EPS-RAN-00015
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-RAN-00015
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
DSP/aDSP121.92.3E-3528168141
StatusReviewed
Ensembl ProteinENSRNOP00000004179
UniProt AccessionQ9JIM4;
Protein NameDual specificity protein phosphatase 12
Protein Synonyms/Alias Glucokinase-associated dual specificity phosphatase; GKAP;
Gene NameDusp12
Gene Synonyms/Alias Dusp12; Gkap;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000003100ENSRNOP00000004179ENSRNOT00000004179
OrganismRattus norvegicus
Functional DescriptionSeems to dephosphorylate glucokinase.
Protein Length339
Protein Sequence
(FASTA)
MLEVQSSNHG CERQAPTTSP ASSAGHAVEV RPGLYLGGAA AVAGPDYLRE AGITAVLTVD 60
SEPAFPAGAG FEGLQSLFVP ALDKPETDLL SHLDRCVAFI GQARSEGRAV LVHCHAGVSR 120
SVAVVTAFIM KTEQLTFEKA YENLQTIKPE AKMNEGFEWQ LKLYEAMGHE VHTSSAVYKQ 180
YRLQKVTEKY PELRNLPREL FAVDPTTVSQ GLKDDILYKC RKCRRSLFRR SSILDHSEGS 240
GPVAFAHKRT GLSSVLTTGN QAQCTSYFIE PVQWMESALL GVMDGQLLCP KCSAKLGSFN 300
WYGEQCSCGR WITPAFQIHK NRVDEVKTLP ALGSQTKKP 339
Nucleotide Sequence
(FASTA)
ATGTTGGAAG TACAGAGCTC TAACCATGGC TGCGAGCGTC AGGCTCCGAC TACCAGCCCC 60
GCCAGCTCGG CAGGGCACGC GGTGGAAGTG CGGCCCGGGC TGTATCTGGG TGGGGCGGCG 120
GCAGTGGCTG GACCGGACTA CCTGAGGGAG GCGGGCATCA CCGCCGTGCT GACGGTGGAC 180
TCGGAACCGG CTTTCCCGGC CGGGGCTGGT TTCGAAGGTC TCCAGAGCCT CTTCGTGCCC 240
GCGCTGGACA AACCCGAGAC CGACCTGCTC AGTCACTTGG ATCGGTGCGT GGCTTTCATC 300
GGCCAGGCTC GCTCCGAAGG CCGTGCGGTG TTGGTGCACT GTCATGCAGG AGTCAGCCGC 360
AGTGTTGCTG TAGTGACGGC TTTCATAATG AAGACCGAAC AGCTTACCTT TGAAAAAGCC 420
TATGAAAACC TCCAGACCAT CAAGCCAGAG GCTAAGATGA ATGAGGGGTT CGAGTGGCAA 480
CTGAAGCTCT ATGAGGCGAT GGGACACGAA GTCCATACCT CCAGTGCCGT TTACAAGCAG 540
TACCGTTTGC AAAAGGTGAC TGAGAAGTAT CCAGAACTTC GGAATTTGCC TCGAGAACTC 600
TTTGCTGTCG ACCCAACTAC CGTTTCACAA GGATTAAAAG ATGACATCCT CTACAAATGT 660
AGAAAGTGCA GGCGATCTTT ATTTAGACGT TCCAGCATTT TGGATCATAG TGAAGGAAGT 720
GGGCCAGTAG CCTTTGCTCA CAAGAGAACA GGACTGTCTT CCGTACTTAC CACAGGGAAT 780
CAGGCTCAGT GTACATCTTA CTTCATCGAA CCTGTGCAGT GGATGGAGTC TGCTTTGTTG 840
GGGGTTATGG ATGGACAGCT TCTTTGCCCA AAATGCAGTG CCAAGTTGGG TTCCTTTAAC 900
TGGTATGGTG AACAGTGCTC GTGTGGCCGA TGGATAACCC CTGCTTTCCA AATCCACAAG 960
AACAGAGTGG ATGAAGTGAA AACATTGCCA GCGCTGGGAT CACAAACAAA GAAACCATGA 1020
Domain Profile
S: 3     teilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvdD  62
          e+ pglylg++a +     L+++git v+++  +       P     +g + + +p+ D
Q: 28    VEVRPGLYLGGAAAVAGPDYLREAGITAVLTVDSEPAF----PAGAGFEGLQSLFVPALD  83
         5899***************************9887666....999999************
S: 63    sdvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAiea  122
         +++tdll+++d++++fi +a+++g++vlvHC+aGvsRS+++v+a++mk+e+l++++A+e+
Q: 84    KPETDLLSHLDRCVAFIGQARSEGRAVLVHCHAGVSRSVAVVTAFIMKTEQLTFEKAYEN  143
         ************************************************************
S: 123   vkrkrpsiepnegfleQLlelekkl  147
         +++ +p++++negf +QL ++e ++
Q: 144   LQTIKPEAKMNEGFEWQLKLYEAMG  168
         **********************997
Domain Sequence
(FASTA)
VEVRPGLYLG GAAAVAGPDY LREAGITAVL TVDSEPAFPA GAGFEGLQSL FVPALDKPET 60
DLLSHLDRCV AFIGQARSEG RAVLVHCHAG VSRSVAVVTA FIMKTEQLTF EKAYENLQTI 120
KPEAKMNEGF EWQLKLYEAM G 141
KeywordAcetylation; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Protein phosphatase; Reference proteome; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EPS-ANC-00020
EPS-BOT-00012
EPS-CAE-00110
EPS-CAJ-00012
EPS-CAF-00018
EPS-CAP-00012
EPS-CHH-00003
EPS-DAR-00033
EPS-DAN-00004
EPS-DRM-00043
EPS-ECT-00011
EPS-EQC-00012
EPS-FEC-00019
EPS-GAG-00020
EPS-GAA-00024
EPS-GOG-00019
EPS-HOS-00012
EPS-ICT-00013
EPS-LAC-00021
EPS-LOA-00012
EPS-MAM-00011
EPS-MOD-00011
EPS-MUM-00012
EPS-MUP-00011
EPS-MYL-00014
EPS-NOL-00016
EPS-OCP-00007
EPS-ORN-00016
EPS-ORC-00012
EPS-ORL-00023
EPS-OTG-00013
EPS-PAT-00012
EPS-POA-00018
EPS-SAH-00014
EPS-SUS-00012
EPS-TAR-00028
EPS-TUT-00012
EPS-VIP-00005
EPS-XET-00101
EPS-XIM-00031
EPS-SAC-00002
EPS-SCP-00029
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0046872; F:metal ion binding
GO:0004725; F:protein tyrosine phosphatase activity
GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity
GO:0035335; P:peptidyl-tyrosine dephosphorylation
GO:0033133; P:positive regulation of glucokinase activity
KEGG
rno:64014;
InterPros
IPR000340; Dual-sp_phosphatase_cat-dom.
IPR020422; Dual-sp_phosphatase_subgr_cat.
IPR024950; DUSP.
IPR016278; DUSP12.
IPR000387; Tyr/Dual-specificity_Pase.
Pfam
PF00782; DSPc; 1.
SMARTs
SM00195; DSPc; 1.
Prosites
PS00383; TYR_PHOSPHATASE_1; FALSE_NEG.
PS50056; TYR_PHOSPHATASE_2; 1.
PS50054; TYR_PHOSPHATASE_DUAL; 1.
Prints
Created Date20-Feb-2013