EKS-RAN-00202

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00202

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	512.3	3.3E-154	4	289	286

Status

Reviewed

Ensembl Protein

ENSRNOP00000049130

UniProt Accession

Q5XIT0;

Protein Name

Cyclin-dependent kinase-like 2

Protein Synonyms/Alias

Gene Name

Cdkl2

Gene Synonyms/Alias

Cdkl2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000002506	ENSRNOP00000049130	ENSRNOT00000050038
ENSRNOG00000002506	ENSRNOP00000045371	ENSRNOT00000046771

Organism

Rattus norvegicus

Functional Description

Protein Length

507

Protein Sequence
(FASTA)

MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH 60

ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LKLFPNGLDY QVVQKYLFQI INGIGFCHSH 120

NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG 180

KAVDIWAIGC LVIEMLMGQP LFPGESDIDQ LHHIMTCLGN LIPRHQELFY KNPVFAGVRL 240

PEIKDIEAEP LESRYPKLPE VVISLAKKCL HIDPDKRPLC ADLLHHDFFQ MDGFAERFSQ 300

ELQLKIEKDA RNNSLPKKFQ IRKKEKDDAL GEERKTLVVQ DTNADPKTKD SKVLKVKGSK 360

IDVEKTEKGT RASNGSCLHD NGTSHKGLSS TSLRDCSNVT IDHPRNPGTA IPPLTHNLSA 420

VAPGINAAMG TIPGVQNYRV DEKTKKYCNP FVKPSQPSPS GIYNMNVSAS VSNCPLPRKS 480

KHSPPLDLAV SMGARRVKLY LETESET 507

Nucleotide Sequence
(FASTA)

ATGGAAAAGT ATGAGAACCT AGGATTGGTT GGAGAGGGGA GTTACGGAAT GGTGATGAAG 60

TGTAGGAACA AAGACAGTGG AAGAATTGTG GCCATTAAGA AGTTCTTAGA GAGCGATGAC 120

GATAAAATGG TTAAGAAGAT CGCTATGCGA GAAATCAAGT TACTAAAGCA ACTGCGGCAT 180

GAAAATTTGG TGAACCTGTT GGAAGTGTGT AAGAAAAAGA AGCGTTGGTA CTTAGTCTTT 240

GAATTTGTTG ACCACACGAT TCTTGATGAC TTGAAACTCT TCCCAAATGG ACTAGACTAT 300

CAAGTAGTTC AAAAGTATTT GTTTCAGATC ATTAATGGAA TTGGATTTTG CCATAGTCAC 360

AATATCATAC ACAGAGATAT AAAACCCGAG AATATATTAG TCTCACAGTC TGGCGTTGTA 420

AAATTATGTG ACTTTGGATT CGCACGGACA TTGGCGGCTC CTGGGGAGGT TTACACTGAC 480

TATGTGGCCA CCCGGTGGTA CAGAGCTCCA GAACTGCTGG TCGGTGATGT CAAGTACGGC 540

AAGGCTGTTG ATATCTGGGC CATTGGTTGT CTGGTCATTG AGATGCTTAT GGGGCAACCA 600

CTATTTCCAG GAGAATCCGA TATTGATCAG CTGCATCATA TTATGACATG TTTAGGTAAT 660

TTAATTCCAA GACACCAGGA GCTATTTTAT AAAAATCCTG TGTTTGCTGG AGTAAGGTTG 720

CCTGAGATCA AAGACATAGA AGCAGAGCCT CTCGAGAGCC GCTATCCGAA GCTCCCTGAA 780

GTTGTGATCA GTTTAGCAAA GAAATGCTTG CACATTGATC CAGACAAAAG GCCCTTGTGT 840

GCTGACCTTC TACACCATGA TTTCTTTCAA ATGGATGGAT TTGCTGAGAG GTTTTCTCAA 900

GAATTGCAGT TAAAAATAGA GAAAGATGCC AGGAATAATT CTTTACCTAA AAAGTTTCAA 960

ATCAGAAAGA AAGAAAAAGA CGATGCCTTA GGTGAAGAAA GAAAAACACT TGTGGTACAG 1020

GATACCAATG CTGATCCCAA AACTAAGGAT TCTAAAGTGT TAAAAGTAAA GGGGTCAAAA 1080

ATCGATGTCG AGAAAACTGA AAAAGGAACT AGAGCTTCAA ATGGCAGCTG TCTCCATGAC 1140

AACGGGACAA GCCACAAAGG CTTGTCTTCC ACAAGCCTCA GAGATTGCAG CAATGTCACC 1200

ATTGATCACC CAAGGAATCC AGGCACAGCG ATTCCTCCCC TCACACACAA TCTTTCTGCA 1260

GTTGCTCCTG GTATCAACGC TGCAATGGGG ACTATTCCTG GAGTTCAGAA TTACAGAGTG 1320

GACGAGAAAA CTAAGAAATA CTGTAATCCT TTTGTTAAAC CAAGCCAGCC TTCTCCATCA 1380

GGGATTTATA ATATGAATGT GAGCGCATCC GTAAGTAACT GCCCTCTGCC ACGAAAGAGC 1440

AAGCACTCGC CGCCTCTAGA CCTCGCCGTA AGCATGGGCG CGAGAAGAGT TAAGCTTTAC 1500

TTGGAGACAG AGAGTGAAAC CTGA 1524

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         ye+lg vGeGsyG+v+kcrnkd+g+ivaikkfles+ddk+vkkia+reikllkql+henl

Q: 4     YENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENL  63

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnllev+++kk++ylvfe+vd+t+ld+l+ +pnG+++++v+k+l+qi+++i fch++nii

Q: 64    VNLLEVCKKKKRWYLVFEFVDHTILDDLKLFPNGLDYQVVQKYLFQIINGIGFCHSHNII  123

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrdikpenil+s+sgvvklcdfGfar+laapg+vytdyvatrwyrapellvgd+kyGk+v

Q: 124   HRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAV  183

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         d+waiGcl++e+l+G+plfpg+sd+dql++i+++lG+liprhq++f+kn+vfaGv+lpe+

Q: 184   DIWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLGNLIPRHQELFYKNPVFAGVRLPEI  243

         ************************************************************

S: 241   edl..eslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         +d+  e+le++ypkl ev+++l+kkcl++dp++r +c++ll+h++f

Q: 244   KDIeaEPLESRYPKLPEVVISLAKKCLHIDPDKRPLCADLLHHDFF  289

         *874479*************************************98

Domain Sequence
(FASTA)

YENLGLVGEG SYGMVMKCRN KDSGRIVAIK KFLESDDDKM VKKIAMREIK LLKQLRHENL 60

VNLLEVCKKK KRWYLVFEFV DHTILDDLKL FPNGLDYQVV QKYLFQIING IGFCHSHNII 120

HRDIKPENIL VSQSGVVKLC DFGFARTLAA PGEVYTDYVA TRWYRAPELL VGDVKYGKAV 180

DIWAIGCLVI EMLMGQPLFP GESDIDQLHH IMTCLGNLIP RHQELFYKNP VFAGVRLPEI 240

KDIEAEPLES RYPKLPEVVI SLAKKCLHID PDKRPLCADL LHHDFF 286

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0007049	; P:cell cycle

KEGG

rno:305242

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013