EKS-RAN-00406

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00406

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	333.9	1.0E-99	1035	1298	264

Status

Unreviewed

Ensembl Protein

ENSRNOP00000005244

UniProt Accession

F1LVM0;

Protein Name

Protein Synonyms/Alias

Protein RGD1566400;

Gene Name

Map3k19

Gene Synonyms/Alias

Map3k19; RGD1566400, Ysk4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000003952	ENSRNOP00000005244	ENSRNOT00000005244

Organism

Rattus norvegicus

Functional Description

Protein Length

1302

Protein Sequence
(FASTA)

ERHAESLLDI CHEAGSTPMD MTVSKTENIT LQSISSSSSE DFALDDDFSP SILAGEGTAP 60

RGEGWPRRTE GVEILVTMFP PDSPQEASQE DLTESSQVTS ERPEWGPGHP VSPAKEVEMV 120

GLTSRMLTTQ PSLLKTEGGS QELCGADVAL SPPRPCLDPS TAIAAVREEA PHVLKVQPRK 180

SDKFPTSDMR YSSRRTELPL PPPSLLPMRS SVFNMEKSPK FPRHGERKVP SLSLSVPKLL 240

EPLSQPLSQS AEFSSAKNQQ EVTWEGPPEH TLRGSDWAIW SRNLCSFRKS RKQRGVAESW 300

RSQETKGGDK TETSGFEEGP FLFSCGSVKE DTAPIERERD SGCHISEISG REDSQYLLSG 360

EKESWTDRAV EKDLEVEHPF LSELLEASNT KITLAEEKEI GNEKVPDSES NSVHRAGTVQ 420

PHAVLEELSV PKNIPRMNSD GPITGLLEGH GDTEENRKLP IEEETNPEMN GAVPLVHITF 480

PGEGTPKGPA RAKPNLQRRK HPVQSSGSPN ILARQEHGKL QTNTHRTKAR NRPPPNLMVS 540

IQASIKPNVR KNSIKTQVFP ALEFMDHRPH PPSKFQRRAP VTEKKSMCQT QKPKKQAFPH 600

ICKNAGIKKP GVVLSVETTD PRLHFLDLKY SDMFKEINSA SNGPGIYEMF GTPVYSHIRE 660

AERHEHRHYH EICAAPSGRS VGNKCQPSQS DRCANSRARL LQKRPHVKPP KPSLGLKQKH 720

RGLISKDKGC KGMGGHVEDS VSEPGWQTRP SANDSLSSKD EAQLTHLTLI PETSPEQRET 780

PPLSDLSIVE EIFTEECADE EGILHNDSLT QSLGDLKALE GLHPQTPLVP SEDSWAVLSE 840

KHSGKHVSPG KHDVGPLDKI NADQMFTGYL EFDSLSDKSK TRVSFSRYSF QEKPESAPSP 900

TEQPWAHSLD QDSLEDDSTT YQRFGKVSQG ILDPGKNEEL TDELLGCLVE ELLAIDEKDN 960

NSCRIMTNEA DTRDLNLVFG RRGNTIEGLD RETTDVKLQR CINGFQIYDE ENFLTSYEER 1020

TLSDNSLKHE EAIFWTKGEI LGRGAYGTVY CGLTSLGQLI AVKQVALDST DKLATEKEYR 1080

KLQEEVDLLK ALKHVNIVAY LGTCLEENTL SIFMEFVPGG SISSIINRFG PLPETVFCKY 1140

TRQILQGVAY LHENCVVHRD IKGNNVMLMP TGIIKLIDFG CAKRLAWAGL NGTHSDMLKS 1200

MRGTPYWMAP EVINESGYGR KSDIWSIGCT VFEMATGKPP LASMDRMAAM FYIGAHRGLM 1260

PPLPDRFSEP AADFVRLCLT RDQHERPSAL QLLTHAFMLR SQ 1302

Nucleotide Sequence
(FASTA)

GAAAGACATG CCGAGTCACT GCTTGACATC TGTCACGAGG CAGGCTCTAC TCCAATGGAT 60

ATGACAGTTT CCAAAACGGA AAATATCACC TTGCAGAGCA TCAGCAGCAG CAGCAGCGAG 120

GACTTTGCCC TTGACGATGA CTTCAGTCCA TCCATATTGG CTGGGGAAGG AACAGCTCCC 180

CGGGGTGAAG GCTGGCCACG AAGGACAGAA GGTGTTGAGA TTCTTGTGAC GATGTTTCCA 240

CCAGATTCTC CCCAAGAAGC AAGCCAGGAA GATTTGACAG AAAGCAGTCA GGTGACTTCA 300

GAGCGTCCGG AGTGGGGACC AGGGCATCCT GTCTCTCCAG CGAAGGAAGT GGAGATGGTG 360

GGCCTCACGT CAAGGATGTT AACTACACAG CCTTCACTTC TGAAGACAGA AGGGGGATCT 420

CAGGAGCTCT GTGGGGCAGA TGTGGCTCTC TCACCACCAA GGCCTTGCTT AGACCCAAGC 480

ACGGCTATAG CTGCAGTCAG GGAGGAGGCT CCTCATGTTC TGAAAGTGCA GCCAAGAAAA 540

TCCGACAAGT TTCCTACCTC TGACATGAGA TACAGTAGCC GAAGAACTGA GCTCCCTCTG 600

CCACCTCCAT CCCTCTTGCC CATGAGATCG TCTGTCTTCA ATATGGAAAA AAGCCCCAAG 660

TTCCCAAGAC ACGGGGAGAG AAAGGTCCCC AGCCTCAGCC TGTCTGTGCC TAAGCTCCTG 720

GAGCCCCTTA GCCAACCTCT TAGCCAATCT GCTGAGTTTA GTTCAGCTAA GAACCAACAA 780

GAAGTCACAT GGGAAGGACC CCCAGAACAC ACCCTCAGGG GTTCTGACTG GGCTATCTGG 840

TCTAGAAATT TGTGCTCTTT CCGGAAGAGC AGAAAACAGA GGGGAGTAGC AGAAAGTTGG 900

CGATCCCAGG AAACGAAAGG TGGGGACAAA ACTGAAACCT CTGGCTTCGA AGAAGGGCCC 960

TTTTTGTTCT CCTGTGGGAG TGTCAAGGAA GACACTGCTC CTATAGAGAG GGAAAGGGAT 1020

AGTGGCTGCC ACATTAGTGA AATCAGCGGG AGAGAGGACT CGCAATATCT TTTATCAGGA 1080

GAAAAAGAGA GTTGGACAGA TAGAGCGGTT GAGAAAGATT TGGAGGTTGA GCACCCCTTT 1140

CTCAGCGAGC TCCTGGAAGC CTCGAATACA AAAATAACCC TAGCAGAGGA GAAAGAGATC 1200

GGAAATGAGA AAGTTCCCGA TTCCGAAAGC AATTCGGTAC ACCGGGCTGG AACAGTGCAG 1260

CCACACGCAG TGTTAGAAGA GCTTAGTGTT CCTAAGAACA TACCCAGGAT GAACTCTGAT 1320

GGCCCCATCA CAGGGCTCCT AGAAGGTCAT GGAGACACAG AAGAGAACAG AAAACTGCCG 1380

ATCGAGGAAG AAACAAACCC AGAAATGAAT GGGGCAGTGC CACTTGTTCA CATCACATTC 1440

CCTGGAGAAG GGACACCCAA GGGACCTGCT AGAGCTAAAC CAAACCTCCA AAGGAGAAAG 1500

CACCCGGTGC AGAGCAGCGG TAGCCCCAAC ATACTCGCTC GACAAGAACA CGGCAAACTC 1560

CAGACAAATA CTCACAGGAC CAAGGCCAGA AACAGACCAC CTCCTAATCT CATGGTTTCC 1620

ATCCAAGCAT CCATTAAACC TAACGTGCGT AAAAACAGCA TCAAAACTCA AGTTTTCCCT 1680

GCTTTGGAAT TTATGGACCA CAGACCTCAT CCGCCATCCA AGTTTCAAAG GAGAGCACCC 1740

GTGACAGAAA AGAAGTCAAT GTGTCAGACC CAGAAACCTA AGAAGCAAGC ATTTCCTCAC 1800

ATCTGTAAAA ATGCAGGCAT AAAAAAGCCA GGCGTTGTCC TCTCTGTTGA AACAACCGAT 1860

CCAAGATTGC ACTTCCTGGA CTTGAAGTAC AGTGACATGT TCAAAGAGAT CAATTCAGCC 1920

TCCAACGGAC CAGGCATCTA TGAGATGTTT GGAACCCCTG TTTATAGTCA CATCCGAGAG 1980

GCAGAAAGGC ACGAACACAG ACATTACCAT GAGATATGTG CAGCTCCATC AGGACGAAGT 2040

GTTGGTAATA AGTGTCAGCC TTCCCAAAGT GACAGATGTG CCAACAGCAG AGCAAGACTT 2100

CTTCAGAAGA GACCTCACGT TAAACCCCCC AAGCCTTCAC TCGGGCTCAA GCAAAAGCAC 2160

AGAGGGTTAA TTTCTAAAGA TAAGGGTTGC AAGGGTATGG GGGGCCACGT AGAGGATAGC 2220

GTTTCAGAAC CAGGTTGGCA GACGAGACCT TCAGCAAATG ACTCTCTGTC TTCCAAAGAT 2280

GAGGCTCAAC TCACGCACTT GACCCTGATC CCTGAGACGT CTCCTGAACA GAGAGAAACC 2340

CCTCCTCTCT CAGATCTATC CATTGTTGAG GAAATCTTCA CGGAGGAGTG TGCAGATGAA 2400

GAAGGCATTC TTCATAATGA CAGTCTTACC CAAAGCCTTG GAGATCTGAA AGCACTTGAA 2460

GGGCTGCACC CCCAGACCCC GCTCGTTCCT TCAGAAGACA GCTGGGCTGT GCTCAGCGAG 2520

AAGCATTCAG GCAAGCATGT GTCACCAGGA AAACATGATG TAGGACCTCT TGACAAAATA 2580

AATGCTGACC AGATGTTCAC GGGTTACCTG GAGTTCGATA GCCTTTCGGA TAAGTCTAAA 2640

ACAAGGGTGA GCTTTTCCAG GTACTCTTTC CAGGAGAAGC CAGAAAGTGC ACCTTCCCCT 2700

ACAGAACAAC CCTGGGCACA TTCCTTGGAT CAGGATAGCT TAGAAGATGA CTCCACCACA 2760

TACCAAAGGT TTGGAAAGGT TTCCCAGGGA ATCTTAGACC CAGGAAAGAA TGAAGAATTG 2820

ACAGACGAGT TGCTGGGTTG TCTGGTCGAA GAACTGTTAG CAATTGACGA GAAAGATAAC 2880

AACTCTTGCC GAATAATGAC AAATGAGGCC GACACCCGGG ACCTGAATCT TGTCTTCGGC 2940

AGGAGAGGCA ACACCATCGA AGGACTGGAC AGAGAGACAA CAGATGTCAA ACTACAGAGG 3000

TGTATTAATG GATTCCAGAT ATACGATGAG GAAAACTTTC TTACCTCATA TGAAGAGAGG 3060

ACACTTTCGG ACAACAGTTT AAAACACGAA GAGGCTATAT TCTGGACCAA GGGTGAGATC 3120

CTTGGGAGAG GAGCCTATGG CACAGTATAT TGTGGGCTCA CCAGCCTGGG GCAGCTGATC 3180

GCTGTAAAGC AGGTGGCCTT GGATTCGACC GACAAACTGG CTACGGAGAA AGAATACCGG 3240

AAACTGCAGG AGGAAGTGGA TTTGCTGAAG GCGCTGAAGC ACGTAAACAT AGTGGCTTAT 3300

CTAGGGACGT GCCTGGAGGA GAACACTCTG AGCATCTTCA TGGAATTCGT CCCTGGTGGT 3360

TCCATCTCTA GCATCATAAA CCGCTTTGGG CCACTGCCTG AGACCGTGTT CTGTAAATAC 3420

ACAAGACAGA TCCTGCAGGG TGTTGCTTAT CTCCATGAGA ACTGTGTGGT GCACCGAGAT 3480

ATCAAAGGAA ACAATGTCAT GCTCATGCCA ACTGGGATAA TAAAGCTGAT CGACTTTGGC 3540

TGCGCCAAGC GTTTGGCCTG GGCAGGCTTA AATGGTACCC ACAGTGACAT GCTCAAGTCT 3600

ATGCGTGGGA CTCCGTACTG GATGGCCCCC GAGGTCATCA ACGAGTCCGG CTACGGAAGG 3660

AAATCAGATA TATGGAGCAT TGGCTGCACC GTGTTTGAGA TGGCCACGGG GAAGCCCCCT 3720

CTGGCTTCCA TGGATCGGAT GGCAGCCATG TTTTACATTG GAGCCCACAG AGGCCTAATG 3780

CCTCCCCTAC CTGACCGGTT CTCAGAACCA GCTGCGGACT TTGTGCGTTT GTGCCTGACC 3840

AGGGACCAGC ACGAGAGACC TTCTGCTCTC CAGCTCCTGA CGCACGCCTT CATGCTGAGA 3900

AGCCAGTGA 3909

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikp.ekksekkevkalkeEikllkelk  59

         w+k+e++g+G++g+vy++l+ + g+l+avK+v++++ +k +++ke+++l+eE++llk+lk

Q: 1035  WTKGEILGRGAYGTVYCGLT-SLGQLIAVKQVALDStDKLATEKEYRKLQEEVDLLKALK  1093

         89****************98.99***********8614556778****************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H niv y+G++ ee++l+if+E+v+gGs+ss+++++g+l e+v++kyt+qil+g+ayLHe

Q: 1094  HVNIVAYLGTCLEENTLSIFMEFVPGGSISSIINRFGPLPETVFCKYTRQILQGVAYLHE  1153

         ************************************************************

S: 120   kkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaae...lesltGtlaymaPEvi  176

         +++vHRDiKg+N++l+ +g++kl DFG++krla++  + ++   l+s++Gt+++maPEvi

Q: 1154  NCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGTHsdmLKSMRGTPYWMAPEVI  1213

         **********************************999988877899**************

S: 177   kkkekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakk.tkPeipeklsee  235

         +++  gygrk+DiWs+gc+v+em+tgk+P a++ +++a+mf +ga++  +P++p+++se

Q: 1214  NES--GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGAHRgLMPPLPDRFSEP  1270

         988..****************************.9**********9979***********

S: 236   gkdflekcleldpkkrpsaeeLLkhefl  263

         + df++ cl++d+++rpsa +LL+h f+

Q: 1271  AADFVRLCLTRDQHERPSALQLLTHAFM  1298

         *************************996

Domain Sequence
(FASTA)

WTKGEILGRG AYGTVYCGLT SLGQLIAVKQ VALDSTDKLA TEKEYRKLQE EVDLLKALKH 60

VNIVAYLGTC LEENTLSIFM EFVPGGSISS IINRFGPLPE TVFCKYTRQI LQGVAYLHEN 120

CVVHRDIKGN NVMLMPTGII KLIDFGCAKR LAWAGLNGTH SDMLKSMRGT PYWMAPEVIN 180

ESGYGRKSDI WSIGCTVFEM ATGKPPLASM DRMAAMFYIG AHRGLMPPLP DRFSEPAADF 240

VRLCLTRDQH ERPSALQLLT HAFM 264

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013