EKS-RAN-00306
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00306
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/DDR498.56.9E-150563848286
StatusUnreviewed
Ensembl ProteinENSRNOP00000003901
UniProt AccessionB1WC09;
Protein Name
Protein Synonyms/Alias Discoidin domain receptor tyrosine kinase 2; Protein Ddr2; RCG46328;
Gene NameDdr2
Gene Synonyms/Alias Ddr2; rCG_46328;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000002881ENSRNOP00000003901ENSRNOT00000003901
OrganismRattus norvegicus
Functional Description
Protein Length854
Protein Sequence
(FASTA)
MILIPRMPLV LLLLLLILGS AKAQVNPAIC RYPLGMSGGH IPDEDITASS QWSESTAAKY 60
GRLDSEEGDG AWCPEIPVQP DDLKEFLQID LRTLHFITLV GTQGRHAGGH GIEFAPMYKI 120
NYSRDGNRWI SWRNRHGKQV LDGNSNPYDV FLKDLEPPIV ARFVRLIPVT DHSMNVCMRV 180
ELYGCVWLDG LVSYNAPAGQ QFVLPGGSII YLNDSVYDGA VGYSMTEGLG QLTDGVSGLD 240
DFTQTHEYHV WPGYDYVGWR NESATNGFIE IMFEFDRVRN FTTMKVHCNN MFAKGVKIFK 300
EVQCYFRSET SEWEPTAVYF PLVLDDVNPS ARFVTVPLHH RMASAIKCQY HFADTWMMFS 360
EITFQSDAAM YNNSGALPTS PMAPTTFDPM LKVDDSNTRI LIGCLVAIIF ILLAVIVIIL 420
WRQFWQKMLE KASRRMLDDE MTVSLSLPSE SSMFNNNHSS SPSEQESNST YDRIFPLRPD 480
YQEPSRLIRK LPEFAPGEEE SGCSGVVKPA QPNGPEGVPH YAEADIVNLQ GVTGGNTYSV 540
PAVTMDLLSG KDVAVEEFPR KLLAFKEKLG EGQFGEVHLC EVEGMEKFKD KDFALDVSAN 600
QPVLVAVKML RADANKNARN DFLKEIKIMS RLKDANIIRL LAVCITEDPL CMITEYMENG 660
DLNQFLSRHE PLSSGSSNAT VSYANLKFMA TQIASGMKYL SSLNFVHRDL ATRNCLVGKN 720
YTIKIADFGM SRNLYSGDYY RIQGRAVLPI RWMSWESILL GKFTTASDVW AFGVTLWETF 780
TFCQEQPYSQ LSDEQVIENT GEFFRDQGRQ IYLPQPAVCP DSVYKLMLSC WRRETKHRPS 840
FQEIHLLLLQ QGAE 854
Nucleotide Sequence
(FASTA)
ATGATCCTGA TTCCCAGAAT GCCTCTGGTG CTGCTGCTGC TCCTGCTCAT CCTGGGTTCT 60
GCAAAAGCTC AGGTTAATCC AGCCATATGT CGCTATCCTC TGGGCATGTC AGGAGGCCAC 120
ATTCCAGATG AGGACATCAC AGCTTCAAGT CAGTGGTCAG AATCCACAGC TGCCAAATAT 180
GGGAGGCTGG ACTCTGAAGA AGGGGATGGA GCTTGGTGCC CTGAGATTCC AGTGCAACCC 240
GATGACCTGA AGGAATTTCT GCAGATTGAT TTACGAACCC TACACTTTAT CACTCTTGTG 300
GGGACCCAGG GACGCCATGC AGGGGGTCAT GGCATTGAAT TTGCACCCAT GTACAAGATC 360
AACTACAGTC GGGATGGCAA CCGCTGGATC TCCTGGCGTA ACCGACATGG GAAACAGGTG 420
CTTGATGGGA ACAGTAACCC TTATGATGTT TTCCTGAAGG ATTTGGAGCC ACCCATTGTA 480
GCTAGATTTG TTCGCCTTAT CCCAGTCACT GACCACTCCA TGAACGTGTG CATGAGGGTC 540
GAGCTTTATG GTTGTGTCTG GCTAGATGGC TTGGTATCTT ACAATGCACC CGCTGGGCAG 600
CAGTTTGTAC TCCCTGGAGG CTCCATCATT TATCTGAATG ATTCTGTCTA TGATGGAGCT 660
GTTGGGTACA GTATGACTGA AGGGCTAGGC CAGTTGACTG ATGGGGTATC TGGCCTGGAT 720
GATTTTACCC AGACCCATGA ATACCATGTG TGGCCCGGCT ATGACTACGT GGGATGGCGG 780
AATGAGAGTG CTACCAATGG TTTCATAGAG ATCATGTTTG AATTTGACCG AGTCAGGAAT 840
TTTACCACCA TGAAGGTCCA CTGCAATAAC ATGTTCGCTA AAGGTGTGAA GATCTTTAAG 900
GAGGTCCAAT GTTACTTCCG CTCTGAAACC AGCGAATGGG AACCTACTGC TGTCTACTTT 960
CCCCTTGTCC TGGATGATGT GAACCCCAGT GCTCGGTTTG TCACGGTGCC CCTCCACCAT 1020
CGAATGGCTA GTGCCATCAA ATGCCAATAC CATTTTGCCG ACACATGGAT GATGTTCAGC 1080
GAGATCACTT TTCAATCAGA TGCTGCAATG TATAATAACT CTGGAGCACT CCCCACCTCT 1140
CCTATGGCAC CCACAACCTT TGATCCCATG CTTAAAGTCG ATGACAGCAA CACTCGGATC 1200
CTGATTGGCT GCTTGGTGGC CATCATCTTC ATCCTGCTGG CTGTCATCGT CATCATCCTG 1260
TGGAGGCAAT TCTGGCAGAA GATGCTAGAG AAGGCTTCAC GGAGGATGCT GGATGATGAA 1320
ATGACAGTTA GCCTTTCCCT GCCCAGCGAG TCCAGCATGT TCAATAACAA CCACTCCTCA 1380
TCACCAAGTG AACAGGAGTC CAACTCTACT TATGATCGAA TCTTTCCCCT TCGCCCTGAC 1440
TACCAGGAGC CATCCAGACT GATCCGAAAG CTCCCAGAAT TTGCTCCAGG AGAGGAAGAG 1500
TCTGGTTGCA GTGGTGTTGT GAAGCCGGCC CAGCCCAATG GACCTGAGGG CGTGCCCCAC 1560
TATGCAGAAG CCGATATAGT GAATCTCCAG GGAGTAACAG GTGGCAACAC CTACTCTGTG 1620
CCTGCCGTCA CCATGGACCT GCTCTCGGGA AAAGATGTGG CTGTGGAAGA GTTCCCCAGG 1680
AAACTGTTAG CCTTCAAAGA GAAGCTGGGA GAAGGCCAGT TTGGGGAGGT TCATCTCTGT 1740
GAAGTGGAGG GAATGGAAAA ATTCAAAGAC AAAGATTTCG CACTAGACGT CAGTGCTAAC 1800
CAGCCTGTCC TGGTGGCCGT GAAAATGCTT CGAGCAGATG CCAACAAGAA TGCCAGGAAT 1860
GATTTTCTTA AGGAGATAAA GATTATGTCT CGGCTCAAGG ACGCAAACAT CATCCGTCTC 1920
TTAGCTGTGT GCATCACTGA GGACCCGCTC TGCATGATCA CGGAATACAT GGAAAACGGA 1980
GACCTCAATC AGTTTCTTTC TCGCCACGAG CCTCTAAGTT CTGGTTCTAG CAATGCCACA 2040
GTCAGTTACG CCAACCTCAA GTTTATGGCT ACCCAGATTG CCTCTGGGAT GAAGTACCTT 2100
TCATCTCTCA ACTTTGTCCA CCGAGATCTG GCCACACGCA ACTGCTTAGT GGGCAAGAAC 2160
TACACCATCA AGATAGCTGA CTTTGGAATG AGCAGAAACC TGTACAGTGG TGACTACTAC 2220
CGGATCCAGG GCCGGGCAGT GCTCCCCATC CGCTGGATGT CCTGGGAAAG CATCTTGCTG 2280
GGCAAATTCA CCACGGCAAG TGATGTGTGG GCCTTTGGGG TGACTCTGTG GGAGACTTTC 2340
ACCTTTTGCC AGGAGCAGCC CTATTCCCAG CTGTCGGACG AGCAGGTTAT TGAGAATACT 2400
GGAGAGTTCT TCCGAGACCA GGGGAGGCAG ATCTATCTCC CTCAACCAGC CGTTTGCCCC 2460
GACTCTGTGT ATAAGCTGAT GCTCAGTTGC TGGAGAAGAG AAACCAAGCA CCGACCATCC 2520
TTCCAAGAAA TACACCTTCT GCTTCTTCAA CAAGGAGCTG AGTGA 2565
Domain Profile
S: 1     LlikeklGeGkfgevklCevegledlkekd.....skgsallvavkslredanknarkdf  55
         L++keklGeG+fgev+lCeveg+e++k+kd     s+++++lvavk+lr+danknar+df
Q: 563   LAFKEKLGEGQFGEVHLCEVEGMEKFKDKDfaldvSANQPVLVAVKMLRADANKNARNDF  622
         789*********************************************************
S: 56    lkeikilsrlkdPnivrllgvcvrdeplclileyvenGdlnqflseheaedselakektl  115
         lkeiki+srlkd ni+rll+vc++++plc+i+ey+enGdlnqfls+he+ +s ++ ++t+
Q: 623   LKEIKIMSRLKDANIIRLLAVCITEDPLCMITEYMENGDLNQFLSRHEPLSSGSS-NATV  681
         *************************************************999876.56**
S: 116   syellvsiatqiasglkyLeslnfvhrdlatrnclvgeeftvkiadfglsrslyagdyyr  175
         sy++l+++atqiasg+kyL+slnfvhrdlatrnclvg+++t+kiadfg+sr+ly+gdyyr
Q: 682   SYANLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYR  741
         ************************************************************
S: 176   vqGravlPiRwmawesillgkfttasDvWafgvtlweiltlcreqPyeeltdeqvienag  235
         +qGravlPiRwm+wesillgkfttasDvWafgvtlwe++t+c+eqPy++l+deqvien+g
Q: 742   IQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTG  801
         ************************************************************
S: 236   elfrdqkrkvvlsrPavcpselyelllrCwrrdeseRPsfeelhkll  282
         e+frdq+r+++l++Pavcp+++y+l+l+Cwrr++++RPsf+e+h+ll
Q: 802   EFFRDQGRQIYLPQPAVCPDSVYKLMLSCWRRETKHRPSFQEIHLLL  848
         ********************************************986
Domain Sequence
(FASTA)
LAFKEKLGEG QFGEVHLCEV EGMEKFKDKD FALDVSANQP VLVAVKMLRA DANKNARNDF 60
LKEIKIMSRL KDANIIRLLA VCITEDPLCM ITEYMENGDL NQFLSRHEPL SSGSSNATVS 120
YANLKFMATQ IASGMKYLSS LNFVHRDLAT RNCLVGKNYT IKIADFGMSR NLYSGDYYRI 180
QGRAVLPIRW MSWESILLGK FTTASDVWAF GVTLWETFTF CQEQPYSQLS DEQVIENTGE 240
FFRDQGRQIY LPQPAVCPDS VYKLMLSCWR RETKHRPSFQ EIHLLL 286
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00271
EKS-ANC-00279
EKS-BOT-00289
EKS-CAE-00252
EKS-CAJ-00295
EKS-CAF-00295
EKS-CAP-00324
EKS-DAR-00636
EKS-DRM-00147
EKS-ECT-00035
EKS-EQC-00280
EKS-FEC-00275
EKS-GAM-00184
EKS-GAG-00242
EKS-GAA-00357
EKS-GOG-00288
EKS-HOS-00295
EKS-ICT-00274
EKS-LAC-00303
EKS-LOA-00299
EKS-MAM-00292
EKS-MEG-00231
EKS-MOD-00284
EKS-MUM-00320
EKS-MUP-00285
EKS-MYL-00292
EKS-NOL-00266
EKS-ORN-00376
EKS-ORC-00271
EKS-ORL-00347
EKS-OTG-00295
EKS-PAT-00274
EKS-PES-00257
EKS-PEM-00160
EKS-POA-00282
EKS-SAH-00271
EKS-SUS-00254
EKS-TAG-00304
EKS-TAR-00379
EKS-TEN-00374
EKS-TUB-00030
EKS-XET-00361
EKS-XIM-00368
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0038062; F:protein tyrosine kinase collagen receptor activity
GO:0031214; P:biomineral tissue development
GO:0007155; P:cell adhesion
GO:0035988; P:chondrocyte proliferation
GO:0030199; P:collagen fibril organization
GO:0003416; P:endochondral bone growth
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090091; P:positive regulation of extracellular matrix disassembly
GO:0010763; P:positive regulation of fibroblast migration
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0045669; P:positive regulation of osteoblast differentiation
GO:0045860; P:positive regulation of protein kinase activity
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046777; P:protein autophosphorylation
GO:0030500; P:regulation of bone mineralization
KEGG
rno:685781;
InterPros
IPR000421; Coagulation_fac_5/8-C_type_dom.
IPR008979; Galactose-bd-like.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00754; F5_F8_type_C; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00231; FA58C; 1.
SM00219; TyrKc; 1.
Prosites
PS01285; FA58C_1; 1.
PS01286; FA58C_2; 1.
PS50022; FA58C_3; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013