EKS-RAN-00119

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00119

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LRRK	370.3	6.3E-111	1883	2130	248

Status

Unreviewed

Ensembl Protein

ENSRNOP00000005438

UniProt Accession

F1LNJ1;

Protein Name

Protein Synonyms/Alias

Protein Lrrk2;

Gene Name

Lrrk2

Gene Synonyms/Alias

Lrrk2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000004048	ENSRNOP00000005438	ENSRNOT00000005438

Organism

Rattus norvegicus

Functional Description

Protein Length

2526

Protein Sequence
(FASTA)

MASGACQGCD EEEEEEALKK LIVRLNNVQE GKQIETLLQL LEDILVFTYS DRASKLFEGK 60

NVHVPLLIVL DSYMRVASVQ QVGWSLLCKL IEVCPGTLQS LIGPQDIGND WEVLGIHRLI 120

LKMLTVHHAN VNLSIVGLKA LDLLLDSGKI TLLILDEECD VFLLIFDAMH RYSANEEVQK 180

LACKALHVLF ERVSEEQLTE FVENKDYMTL LSTFRSFKRD EEIVHHVLCC LHSLAVTCSN 240

VEVLMSGNVR CYNIVVEAMK TFPTSENIQE VSCSLLHKLT LGNFFNILVL NEVHVFVVKA 300

VQRYPENVAL QISALSCLAL LTETIFLNQD LEERSETQEN SDEDSEKPFW LEPCYKALMR 360

HRKNKHVQEA ACWALNNLLM YQSSLHEKIG DEDGQFPAHR EVMLSMLMHS SSKDVFQAAA 420

HALSTLLEQN VNFRKILLAK GVYLNVLELM QRHAQVPEVA ESGCKMLSHL FEGSNPSLDT 480

VAAVIPKILT VMRTHGTSLS VQLEALRALL HFVVPGVSED SRDDSRCQPN VLRTQCFRTD 540

IHKLVLAALN RFIGNPGIQK CGLKVISSFA HLPDALEMLS LHGAVDSVLH TLQMYPDDQE 600

IQCLGLHLMG CLMTKKNFCI GTGHLLAKIL ASTLQRFKDV AEVQTTGLQT VLSMLDLSVS 660

FSKLLVHYSF DVVMFHQMSS GVLEQKDEQF LNLCCKCFAK VAVDDELKSK MLERACDQNN 720

SIMVECLLLL GADANQAKGA TSLIYQVCEK ESSPKLVELL LNSGCREQDV RKALTVSIQK 780

GDNQVISLLL RRLALDLANN SICLGGFCIG KLDPSWLGPL FPDKSSNLRK QTNAGSVLAR 840

KVLRYQMRNT LQEGVASGSE GNFSEDALAK FGEWTFIPDS SMDSVFGQSD DLDSEGSESS 900

FLVKKKSNSV SVGEVYRDLA LQRCSPNAQR HSSSLGPVFD HEDLLRRKRK ILSSDESLRS 960

SRLQSHTRQS DSSSSLASER EHITSLDLSA NELKDIDALG QKCCLSSHLE HLTKLELHQN 1020

SLTSFPQQLC ETLKCLTHLD LHSNKFATFP SFMLKMPSVI HLDASRNDIG PTVVLDPVVK 1080

CPSLKQFNLS YNQLSSIPEN LDQVVEKLEQ LLLEGNKISG ICSPLSLKEL KILNLSKNHI 1140

PSLPEDFLEA CPKVESFSAR MNFLAAMPAL PSSITSLKLS QNSFTCIPEA IFSLPHLRSL 1200

DMSHNNIEHL PGPAHWKSLN LRELIFSKNQ ISTLDLSENP HIWSRVEKLH LSHNKLKEIP 1260

PEIGRLENLT SLDVSYNLEL RSFPNEMGKL SKIWDLPLDG LHLNFDFKHI GCKAKDIIRF 1320

LQQRLKKAVP YNRMKLMIVG NTGSGKTTLL QQLMKMKKSE LGMQGATVGI DVRDWPIQIR 1380

GKRKKDLVLN VWDFAGREEF YSTHPHFMTQ RALYLAVYDL SKGQAEVDAM KPWLFNIKAR 1440

ASSSPVILVG THLDVSDEKQ RKACIGKITK ELLNKRGFPT IRDYHFVNAT EESDALAKLR 1500

KTIINESLNF KIRDQPVVGQ LIPDCYVELE KIILSERKAV PTEFPVINRK HLLQLVKEHQ 1560

LQLDENELPH AVHFLNESGV LLHFQDPALQ LSDLYFVEPK WLCKVMAQIL TVKVDGCLKH 1620

PKGIISRRDV EKFLSKKKRF PKNYMAQYFK LLEKFQIALP IGEEYLLVPS SLSDHRPVIE 1680

LPHCENSEII IRLYEMPYFP MGFWSRLINR LLEISPFMLS GRERALRPNR MYWRQGIYLN 1740

WSPEAYCLVG SEVLDSRPES FLKITVPSCR KGCILLGRVV DHIDSLMEEW FPGLLEIDIC 1800

GEGETLLKKW ALYSFNDGEE HQKILLDELM KKAEEGDLLI NPDQPRLTIP ISQIAPDLIL 1860

ADLPRNIMLN NDELEFEEAP EFLLGDGSFG SVYRAAYEGE EVAVKIFNKH TSLRLLRQEL 1920

VVLCHLHHPS LISLLAAGIR PRMLVMELAS KGSLDRLLQQ DKASLTRTLQ HRIALHVADG 1980

LRYLHSAMII YRDLKPHNVL LFTLYPNAAI IAKIADYGIA QYCCRMGIKT SEGTPGFRAP 2040

EVARGNVIYN QQADVYSFGL LLHDIWTTGN RIMEGLRFPN EFDELAIQGK LPDPVKEYGC 2100

APWPMVEKLI TKCLKENPQE RPTSAQVFDI LNSAELICLM RHIFIPKDIT VECIAATNLN 2160

SKRATLWLGC GNTEKGQLSL LDLNTERYSY EEVTDSRILC LALVHLAAEK ESWVVCGTQS 2220

GALLVINAED ETRRHTLDKM TDSVTCLYCN SFAKQSKQSH FLLVGTADGN LMIFEDKTIK 2280

CKGAAPLKTL HIGDVSTPLM CLSESMNSSE RHITWGGCGT KIFSFSNDFT IQKLIETRTN 2340

QLFSYSAFSD SNIIAVAVDT ALYIAKKNSP VVEVWDKKTE KLCELIDCVH FLKEVMVKIN 2400

KDSKHKLSYS GRVKALCLQK NTALWIGTGG GHILLLDLST RRVIRTIHNF CDSVRAMATA 2460

QLGNLKNVML VLGYKRKSTE GTQEQKEIQS CLSIWDLNLP HEVQNLEKHI EVRTELADKM 2520

RKTSVE 2526

Nucleotide Sequence
(FASTA)

ATGGCCAGTG GCGCCTGTCA GGGCTGCGAC GAGGAAGAGG AGGAGGAGGC TCTGAAGAAG 60

TTGATAGTCA GGCTGAATAA TGTCCAGGAA GGCAAGCAGA TCGAGACGTT GCTCCAGCTC 120

CTGGAGGACA TTCTGGTGTT CACCTACTCC GACCGCGCCT CCAAGTTATT TGAAGGCAAA 180

AATGTCCACG TGCCTCTGTT GATAGTCCTG GACTCCTACA TGAGAGTCGC CAGTGTGCAG 240

CAGGTGGGGT GGTCACTTCT GTGCAAATTA ATAGAAGTCT GTCCAGGGAC ATTGCAAAGC 300

TTAATAGGAC CCCAGGATAT TGGGAATGAT TGGGAAGTCC TTGGTATTCA CCGACTGATT 360

CTTAAAATGT TAACTGTTCA TCATGCCAAC GTAAACCTGT CAATAGTTGG ACTAAAAGCC 420

TTAGATCTCC TCCTAGATTC AGGTAAAATT ACTCTGCTGA TACTGGATGA AGAATGTGAT 480

GTTTTCCTGT TAATTTTTGA TGCCATGCAC AGATATTCAG CCAACGAGGA AGTCCAGAAG 540

CTTGCGTGCA AGGCTTTACA TGTGCTGTTC GAGAGAGTGT CCGAGGAGCA ACTGACTGAG 600

TTTGTGGAGA ACAAAGATTA CATGACCCTG CTGAGTACGT TCCGCAGCTT CAAGAGGGAC 660

GAGGAGATTG TGCACCATGT ACTCTGCTGC CTGCATTCTC TGGCCGTCAC TTGCAGCAAT 720

GTGGAGGTCC TCATGAGTGG GAATGTCAGG TGTTACAATA TTGTGGTGGA AGCCATGAAA 780

ACATTCCCCA CCAGTGAAAA CATTCAAGAG GTGAGCTGCT CCTTGCTCCA CAAGCTTACA 840

TTAGGTAATT TTTTCAACAT CCTGGTGTTG AACGAAGTCC ATGTCTTTGT GGTGAAAGCC 900

GTCCAGCGGT ATCCCGAGAA CGTAGCCTTA CAGATCTCTG CACTCAGCTG CTTAGCCCTC 960

CTCACCGAGA CTATTTTCTT AAACCAAGAC CTGGAAGAAA GAAGTGAGAC TCAGGAAAAC 1020

AGCGATGAGG ACAGTGAGAA GCCTTTCTGG TTGGAACCCT GCTATAAAGC CCTGATGCGC 1080

CATCGAAAGA ACAAACACGT GCAGGAGGCC GCCTGCTGGG CCCTAAATAA TCTCCTCATG 1140

TACCAGAGCA GTTTGCACGA GAAGATTGGA GATGAAGATG GCCAGTTCCC GGCGCACAGG 1200

GAAGTGATGC TGTCTATGCT GATGCACTCT TCTTCCAAAG ACGTCTTCCA AGCAGCTGCG 1260

CATGCTCTGT CCACTCTCTT GGAACAAAAC GTTAATTTCA GGAAAATCCT GCTTGCAAAA 1320

GGAGTGTACC TGAATGTCTT GGAGTTGATG CAGCGGCACG CCCAGGTTCC TGAGGTGGCA 1380

GAGAGTGGCT GCAAGATGCT GAGTCATCTG TTTGAAGGAA GCAACCCTTC TTTGGATACA 1440

GTGGCGGCAG TGATCCCCAA AATACTAACA GTGATGAGAA CCCATGGAAC GTCTCTGTCA 1500

GTCCAGCTGG AGGCACTGCG AGCTCTTCTG CATTTTGTGG TGCCGGGAGT ATCAGAAGAT 1560

TCCAGGGATG ACTCGCGATG CCAACCAAAC GTGCTCAGAA CACAGTGCTT CAGGACTGAC 1620

ATCCACAAGC TGGTTCTAGC CGCTCTGAAC AGGTTCATTG GGAATCCCGG GATTCAGAAA 1680

TGTGGATTGA AAGTCATCTC TTCTTTCGCA CATCTTCCCG ATGCCTTAGA GATGTTATCC 1740

CTGCATGGAG CAGTTGACTC AGTCCTCCAT ACCTTACAGA TGTATCCAGA TGACCAAGAA 1800

ATTCAGTGTC TGGGCTTACA CCTTATGGGA TGCCTGATGA CAAAGAAGAA TTTCTGCATA 1860

GGGACAGGGC ACCTCCTGGC AAAAATTCTG GCTTCCACCT TGCAGCGATT TAAAGATGTT 1920

GCTGAAGTAC AGACTACAGG ATTACAGACG GTCTTGTCAA TGCTTGACCT GTCCGTATCT 1980

TTCTCCAAGC TGCTAGTGCA CTATTCATTT GATGTGGTGA TGTTTCATCA GATGTCTTCC 2040

GGTGTCCTGG AACAAAAGGA TGAGCAGTTT CTCAACTTAT GCTGCAAATG CTTTGCAAAA 2100

GTGGCTGTGG ATGATGAGCT GAAAAGCAAG ATGCTAGAGA GAGCCTGCGA TCAGAACAAC 2160

AGCATCATGG TCGAATGTTT GCTCCTCTTG GGAGCCGATG CCAATCAAGC GAAGGGGGCA 2220

ACTTCTTTAA TCTATCAGGT ATGTGAGAAA GAGAGCAGCC CTAAATTGGT GGAACTATTG 2280

CTTAACAGTG GGTGCCGTGA ACAAGATGTA CGGAAAGCCC TGACAGTAAG CATCCAAAAG 2340

GGCGACAACC AGGTCATCAG CTTACTCCTG AGGAGACTTG CCCTGGACCT GGCCAACAAC 2400

AGCATTTGCC TTGGAGGATT TTGCATAGGA AAACTTGATC CTTCTTGGCT AGGCCCTTTA 2460

TTTCCAGATA AGTCATCTAA TTTGAGGAAA CAAACAAATG CGGGGTCTGT CCTAGCGAGG 2520

AAAGTGCTCC GGTATCAGAT GAGAAACACT CTTCAAGAAG GCGTGGCCTC AGGCAGTGAG 2580

GGCAACTTCT CTGAGGATGC GCTGGCGAAA TTTGGCGAAT GGACCTTCAT TCCCGACTCT 2640

TCTATGGACA GTGTGTTTGG CCAGAGTGAC GATCTGGATA GCGAAGGCAG CGAGAGCTCC 2700

TTTCTGGTGA AGAAGAAGTC CAACTCAGTT AGTGTAGGAG AAGTTTACAG GGACCTAGCT 2760

CTGCAGCGCT GCTCACCAAA TGCTCAGAGG CACTCCAGTT CCTTGGGTCC TGTTTTTGAT 2820

CACGAAGATC TACTGAGACG AAAAAGAAAA ATACTGTCCT CAGATGAGTC TCTCAGATCC 2880

TCAAGGCTGC AGTCCCATAC GAGACAATCA GATAGCTCTT CTTCTCTGGC TTCTGAGAGA 2940

GAACACATCA CGTCTTTAGA CCTTTCTGCC AACGAACTGA AAGATATTGA TGCTCTGGGC 3000

CAGAAGTGTT GCCTCAGTAG CCACCTGGAG CATCTCACCA AGCTGGAACT TCACCAGAAT 3060

TCACTCACGA GCTTCCCACA ACAGCTGTGT GAGACTCTGA AGTGCTTGAC ACATCTGGAT 3120

TTGCACAGTA ACAAATTCGC CACCTTTCCC TCCTTCATGT TGAAAATGCC AAGTGTTATC 3180

CACCTAGACG CCTCTCGAAA TGACATCGGA CCAACAGTTG TTTTAGACCC TGTGGTGAAG 3240

TGTCCAAGCC TCAAACAGTT TAACCTGTCC TACAACCAGC TCTCTTCCAT CCCAGAGAAC 3300

CTGGACCAAG TGGTGGAGAA ACTGGAGCAG CTCCTACTGG AAGGAAACAA AATATCCGGG 3360

ATTTGTTCTC CCTTGAGCCT GAAGGAACTG AAGATTTTAA ACCTTAGTAA AAACCACATT 3420

CCATCCCTAC CTGAAGACTT TCTCGAGGCT TGCCCGAAAG TGGAGAGCTT CAGTGCCCGC 3480

ATGAATTTTC TCGCTGCAAT GCCTGCCTTA CCGTCTTCCA TAACTAGCTT AAAATTGTCT 3540

CAAAACTCTT TCACGTGCAT TCCAGAAGCG ATCTTCAGTC TTCCACACTT GCGGTCCTTG 3600

GATATGAGTC ACAACAACAT TGAACACCTG CCGGGACCTG CACATTGGAA GTCTCTGAAC 3660

TTAAGGGAAC TCATTTTTAG CAAGAATCAG ATCAGCACCT TAGACTTGAG CGAAAACCCA 3720

CACATATGGT CAAGAGTAGA GAAGCTGCAT CTCTCTCATA ATAAACTGAA AGAGATTCCT 3780

CCAGAAATTG GCCGTCTTGA AAACCTGACA TCTCTTGATG TCAGTTACAA CCTGGAACTG 3840

AGGTCCTTTC CAAACGAAAT GGGGAAGTTA AGCAAAATAT GGGATCTTCC CTTGGATGGA 3900

CTGCACCTCA ACTTTGACTT TAAGCACATA GGATGCAAAG CCAAAGACAT CATAAGGTTT 3960

CTACAACAAC GTCTGAAAAA GGCCGTGCCC TACAACCGAA TGAAGCTCAT GATTGTGGGC 4020

AATACGGGGA GTGGTAAGAC CACTCTACTG CAGCAGCTCA TGAAAATGAA GAAATCAGAA 4080

CTCGGCATGC AGGGCGCCAC GGTTGGCATA GACGTGCGAG ACTGGCCCAT CCAAATACGA 4140

GGCAAAAGGA AAAAGGACCT TGTTCTAAAC GTGTGGGACT TTGCAGGCCG TGAGGAATTC 4200

TACAGCACTC ACCCCCACTT CATGACCCAG AGAGCCCTGT ACCTGGCTGT CTACGACCTC 4260

AGCAAGGGGC AGGCGGAGGT GGATGCCATG AAGCCCTGGC TCTTCAACAT CAAGGCTCGT 4320

GCCTCTTCTT CCCCGGTGAT TCTGGTGGGC ACACATTTGG ATGTTTCTGA TGAGAAGCAG 4380

CGCAAAGCCT GCATAGGCAA AATCACGAAG GAACTCCTTA ATAAGCGAGG ATTCCCCACC 4440

ATCCGGGACT ACCACTTCGT GAATGCCACT GAGGAGTCGG ATGCGCTGGC AAAGCTCCGG 4500

AAAACCATCA TAAATGAGAG TCTTAATTTC AAGATCCGAG ATCAGCCCGT GGTTGGGCAG 4560

CTAATTCCAG ATTGCTACGT AGAACTGGAG AAAATAATCT TATCGGAGCG TAAAGCTGTA 4620

CCAACGGAGT TTCCTGTAAT TAACCGGAAA CACTTACTCC AGCTGGTGAA GGAACACCAG 4680

CTGCAGCTGG ATGAGAACGA GCTCCCCCAC GCTGTTCACT TCCTGAATGA GTCAGGAGTT 4740

CTTCTGCATT TTCAAGACCC CGCATTGCAG CTGAGTGACC TGTACTTTGT GGAACCCAAG 4800

TGGCTTTGTA AAGTCATGGC ACAGATTTTG ACCGTGAAAG TGGACGGCTG CCTGAAGCAT 4860

CCTAAGGGCA TCATTTCACG GAGAGATGTG GAAAAATTCC TTTCCAAGAA AAAGCGATTC 4920

CCTAAGAACT ACATGGCGCA GTACTTCAAA CTTTTAGAAA AATTTCAGAT CGCATTACCA 4980

ATAGGGGAAG AATATCTGCT GGTTCCAAGC AGCTTATCTG ACCACAGGCC AGTGATAGAG 5040

CTCCCCCACT GTGAGAACTC TGAGATCATC ATCCGGCTGT ATGAAATGCC ATACTTTCCA 5100

ATGGGATTTT GGTCAAGATT GATTAACCGA TTACTTGAAA TCTCACCTTT CATGCTTTCT 5160

GGAAGAGAGA GAGCACTACG CCCAAACCGA ATGTACTGGC GCCAAGGCAT CTACTTGAAT 5220

TGGTCTCCAG AAGCCTACTG TCTGGTGGGC TCTGAAGTCT TAGACAGTCG CCCAGAGAGT 5280

TTCTTGAAAA TCACAGTTCC ATCTTGTAGA AAAGGTTGTA TTCTTTTGGG CCGAGTTGTG 5340

GATCATATTG ACTCACTCAT GGAAGAATGG TTTCCTGGAT TGCTGGAGAT TGACATTTGT 5400

GGGGAAGGAG AAACTTTGTT GAAAAAATGG GCATTGTATA GTTTTAATGA TGGCGAAGAA 5460

CATCAGAAGA TCTTGCTTGA TGAGTTGATG AAGAAGGCTG AAGAAGGAGA CCTGTTAATA 5520

AATCCAGATC AACCAAGGCT CACCATTCCA ATATCCCAGA TTGCTCCGGA CTTGATCTTG 5580

GCTGACCTGC CTAGAAATAT TATGTTGAAC AATGACGAAC TGGAATTTGA GGAAGCACCC 5640

GAGTTTCTCT TAGGTGATGG AAGTTTCGGA TCAGTTTATC GAGCTGCCTA CGAAGGAGAG 5700

GAAGTGGCTG TGAAGATTTT TAATAAGCAC ACATCGCTTA GGCTGTTAAG ACAAGAGTTG 5760

GTGGTACTCT GTCATCTCCA CCATCCCAGC TTGATCTCCC TGTTGGCGGC TGGGATTCGT 5820

CCTCGGATGC TGGTAATGGA GTTGGCCTCC AAGGGTTCCT TGGATCGCCT GCTGCAGCAG 5880

GACAAAGCCA GCCTCACCCG GACCCTCCAG CACAGAATCG CATTGCATGT GGCCGATGGC 5940

CTGAGATATC TGCACTCGGC CATGATTATT TACCGTGATC TGAAGCCCCA CAACGTGCTA 6000

CTCTTCACCC TGTATCCCAA TGCCGCCATC ATTGCGAAGA TTGCGGACTA CGGGATTGCA 6060

CAGTACTGCT GTAGGATGGG AATAAAGACC TCAGAGGGCA CCCCAGGGTT CCGAGCACCT 6120

GAAGTTGCCA GAGGAAATGT CATTTATAAC CAACAGGCTG ATGTTTATTC TTTTGGCTTA 6180

CTACTTCATG ATATCTGGAC AACTGGGAAT AGAATCATGG AGGGTTTGAG GTTTCCAAAT 6240

GAGTTTGATG AACTGGCCAT ACAAGGGAAA TTGCCAGACC CAGTTAAAGA ATATGGCTGT 6300

GCCCCGTGGC CTATGGTTGA GAAGTTAATT ACAAAATGTT TGAAAGAAAA TCCTCAAGAA 6360

AGACCCACTT CTGCCCAGGT CTTTGACATT TTGAATTCAG CTGAGTTAAT TTGCCTCATG 6420

CGACACATTT TCATACCTAA GGACATCACT GTTGAATGCA TAGCTGCTAC AAACCTCAAT 6480

AGCAAGCGAG CGACTCTCTG GTTGGGCTGT GGGAACACAG AAAAAGGGCA GCTTTCCTTA 6540

CTTGACTTGA ACACGGAAAG ATACAGCTAT GAGGAAGTTA CTGATAGTAG AATACTGTGC 6600

CTGGCTTTGG TGCATCTTGC TGCTGAGAAA GAGAGCTGGG TTGTGTGTGG GACACAGTCC 6660

GGAGCTCTCC TGGTCATCAA TGCTGAAGAT GAGACAAGGA GACACACCCT CGACAAGATG 6720

ACTGATTCTG TTACTTGCTT GTATTGCAAT TCCTTTGCCA AGCAGAGCAA GCAAAGTCAC 6780

TTCCTTTTGG TGGGAACTGC TGATGGCAAC TTAATGATAT TTGAAGATAA GACCATTAAG 6840

TGTAAAGGAG CTGCCCCATT GAAGACACTA CACATAGGCG ATGTCAGTAC GCCCCTGATG 6900

TGCCTGAGCG AGTCCATGAA TTCATCTGAA AGACACATCA CATGGGGAGG GTGTGGCACA 6960

AAGATCTTCT CCTTTTCCAA TGATTTCACC ATTCAGAAAC TCATCGAGAC AAGAACCAAC 7020

CAGCTGTTTT CTTACTCAGC GTTCAGCGAT TCTAACATCA TAGCGGTGGC AGTGGACACA 7080

GCGCTTTATA TTGCCAAGAA AAACAGCCCT GTCGTAGAGG TGTGGGACAA GAAGACAGAA 7140

AAACTCTGTG AACTAATAGA CTGTGTGCAC TTCTTAAAGG AGGTGATGGT GAAAATAAAC 7200

AAGGACTCGA AGCACAAGCT GTCCTACTCT GGGAGGGTGA AGGCACTCTG CCTGCAGAAG 7260

AACACAGCTC TCTGGATCGG AACTGGAGGA GGCCACATCT TACTCCTGGA TCTTTCTACA 7320

CGGCGAGTCA TCCGCACCAT CCACAATTTC TGTGATTCCG TGAGAGCCAT GGCCACAGCT 7380

CAGTTAGGCA ACCTTAAAAA TGTCATGCTG GTTTTGGGGT ACAAGCGGAA GAGTACAGAA 7440

GGAACCCAAG AACAAAAAGA GATACAATCT TGTTTGTCTA TTTGGGACCT CAATCTTCCA 7500

CATGAAGTGC AAAACTTAGA AAAACACATT GAAGTAAGAA CAGAACTGGC TGATAAAATG 7560

AGGAAAACAT CTGTCGAATA G 7581

Domain Profile

S: 6     llGrGafGsvyraavkGeevavkafkiaadklkrdslelalkayselrqelsvLlalkhP  65

         llG+G+fGsvyraa++Geevavk+f+      k++sl+l       lrqel+vL++l+hP

Q: 1883  LLGDGSFGSVYRAAYEGEEVAVKIFN------KHTSLRL-------LRQELVVLCHLHHP  1929

         79************************......*******.......**************

S: 66    sivsLvgisikPlalvleLaplgsLdrlLsedkksssklgrtltkkialqvargleyLhk  125

         s++sL++++i+P++lv+eLa++gsLdrlL++dk+s   l+rtl+++ial+va+gl+yLh+

Q: 1930  SLISLLAAGIRPRMLVMELASKGSLDRLLQQDKAS---LTRTLQHRIALHVADGLRYLHS  1986

         *********************************99...**********************

S: 126   kkiiyrdLksenvLvwslspkeailikladyGisrqslrsGakgveGteGfraPeivrge  185

         ++iiyrdLk++nvL+++l+p++ai++k+adyGi+++++r+G+k++eGt+GfraPe++rg+

Q: 1987  AMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGN  2046

         ************************************************************

S: 186   vvydekvdvfsfGlllyell.sgkrpvegeeqlkivekl.lkGkrPvlvkeeevlptpll  243

         v+y++++dv+sfGlll++++ +g+r++eg ++++++++l ++Gk+P++vke++++p+p++

Q: 2047  VIYNQQADVYSFGLLLHDIWtTGNRIMEGLRFPNEFDELaIQGKLPDPVKEYGCAPWPMV  2106

         ********************99**************************************

S: 244   d.LlveCwkekPekrPtasqvvsi  266

         + L+++C+ke+P++rPt++qv++i

Q: 2107  EkLITKCLKENPQERPTSAQVFDI  2130

         99********************96

Domain Sequence
(FASTA)

LLGDGSFGSV YRAAYEGEEV AVKIFNKHTS LRLLRQELVV LCHLHHPSLI SLLAAGIRPR 60

MLVMELASKG SLDRLLQQDK ASLTRTLQHR IALHVADGLR YLHSAMIIYR DLKPHNVLLF 120

TLYPNAAIIA KIADYGIAQY CCRMGIKTSE GTPGFRAPEV ARGNVIYNQQ ADVYSFGLLL 180

HDIWTTGNRI MEGLRFPNEF DELAIQGKLP DPVKEYGCAP WPMVEKLITK CLKENPQERP 240

TSAQVFDI 248

Keyword

ATP-binding; Complete proteome; GTP-binding; Leucine-rich repeat; Nucleotide-binding; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0032839	; C:dendrite cytoplasm
GO:0032473	; C:external side of mitochondrial outer membrane
GO:0045121	; C:membrane raft
GO:0043025	; C:neuronal cell body
GO:0005886	; C:plasma membrane
GO:0008021	; C:synaptic vesicle
GO:0005802	; C:trans-Golgi network
GO:0005524	; F:ATP binding
GO:0005525	; F:GTP binding
GO:0034211	; F:GTP-dependent protein kinase activity
GO:0005096	; F:GTPase activator activity
GO:0003924	; F:GTPase activity
GO:0004708	; F:MAP kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0008340	; P:determination of adult lifespan
GO:0035640	; P:exploration behavior
GO:0048312	; P:intracellular distribution of mitochondria
GO:2000173	; P:negative regulation of branching morphogenesis of a nerve
GO:0061002	; P:negative regulation of dendritic spine morphogenesis
GO:0034260	; P:negative regulation of GTPase activity
GO:0007406	; P:negative regulation of neuroblast proliferation
GO:0014043	; P:negative regulation of neuron maturation
GO:0007528	; P:neuromuscular junction development
GO:0070997	; P:neuron death
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0010508	; P:positive regulation of autophagy
GO:0060161	; P:positive regulation of dopamine receptor signaling pathway
GO:0043068	; P:positive regulation of programmed cell death
GO:0032436	; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398	; P:positive regulation of protein ubiquitination
GO:0046777	; P:protein autophosphorylation
GO:0035564	; P:regulation of kidney size
GO:0040012	; P:regulation of locomotion
GO:0042391	; P:regulation of membrane potential
GO:0006979	; P:response to oxidative stress
GO:0007264	; P:small GTPase mediated signal transduction
GO:0022028	; P:tangential migration from the subventricular zone to the olfactory bulb

KEGG

InterPros

IPR020683	; Ankyrin_rpt-contain_dom.
IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR011009	; Kinase-like_dom.
IPR001611	; Leu-rich_rpt.
IPR025875	; Leu-rich_rpt_4.
IPR013684	; MIRO-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020859	; ROC_GTPase.
IPR008271	; Ser/Thr_kinase_AS.
IPR005225	; Small_GTP-bd_dom.
IPR001806	; Small_GTPase.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR001680	; WD40_repeat.
IPR017986	; WD40_repeat_dom.

Pfam

PF00560	; LRR_1; 2.
PF12799	; LRR_4; 1.
PF08477	; Miro; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00320

; WD40; 2.

Prosites

PS51450	; LRR; 11.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS51424	; ROC; 1.

Prints

PR00449

; RASTRNSFRMNG.

Created Date

20-Feb-2013