EKS-RAN-00418
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00418
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR596.42.4E-179591925335
StatusUnreviewed
Ensembl ProteinENSRNOP00000003050
UniProt AccessionQ63116;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameKit
Gene Synonyms/Alias Kit; KIT; rCG_56893;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000002227ENSRNOP00000003050ENSRNOT00000003050
OrganismRattus norvegicus
Functional Description
Protein Length978
Protein Sequence
(FASTA)
MRGARGAWDL LCVLLVLLRG QTGTSQPSAS PGEPSPPSIQ PAQSELIVEA GDTIRLTCTD 60
PAFVKWTFEI LDVRIENKQS EWIREKAEAT HTGKYTCVSG SGLRSSIYVF VRDPAVLFLV 120
GLPLFGKEDN DALVRCPLTD PQVSNYSLIE CDGKSLPTDL KFVPNPKAGI TIKNVKRAYH 180
RLCIRCAAQR EGKWMRSDKF TLKVRAAIKA IPVVSVPETS HLLKEGDTFT VICTIKDVST 240
SVDSMWIKLN PQPQSKAQVK RNSWHQGDFN YERQETLTIS SARVNDSGVF MCYANNTFGS 300
ANVTTTLKVV EKGFINIFPV KNTTVFVTDG ENVDLVVEFE AYPKPEHQQW IYMNRTPTNR 360
GEDYVKSDNQ SNIRYVNELR LTRLKGTEGG TYTFLVSNSD VSASVTFDVY VNTKPEILTY 420
DRLMNGRLQC VAAGFPEPTI DWYFCTGAEQ RCTVPVPPVD VQIQNASVSP FGKLVVQSSI 480
DSSVFRHNGT VECKASNAVG KSSAFFNFAF KGNSKEQIQP HTLFTPLLIG FVVTAGLMGI 540
IVMVLAYKYL QKPMYEVQWK VVEEINGNNY VYIDPTQLPY DHKWEFPRNR LSFGKTLGAG 600
AFGKVVEATA YGLIKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG NHMNIVNLLG 660
ACTVGGPTLV ITEYCCYGDL LNFLRRKRDS FIFSKQEEQA DAALYKNLLH SKESSCDSSN 720
EYMDMKPGVS YVVPTKTDKR RSARIDSYIE RDVTPAIMED DELALDLEDL LSFSYQVAKG 780
MAFLASKNCI HRDLAARNIL LTHGRITKIC DFGLARDIRN DSNYVVKGNA RLPVKWMAPE 840
SIFNCVYTFE SDVWSYGIFL WELFSLGSSP YPGMPVDSKF YKMIKEGFRM LSPEHAPAAM 900
YEVMKTCWDA DPLKRPTFKQ VVQLIEKQIS DSSKHIYSNL ANCNPNPENP VVVDHSVRVN 960
SVGSSTSSTQ PLLVHEDA 978
Nucleotide Sequence
(FASTA)
ATGAGAGGCG CTCGCGGCGC CTGGGATCTG CTCTGCGTCC TGTTGGTCCT GCTCCGTGGC 60
CAGACAGGGA CTTCTCAGCC ATCTGCGAGT CCAGGGGAGC CGTCTCCACC ATCCATCCAG 120
CCGGCCCAGT CAGAGTTAAT AGTTGAAGCC GGCGACACCA TCAGGCTGAC GTGCACTGAC 180
CCCGCCTTTG TCAAATGGAC TTTCGAGATC CTCGATGTAA GGATTGAGAA TAAGCAGAGC 240
GAATGGATTC GAGAAAAAGC CGAGGCCACT CACACGGGCA AATACACGTG CGTCAGCGGC 300
AGCGGCCTCA GGAGCTCTAT TTACGTGTTC GTTAGAGATC CTGCCGTACT TTTCCTGGTT 360
GGCCTTCCCT TGTTTGGCAA AGAAGACAAT GACGCACTGG TCCGCTGCCC CCTGACAGAC 420
CCACAGGTGT CCAATTACTC CCTCATTGAG TGTGATGGGA AATCTCTCCC CACGGACCTG 480
AAGTTCGTCC CCAACCCCAA GGCTGGCATC ACCATCAAAA ACGTGAAGCG CGCCTACCAC 540
CGGCTGTGCA TCCGGTGTGC TGCCCAGCGT GAGGGCAAAT GGATGCGGTC TGACAAATTC 600
ACCCTCAAAG TGAGGGCAGC CATCAAAGCT ATCCCAGTGG TGTCTGTGCC CGAAACAAGT 660
CATCTCCTTA AGGAAGGGGA CACATTTACG GTGATATGCA CCATAAAAGA CGTGTCTACA 720
TCCGTGGACT CCATGTGGAT AAAGTTGAAC CCTCAGCCTC AGAGCAAAGC CCAGGTAAAG 780
CGCAATAGCT GGCATCAGGG CGACTTCAAT TACGAACGCC AGGAGACGCT GACTATCAGC 840
TCAGCAAGAG TTAACGATTC CGGAGTGTTC ATGTGTTATG CCAATAATAC TTTTGGATCA 900
GCAAATGTCA CAACAACCTT GAAAGTAGTA GAAAAGGGAT TCATCAACAT CTTCCCTGTG 960
AAGAACACTA CGGTATTTGT AACTGATGGG GAAAATGTAG ACTTGGTTGT TGAGTTCGAG 1020
GCCTACCCTA AACCTGAACA CCAGCAGTGG ATCTACATGA ACAGGACGCC TACTAACAGA 1080
GGGGAGGATT ATGTCAAATC CGACAACCAA AGCAACATCA GATATGTGAA CGAACTTCGC 1140
CTGACCAGAT TGAAAGGCAC AGAAGGAGGC ACTTACACCT TTCTGGTGTC CAACTCTGAT 1200
GTCAGTGCTT CCGTGACATT TGATGTTTAT GTGAACACAA AACCAGAAAT CCTGACATAT 1260
GACAGGCTCA TGAATGGCAG GCTCCAGTGT GTGGCGGCGG GATTCCCGGA GCCCACAATA 1320
GATTGGTATT TTTGTACAGG GGCAGAGCAA AGGTGTACCG TTCCTGTCCC GCCAGTAGAC 1380
GTACAGATCC AGAATGCGTC TGTGTCACCA TTTGGAAAAC TGGTGGTTCA GAGTTCCATA 1440
GACTCCAGCG TCTTCCGGCA CAACGGCACG GTGGAGTGTA AGGCCTCCAA CGCTGTGGGC 1500
AAGAGCTCTG CCTTCTTTAA CTTTGCATTT AAAGGTAACA GCAAAGAGCA AATCCAGCCC 1560
CACACCCTGT TCACGCCGCT GCTCATTGGC TTCGTGGTCA CAGCCGGCTT GATGGGGATC 1620
ATTGTGATGG TTCTTGCCTA CAAATATTTG CAGAAACCCA TGTATGAAGT ACAATGGAAG 1680
GTTGTCGAGG AGATAAATGG GAACAATTAT GTTTACATAG ACCCAACGCA GCTTCCTTAT 1740
GACCACAAAT GGGAGTTTCC CAGAAACAGG CTGAGTTTTG GAAAGACCTT GGGAGCTGGT 1800
GCCTTTGGGA AGGTAGTTGA GGCCACTGCC TATGGCTTAA TTAAGTCGGA TGCCGCCATG 1860
ACGGTTGCCG TGAAGATGCT CAAACCAAGT GCCCATTTAA CGGAAAGGGA GGCCCTAATG 1920
TCAGAACTGA AGGTCCTGAG CTACCTGGGT AATCACATGA ATATCGTCAA CCTCCTTGGA 1980
GCGTGTACCG TGGGAGGGCC CACCCTGGTC ATTACAGAAT ACTGTTGCTA TGGTGATCTT 2040
TTGAATTTCT TGAGAAGAAA GCGTGACTCG TTTATTTTCT CAAAGCAAGA AGAACAGGCA 2100
GACGCCGCAC TTTATAAGAA CCTTCTGCAT TCAAAGGAGT CTTCCTGTGA CAGCTCAAAC 2160
GAGTACATGG ACATGAAGCC TGGCGTTTCC TACGTCGTAC CAACCAAGAC AGACAAAAGG 2220
AGATCCGCAA GAATAGACTC GTATATAGAA AGAGACGTGA CTCCCGCCAT CATGGAAGAT 2280
GACGAGCTGG CTCTGGACCT GGAAGATTTG CTGAGCTTTT CCTACCAGGT GGCCAAGGGC 2340
ATGGCGTTCC TCGCCTCCAA GAACTGTATT CACAGAGATT TGGCAGCCAG GAATATCCTC 2400
CTCACTCACG GGCGGATCAC AAAGATTTGC GATTTCGGCC TAGCCAGAGA CATCAGGAAT 2460
GATTCGAATT ACGTGGTAAA AGGAAATGCA CGGCTGCCCG TGAAGTGGAT GGCACCGGAG 2520
AGCATTTTCA ACTGCGTGTA CACATTTGAA AGTGACGTCT GGTCCTATGG GATTTTCCTC 2580
TGGGAGCTAT TCTCTCTAGG AAGCAGCCCC TACCCAGGGA TGCCGGTCGA TTCCAAGTTT 2640
TACAAGATGA TCAAGGAAGG TTTCCGAATG CTCAGCCCTG AGCACGCGCC TGCCGCAATG 2700
TATGAAGTTA TGAAGACTTG CTGGGATGCT GATCCCCTGA AAAGGCCAAC ATTCAAGCAG 2760
GTTGTTCAGC TCATTGAGAA GCAGATCTCA GACAGCAGCA AACATATTTA CTCCAACTTA 2820
GCAAACTGTA ACCCCAACCC AGAGAACCCC GTGGTGGTGG ACCATTCTGT GAGGGTCAAT 2880
TCCGTCGGCA GCAGCACCTC TTCCACACAG CCTCTCCTTG TGCATGAGGA CGCCTGA 2937
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveatayGl+ksda+++vavkmlk++a+ +e+ealmselk+ls+lG
Q: 591   LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG  650
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGact+gGp++viteyccyGdlln+lrrkr+sf+   ++k++e++ ++ +k+
Q: 651   NHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDSFI---FSKQEEQADAALYKN  707
         ******************************************...888889999999999
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         l     l+sk+s++ +ss+ey+d+k++vs+v ++k+dk++s++++s++er+v++a++e+d
Q: 708   L-----LHSKESSC-DSSNEYMDMKPGVSYVVPTKTDKRRSARIDSYIERDVTPAIMEDD  761
         8.....88887766.999******************************************
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
         + +l+ledllsfsyqvakGm+flasknc+hrdlaarn+llt+G+++kicdfGlardi++d
Q: 762   ELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRND  821
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvvkGnarlpvkwmapesif+++yt++sdvwsyGi+lwe+fslGs+pypg++vdskfy
Q: 822   SNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFY  881
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         k+ikeG+rm +p++a++ +ye+m++cw+a+p krp+fkq+v+l+
Q: 882   KMIKEGFRMLSPEHAPAAMYEVMKTCWDADPLKRPTFKQVVQLI  925
         *****************************************996
Domain Sequence
(FASTA)
LSFGKTLGAG AFGKVVEATA YGLIKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG 60
NHMNIVNLLG ACTVGGPTLV ITEYCCYGDL LNFLRRKRDS FIFSKQEEQA DAALYKNLLH 120
SKESSCDSSN EYMDMKPGVS YVVPTKTDKR RSARIDSYIE RDVTPAIMED DELALDLEDL 180
LSFSYQVAKG MAFLASKNCI HRDLAARNIL LTHGRITKIC DFGLARDIRN DSNYVVKGNA 240
RLPVKWMAPE SIFNCVYTFE SDVWSYGIFL WELFSLGSSP YPGMPVDSKF YKMIKEGFRM 300
LSPEHAPAAM YEVMKTCWDA DPLKRPTFKQ VVQLI 335
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0005737; C:cytoplasm
GO:0009897; C:external side of plasma membrane
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005020; F:stem cell factor receptor activity
GO:0031532; P:actin cytoskeleton reorganization
GO:0000187; P:activation of MAPK activity
GO:0097067; P:cellular response to thyroid hormone stimulus
GO:0048066; P:developmental pigmentation
GO:0038093; P:Fc receptor signaling pathway
GO:0035234; P:germ cell programmed cell death
GO:0006687; P:glycosphingolipid metabolic process
GO:0007243; P:intracellular protein kinase cascade
GO:0002320; P:lymphoid progenitor cell differentiation
GO:0008584; P:male gonad development
GO:0002551; P:mast cell chemotaxis
GO:0032762; P:mast cell cytokine production
GO:0043303; P:mast cell degranulation
GO:0002573; P:myeloid leukocyte differentiation
GO:0002318; P:myeloid progenitor cell differentiation
GO:0043069; P:negative regulation of programmed cell death
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:0010628; P:positive regulation of gene expression
GO:0043410; P:positive regulation of MAPK cascade
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0048070; P:regulation of developmental pigmentation
GO:0009314; P:response to radiation
GO:0007286; P:spermatid development
KEGG
rno:64030;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013