EKS-RAN-00204

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00204

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	464.3	1.4E-139	13	297	285

Status

Unreviewed

Ensembl Protein

ENSRNOP00000067316

UniProt Accession

E1U7Q0;

Protein Name

Protein Synonyms/Alias

Cyclin-dependent kinase-like 5;

Gene Name

Cdkl5

Gene Synonyms/Alias

Cdkl5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000003742	ENSRNOP00000005061	ENSRNOT00000005061
ENSRNOG00000003742	ENSRNOP00000067316	ENSRNOT00000072627

Organism

Rattus norvegicus

Functional Description

Protein Length

877

Protein Sequence
(FASTA)

MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN EEVKETTLRE 60

LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL EEMPNGVPPE KVKSYIYQLI 120

KAIHWCHKND IVHRDIKPEN LLISHNDVLK LCDFGFARNL SEGNNANYTE YVATRWYRSP 180

ELLLGAPYGK SVDMWSVGCI LGELSDGQPL FPGESEIDQL FTIQKVLGPL PSEQMKLFYS 240

NPRFHGLRFP AVNHPQSLER RYLGILNSVL LDLMKNLLKL DPADRYLTEQ CLNHPTFQTQ 300

RLLDRSPSRS TKRKPYHVES STLSNRSQST KGGALQTHHR SNSKDIQNLS VGLPRAEEGL 360

PANESFLNGN LAGATLSPMH TKTYQASTQP GSSSKDLTNN NIPHLLSPKE AKSKTEFDFN 420

IDPKPSEGPG TKYLKSSTRS QQNRHSFMES SQSKAGTLQP SEKQSRHSYI DTIPQSSRSP 480

SYRTKAKSHG ALSDSKSVSN LSEARAQITE TNTSRYFPSS CLDLNSPTSP TPTRHTDTRT 540

LLSPSGRNNR NEGTLDSRRT TTRHSKTMEE LKLPEHMDSS HSHSLSAPHE SFSYGLGYTS 600

PFSSQQRPHR HSMYVTRDKV RAKGIDGSLS IGQGMAARAN SLQLLSPQPG EQLPPEMTVA 660

RPSVKESSRE GTSSFHTRQK SEGGVYHDPH SDDGTAPKEN RHLYNDPVPR RVGSFYRVPS 720

PRPDNSFHEN NVSTRVSSLP SDSSSGTNHS KRQPGFDPWK SPENISHSDQ LKEKEKQGFF 780

RSMKKKKKKT QTVPNTDGPD LLTLQKAIHS SSTASSRPKE WRPEKLSDLQ TQIPPPTGFL 840

ALSPRGPTGC INVELPRLLW RDKREDQSPN LPLTSIC 877

Nucleotide Sequence
(FASTA)

ATGAAGATTC CTAACATTGG TAATGTGATG AATAAATTTG AGATCCTTGG GGTTGTTGGT 60

GAAGGAGCCT ATGGAGTTGT ACTTAAATGC AGACACAAGG AAACACATGA AATTGTGGCA 120

ATCAAGAAAT TCAAGGACAG TGAAGAAAAT GAAGAAGTCA AGGAGACGAC TTTACGAGAG 180

CTTAAAATGC TTCGCACTCT CAAGCAGGAA AACATTGTGG AGCTGAAGGA AGCTTTTCGT 240

CGGAGAGGAA AACTATACCT GGTGTTTGAA TATGTTGAGA AAAATATGCT TGAATTGCTG 300

GAAGAGATGC CAAACGGAGT TCCACCTGAA AAGGTTAAAA GCTATATCTA CCAACTAATC 360

AAAGCCATCC ACTGGTGCCA CAAGAACGAC ATTGTCCACA GAGATATAAA GCCTGAAAAT 420

CTCTTAATCA GCCACAATGA TGTCCTGAAA CTGTGTGACT TTGGTTTTGC TCGGAATCTC 480

TCAGAAGGAA ACAATGCTAA TTACACAGAA TACGTGGCTA CTCGGTGGTA CCGATCTCCA 540

GAACTGCTAC TTGGAGCCCC CTATGGAAAG TCAGTGGACA TGTGGTCAGT GGGCTGTATT 600

CTTGGAGAGC TCAGTGATGG ACAGCCCTTA TTTCCTGGGG AAAGTGAAAT TGACCAACTC 660

TTTACTATTC AGAAGGTGCT AGGACCACTT CCGTCTGAGC AGATGAAGCT CTTCTACAGT 720

AATCCTCGTT TCCATGGGCT CCGGTTTCCA GCTGTTAACC ATCCTCAGTC ATTAGAGAGA 780

CGATACCTTG GAATTTTAAA TAGTGTTTTA CTTGACCTAA TGAAGAATTT ACTGAAGTTG 840

GACCCAGCTG ACAGATACTT GACGGAGCAG TGTTTGAATC ACCCTACATT TCAAACTCAG 900

AGACTTTTGG ACCGGTCTCC TTCAAGGTCA ACAAAAAGGA AGCCTTACCA TGTGGAAAGC 960

AGCACACTGT CTAATAGAAG CCAATCCACC AAGGGTGGTG CTTTACAGAC TCATCACAGA 1020

TCCAACAGCA AGGACATTCA GAACTTAAGT GTGGGTCTGC CCAGAGCTGA GGAAGGCCTG 1080

CCTGCAAATG AAAGCTTCCT AAATGGAAAC CTTGCTGGAG CAACTCTCAG TCCAATGCAC 1140

ACCAAAACGT ACCAAGCAAG TACCCAGCCT GGGTCTTCCA GCAAAGATCT CACAAACAAC 1200

AATATACCGC ACCTTCTCAG TCCAAAAGAA GCCAAGTCCA AAACAGAGTT TGACTTCAAT 1260

ATTGACCCAA AGCCTTCAGA AGGTCCAGGC ACAAAGTACC TCAAGTCCAG CACCAGATCT 1320

CAACAGAACA GACACTCATT CATGGAAAGT TCCCAGAGCA AAGCTGGGAC ACTGCAGCCT 1380

AGTGAGAAGC AGAGTCGGCA CAGCTATATT GACACCATCC CCCAGTCTTC CAGGAGTCCA 1440

TCCTACAGGA CAAAGGCCAA AAGCCATGGG GCTTTGAGTG ACTCCAAGTC TGTGAGCAAC 1500

CTTTCAGAAG CCAGAGCCCA AATCACAGAG ACTAATACCA GTAGATATTT CCCATCCAGT 1560

TGTTTGGACT TGAACTCTCC CACCAGCCCA ACACCCACCA GGCACACTGA TACGAGAACT 1620

TTGCTCAGCC CTTCCGGGAG AAATAATCGA AATGAGGGCA CTCTGGACTC CCGGCGAACC 1680

ACCACCAGAC ACTCAAAAAC CATGGAAGAG TTGAAGCTGC CTGAACACAT GGATAGCAGC 1740

CATTCACATT CGCTGTCTGC ACCTCATGAA TCATTTTCTT ATGGGCTAGG CTATACCAGC 1800

CCCTTCTCCT CTCAACAACG TCCTCACAGG CATTCCATGT ATGTGACCCG GGACAAAGTG 1860

AGAGCTAAAG GCATTGACGG AAGCTTGAGC ATAGGGCAAG GGATGGCAGC CAGAGCCAAC 1920

AGCTTGCAGC TGTTATCACC CCAGCCTGGA GAACAGCTTC CTCCAGAAAT GACTGTGGCA 1980

AGACCTTCTG TAAAAGAGTC CTCCCGAGAA GGCACCTCTT CGTTCCACAC CCGTCAGAAA 2040

TCTGAGGGTG GAGTATACCA TGACCCACAC TCTGACGACG GCACGGCTCC CAAAGAAAAT 2100

CGGCATCTGT ACAATGATCC TGTCCCAAGG AGAGTTGGTA GCTTTTATAG AGTGCCATCT 2160

CCACGACCAG ACAATTCTTT CCATGAAAAT AATGTGTCCA CTCGAGTTTC TTCTCTGCCA 2220

TCGGATAGTA GTTCTGGCAC AAATCATTCA AAAAGACAAC CAGGATTTGA TCCGTGGAAA 2280

AGTCCTGAAA ACATTAGTCA TTCCGATCAA CTCAAAGAAA AGGAGAAGCA AGGCTTTTTC 2340

AGGTCAATGA AAAAGAAAAA GAAGAAAACT CAAACAGTGC CCAACACTGA TGGTCCTGAT 2400

TTATTGACCT TACAGAAAGC CATTCATTCT TCTAGCACTG CAAGCAGCAG ACCAAAGGAG 2460

TGGCGACCTG AAAAGCTTTC AGATCTACAG ACCCAGATTC CCCCACCTAC TGGTTTCCTG 2520

GCCCTCAGCC CCAGAGGACC TACTGGTTGC ATAAACGTCG AGTTGCCAAG ACTTTTGTGG 2580

AGAGATAAAA GAGAGGATCA AAGCCCAAAT CTGCCACTGA CGAGCATCTG CTAA 2634

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         +e lg+vGeG+yGvvlkcr+k+t++ivaikkf++se+++evk+++lre+k+l++lk+en+

Q: 13    FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI  72

         799*********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         v+l+e+frr+ klylvfeyv+k++l+ le++pnGv+ e+vk+++yq++kai++chkn+i+

Q: 73    VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIV  132

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarlla.apgdvytdyvatrwyrapellvgdtkyGks  179

         hrdikpen+lis+++v+klcdfGfar+l+ +++++yt+yvatrwyr+pell+g + yGks

Q: 133   HRDIKPENLLISHNDVLKLCDFGFARNLSeGNNANYTEYVATRWYRSPELLLG-APYGKS  191

         ****************************98999********************.9*****

S: 180   vdvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpe  239

         vd+w++Gc+l el++G+plfpg+s++dql++i+k+lG+l ++++k+f++n++f+G+++p+

Q: 192   VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPA  251

         ************************************************************

S: 240   vedleslekkyp.klnevlldllkkclkldpaerlsceellkheyf  284

         v++++sle++y   ln+vlldl+k++lkldpa+r+++e++l+h++f

Q: 252   VNHPQSLERRYLgILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF  297

         ***********9899****************************998

Domain Sequence
(FASTA)

FEILGVVGEG AYGVVLKCRH KETHEIVAIK KFKDSEENEE VKETTLRELK MLRTLKQENI 60

VELKEAFRRR GKLYLVFEYV EKNMLELLEE MPNGVPPEKV KSYIYQLIKA IHWCHKNDIV 120

HRDIKPENLL ISHNDVLKLC DFGFARNLSE GNNANYTEYV ATRWYRSPEL LLGAPYGKSV 180

DMWSVGCILG ELSDGQPLFP GESEIDQLFT IQKVLGPLPS EQMKLFYSNP RFHGLRFPAV 240

NHPQSLERRY LGILNSVLLD LMKNLLKLDP ADRYLTEQCL NHPTF 285

Keyword

ATP-binding; Kinase; Nucleotide-binding; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0032839	; C:dendrite cytoplasm
GO:0044294	; C:dendritic growth cone
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0001764	; P:neuron migration
GO:0045773	; P:positive regulation of axon extension
GO:0050775	; P:positive regulation of dendrite morphogenesis
GO:0032855	; P:positive regulation of Rac GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013