EKS-RAN-00149

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00149

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	516.5	2.5E-155	90	383	294

Status

Unreviewed

Ensembl Protein

ENSRNOP00000002502

UniProt Accession

A4GW50;

Protein Name

Protein Synonyms/Alias

RCG29601; Serine/threonine kinase 38 like; Serine/threonine kinase 38-like;

Gene Name

Stk38l

Gene Synonyms/Alias

Stk38l; rCG_29601;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000001828	ENSRNOP00000002502	ENSRNOT00000002502

Organism

Rattus norvegicus

Functional Description

Protein Length

464

Protein Sequence
(FASTA)

MAMTAGATTT FPMSSHTRER VTVAKLTLEN FYSNLILQHE ERETRQKKLE VAMEEEGLAD 60

EEKKLRRSQH ARKETEFLRL KRTRLGLDDF ESLKVIGRGA FGEVRLVQKK DTGHIYAMKI 120

LRKADMLEKE QVAHIRAERD ILVEADGAWV VKMFYSFQDK RNLYLIMEFL PGGDMMTLLM 180

KKDTLTEEET QFYISETVLA IDAIHQLGFI HRDIKPDNLL LDAKGHVKLS DFGLCTGLKK 240

AHRTEFYRNL THNPPSDFSF QNMNSKRKAE TWKKNRRQLA YSTVGTPDYI APEVFMQTGY 300

NKLCDWWSLG VIMYEMLIGF PPFCSETPQE TYRKVMSWKE TLAFPPEVPV SEKAKDLILR 360

FCTDSENRIG NGGVEEIKGH PFFEGVDWGH IRERPAAIPI EIRSIDDTSN FDDFPESDIL 420

QPVPNTTEPD YKSKDWVFLN YTYKRFEGLT QRGSIPTYMK AGKL 464

Nucleotide Sequence
(FASTA)

ATGGCAATGA CGGCAGGGGC AACAACCACC TTTCCTATGA GCAGCCATAC CCGGGAACGA 60

GTCACTGTGG CCAAGCTCAC GCTGGAGAAT TTTTACAGCA ACCTAATTTT GCAGCATGAA 120

GAGAGAGAAA CCAGGCAGAA GAAGTTAGAA GTGGCTATGG AAGAAGAAGG ACTGGCAGAC 180

GAGGAGAAAA AGTTACGCCG GTCACAGCAT GCTCGGAAAG AAACAGAGTT CCTACGCCTG 240

AAGAGGACCA GACTTGGCCT GGATGACTTC GAGTCTCTGA AGGTCATAGG AAGAGGAGCT 300

TTCGGAGAGG TGCGGCTGGT CCAGAAGAAG GACACAGGGC ACATCTATGC CATGAAGATC 360

CTGAGGAAAG CTGACATGCT TGAGAAGGAG CAGGTGGCTC ATATCCGAGC GGAGAGAGAC 420

ATTCTGGTGG AGGCAGACGG AGCCTGGGTA GTGAAGATGT TCTACAGCTT TCAGGACAAG 480

CGGAACCTCT ATCTCATCAT GGAGTTCCTT CCTGGAGGTG ACATGATGAC ATTGCTGATG 540

AAGAAGGACA CCTTAACAGA AGAGGAGACG CAGTTCTACA TCTCAGAGAC TGTCTTGGCG 600

ATTGACGCAA TCCACCAGCT AGGCTTCATC CACCGGGACA TCAAGCCAGA CAACCTTTTA 660

CTGGATGCCA AGGGACATGT AAAACTATCT GATTTTGGTT TGTGCACGGG GTTAAAGAAG 720

GCTCACAGGA CTGAATTCTA CAGAAACCTC ACACACAACC CACCAAGCGA CTTCTCATTT 780

CAGAACATGA ACTCGAAGCG GAAAGCAGAG ACGTGGAAGA AGAACAGGAG GCAGCTGGCT 840

TATTCCACAG TTGGAACACC AGACTACATT GCTCCAGAGG TCTTCATGCA GACAGGGTAC 900

AACAAGCTGT GTGACTGGTG GTCCTTGGGA GTGATTATGT ATGAGATGCT AATAGGCTTT 960

CCACCTTTCT GCTCCGAGAC ACCTCAAGAA ACGTACAGGA AAGTTATGAG CTGGAAGGAG 1020

ACGCTGGCAT TTCCTCCAGA GGTGCCCGTC TCTGAGAAAG CCAAGGACTT GATTCTCAGA 1080

TTTTGTACTG ATTCTGAAAA CAGAATTGGG AATGGTGGTG TGGAAGAGAT CAAAGGTCAT 1140

CCGTTCTTTG AGGGTGTGGA CTGGGGGCAC ATAAGGGAAA GACCAGCAGC TATCCCTATA 1200

GAAATCCGGA GCATAGATGA CACCTCAAAC TTCGATGACT TCCCTGAGTC TGATATCTTA 1260

CAGCCAGTGC CGAATACCAC AGAGCCTGAC TACAAATCCA AAGACTGGGT CTTTCTCAAT 1320

TACACCTACA AAAGGTTTGA AGGGCTGACC CAGCGAGGCT CCATCCCCAC GTACATGAAA 1380

GCTGGGAAGT TATGA 1395

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         fe+lkvig+GafGevrlv+kkdt+++ya+kilrk+d+l+k+qvah++aerdil+ead +w

Q: 90    FESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKADMLEKEQVAHIRAERDILVEADGAW  149

         899*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vvk++ysfqdk+nlyl+me+lPGGd+mtll+kk++l+ee+++fyi+e+vla++++h+lGf

Q: 150   VVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGF  209

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddleaseelkvler  180

         ihrd+kPdnll+dakGh+kl+dfGlctGlkk+hr+e+y++l+++ ++d+++++  ++ +

Q: 210   IHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQNMNSKRKA  269

         *************************************************65555555555

S: 181   rkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyemlvGypPflaetpq  240

            kknrr+lays+vGtpdyiapev++++gynklcdwWslGvi+yeml+G+pPf++etpq

Q: 270   ETWKKNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGFPPFCSETPQ  329

         555*********************************************************

S: 241   etykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdeikkhpff  294

         ety+kv++wketl+fp+ev++se+akdli r+++d+e+r+g+ Gv+eik hpff

Q: 330   ETYRKVMSWKETLAFPPEVPVSEKAKDLILRFCTDSENRIGNGGVEEIKGHPFF  383

         *****************************************************9

Domain Sequence
(FASTA)

FESLKVIGRG AFGEVRLVQK KDTGHIYAMK ILRKADMLEK EQVAHIRAER DILVEADGAW 60

VVKMFYSFQD KRNLYLIMEF LPGGDMMTLL MKKDTLTEEE TQFYISETVL AIDAIHQLGF 120

IHRDIKPDNL LLDAKGHVKL SDFGLCTGLK KAHRTEFYRN LTHNPPSDFS FQNMNSKRKA 180

ETWKKNRRQL AYSTVGTPDY IAPEVFMQTG YNKLCDWWSL GVIMYEMLIG FPPFCSETPQ 240

ETYRKVMSWK ETLAFPPEVP VSEKAKDLIL RFCTDSENRI GNGGVEEIKG HPFF 294

Keyword

ATP-binding; Kinase; Nucleotide-binding; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

rno:691337

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013