAGTGAGG ACCCAGACCC CCTGTCCAGC GACTTCAAGA GACTTGGCCT GAGGAAGCCA 1620

GCCCTGCCCC GAGGGCTCTG GCTGGCAAAG CCCTCAGCCC GGGTGCCAGG CACCAAGGCA 1680

GGCCGCAGCA GTGGGGGTGA GGTCACACTC ATCGACTTCG GCGAGGAGCC TGTAGCCCCA 1740

ACCCCACGGC CCTGTGCACC TTCCTTGGCA CAGTTGGCCA TGGATGCCTG CTCCCTGCTG 1800

GACAAGACAC CACCACAGAG CCCCACACGG GCACTGCCAC GACCTTTACA TCCTACACCT 1860

GTGGTGGACT GGGACGCTCG CCCGCTGCCC CCGCCCCCTG CCTACGATGA TGTGGCCCAA 1920

GATGAGGATG ACTTCGAGGT GTGCTCTATC AACAGCACCC TAGTGAGTGC AGGCCTCCCT 1980

ACCGGGCCTA GCCAAGGCGA GACCAATTAT GCGTTTGTAC CTGAGCAGGC CCAGCTGCCC 2040

CCTGCCCTGG AGGATAACCT GTTCCTGCCA CCGCAGGGTG GAGGCCAGCC ACCCAGCTCA 2100

GCCCAGACTG CAGAGATTTT CCAGGCACTG CAGCAGGAGT GTATGCGGCA GCTACAGGTC 2160

CCCACTGGCC AGCTGACCCC GTCCCCTACC CCAGGAGGTG ATGACAAGCC CCAGGTGCCA 2220

CCCCGGGTAC CTATTCCCCC TCGGCCCACA CGTCCACGTG TGGGACTATC TCCAGCTCCC 2280

TTAGGTGAGG AAGAGGCAAG TCGGTGGCCT GGACCCTCCT CCCCTCCCCG AGTGCCTCCC 2340

CGGGAACCCC TGTCTCCTCA AGGGTCGAGG ACCCCAAGCC CCCTAGTACC ACCTGGCAGC 2400

TCCCCACTAC CGCATCGGCT CTCGAGCTCA CCTGGAAAGA CCATGCCCAC CACCCAGAGC 2460

TTTGCCTCAG ACCCTAAGTA CGCCACTCCA CAAGTGATCC AGGCTCCTGG CCCACGGGCT 2520

GGCCCCTGCA TCCTGCCCAT TGTCCGTGAT GGCAGGAAGG TCAGCAGCAC CCACTATTAC 2580

CTGCTGCCAG AGCGCCCTCC CTACCTCGAG CGCTACCAGC GCTTCCTGAG GGAGGCCCAG 2640

AGCCCCGAGG AGCCGGCCGC CCTGCCCGTT CCCCCACTGC TGCCCCCGCC TAGCACTCCA 2700

GCCCCTGCCG CCCCCACTGC CACCGTCCGA CCTATGCCTC AGGCTGCCCC AGACCCAAAG 2760

GCCAACTTCT CCACCAATAA CAGCAACCCA GGGGCGCAGC CACCATCCCT GAGGGCCAGT 2820

GCACGGCTGC CGCAGAGGGG CTGCCCAGGG GATGGGCAAG AGGCTGCCCG GCCAGCAGAC 2880

AAAGTCCAGA TGCTGCAGGC CATGGTGCAT GGGGTGACCA CAGAGGAGTG CCAGGCGGCC 2940

CTGAGGAGCC ACAGCTGGAG TATTCAGAGG GCTGCCCAGT ATCTGAAGGT GGAGCAGCTC 3000

TTTGGGCTGG GTCTTCGGCC ACGGGTGGAG TGCCACAAAG TGCTAGAGAT GTTCGACTGG 3060

AACCTAGAGC AAGCCGGCTG TCACCTTCTG GGGTCCTGTG GCCCTGCCCA CCACAAACGC 3120

TGA 3123

Domain Profile

S: 2     klleklGeGsfgvvkrgeWsapsgksvqvavkvlksdkllstel.ddflrevsvllkleh  60

         +lleklG+Gsfgvv+rgeW+ap+gk+v+vavk+lk+d+l+++e+ ddf+rev+++++l+h

Q: 127   RLLEKLGDGSFGVVRRGEWDAPAGKTVSVAVKCLKPDVLSQPEAmDDFIREVNAMHSLDH  186

         789****************************************99***************

S: 61    enlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglayle  120

         +nl+rlyGvvlt p+k+vtela+lgslldrlrk++   ++l+ +l++yavq+aeg+ yle

Q: 187   RNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQG--HFLLGTLSRYAVQVAEGMGYLE  244

         ***********************************9..9*********************

S: 121   skrlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPeslrt  180

         skr++hrdlaarnllla+++lvki+dfGl+ral++++d+yv++e++kvPfaWcaPesl+t

Q: 245   SKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKT  304

         ************************************************************

S: 181   rkfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediysll  240

         r+fs+asd+W+fGvtlWemf+yG+ePW+gl+g+qil+kidke+erl++Pe+cp+diy+++

Q: 305   RTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVM  364

         ************************************************************

S: 241   lkcWakkpadrpkfsalkekl  261

         ++cWa+kp+drp+f+al+++l

Q: 365   VQCWAHKPEDRPTFVALRDFL  385

         ******************986

Domain Sequence
(FASTA)

RLLEKLGDGS FGVVRRGEWD APAGKTVSVA VKCLKPDVLS QPEAMDDFIR EVNAMHSLDH 60

RNLIRLYGVV LTPPMKMVTE LAPLGSLLDR LRKHQGHFLL GTLSRYAVQV AEGMGYLESK 120

RFIHRDLAAR NLLLATRDLV KIGDFGLMRA LPQNDDHYVM QEHRKVPFAW CAPESLKTRT 180

FSHASDTWMF GVTLWEMFTY GQEPWIGLNG SQILHKIDKE GERLPRPEDC PQDIYNVMVQ 240

CWAHKPEDRP TFVALRDFL 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0030424	; C:axon
GO:0030136	; C:clathrin-coated vesicle
GO:0005905	; C:coated pit
GO:0030425	; C:dendrite
GO:0070436	; C:Grb2-EGFR complex
GO:0030426	; C:growth cone
GO:0043025	; C:neuronal cell body
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004712	; F:protein serine/threonine/tyrosine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0050731	; P:positive regulation of peptidyl-tyrosine phosphorylation
GO:2000369	; P:regulation of clathrin-mediated endocytosis

KEGG

InterPros

IPR015116	; GTPase_binding.
IPR021619	; Inhibitor_Mig-6.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR000449	; UBA/transl_elong_EF1B_N.

Pfam

PF09027	; GTPase_binding; 1.
PF11555	; Inhibitor_Mig-6; 1.
PF07714	; Pkinase_Tyr; 1.
PF00627	; UBA; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50002	; SH3; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013