EPS-RAN-00023

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-RAN-00023

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	268.5	9.0E-80	68	366	299

Status

Unreviewed

Ensembl Protein

ENSRNOP00000004540

UniProt Accession

B1WCA0;

Protein Name

Protein Synonyms/Alias

Ppm1d protein; Protein Ppm1d; Protein phosphatase 1D magnesium-dependent, delta isoform (Predicted), isoform CRA_b;

Gene Name

Ppm1d

Gene Synonyms/Alias

Ppm1d; Ppm1d_predicted; rCG_33706;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000003329	ENSRNOP00000004540	ENSRNOT00000004540

Organism

Rattus norvegicus

Functional Description

Protein Length

598

Protein Sequence
(FASTA)

MAGLYSLGVS VFSDQGGRKY MEDVTQIVVE PEPAAEDKPA PVPRRALGLP ATPSLVGVGP 60

SGKGPAAARD PAPDAAASLP AGRCCRRRSS VAFFAVCDGH GGREAAQFAR EHLWGFIKKQ 120

KGFTSSEPAK VCAAIRKGFL ACHLAMWKKL AEWPKTMTGL PSTSGTTASV VIIRGMKMYV 180

AHVGDSGVVL GIQDDPKDDF VRAVEVTQDH KPELPKERER IEGLGGSVMN KSGVNRVVWK 240

RPRLTHSGPV RRSTVIDQIP FLAVARALGD LWSYDFFSGK FVVSPEPDTS VHTLDPQKHK 300

YIILGSDGLW NMVPPQDAIS MCQDQEEKKY LMGEQGQSCA KMLVNRALGR WRQRMLRADN 360

TSAIVICISP EVDNQGNFTN EDELFLNLTD SPTYNSQETC VMTPSPSSTP PVKSLEEDPW 420

PRLNSKDHIP ALVRSNAFSE KFLEVPAEIA RGSIQTVVMT SKDSETLEEN CPKALTLRIH 480

DSLNNTLSVG LMPTNSTNTI MDQKNLKMST PGQMKAQEVE RTPPANFKRT LEESNSGPLM 540

KKHRRNGLSR NSGAQASSLP TASQRRHSVT LTMRRRLRGQ KKMGNPLLHQ HRKTVCVC 598

Nucleotide Sequence
(FASTA)

ATGGCGGGGC TGTACTCTCT GGGAGTGAGC GTCTTCTCTG ACCAGGGCGG GAGGAAGTAC 60

ATGGAGGACG TAACTCAGAT TGTGGTGGAA CCCGAGCCCG CTGCGGAGGA CAAGCCGGCG 120

CCGGTACCCC GGCGGGCGCT CGGGCTGCCG GCGACCCCAT CTCTCGTCGG CGTCGGGCCA 180

TCGGGAAAAG GCCCGGCGGC GGCCCGCGAC CCTGCCCCGG ACGCCGCGGC CTCGCTACCC 240

GCTGGACGCT GCTGTCGCCG CCGCTCCTCG GTGGCCTTCT TCGCTGTGTG CGACGGGCAC 300

GGCGGGCGGG AGGCGGCACA GTTTGCCCGG GAGCACTTGT GGGGTTTCAT CAAGAAGCAG 360

AAAGGCTTCA CCTCGTCCGA GCCCGCCAAG GTGTGCGCTG CCATCCGCAA AGGCTTCCTC 420

GCCTGTCACC TCGCCATGTG GAAGAAACTG GCAGAATGGC CAAAGACTAT GACAGGTCTT 480

CCCAGCACGT CCGGAACAAC TGCCAGTGTG GTTATCATAC GGGGCATGAA GATGTATGTA 540

GCTCATGTAG GTGACTCTGG AGTGGTCCTT GGAATTCAGG ATGACCCAAA GGATGATTTT 600

GTGAGAGCTG TGGAGGTGAC ACAAGATCAC AAGCCAGAAC TTCCCAAGGA AAGAGAAAGA 660

ATTGAAGGAC TTGGCGGGAG TGTGATGAAC AAGTCTGGAG TGAATCGTGT AGTTTGGAAA 720

AGACCTCGGC TCACTCACAG TGGACCTGTG AGAAGGAGTA CAGTCATTGA TCAGATTCCT 780

TTCTTGGCCG TAGCAAGAGC ACTTGGTGAC TTGTGGAGCT ATGATTTCTT CAGTGGTAAG 840

TTTGTGGTGT CACCTGAACC GGACACCAGT GTCCACACAC TTGACCCCCA GAAGCACAAG 900

TATATTATCC TGGGAAGTGA TGGGCTTTGG AATATGGTTC CACCTCAAGA TGCCATCTCC 960

ATGTGCCAAG ACCAAGAGGA GAAAAAATAC TTGATGGGTG AGCAAGGACA GTCTTGTGCT 1020

AAAATGCTTG TGAATCGAGC ACTTGGCCGC TGGAGGCAGC GTATGCTTCG AGCAGATAAC 1080

ACAAGTGCCA TAGTAATCTG CATCTCTCCA GAAGTAGATA ATCAAGGGAA CTTTACCAAT 1140

GAAGATGAGC TCTTTCTGAA CCTGACTGAT AGCCCTACTT ACAACAGCCA AGAAACCTGT 1200

GTGATGACTC CTTCTCCAAG TTCTACACCA CCAGTCAAGT CACTGGAAGA AGATCCATGG 1260

CCAAGGCTGA ACTCTAAGGA CCATATACCT GCCCTTGTTC GCAGTAATGC CTTCTCAGAG 1320

AAGTTTTTAG AGGTCCCAGC TGAGATAGCT CGAGGAAGTA TCCAGACTGT AGTCATGACC 1380

TCAAAAGACT CAGAGACACT TGAAGAAAAT TGCCCCAAAG CCCTGACTTT AAGGATTCAT 1440

GATTCTTTGA ATAATACTCT GTCAGTTGGC CTCATGCCAA CCAATTCAAC AAATACTATC 1500

ATGGACCAAA AAAATTTAAA GATGTCAACT CCAGGTCAAA TGAAAGCTCA AGAAGTTGAA 1560

AGAACCCCTC CAGCCAATTT TAAAAGGACA TTAGAAGAAT CCAACTCTGG TCCCCTTATG 1620

AAGAAGCATC GACGAAATGG CTTAAGTCGA AATAGCGGGG CCCAAGCTTC GAGTCTCCCC 1680

ACAGCATCCC AGCGCAGGCA CTCTGTCACA CTGACCATGA GGCGCAGACT CCGGGGCCAG 1740

AAGAAGATGG GGAATCCTCT TTTACATCAG CACCGGAAAA CAGTGTGTGT GTGCTGA 1797

Domain Profile

S: 18    avtsspnflkspekkdr......laffgvyDGhggsevakfcseklheilaeelessese  71

         a++++p++++s  + ++      +aff+v+DGhgg+e+a+f++e+l+ ++++++ +++se

Q: 68    ARDPAPDAAASLPAGRCcrrrssVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSE  127

         55566666666666666677777*************************************

S: 72    erkvkkalakaFlstdeel.....kvleeksldidksGstavvalikdsklyvanvGdSr  126

          +kv++a++k+Fl+++ ++     +++++++  +++sG+ta+v++i+++k+yva+vGdS+

Q: 128   PAKVCAAIRKGFLACHLAMwkklaEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSG  187

         ************************************************************

S: 127   avLcrngk.......avelssdHkpsredEleRieeaggsvilkdga.Rv..........  168

         +vL+ +++       ave+++dHkp+ ++E+eRie  ggsv++k+g+ Rv

Q: 188   VVLGIQDDpkddfvrAVEVTQDHKPELPKERERIEGLGGSVMNKSGVnRVvwkrprlths  247

         *****77656999999********************************************

S: 169   ...........lGvLavsRalGdlylk......pyvtpePevtshrltsede.fliLasD  210

                    +++Lav+RalGdl+++      ++v+peP++++h+l+++++ ++iL+sD

Q: 248   gpvrrstvidqIPFLAVARALGDLWSYdffsgkFVVSPEPDTSVHTLDPQKHkYIILGSD  307

         ********************************9***************************

S: 211   Glwdvvsneeavslvrdvle....kkeaeqeaakkLvklalargsk.....dnvsaivv  260

         Glw++v++++a+s+++d++e    ++e+ q++ak+Lv++al r+++     dn+saiv+

Q: 308   GLWNMVPPQDAISMCQDQEEkkylMGEQGQSCAKMLVNRALGRWRQrmlraDNTSAIVI  366

         *********************************************************97

Domain Sequence
(FASTA)

ARDPAPDAAA SLPAGRCCRR RSSVAFFAVC DGHGGREAAQ FAREHLWGFI KKQKGFTSSE 60

PAKVCAAIRK GFLACHLAMW KKLAEWPKTM TGLPSTSGTT ASVVIIRGMK MYVAHVGDSG 120

VVLGIQDDPK DDFVRAVEVT QDHKPELPKE RERIEGLGGS VMNKSGVNRV VWKRPRLTHS 180

GPVRRSTVID QIPFLAVARA LGDLWSYDFF SGKFVVSPEP DTSVHTLDPQ KHKYIILGSD 240

GLWNMVPPQD AISMCQDQEE KKYLMGEQGQ SCAKMLVNRA LGRWRQRMLR ADNTSAIVI 299

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0009617	; P:response to bacterium

KEGG

rno:287585

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013