EPS-RAN-00027

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-RAN-00027

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	208.6	1.7E-61	1136	1381	246

Status

Unreviewed

Ensembl Protein

ENSRNOP00000003840

UniProt Accession

F1LNC3;

Protein Name

Protein Synonyms/Alias

PH domain leucine-rich repeat protein phosphatase 1;

Gene Name

Phlpp1

Gene Synonyms/Alias

Phlpp1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000002821	ENSRNOP00000003840	ENSRNOT00000003840

Organism

Rattus norvegicus

Functional Description

Protein Length

1696

Protein Sequence
(FASTA)

MEPAAAAPAQ RLADPTGEDR APAAAAAAEG GRSPDSVLSA AAPSGNGGAA REEAPCEAPR 60

GLPGRAGGTG RRRRRGVPQP AAGGAAPVTA AGGGANSLLL RRGRLKRNLS AAASSSSSPS 120

SASSAAGGLP ASCSASASLC TRSLDRKTLL QKHRQLLQLQ PSDRDWVRHQ LQRGCVHVFD 180

RHMASSYLRP VLCTLDTTAA EVAARLLQLG HKGGGVVKVL GHGPPPAAAP AASDQTPATE 240

LGRDVEPPPS SSTVGAVRGP ARAPPADLPL PGGAWTRCAP RVNPAPSDSS PGELFAGGPC 300

SPSRAPRPAS DTESFSLSPS AESVSDRLDP YSSGGGSSSS SEELEADPAT VLTGPSGPPH 360

HPVRSSQPRP PSPKTSALLQ PKAPTGVDGT GLVVGEGPGD DKAVAAAAPG VPLWTPGRIR 420

ETVQKTSSPP SLYVQLHGET TRRLEADEKP LQIQNDYLFQ LGFGELWRVQ EEGMDSEIGC 480

LIRFYAGKPH STGSSERIQL SGMYNVRKGK MQLPVNRWTR RQVILCGTCL IVSSVKDSSS 540

GKMHVLPLIG GKVEEVKKHQ HCLAFSSSGP QSQTYYICFD TFTEYLRWLR QVSKVASQRI 600

SSVDLSCCSL EHLPANLFYS QDLTHLNLKQ NFLRQNPSLP AARGLGELQR FTKLKSLNLS 660

NNHLGAFPSA VCSIPTLAEL NVSCNALREV PAAVGAMQNL QTFLLDGNFL QSLPAELENM 720

HQLSYLGLSF NEFTDIPEVL EKLTAVDKLC MAGNCMETLR LQALRRMPHI KHVDLRLNIL 780

RKLITDEVDF LQHVTQLDLR DNKLGDLDAM IFNNIEVLHC ERNQLVTLNI CGYFLKALYA 840

SSNELVQLDV YPVPNYLSYM DVSRNCLESV PEWVCESRKL EVLDIGHNQI CELPARLFCN 900

SSLRKLLAGH NRLARLPERL ERTSVEVLDV QHNQIIELPP NLLMKADSLR FLNASANKLE 960

TLPPATLSEE TSSILQELYL TNNSLTDKCV PLLTGHPRLK ILHMAYNRLQ SFPASKMAKL 1020

EELEEIDISG NKLKAIPTTI MNCRRMHTVI AHSNCIEVFP EVMQLPEVKC VDLSCNELSE 1080

ITLPENLPPK LQELDLTGNP RLALDHKSLE LLNNIRCFKI DQPSAGDASG APAVWSHGYT 1140

EASGVKNKLC VAALSVNNFR DNREALYGVF DGDRNVEVPY LLQCTMSDIL AEELQKTKNE 1200

EEYMVNTFIV MQRKLGTAGQ KLGGAAVLCH IRHDPVDLGG SFTLTSANVG KCQTVLCRNG 1260

KPLSLSRSYT MSCEEERKRI KQHKAIITED GKVNGVTEST RILGYTFLHP SVVPRPHVQS 1320

VLLTPQDEFF ILGSKGLWDS LSIEEAVEAV RNVPDALAAA KKLCTLAQSY GCHDSISAVV 1380

VQLSVTEDSF CCCELSVGGS MPPPSPGIFP PSVSMVIKDR PSDGLGVPSS SSGMASEISS 1440

ELSTSEMSSE VGSTASDEPP SGALSESSPA YPSEQRCMLH PVCLSNSFQR QLSSATFSSA 1500

FSDNGLDSDD EEPIEGVFSN GSRVEVEVDI HCSRAKEKER QQHLLQVPAE ASDEGIVISA 1560

NEDESGLSKK TDISAVGTIG RRRANGSVAP QERSHNVIEV ATDAPLRKPG GYFAAPAQPD 1620

PDDQFIIPPE LEEEVKEIMK HHQEQQQQQQ QQQQQQQQQQ QPPPPPQPPQ AQAQAQAQAQ 1680

RPFQMDHLPD CYDTPL 1696

Nucleotide Sequence
(FASTA)

ATGGAGCCCG CCGCCGCAGC CCCGGCACAG CGACTCGCGG ACCCCACGGG TGAGGACCGA 60

GCCCCGGCGG CGGCGGCGGC GGCCGAGGGC GGACGGAGTC CGGATTCTGT GCTGAGCGCG 120

GCGGCCCCGA GCGGGAACGG CGGCGCGGCG CGAGAGGAGG CCCCCTGCGA GGCGCCGCGG 180

GGCCTGCCCG GCCGCGCGGG AGGCACCGGA CGCAGGCGTC GGCGCGGGGT GCCCCAGCCC 240

GCGGCCGGCG GGGCCGCCCC GGTGACCGCG GCCGGCGGCG GCGCCAACTC GCTGCTGCTG 300

AGGAGAGGGC GGCTGAAGAG GAATCTGTCG GCCGCCGCTT CGTCGTCCTC ATCGCCGTCC 360

TCGGCGTCTT CGGCCGCTGG CGGCCTCCCG GCGTCCTGCT CGGCCTCGGC GTCGCTGTGC 420

ACCCGGAGTC TGGACAGGAA GACGCTGCTC CAGAAGCACC GGCAGCTGCT TCAGCTGCAG 480

CCGTCGGACC GGGACTGGGT GAGGCACCAG CTCCAGCGGG GCTGTGTGCA CGTCTTTGAC 540

CGCCACATGG CCTCGTCCTA CCTGCGCCCA GTGCTCTGCA CGCTGGACAC CACAGCCGCC 600

GAGGTGGCCG CCCGGCTTCT GCAGCTGGGC CACAAAGGCG GCGGGGTGGT GAAGGTGCTG 660

GGCCACGGGC CACCTCCGGC CGCTGCCCCG GCCGCCAGCG ATCAGACCCC GGCCACAGAG 720

CTCGGAAGAG ACGTGGAGCC ACCGCCCTCG AGCAGCACGG TCGGTGCTGT CCGGGGCCCT 780

GCGCGCGCGC CTCCTGCCGA TCTGCCGCTG CCCGGGGGCG CCTGGACGCG CTGTGCACCT 840

CGGGTCAACC CTGCGCCCTC GGACTCCAGC CCCGGAGAGC TGTTCGCGGG CGGCCCCTGT 900

TCCCCGTCCC GCGCCCCGCG CCCGGCCTCC GACACCGAGA GCTTCAGCCT GAGCCCCAGC 960

GCCGAGAGCG TGTCAGACCG GCTGGACCCC TATAGCAGCG GCGGCGGCTC CTCCTCTTCG 1020

TCCGAGGAAC TAGAAGCTGA CCCGGCCACG GTCTTGACGG GGCCTTCCGG GCCGCCCCAC 1080

CACCCAGTCC GCTCCTCACA GCCTCGACCG CCTTCCCCGA AGACCTCGGC GTTACTGCAG 1140

CCGAAAGCCC CGACGGGCGT AGACGGCACT GGCCTAGTGG TGGGCGAAGG TCCCGGAGAC 1200

GACAAGGCGG TGGCAGCTGC AGCTCCAGGC GTTCCTCTGT GGACTCCAGG GAGGATCCGG 1260

GAGACCGTGC AAAAGACGTC TTCTCCGCCC TCCCTGTATG TACAGCTCCA TGGGGAGACT 1320

ACCCGGCGCC TGGAGGCGGA CGAGAAGCCA TTGCAGATCC AAAATGACTA CCTCTTCCAA 1380

CTGGGATTTG GGGAGCTGTG GAGGGTGCAG GAGGAAGGCA TGGATTCGGA GATTGGCTGC 1440

CTCATCCGAT TCTATGCAGG AAAGCCTCAT AGCACTGGGA GCTCTGAGCG GATTCAGCTC 1500

TCGGGAATGT ACAATGTCCG AAAAGGCAAA ATGCAGTTGC CAGTGAACAG ATGGACAAGA 1560

CGCCAGGTCA TTCTGTGTGG GACGTGCTTG ATAGTGTCGT CTGTGAAAGA CAGCTCGAGT 1620

GGGAAGATGC ACGTTCTGCC TCTCATTGGT GGAAAAGTGG AAGAAGTGAA AAAGCACCAG 1680

CACTGTCTAG CGTTCAGCTC TTCCGGGCCC CAGAGCCAGA CTTACTACAT CTGCTTCGAT 1740

ACTTTCACGG AGTACTTACG ATGGCTGCGT CAAGTCTCCA AGGTTGCATC ACAACGCATA 1800

AGCTCAGTAG ACCTCTCATG TTGTAGCCTT GAGCATCTGC CTGCCAACCT CTTTTACAGC 1860

CAAGACCTTA CTCATCTCAA TTTAAAACAG AACTTCCTAA GGCAGAACCC CAGCCTCCCA 1920

GCTGCCAGAG GACTTGGTGA ACTGCAGAGA TTCACCAAAT TGAAGAGCCT TAACCTTTCC 1980

AATAACCACC TAGGAGCCTT TCCGTCAGCA GTCTGCAGCA TCCCAACCCT GGCAGAGCTG 2040

AATGTGTCTT GCAATGCCCT GCGAGAAGTC CCAGCAGCTG TTGGAGCTAT GCAGAACTTA 2100

CAGACGTTCT TGCTGGATGG AAATTTTCTC CAGTCCCTTC CTGCTGAGTT GGAGAACATG 2160

CACCAGCTCA GCTATCTGGG TCTTTCCTTT AATGAATTCA CTGACATTCC AGAGGTGTTG 2220

GAGAAGCTGA CTGCTGTGGA TAAACTGTGC ATGGCTGGGA ACTGTATGGA GACCCTTAGA 2280

CTACAGGCCT TAAGAAGGAT GCCTCATATT AAACACGTGG ACCTAAGACT GAACATACTC 2340

AGAAAGCTTA TAACAGATGA AGTGGACTTT CTGCAACATG TCACTCAGCT TGACCTGCGA 2400

GACAATAAAC TTGGTGATCT AGATGCTATG ATCTTCAACA ACATAGAAGT TCTGCACTGC 2460

GAGAGGAATC AGCTGGTGAC ACTGAACATT TGTGGCTATT TCCTAAAAGC ACTCTATGCT 2520

TCTTCTAACG AACTCGTTCA ACTTGATGTC TACCCAGTTC CAAATTATCT ATCGTACATG 2580

GATGTCTCAA GAAACTGCCT AGAAAGTGTG CCTGAGTGGG TATGTGAAAG CCGGAAGTTA 2640

GAAGTTTTGG ATATTGGCCA TAATCAAATA TGTGAACTTC CTGCCCGCTT ATTTTGTAAT 2700

AGTAGTCTCC GGAAATTGCT GGCAGGACAC AACCGGTTGG CAAGGCTTCC TGAAAGGCTG 2760

GAGAGAACAT CAGTGGAGGT CTTGGACGTA CAGCATAACC AGATCATTGA GCTCCCACCA 2820

AACCTTCTCA TGAAGGCTGA CAGCCTGAGA TTCCTCAATG CGTCCGCAAA CAAACTGGAA 2880

ACCCTGCCTC CAGCCACACT TTCTGAGGAG ACAAGCAGTA TATTACAGGA GTTGTACTTG 2940

ACAAACAACA GCCTCACTGA TAAGTGTGTG CCCTTGTTAA CAGGGCACCC CCGCCTGAAG 3000

ATCCTACACA TGGCTTATAA CCGGCTTCAG AGCTTCCCAG CAAGTAAAAT GGCGAAACTG 3060

GAGGAGCTTG AAGAAATCGA TATCAGTGGG AATAAGCTGA AAGCCATCCC AACAACCATC 3120

ATGAACTGCA GGCGCATGCA CACGGTGATT GCTCACTCGA ACTGCATCGA AGTCTTTCCT 3180

GAAGTCATGC AGCTCCCAGA AGTCAAGTGT GTAGATCTGA GCTGTAATGA GCTGAGTGAA 3240

ATCACCCTAC CAGAAAACCT GCCACCTAAA CTGCAGGAAC TAGATCTGAC CGGAAACCCA 3300

CGCCTTGCCC TGGACCACAA AAGCTTGGAG CTGCTCAATA ACATCCGCTG TTTCAAGATT 3360

GACCAGCCGT CAGCAGGAGA TGCATCTGGA GCCCCAGCAG TATGGAGTCA TGGTTACACT 3420

GAAGCATCGG GAGTAAAAAA CAAGCTGTGT GTCGCAGCCC TGTCTGTGAA TAACTTCCGT 3480

GACAACCGAG AGGCTCTCTA CGGTGTGTTT GATGGAGACC GGAATGTGGA AGTGCCCTAC 3540

CTTCTCCAGT GCACCATGAG TGACATCTTA GCTGAGGAGC TTCAGAAAAC GAAAAATGAA 3600

GAAGAATACA TGGTCAATAC ATTTATAGTC ATGCAAAGGA AACTGGGAAC GGCTGGGCAG 3660

AAACTCGGTG GTGCTGCTGT CCTGTGTCAC ATCAGGCATG ACCCTGTGGA CCTGGGAGGA 3720

TCCTTTACCC TGACCTCTGC TAATGTTGGC AAGTGCCAAA CGGTTCTCTG TCGAAACGGG 3780

AAGCCGCTGT CTCTGTCCAG GTCCTATACC ATGAGCTGTG AAGAAGAGCG AAAGAGGATT 3840

AAGCAGCACA AAGCCATCAT CACTGAGGAT GGCAAGGTCA ATGGAGTGAC AGAGTCCACA 3900

CGCATCCTGG GCTACACCTT CCTTCACCCC AGTGTGGTGC CTCGCCCCCA CGTACAGTCG 3960

GTGCTTCTGA CTCCACAGGA TGAGTTTTTC ATCCTGGGCA GCAAAGGGCT GTGGGACAGC 4020

CTGTCCATCG AAGAGGCTGT GGAAGCCGTG CGCAACGTTC CAGATGCTCT AGCCGCCGCC 4080

AAGAAGCTAT GCACCCTGGC CCAGAGCTAC GGCTGCCACG ACAGCATCAG TGCTGTGGTG 4140

GTGCAACTCA GTGTCACGGA AGACAGCTTC TGCTGCTGTG AGCTCAGTGT GGGAGGGAGC 4200

ATGCCACCGC CCAGTCCCGG AATCTTCCCG CCCTCCGTCA GCATGGTGAT CAAGGACCGG 4260

CCCTCAGATG GGCTGGGCGT GCCGTCCTCC AGCAGCGGCA TGGCATCTGA GATCAGCAGT 4320

GAATTGTCTA CCTCTGAGAT GAGTAGTGAG GTGGGCTCCA CAGCTTCTGA CGAGCCGCCG 4380

TCGGGAGCCC TGAGTGAGAG CAGCCCCGCC TACCCCAGCG AGCAGCGCTG CATGCTCCAC 4440

CCGGTCTGCC TGTCCAACTC CTTCCAGCGC CAGCTGTCCA GCGCCACTTT CTCCAGTGCG 4500

TTCTCTGACA ACGGCCTTGA CAGTGATGAC GAGGAACCCA TTGAGGGCGT GTTCAGCAAC 4560

GGCAGCCGGG TGGAGGTGGA AGTGGACATC CATTGCAGCC GGGCCAAGGA GAAGGAGAGA 4620

CAGCAGCACC TGCTTCAGGT GCCAGCTGAA GCCAGTGATG AGGGCATTGT CATCAGTGCC 4680

AATGAGGATG AGTCAGGTCT GTCCAAGAAG ACAGACATTT CTGCTGTGGG GACCATTGGG 4740

CGACGCAGGG CTAACGGCTC TGTAGCTCCC CAGGAAAGGA GCCATAATGT AATAGAGGTT 4800

GCCACAGATG CACCTCTCCG GAAGCCGGGA GGCTATTTTG CAGCCCCTGC TCAACCAGAT 4860

CCAGATGATC AGTTTATCAT CCCCCCAGAG CTGGAAGAGG AAGTCAAAGA AATCATGAAA 4920

CATCACCAGG AGCAGCAGCA GCAGCAGCAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG 4980

CAGCCACCAC CTCCACCCCA GCCGCCACAG GCACAGGCAC AGGCACAGGC ACAGGCACAG 5040

AGGCCCTTCC AGATGGATCA CCTGCCGGAC TGTTACGACA CACCACTATG A 5091

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g+++ +g +n+++ a+ s++nf +++e+     ++gv+DG+++ ev + +++++++il

Q: 1136  SHGYTEASGVKNKLCVAALSVNNFRDNREA-----LYGVFDGDRNVEVPYLLQCTMSDIL  1190

         689**********************99775.....9************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

         aeel+    ++++ ++++ ++F+ ++++l       ++ +k G +av+++i+++

Q: 1191  AEELQ----KTKNEEEYMVNTFIVMQRKL------GTAGQKLGGAAVLCHIRHDpvdlgg  1240

         ***99....999*****************......99***********************

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLa  173

           +l+ anvG++++vLcrngk+++ls+ +++s+e+E++Ri+++++ ++++   +v+Gv++

Q: 1241  sfTLTSANVGKCQTVLCRNGKPLSLSRSYTMSCEEERKRIKQHKAIITEDG--KVNGVTE  1298

         999*****************************************9999998..*******

S: 174   vsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekke  233

          +R lG ++l+p v+p+P+v+s+ lt++def+iL+s+Glwd +s eeav++vr+v +

Q: 1299  STRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSIEEAVEAVRNVPD---  1355

         *********************************************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

          + +aakkL++la+++g++d++sa+vv

Q: 1356  -ALAAAKKLCTLAQSYGCHDSISAVVV  1381

         .************************97

Domain Sequence
(FASTA)

SHGYTEASGV KNKLCVAALS VNNFRDNREA LYGVFDGDRN VEVPYLLQCT MSDILAEELQ 60

KTKNEEEYMV NTFIVMQRKL GTAGQKLGGA AVLCHIRHDP VDLGGSFTLT SANVGKCQTV 120

LCRNGKPLSL SRSYTMSCEE ERKRIKQHKA IITEDGKVNG VTESTRILGY TFLHPSVVPR 180

PHVQSVLLTP QDEFFILGSK GLWDSLSIEE AVEAVRNVPD ALAAAKKLCT LAQSYGCHDS 240

ISAVVV 246

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>