EKS-RAN-00416
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00416
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR611.37.0E-184592949358
StatusUnreviewed
Ensembl ProteinENSRNOP00000003077
UniProt AccessionG3V6A0;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePdgfra
Gene Synonyms/Alias Pdgfra; rCG_57147;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000002244ENSRNOP00000003077ENSRNOT00000003077
OrganismRattus norvegicus
Functional Description
Protein Length1088
Protein Sequence
(FASTA)
MGTSQAFLVL SCLLTGPSLI VCQLLLPSIL PNENEKIVPL SSSFSLRCFG ESEVSWQHPM 60
SEEEDPNVEI RTEENNSSLF VTVLEVVNAS AAHTGWYTCY YNHTQTEESE IEGRHIYIYV 120
PDPDMAFVPL GMTDSLVIVE EDDSAIIPCR TTDPDTEVTL HNNGRLVPAS YDSRQGFNGT 180
FSVGPYICEA TVRGRTFKTS EFNVYALKAT SELNLEMDTR QTVYKAGETI VVTCAVFNNE 240
VVDLQWTYPG EVRNKGITML EEIKLPSIKL VYTLTVPKAT VKDSGDYECA ARQATKEVKE 300
MKTVTISVHE KGFVQIRPTF GHLETVNLHQ VREFVVEVQA YPTPRISWLK DNLTLIENLT 360
EITTDVQRSQ ETRYQSKLKL IRAKEEDSGH YTIIVQNDDD MKSYTFELST LVPASILELV 420
DDHHGSGGGQ TVRCTAEGTP LPNIEWMICK DIKKCNNDTS WTVLASNVSN IITEFHQRGR 480
STVEGRVSFA KVEETIAVRC LAKNDLGIGN RELKLVAPTL RSELTVAAAV LVLLVIVIVS 540
LIVLVVIWKQ KPRYEIRWRV IESISPDGHE YIYVDPMQLP YDSRWEFPRD GLVLGRILGS 600
GAFGKVVEGT AYGLSRSQPV MKVAVKMLKP TARSSEKQAL MSELKIMTHL GPHLNIVNLL 660
GACTKSGPIY IITEYCFYGD LVNYLHKNRD SFMSRHPEKP KKDLDIFGLN PADESTRSYV 720
ILSFENNGDY VDMKQADTTQ YVPMLERKEV SKYSDIQRSL YDRPASYKKK SMLDSEAKNL 780
LSDDDSEGLT LLDLLSFTYQ VARGMEFLAS KNCVHRDLAA RNVLLAQGKI VKICDFGLAR 840
DIMHDSNYVS KGSTFLPVKW MAPESIFDNL YTTLSDVWSY GVLLWEIFSL GGTPYPGMMV 900
DSTFYNKIKS GYRMAKPDHA TSEVYEIMVQ CWNSEPEKRP SFYHLSEIVE NLLPGQYKKS 960
YEKIHLDFLK SDHPAVARMR VDSDNAYIGV TYKNEEDKLK EWEGGLDEQR LSADSGYIIP 1020
LPDIDPVPEE EDLGKRNRHS SQTSEESAIE TGSSSSTFIK REDETIEDID MMDDIGIDSS 1080
DLVEDSFL 1088
Nucleotide Sequence
(FASTA)
ATGGGGACCT CCCAGGCCTT TCTGGTCCTC AGCTGTCTCC TCACAGGGCC GAGCCTCATC 60
GTCTGCCAGC TCTTATTACC CTCCATCCTT CCAAATGAGA ATGAGAAGAT TGTGCCGCTG 120
AGTTCGTCCT TCTCTCTGAG ATGCTTCGGG GAGAGCGAAG TGAGCTGGCA GCACCCCATG 180
TCTGAAGAAG AGGACCCCAA CGTGGAAATC AGAACCGAGG AGAACAACAG TAGCCTCTTT 240
GTCACGGTGC TGGAAGTGGT CAACGCCTCA GCGGCCCACA CCGGATGGTA CACTTGCTAT 300
TACAACCACA CTCAGACAGA AGAGAGTGAG ATCGAAGGCA GGCACATTTA TATCTATGTA 360
CCAGACCCAG ACATGGCCTT CGTGCCTCTC GGCATGACGG ATTCTTTAGT CATTGTGGAA 420
GAGGACGATT CTGCCATCAT ACCCTGCCGC ACCACGGATC CAGACACTGA AGTAACCTTG 480
CACAATAACG GGAGGCTGGT GCCTGCCTCC TACGACAGCA GGCAGGGCTT CAACGGAACC 540
TTCAGTGTGG GGCCTTACAT CTGTGAGGCC ACCGTCAGAG GGAGGACGTT CAAGACCAGC 600
GAGTTTAACG TTTATGCCTT GAAAGCCACG TCAGAACTGA ATCTGGAGAT GGACACACGC 660
CAGACTGTGT ATAAGGCAGG AGAAACGATC GTGGTGACCT GCGCCGTCTT TAACAATGAG 720
GTGGTTGACC TGCAGTGGAC TTACCCTGGA GAGGTGAGAA ACAAAGGCAT CACCATGCTG 780
GAGGAGATCA AACTCCCGTC CATCAAACTG GTGTACACGC TGACCGTCCC CAAGGCCACG 840
GTGAAGGACA GTGGAGATTA TGAATGTGCT GCCCGCCAGG CCACGAAAGA GGTCAAGGAA 900
ATGAAGACAG TCACCATTTC TGTTCACGAG AAAGGCTTCG TCCAGATCAG GCCCACCTTT 960
GGCCATCTGG AAACTGTGAA CCTGCATCAG GTCAGAGAGT TCGTGGTGGA GGTGCAGGCC 1020
TACCCGACCC CCAGGATATC CTGGCTGAAG GACAACTTGA CCCTGATTGA GAATCTCACT 1080
GAGATCACCA CCGATGTGCA GAGGAGCCAG GAGACGAGGT ATCAAAGCAA ATTAAAGCTG 1140
ATCCGGGCTA AGGAAGAAGA CAGCGGCCAT TATACCATTA TAGTTCAGAA TGACGACGAC 1200
ATGAAGAGCT ACACGTTTGA GCTGTCAACT CTAGTTCCTG CCTCCATTCT GGAGCTTGTG 1260
GATGACCACC ATGGCTCTGG CGGGGGACAG ACTGTGAGGT GCACGGCTGA AGGCACCCCT 1320
CTTCCGAACA TCGAGTGGAT GATCTGCAAG GATATTAAGA AATGTAATAA TGACACTTCA 1380
TGGACAGTTT TGGCCAGCAA CGTCTCGAAT ATTATCACGG AGTTCCACCA GCGAGGCAGG 1440
AGTACAGTGG AGGGACGAGT GTCCTTCGCC AAGGTGGAAG AGACCATCGC AGTTCGGTGC 1500
TTGGCAAAGA ACGACCTTGG CATTGGGAAC AGAGAGCTGA AGCTGGTGGC TCCCACCCTG 1560
CGATCTGAGC TCACGGTGGC GGCCGCGGTG CTGGTGCTGT TGGTGATTGT CATTGTCTCT 1620
CTCATTGTCC TGGTTGTCAT TTGGAAGCAG AAACCACGGT ATGAAATTCG ATGGAGGGTC 1680
ATTGAGTCAA TCAGCCCTGA TGGACATGAG TATATTTATG TGGACCCCAT GCAGCTGCCT 1740
TACGACTCCA GATGGGAGTT CCCGAGAGAT GGACTAGTGC TTGGTCGGAT CTTGGGATCC 1800
GGTGCATTTG GGAAAGTGGT TGAAGGCACA GCTTATGGAT TAAGCCGGTC CCAGCCTGTA 1860
ATGAAGGTGG CTGTGAAGAT GCTCAAACCC ACAGCCAGGT CTAGTGAGAA GCAAGCTCTC 1920
ATGTCTGAGC TGAAGATAAT GACTCACTTG GGACCGCATC TGAACATTGT GAATTTGCTG 1980
GGAGCCTGCA CCAAGTCAGG CCCCATTTAC ATCATCACAG AATACTGCTT CTATGGGGAT 2040
TTGGTCAATT ACCTGCATAA GAACAGAGAT AGCTTCATGA GCCGACACCC AGAGAAGCCA 2100
AAGAAAGACC TGGACATCTT TGGATTGAAT CCTGCAGATG AGAGTACCAG GAGTTACGTG 2160
ATTTTATCTT TTGAAAACAA TGGTGACTAC GTGGACATGA AGCAGGCTGA CACCACACAG 2220
TACGTGCCAA TGCTGGAAAG GAAGGAGGTT TCCAAATACT CCGACATCCA GAGATCGCTG 2280
TACGATCGGC CGGCCTCCTA TAAGAAGAAA TCCATGCTAG ACTCAGAAGC TAAAAACCTC 2340
CTTTCGGATG ATGACTCCGA GGGTCTGACT TTGCTGGACC TACTAAGCTT CACCTACCAA 2400
GTGGCCCGAG GGATGGAATT TTTGGCTTCG AAAAATTGTG TCCACCGGGA CCTGGCTGCC 2460
CGCAACGTCC TTCTGGCGCA GGGGAAAATC GTGAAGATCT GTGACTTCGG GCTGGCCAGA 2520
GACATCATGC ACGATTCTAA CTACGTGTCA AAGGGCAGCA CTTTCCTGCC TGTGAAGTGG 2580
ATGGCACCTG AGAGCATTTT TGACAACCTC TACACCACGC TGAGTGACGT CTGGTCTTAT 2640
GGCGTTCTGC TCTGGGAAAT ATTCTCCCTT GGTGGCACAC CCTACCCTGG CATGATGGTT 2700
GATTCTACTT TCTACAATAA GATCAAGAGC GGATACAGGA TGGCCAAACC CGACCATGCC 2760
ACCAGTGAAG TCTATGAGAT TATGGTGCAG TGCTGGAACA GTGAACCCGA AAAGAGACCC 2820
TCCTTCTACC ACCTCAGCGA GATAGTGGAG AATCTGCTGC CTGGACAGTA CAAAAAGAGT 2880
TATGAAAAGA TTCACCTGGA CTTCCTAAAG AGTGACCATC CGGCTGTGGC ACGCATGCGT 2940
GTGGACTCTG ACAACGCGTA CATCGGTGTC ACTTACAAAA ATGAAGAGGA CAAGCTGAAG 3000
GAATGGGAAG GTGGCCTGGA TGAACAGAGA TTGAGCGCAG ATAGTGGCTA CATCATTCCC 3060
CTGCCAGACA TTGACCCTGT TCCAGAGGAG GAAGACCTGG GCAAGAGGAA CAGACACAGC 3120
TCGCAGACTT CGGAAGAGAG CGCCATCGAG ACGGGTTCCA GTAGTTCCAC TTTCATCAAG 3180
AGAGAGGACG AGACCATTGA GGACATCGAC ATGATGGATG ATATTGGCAT AGATTCCTCA 3240
GACCTGGTGG AGGACAGCTT CCTGTAA 3267
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafGkvve+tayGls+s++v+kvavkmlk+tarssek+almselki++hlG
Q: 592   LVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLG  651
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk+Gpiy+iteyc+yGdl+nyl+++r+sf++++ ek   ++++ld+++
Q: 652   PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFMSRHPEK---PKKDLDIFG  708
         *********************************************999...999******
S: 121   l.ladkslrsksslssesseeyvdlkkd................vsdvssskadklasek  163
         l +ad+s+rs+++ls+e++++yvd+k++                +sd+++s +d++as+k
Q: 709   LnPADESTRSYVILSFENNGDYVDMKQAdttqyvpmlerkevskYSDIQRSLYDRPASYK  768
         *9*************************9********************************
S: 164   kksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         kks+l++e+k+ l+++dse+l+l dllsf+yqva+Gmeflaskncvhrdlaarnvll++G
Q: 769   KKSMLDSEAKNLLSDDDSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQG  828
         ************************************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardim+dsnyv+kG+++lpvkwmapesifd+lyt+ sdvwsyG+llweif
Q: 829   KIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGVLLWEIF  888
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         slG+tpypg++vds+fy++ik+Gyrma+p++at+e+yeim++cw++epekrpsf++l+e+
Q: 889   SLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVQCWNSEPEKRPSFYHLSEI  948
         *********************************************************998
S: 344   l  344
         +
Q: 949   V  949
         6
Domain Sequence
(FASTA)
LVLGRILGSG AFGKVVEGTA YGLSRSQPVM KVAVKMLKPT ARSSEKQALM SELKIMTHLG 60
PHLNIVNLLG ACTKSGPIYI ITEYCFYGDL VNYLHKNRDS FMSRHPEKPK KDLDIFGLNP 120
ADESTRSYVI LSFENNGDYV DMKQADTTQY VPMLERKEVS KYSDIQRSLY DRPASYKKKS 180
MLDSEAKNLL SDDDSEGLTL LDLLSFTYQV ARGMEFLASK NCVHRDLAAR NVLLAQGKIV 240
KICDFGLARD IMHDSNYVSK GSTFLPVKWM APESIFDNLY TTLSDVWSYG VLLWEIFSLG 300
GTPYPGMMVD STFYNKIKSG YRMAKPDHAT SEVYEIMVQC WNSEPEKRPS FYHLSEIV 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00373
EKS-ANC-00388
EKS-BOT-00401
EKS-CAJ-00405
EKS-CAF-00401
EKS-CAP-00430
EKS-EQC-00393
EKS-FEC-00385
EKS-GAG-00339
EKS-GAA-00490
EKS-GOG-00393
EKS-HOS-00407
EKS-ICT-00380
EKS-LAC-00417
EKS-LOA-00410
EKS-MAM-00400
EKS-MEG-00333
EKS-MOD-00390
EKS-MUM-00433
EKS-MUP-00395
EKS-MYL-00396
EKS-NOL-00366
EKS-OCP-00085
EKS-ORN-00512
EKS-ORA-00350
EKS-ORC-00376
EKS-ORL-00470
EKS-OTG-00403
EKS-PAT-00380
EKS-PES-00356
EKS-POA-00392
EKS-SAH-00370
EKS-TAG-00476
EKS-TAR-00508
EKS-TEN-00509
EKS-TUT-00117
EKS-XET-00512
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
rno:25267;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013