EPS-RAN-00010

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-RAN-00010

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	152.9	6.6E-45	133	278	146

Status

Unreviewed

Ensembl Protein

ENSRNOP00000004965

UniProt Accession

D3ZRM0;

Protein Name

Protein Synonyms/Alias

Protein Dusp27;

Gene Name

Dusp27

Gene Synonyms/Alias

Dusp27;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000003722	ENSRNOP00000004965	ENSRNOT00000004965

Organism

Rattus norvegicus

Functional Description

Protein Length

1137

Protein Sequence
(FASTA)

MATSGDTEEE QVVPNEEDEA DVRAVQAHYL RSPSPSQYSV VSDAETESIF MEPIHLSSAV 60

AAKQIINEEL KPRGLRTDTE CPGMLESAEQ LLVEDLYNRV REKMDDKSLF NTPCVLDLQR 120

ALIQDRQEAP RNEVDEVWPN VFIAEKSVAV NKGRLKRLGI THILNAAHGT GVYTGPEFYT 180

GLEIQYLGVE VDDFPEVDIS QHFRKAAEFL DEALLTYRGK VLVSSEMGIS RSAVLVVAYL 240

MIFHNMAILE ALMTVRRKRA IYPNDGFLKQ LRELNEKLME EREEEDDEEE PEEDAGSTLG 300

ARVNSLMVEE EDDATSHLSG SSLGKASQVS QPVTLIDEEE EERLYEEWRK GQGFPKAEAS 360

QGRKGSCSAS SEQDGDDCED GAVERIIQEW QSRNERYQAK GHKQWNREED EEEENSYTSR 420

RRRHTLSESS ASESVSSHDI RVLKQQLKRT SQSRHDRHRS DSESTESTWD MWNERLVEIE 480

KEAARKYRSK SKREELDADS EAGSRVREDD EESVLSEASS FYNFCSRNKD KLTALERWKV 540

KRIQFGFHKK DSEVVDAGSE DGTEEATGEK NLSDVNLTAY QAWKLKHQKK VGNENKEEVV 600

EMSKGEDTAL AKKRQRRLEL LERSRQTLEE SRSMGSWEGD SSTASRSIPL SAFWSAAPSV 660

SVDGDTASVL SAQSQHSHLS QPASNMPTTP LPNLPVGPGD TISIASIQNW IASVVNETLA 720

QKQNEMLTLS RAPSVASMRA APAASCLGDD QLSVLSTSLS GCLPPQSQGR PSSDVQSVLS 780

STSSLTSRAE GSENKVRGTS KPIYSLFADN VNLKELGRKE KEMQMELQEK MSEYKMEKLA 840

SDNKRSSLFK KKKAKDDEDI SVGDRDEDTD SAIGSFRYSS RSNSQKPETD ASSSLAISDH 900

FRNGRSVGNE VGSNINTWLS GLRMEEKSPP QSDWSGSSRG RYSRSSLFRE TESKSCSYKF 960

SKSRSQEQDS SFHETDGNTV RNTSRFSSST TKEGREMHKF SRSTFSETSS SREESPEPYF 1020

FRRTPEPSDG EESPELRRPN WTRPRDWEDV EESSKSDFAE FGAKRKFTQS FMRSEEEGEK 1080

ERTENREEGR FASGRQSQYR RSTNRQEEEE MDDEAIIAAW RKRQEETRTK LQRRRED 1137

Nucleotide Sequence
(FASTA)

ATGGCTACCA GTGGAGACAC AGAGGAGGAG CAGGTAGTTC CAAACGAGGA GGATGAAGCC 60

GACGTGAGAG CTGTACAGGC CCACTACCTC CGGAGTCCCT CCCCAAGCCA GTACTCAGTG 120

GTCTCAGACG CAGAAACTGA AAGTATTTTC ATGGAGCCCA TCCATCTCTC CTCGGCCGTA 180

GCTGCCAAGC AGATCATCAA CGAAGAACTC AAGCCTCGGG GTCTCAGAAC AGACACGGAG 240

TGCCCAGGCA TGCTGGAGTC TGCTGAACAG CTGCTGGTGG AAGACCTGTA CAACCGTGTC 300

CGGGAGAAGA TGGATGACAA AAGCCTGTTC AACACCCCCT GTGTGCTGGA CCTGCAGCGG 360

GCACTGATCC AGGACCGGCA AGAGGCCCCT CGGAATGAGG TGGACGAGGT CTGGCCCAAC 420

GTCTTCATAG CTGAGAAGAG TGTGGCTGTG AACAAGGGGC GACTGAAAAG GCTGGGAATC 480

ACCCACATCC TGAACGCTGC CCATGGCACT GGCGTTTACA CTGGTCCCGA ATTCTACACT 540

GGCCTGGAGA TCCAGTACCT GGGGGTGGAA GTGGATGATT TCCCAGAGGT GGACATCTCC 600

CAGCATTTCC GGAAGGCAGC TGAGTTTCTT GATGAAGCCC TGCTGACCTA TAGAGGGAAA 660

GTCCTGGTCA GCAGTGAGAT GGGTATCAGC AGGTCAGCAG TGCTGGTGGT CGCCTACCTG 720

ATGATCTTCC ACAACATGGC CATCCTGGAA GCCTTGATGA CTGTCCGCCG AAAGCGGGCT 780

ATCTACCCCA ACGACGGCTT CCTCAAACAG CTGCGGGAGC TCAACGAGAA ACTGATGGAG 840

GAGAGGGAAG AAGAGGATGA TGAAGAGGAG CCTGAGGAGG ATGCCGGGAG CACACTGGGT 900

GCTAGAGTAA ATTCCTTGAT GGTGGAAGAA GAAGATGATG CCACCAGCCA CCTGAGTGGC 960

TCCTCCTTGG GGAAGGCCAG CCAGGTCTCC CAGCCAGTCA CCCTCATTGA TGAAGAGGAG 1020

GAAGAGAGGC TGTATGAGGA GTGGAGGAAG GGGCAGGGCT TCCCCAAGGC TGAGGCTTCT 1080

CAGGGTAGAA AGGGTAGCTG TTCTGCGTCC TCCGAGCAAG ACGGGGACGA CTGTGAGGAT 1140

GGGGCTGTGG AGAGGATAAT CCAGGAGTGG CAGAGCCGAA ATGAGAGGTA CCAAGCCAAA 1200

GGGCACAAGC AGTGGAATCG GGAGGAAGAC GAGGAGGAAG AGAACTCCTA CACCAGCAGA 1260

AGGCGCAGAC ACACCCTAAG CGAGAGCAGC GCCTCTGAGA GCGTGAGCAG CCATGACATC 1320

CGGGTCCTGA AGCAGCAACT GAAGAGGACC AGCCAAAGCC GCCACGACAG ACACCGCTCT 1380

GACTCCGAGT CCACGGAGAG CACCTGGGAC ATGTGGAACG AGAGGCTGGT GGAGATCGAG 1440

AAGGAGGCTG CCCGGAAGTA TCGCTCCAAG AGCAAGAGGG AGGAGCTGGA TGCCGATTCA 1500

GAGGCAGGGA GCAGGGTCCG AGAGGACGAT GAGGAGAGTG TATTGTCCGA GGCCAGCTCC 1560

TTCTACAACT TCTGCAGTAG GAACAAGGAC AAGCTCACTG CCCTGGAAAG GTGGAAGGTT 1620

AAGAGAATCC AATTTGGATT TCACAAGAAA GACTCAGAGG TGGTAGACGC GGGCAGTGAG 1680

GATGGTACGG AAGAGGCAAC AGGAGAGAAG AACCTTTCTG ATGTCAACCT GACAGCCTAC 1740

CAGGCCTGGA AGCTGAAACA CCAGAAGAAG GTGGGCAATG AGAACAAGGA GGAGGTGGTT 1800

GAGATGAGCA AAGGAGAGGA CACAGCCTTA GCTAAGAAGA GACAACGGAG ACTAGAGTTA 1860

CTGGAGAGAA GCAGGCAGAC GCTGGAGGAG AGCCGGTCCA TGGGAAGCTG GGAGGGAGAC 1920

AGCTCAACTG CCAGCAGGAG CATCCCCCTG TCTGCATTCT GGTCTGCAGC CCCCTCTGTC 1980

AGTGTGGATG GGGACACAGC GTCAGTACTC AGCGCCCAGA GCCAGCATTC TCACCTGTCT 2040

CAGCCTGCAA GTAACATGCC CACCACACCC CTGCCTAACC TGCCAGTGGG TCCGGGAGAC 2100

ACCATTTCCA TTGCCAGTAT CCAGAACTGG ATCGCCAGTG TCGTCAATGA AACCCTTGCC 2160

CAAAAGCAAA ACGAAATGCT CACGTTGTCC CGCGCCCCCT CTGTTGCAAG CATGAGGGCA 2220

GCTCCAGCAG CCAGCTGCCT TGGGGATGAC CAACTCTCGG TGCTCAGCAC CTCCCTGAGT 2280

GGCTGCCTAC CGCCTCAGAG CCAGGGGAGA CCCAGCTCCG ACGTGCAATC TGTGCTGTCC 2340

TCCACCAGCT CCCTGACCTC CAGGGCTGAA GGCAGTGAGA ACAAAGTGAG AGGGACCAGC 2400

AAGCCCATCT ACAGCCTCTT TGCTGACAAC GTGAACCTGA AGGAGCTCGG CCGGAAGGAG 2460

AAAGAAATGC AGATGGAGCT GCAGGAGAAG ATGTCCGAAT ATAAAATGGA GAAGCTGGCC 2520

TCTGATAACA AGCGTAGCTC TCTCTTCAAG AAGAAGAAGG CCAAGGACGA CGAGGACATC 2580

AGCGTGGGTG ACAGAGACGA GGACACAGAC AGTGCCATTG GAAGCTTCCG GTATTCCTCC 2640

CGAAGTAATT CCCAGAAGCC TGAGACAGAT GCCTCCTCCT CTCTGGCCAT CTCCGATCAC 2700

TTTAGAAATG GCCGCAGCGT GGGCAACGAG GTAGGTAGCA ATATTAATAC ATGGCTCAGT 2760

GGCCTCAGGA TGGAAGAAAA ATCTCCTCCT CAAAGTGATT GGTCTGGAAG CTCCAGGGGG 2820

AGGTACTCCA GGTCTTCCCT GTTCCGGGAA ACAGAGTCTA AATCCTGCAG TTACAAGTTC 2880

TCCAAATCTA GGTCACAGGA ACAGGACTCC TCCTTCCACG AAACCGATGG CAACACTGTG 2940

CGAAACACCT CCCGGTTCTC CTCTTCCACC ACCAAGGAGG GCAGAGAGAT GCACAAGTTC 3000

TCCAGGTCCA CATTCAGCGA GACCTCGAGC TCCCGAGAGG AGAGCCCAGA ACCCTATTTC 3060

TTCCGCCGAA CCCCTGAACC GTCCGATGGG GAAGAGTCCC CCGAGCTAAG GCGTCCAAAC 3120

TGGACCAGGC CCAGGGATTG GGAAGACGTA GAAGAGTCAT CTAAATCAGA CTTCGCTGAG 3180

TTTGGGGCCA AGAGGAAATT CACCCAGAGC TTCATGAGGT CTGAAGAGGA GGGAGAGAAG 3240

GAGAGGACAG AAAACCGAGA GGAAGGGAGG TTTGCATCTG GGCGTCAGTC CCAGTATCGG 3300

AGAAGCACAA ACCGGCAAGA GGAAGAAGAA ATGGATGATG AAGCCATCAT TGCTGCTTGG 3360

AGAAAGCGGC AAGAAGAAAC CAGAACCAAA CTGCAAAGAA GGAGAGAGGA CTGA 3414

Domain Profile

S: 1     evteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipv  60

         ev+e++p+++++++ +a+++  L++lgit+++na++++    ++Pe+++  +i+y++++v

Q: 133   EVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGV-YTGPEFYTGLEIQYLGVEV  191

         69**********************************8765.79*****************

S: 61    dDsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdA  119

         dD ++ d++q+f++aaef+dea  + +gkvlv +++G+sRSa+lv+aYLm+++++++ +A

Q: 192   DDFPEVDISQHFRKAAEFLDEAlLTYRGKVLVSSEMGISRSAVLVVAYLMIFHNMAILEA  251

         **********************8999**********************************

S: 120   ieavkrkrpsiepnegfleQLlelekkl  147

         +++v+rkr +i+pn+gfl+QL+el++kl

Q: 252   LMTVRRKR-AIYPNDGFLKQLRELNEKL  278

         ********.***************9987

Domain Sequence
(FASTA)

EVDEVWPNVF IAEKSVAVNK GRLKRLGITH ILNAAHGTGV YTGPEFYTGL EIQYLGVEVD 60

DFPEVDISQH FRKAAEFLDE ALLTYRGKVL VSSEMGISRS AVLVVAYLMI FHNMAILEAL 120

MTVRRKRAIY PNDGFLKQLR ELNEKL 146

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

rno:498267

;

InterPros

IPR020417	; Atypical_DUSP.
IPR020405	; Atypical_DUSP_famA.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

PR01908	; ADSPHPHTASE.
PR01909	; ADSPHPHTASEA.

Created Date

20-Feb-2013