EKS-RAN-00452

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00452

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	496.4	2.4E-149	77	343	267

Status

Unreviewed

Ensembl Protein

ENSRNOP00000003837

UniProt Accession

G3V6C9;

Protein Name

Protein Synonyms/Alias

CDC42 binding protein kinase alpha, isoform CRA_a; Serine/threonine-protein kinase MRCK alpha;

Gene Name

Cdc42bpa

Gene Synonyms/Alias

Cdc42bpa; rCG_20326;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000002841	ENSRNOP00000003837	ENSRNOT00000003837

Organism

Rattus norvegicus

Functional Description

Protein Length

1732

Protein Sequence
(FASTA)

MSGEVRLRQL EQFILDGPAQ TNGQCFSVET LLDILICLYD ECNNSPLRRE KNILEYLEWA 60

KPFTSKVKQM RLHREDFEIL KVIGRGAFGE VAVVKLKNAD KVFAMKILNK WEMLKRAETA 120

CFREERDVLV NGDSKWITTL HYAFQDDNNL YLVMDYYVGG DLLTLLSKFE DRLPEEMARF 180

YLAEMVIAID SVHQLHYVHR DIKPDNILMD MNGHIRLADF GSCLKLMEDG TVQSSVAVGT 240

PDYISPEILQ AMEDGKGRYG PECDWWSLGV CMYEMLYGET PFYAESLVET YGKIMNHKER 300

FQFPTQVTDV SENAKDLIRR LICSREHRLG QNGIEDFKKH PFFSGIDWDN IRNCEAPYIP 360

EVSSPTDTSN FDVDDDCLKN SETMPPPTHT AFSGHHLPFV GFTYTSSCVL SDRSCLRVTA 420

GPTSLDLDVN VQRTLDNNLA TEAYERRIKR LEQEKLELTR KLQESTQTVQ ALQYSTVDGP 480

LTASKDLEIK SLKEEIEKLR KQVAEVNHLE QQLEEANSVR RELDDAFRQI KAFEKQIKTL 540

QQEREELNKE LVQASERLKN QSKELKDAHC QRKLAMQEFM EINERLTELH TQKQKLARHV 600

RDKEEEVDLV MQKAESLRQE LRRAERAKKE LEVHTEALIA EASKDRKLRE QSEHYSKQLE 660

NELEGLKQKQ ISYSPGICSI EHQQEITKLK TDLEKKSIFY EEEISKREGI HASEIKNLKK 720

ELHDSEGQQL ALNKEIMVLK DKLEKTRRES QSEREEFENE FKQQYEREKV LLTEENKKLT 780

SELDKLTSLY ESLSLRNQHL EEEVKDLADK KESVAHWEAQ ITEIIQWVSD EKDARGYLQA 840

LASKMTEELE ALRNSSLGTR ATDMPWKMRR FAKLDMSARL ELQSALDAEI RAKQAIQEEL 900

NKVKASNIIT ECKLKDSEKK NLELLSEIEQ LIKDTEELRS EKGVEHRDSQ HSFLAFLNTP 960

TDALDQFERS PSCTPAGKGR RIADSAPLPV HTPTLRKKGC PASAGFPPKR KTHQFFVKSF 1020

TAPTKCHQCT SLMVGLIRQG CSCEVCGFSC HITCVNKAPT TCPVPPEQTK GPLGIDPQKG 1080

VGTAYEGHVR IPKPAGVKKG WQRALAVVCD FKLFLYDIAE GKASQPSSVI SQVIDMRDEE 1140

FSVSSVLASD VIHASRKDIP CIFRVTASQL SAPSDKCSIL MLADSETERS KWVGVLSELH 1200

KVLKKNKFRD RSVYVPKEAY DSTLPLIKTT QAAAIIDHER VALGNEEGLF VVHVTKDEII 1260

RVGDNKKIHQ IELIPSDQLV AVISGRNRHV RLFPMSALDG RETDFYKLAE TKGCQTIAAG 1320

KVRHGALSCL CVAMKRQVLC YELFQSKTRH RKFKEIQVPC NVQWMAIFSE HLCVGFQSGF 1380

LRYPLNGEGS PCNMLHSNDH TLAFITHQPM DAICAVEISN KEYLLCFSSI GIYTDCQGRR 1440

SRQQELMWPA NPSSCCYNAP YLSIYSENAV DIFDVNSMEW IQTLPLKKVR PLNTEGSLNL 1500

LGLETIRLIY FKNKMAEGDE LVVPETSDNS RKQMVRNINN KRRYSFRVPE EERMQQRREM 1560

LRDPEMRNKL ISNPTNFNHI AHMGPGDGIQ ILKDLPMNPR PQESRTVFSG SVSIPSITKS 1620

RPEPGRSMSA SSGLSARSSA QNGSALKREF SGGSYNTKRQ PMPSPSEGSL SSGGVDQGSD 1680

APVRDYDGED SDSPRHSTAS NSSNLSSPPS PVSPRKTKSL SLESTDRGSW DP 1732

Nucleotide Sequence
(FASTA)

ATGTCTGGAG AAGTGCGTTT GAGGCAGTTG GAACAGTTTA TTTTAGATGG GCCAGCTCAG 60

ACCAATGGGC AGTGCTTCAG TGTGGAGACG TTACTGGACA TACTCATCTG TCTTTATGAT 120

GAATGCAATA ATTCTCCATT GAGAAGAGAG AAGAACATTC TTGAATATCT AGAATGGGCT 180

AAACCATTCA CTTCTAAAGT GAAGCAAATG CGCTTACATA GAGAAGACTT CGAAATATTA 240

AAGGTGATTG GTCGAGGAGC TTTTGGTGAG GTTGCTGTAG TTAAACTGAA AAATGCAGAT 300

AAAGTATTTG CCATGAAAAT TCTGAACAAG TGGGAAATGC TGAAAAGAGC TGAGACAGCG 360

TGCTTTCGTG AAGAGAGGGA TGTGTTGGTA AATGGAGACA GTAAGTGGAT AACCACTCTG 420

CACTATGCTT TTCAGGATGA CAATAACTTA TACCTGGTTA TGGATTATTA TGTTGGTGGG 480

GATTTACTTA CTCTGCTCAG CAAATTTGAA GATCGATTGC CAGAAGAGAT GGCTCGGTTT 540

TACTTGGCTG AGATGGTGAT AGCCATTGAC TCAGTTCACC AGCTCCACTA TGTTCACAGA 600

GACATCAAAC CTGACAATAT ATTGATGGAT ATGAATGGAC ATATTCGTTT AGCAGATTTT 660

GGTTCTTGTC TGAAGCTGAT GGAAGATGGA ACGGTCCAGT CCTCAGTGGC AGTTGGAACT 720

CCAGACTACA TTTCCCCGGA AATCCTTCAG GCTATGGAGG ACGGGAAAGG CAGATATGGA 780

CCAGAGTGTG ACTGGTGGTC CTTGGGAGTC TGCATGTATG AGATGCTTTA CGGAGAAACA 840

CCATTCTATG CGGAATCTCT GGTGGAGACA TATGGAAAAA TTATGAATCA TAAAGAGAGG 900

TTTCAGTTTC CAACCCAAGT GACTGATGTG TCTGAAAATG CTAAAGATCT TATTCGAAGA 960

CTCATTTGTA GCAGAGAACA TCGACTTGGC CAGAATGGAA TAGAAGACTT TAAGAAACAT 1020

CCGTTTTTCA GTGGAATTGA TTGGGATAAC ATCCGAAACT GTGAAGCACC TTACATTCCA 1080

GAAGTTAGTA GTCCAACAGA CACGTCAAAT TTCGATGTGG ATGACGACTG TTTAAAAAAC 1140

TCTGAAACAA TGCCCCCACC AACACATACT GCATTTTCTG GCCATCATCT ACCATTTGTT 1200

GGGTTTACAT ATACTAGTAG CTGTGTTCTT TCTGATCGGA GCTGTTTAAG AGTCACAGCA 1260

GGTCCCACCT CACTGGATCT TGACGTCAAT GTCCAGAGGA CTCTAGATAA TAACTTAGCA 1320

ACTGAAGCTT ATGAAAGAAG AATTAAACGG CTAGAACAGG AAAAGCTTGA ACTTACTAGA 1380

AAACTTCAAG AGTCAACACA GACTGTTCAA GCCCTGCAGT ATTCAACTGT TGATGGTCCA 1440

CTAACGGCAA GCAAAGATTT AGAAATTAAA AGTCTGAAAG AAGAGATTGA AAAACTAAGA 1500

AAACAAGTAG CAGAAGTGAA TCATTTGGAA CAACAACTTG AAGAAGCTAA TTCTGTGAGA 1560

CGAGAACTAG ATGATGCTTT TAGGCAAATC AAAGCTTTTG AAAAACAAAT CAAAACTTTG 1620

CAGCAGGAAA GAGAAGAGCT AAATAAGGAA CTAGTCCAGG CTAGTGAGCG ATTAAAAAAC 1680

CAATCCAAAG AGCTGAAAGA CGCACACTGT CAGAGGAAAC TGGCCATGCA GGAGTTCATG 1740

GAGATCAATG AGCGACTAAC AGAATTGCAC ACCCAAAAGC AGAAACTTGC TCGCCATGTC 1800

CGAGATAAGG AAGAAGAGGT GGACCTGGTG ATGCAAAAAG CTGAGAGCTT AAGGCAGGAG 1860

CTTCGCAGAG CAGAAAGAGC CAAGAAAGAG CTGGAGGTTC ACACTGAAGC TCTAATTGCT 1920

GAAGCCTCAA AGGACCGGAA GCTCCGAGAG CAGAGCGAAC ATTATTCTAA ACAGCTGGAA 1980

AATGAATTGG AGGGACTGAA GCAAAAACAA ATTAGTTACT CACCAGGAAT ATGCAGCATA 2040

GAACACCAGC AAGAGATAAC TAAACTGAAA ACTGACTTGG AAAAGAAAAG TATCTTTTAT 2100

GAAGAAGAAA TCTCTAAAAG AGAAGGAATT CATGCAAGTG AGATTAAAAA TCTGAAGAAG 2160

GAGCTGCATG ACTCAGAAGG CCAGCAACTT GCTCTCAACA AAGAAATTAT GGTTTTAAAA 2220

GACAAATTGG AAAAAACCAG AAGGGAAAGT CAAAGTGAAA GGGAAGAATT TGAAAATGAG 2280

TTCAAGCAAC AATATGAACG GGAAAAAGTA TTATTAACTG AAGAGAATAA AAAGTTAACG 2340

AGTGAACTCG ATAAGCTAAC TTCGTTGTAT GAGAGCTTAA GTTTGCGCAA CCAGCACTTA 2400

GAAGAAGAGG TCAAAGATCT AGCAGATAAG AAGGAATCAG TTGCCCACTG GGAAGCCCAA 2460

ATCACAGAGA TAATCCAATG GGTGAGTGAT GAGAAGGACG CACGGGGCTA TCTTCAGGCC 2520

TTAGCTTCTA AAATGACTGA AGAATTAGAA GCGTTAAGGA ATTCCAGCCT GGGGACACGA 2580

GCGACAGATA TGCCCTGGAA AATGCGTCGT TTTGCAAAAC TGGACATGTC AGCTAGACTA 2640

GAGTTGCAAT CTGCCCTGGA TGCAGAAATC AGAGCTAAGC AGGCCATCCA GGAAGAGCTG 2700

AATAAAGTCA AAGCATCCAA CATCATAACA GAATGTAAAC TGAAAGATTC AGAGAAGAAG 2760

AACTTGGAAC TGTTGTCCGA AATCGAGCAG CTGATAAAGG ACACTGAAGA GCTTAGATCT 2820

GAAAAGGGTG TAGAGCACCG AGACTCACAG CACTCTTTCT TGGCATTTTT GAATACGCCT 2880

ACCGATGCTC TGGATCAATT TGAACGCTCT CCGTCCTGTA CTCCAGCTGG CAAAGGCAGA 2940

CGTATTGCAG ACTCTGCTCC GCTTCCAGTT CACACACCAA CTTTAAGGAA AAAGGGATGC 3000

CCAGCTTCAG CTGGTTTTCC ACCTAAGCGC AAGACTCATC AGTTTTTCGT GAAGTCTTTC 3060

ACTGCCCCTA CCAAGTGCCA TCAGTGTACC TCCTTGATGG TCGGTTTGAT AAGACAGGGC 3120

TGTTCCTGCG AAGTCTGTGG GTTCTCATGT CATATAACTT GTGTGAACAA AGCCCCGACC 3180

ACTTGCCCAG TTCCTCCTGA GCAAACTAAA GGCCCACTCG GTATAGACCC CCAGAAGGGA 3240

GTAGGGACAG CGTATGAGGG CCATGTCCGG ATCCCTAAGC CGGCGGGAGT GAAGAAAGGG 3300

TGGCAGAGAG CACTGGCTGT GGTCTGTGAC TTCAAACTGT TTCTTTATGA TATCGCGGAG 3360

GGAAAAGCAT CGCAGCCCAG CTCCGTCATT AGTCAAGTGA TCGACATGAG AGATGAAGAA 3420

TTTTCCGTGA GTTCAGTCTT GGCTTCTGAT GTTATTCATG CAAGTCGAAA AGATATTCCC 3480

TGTATATTTA GAGTCACAGC CTCCCAGCTC TCAGCACCTA GTGACAAATG TTCCATCCTG 3540

ATGCTAGCCG ACAGCGAGAC TGAGAGGAGT AAGTGGGTGG GAGTGCTGAG TGAACTCCAC 3600

AAGGTTCTGA AGAAAAACAA GTTCAGAGAC CGCTCAGTGT ATGTCCCCAA AGAGGCTTAC 3660

GACAGCACTC TACCCCTCAT TAAAACAACG CAGGCCGCGG CAATCATAGA TCATGAGCGG 3720

GTAGCTTTGG GAAATGAAGA AGGATTATTT GTTGTGCATG TCACTAAAGA TGAGATTATT 3780

AGAGTTGGTG ATAATAAGAA AATTCATCAG ATTGAACTCA TTCCAAGTGA CCAGCTTGTT 3840

GCTGTGATCT CAGGCCGAAA TCGCCACGTC CGACTTTTCC CTATGTCAGC TTTGGATGGG 3900

CGAGAGACGG ATTTTTATAA ACTGGCAGAG ACTAAAGGGT GTCAAACCAT AGCTGCTGGG 3960

AAGGTGCGCC ATGGAGCTCT GTCCTGCCTG TGTGTGGCCA TGAAAAGACA GGTCCTCTGC 4020

TATGAACTGT TCCAAAGCAA GACCAGGCAC AGGAAGTTTA AGGAGATTCA AGTCCCATGT 4080

AATGTCCAGT GGATGGCCAT CTTCAGTGAA CATCTCTGTG TGGGATTCCA GTCAGGATTT 4140

CTCAGATACC CCCTGAATGG GGAAGGAAGT CCATGCAATA TGCTCCATTC AAATGACCAC 4200

ACACTGGCAT TCATTACACA CCAACCAATG GATGCTATCT GTGCCGTTGA GATCTCCAAC 4260

AAAGAGTATT TGCTGTGTTT TAGCAGCATT GGGATATACA CGGACTGCCA GGGCCGAAGA 4320

TCTAGACAGC AGGAACTGAT GTGGCCAGCA AATCCTTCCT CCTGTTGTTA CAATGCACCA 4380

TATCTCTCCA TTTACAGTGA AAATGCAGTT GATATCTTTG ATGTAAACTC CATGGAATGG 4440

ATACAGACGC TTCCTCTCAA GAAGGTTCGA CCTTTAAACA CTGAAGGATC ATTAAATCTT 4500

TTAGGGTTGG AGACCATTAG ATTAATATAT TTCAAAAATA AGATGGCAGA AGGGGATGAA 4560

CTTGTAGTTC CTGAAACATC AGATAATAGC CGAAAACAGA TGGTTAGAAA CATCAACAAC 4620

AAACGGCGTT ACTCCTTCCG GGTCCCAGAA GAAGAGAGGA TGCAGCAGAG AAGGGAGATG 4680

CTACGAGATC CAGAAATGAG AAATAAATTA ATTTCTAACC CAACTAATTT TAACCACATA 4740

GCACACATGG GTCCTGGAGA TGGAATACAG ATCCTAAAAG ACCTGCCCAT GAACCCACGG 4800

CCTCAGGAAA GCCGGACAGT ATTCAGTGGC TCCGTCAGTA TTCCCTCCAT CACCAAGTCC 4860

CGCCCTGAGC CAGGCCGCTC CATGAGTGCC AGCAGTGGCC TGTCTGCACG GTCATCAGCC 4920

CAGAATGGCA GTGCGCTAAA GAGGGAATTC TCTGGAGGAA GCTACAACAC GAAGCGACAG 4980

CCCATGCCCT CTCCCTCAGA AGGCTCTTTG TCATCAGGAG GCGTGGACCA AGGAAGTGAC 5040

GCCCCCGTGA GGGACTATGA TGGAGAGGAC TCTGATTCTC CAAGGCATTC CACAGCTTCC 5100

AACAGCTCTA ACCTGAGCAG CCCCCCAAGC CCCGTTTCAC CCCGAAAGAC CAAGAGCCTC 5160

TCCTTGGAGA GCACAGACCG TGGGAGCTGG GATCCATGA 5199

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         feilkviGrGafgevavv+ k+++kv+amkil+k+e+lkrae+a+freerdvlv++ds+w

Q: 77    FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSKW  136

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqd+++lylvm+y+vGGdlltllsk+ed+lpee+arfylae+v+a+dsvh+l+

Q: 137   ITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLH  196

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrdikpdnil+d++Ghi+ladfGsclkl+edgtv+ssvavGtpdyispe+l+a+e+gk

Q: 197   YVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGK  256

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nhke+++fp+++ +vse+akd

Q: 257   GRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQVtDVSENAKD  316

         **************************************************99********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++l++sre+rlg++gied+kkhpff

Q: 317   LIRRLICSREHRLGQNGIEDFKKHPFF  343

         **************************9

Domain Sequence
(FASTA)

FEILKVIGRG AFGEVAVVKL KNADKVFAMK ILNKWEMLKR AETACFREER DVLVNGDSKW 60

ITTLHYAFQD DNNLYLVMDY YVGGDLLTLL SKFEDRLPEE MARFYLAEMV IAIDSVHQLH 120

YVHRDIKPDN ILMDMNGHIR LADFGSCLKL MEDGTVQSSV AVGTPDYISP EILQAMEDGK 180

GRYGPECDWW SLGVCMYEML YGETPFYAES LVETYGKIMN HKERFQFPTQ VTDVSENAKD 240

LIRRLICSRE HRLGQNGIED FKKHPFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013