EKS-RAN-00249

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00249

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	318.6	3.3E-95	16	269	254

Status

Reviewed

Ensembl Protein

ENSRNOP00000005422

UniProt Accession

Q63553;

Protein Name

SNF-related serine/threonine-protein kinase

Protein Synonyms/Alias

SNF1-related kinase;

Gene Name

Snrk

Gene Synonyms/Alias

Snrk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000004050	ENSRNOP00000005422	ENSRNOT00000005422

Organism

Rattus norvegicus

Functional Description

May play a role in hematopoietic cell proliferation ordifferentiation. Potential mediator of neuronal apoptosis.

Protein Length

746

Protein Sequence
(FASTA)

MAGFKRGYDG KIAGLYDLDK TLGRGHFAVV KLARHVFTGE KVAVKVIDKT KLDTLATGHL 60

FQEVRCMKLV QHPNIVRLYE VIDTQTKLYL ILELGDGGDM FDYIMKHEEG LNEDLAKKYF 120

AQIVHAISYC HKLHVVHRDL KPENVVFFEK QGLVKLTDFG FSNKFQPGKK LTTSCGSLAY 180

SAPEILLGDE YDAPAVDIWS LGVILFMLVC GQPPFQEAND SETLTMIMDC KYTVPPRVSA 240

GCRDLITRML QRDPKRRASL EEIESHPWLQ GVDPSPATKY NIPLVSYKNL SEEEHNSIIQ 300

RMVLGDIADR DAIVEALETN RYNHITATYF LLAERILREK QEKEIQTRSA SPSNIKAQFR 360

QSWPTKIDVP QDLEDDLTAT PLSHATVPQS PARAGDSVLN GHRSKGLCDP AKKDELPELA 420

GPALSTVPPA SLKPAASGRK CLFRVEEDEE EDEEDKKPVS LSTQVVLRRK PSVTNRLTSR 480

KSAPVLNQIF EEGESDDEFD MDENLPPKLS RLKMNIASPG TVHKRYHRRK SQGRGSSCSS 540

SETSDDDSES RRRLDKDSGL AYSWHRRDSS EGPPGSEGDG GGQSKPSGGG GVDKASPGEQ 600

GTGGSGQGGS GGTPSGTAGS SRRCAGPDSS SSSPASAAPR GAELVQSLKL VSLCLGSQLH 660

GAKYILDPQK ALLSSVKVQE RSTWKMCISA PGPGPSADLD PVRTKKLRNN VLQLPLCEKT 720

ISVNIQRSRK EGLLCASSPA SCCHVI 746

Nucleotide Sequence
(FASTA)

ATGGCAGGGT TCAAGCGAGG CTATGATGGA AAAATTGCTG GATTGTATGA TCTGGATAAA 60

ACCTTGGGTC GAGGTCACTT CGCAGTGGTC AAACTGGCCA GGCATGTCTT CACAGGTGAG 120

AAGGTGGCAG TGAAAGTCAT TGACAAGACA AAGCTGGACA CTCTAGCCAC TGGTCACCTC 180

TTCCAGGAAG TCAGGTGCAT GAAGCTAGTG CAGCACCCCA ACATCGTGCG TCTCTATGAG 240

GTCATAGACA CCCAGACCAA ACTGTATCTC ATTCTAGAAC TTGGAGATGG AGGAGATATG 300

TTTGACTACA TAATGAAGCA CGAGGAGGGT CTTAATGAAG ACTTGGCAAA GAAGTACTTT 360

GCTCAGATAG TTCACGCTAT ATCCTATTGC CATAAACTCC ATGTGGTTCA CAGAGACTTG 420

AAACCAGAGA ATGTAGTCTT TTTTGAAAAA CAAGGTCTTG TGAAGTTGAC AGACTTTGGC 480

TTCAGCAACA AGTTTCAGCC TGGAAAGAAG CTCACTACAA GCTGTGGATC TCTTGCGTAC 540

TCTGCTCCGG AAATCCTGCT TGGCGATGAG TACGATGCCC CTGCAGTAGA CATATGGAGC 600

CTGGGTGTGA TCCTTTTCAT GCTGGTGTGT GGGCAGCCGC CCTTCCAAGA AGCCAACGAC 660

AGTGAGACGC TGACCATGAT CATGGACTGC AAGTACACTG TGCCGCCCCG TGTGTCTGCA 720

GGGTGCAGGG ACCTCATCAC ACGGATGCTG CAGAGAGACC CCAAAAGGAG AGCCTCTCTG 780

GAAGAGATTG AAAGCCACCC TTGGCTCCAG GGAGTGGACC CCTCACCAGC CACCAAGTAT 840

AACATTCCCC TCGTGTCCTA CAAGAACCTC TCAGAAGAGG AGCACAATAG CATCATCCAG 900

CGCATGGTGC TTGGGGACAT CGCAGATCGA GATGCCATCG TAGAAGCCCT GGAAACCAAC 960

AGGTACAACC ACATCACCGC CACTTACTTC TTACTTGCTG AAAGGATCCT GCGAGAAAAG 1020

CAAGAGAAAG AAATACAGAC CAGGTCTGCA AGCCCCAGCA ACATCAAGGC CCAGTTCAGG 1080

CAGTCGTGGC CAACTAAAAT TGATGTTCCC CAAGACCTTG AAGATGATCT CACTGCCACC 1140

CCTCTGTCAC ATGCCACAGT CCCGCAGTCT CCTGCTCGGG CTGGTGACAG TGTCCTCAAT 1200

GGCCACAGGA GCAAAGGCCT GTGTGACCCA GCCAAGAAAG ATGAGCTCCC GGAGCTGGCG 1260

GGGCCAGCAC TGTCCACTGT TCCACCCGCA AGCCTGAAGC CCGCAGCCAG TGGGCGGAAG 1320

TGTCTCTTCA GGGTGGAAGA AGATGAAGAG GAAGATGAGG AGGACAAGAA GCCTGTGTCC 1380

CTGTCCACGC AGGTGGTGCT GCGCCGGAAG CCATCAGTCA CCAACCGCCT GACATCTCGA 1440

AAGAGTGCCC CGGTGCTCAA TCAGATCTTC GAGGAGGGCG AGTCTGACGA CGAGTTTGAC 1500

ATGGACGAGA ACCTACCACC CAAGCTGAGC CGGCTGAAGA TGAACATCGC GTCACCAGGC 1560

ACAGTGCACA AGCGCTACCA CCGCAGGAAA AGCCAGGGCC GTGGCTCGAG CTGCAGCAGC 1620

TCTGAGACCA GCGATGATGA CTCTGAGAGC CGCCGGCGGC TGGACAAGGA CAGTGGCTTG 1680

GCTTACTCGT GGCACCGGCG TGACAGCAGT GAGGGGCCAC CAGGCAGTGA GGGCGATGGT 1740

GGCGGTCAGA GCAAACCTAG CGGCGGTGGT GGTGTGGACA AGGCGAGTCC AGGAGAGCAG 1800

GGCACGGGCG GCAGTGGCCA GGGAGGCTCA GGTGGGACCC CATCGGGTAC AGCAGGTTCC 1860

TCCAGGCGCT GTGCAGGCCC TGACTCCTCC TCATCCTCCC CCGCCTCTGC CGCTCCACGT 1920

GGTGCAGAGC TTGTGCAGAG CCTCAAACTC GTGAGCCTGT GTCTAGGCTC GCAGCTCCAT 1980

GGCGCCAAGT ACATTCTGGA CCCGCAGAAG GCCTTGTTGT CCAGCGTGAA GGTGCAGGAG 2040

AGGTCCACTT GGAAGATGTG CATCAGTGCC CCAGGCCCCG GCCCCTCTGC TGACCTTGAC 2100

CCTGTGAGGA CCAAGAAGCT GAGGAACAAC GTGCTCCAGC TACCTCTGTG CGAGAAGACC 2160

ATCTCCGTGA ACATCCAACG CAGCCGCAAG GAAGGGCTGC TCTGCGCCTC CAGCCCCGCC 2220

AGCTGCTGCC ACGTCATCTG A 2241

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+l ktlG+g+f+ Vkla+h  t+ekvavK+i+k+kl++ ++ ++++E++++k ++hpni

Q: 16    YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNI  75

         8999********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgr.lkekearklfkqlvsavkYlhskgi  119

         ++l+evi+t++klyl+le+ +gg++fdyi ++++ l+e+ a+k+f+q+v+a++Y+h+ ++

Q: 76    VRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEgLNEDLAKKYFAQIVHAISYCHKLHV  135

         *****************************988765*************************

S: 120   vHrDlKpeNllldkke.nikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpk  178

         vHrDlKpeN+++ +k+  +k++DFG++n+f++gk+l+t+cGs++Y aPe+l g++Y++p+

Q: 136   VHRDLKPENVVFFEKQgLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPA  195

         *********987655549******************************************

S: 179   vDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpe  238

         vD+WslGv+L++lv+g+ Pf+e+n +e+l+ i++ k+++p  +s+ +++L++++L++dp+

Q: 196   VDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPPRVSAGCRDLITRMLQRDPK  255

         ************************************************************

S: 239   kRatieeilkhewl  252

         +Ra++eei++h+wl

Q: 256   RRASLEEIESHPWL  269

         *************7

Domain Sequence
(FASTA)

YDLDKTLGRG HFAVVKLARH VFTGEKVAVK VIDKTKLDTL ATGHLFQEVR CMKLVQHPNI 60

VRLYEVIDTQ TKLYLILELG DGGDMFDYIM KHEEGLNEDL AKKYFAQIVH AISYCHKLHV 120

VHRDLKPENV VFFEKQGLVK LTDFGFSNKF QPGKKLTTSC GSLAYSAPEI LLGDEYDAPA 180

VDIWSLGVIL FMLVCGQPPF QEANDSETLT MIMDCKYTVP PRVSAGCRDL ITRMLQRDPK 240

RRASLEEIES HPWL 254

Keyword

Acetylation; ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0043523	; P:regulation of neuron apoptotic process

KEGG

rno:170837

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013