EKS-RAN-00341

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00341

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	322.0	3.5E-96	36	294	259

Status

Reviewed

Ensembl Protein

ENSRNOP00000044325

UniProt Accession

E9PTG8; D3ZUC0;

Protein Name

Serine/threonine-protein kinase 10

Protein Synonyms/Alias

Gene Name

Stk10

Gene Synonyms/Alias

Stk10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000004217	ENSRNOP00000044325	ENSRNOT00000047011

Organism

Rattus norvegicus

Functional Description

Serine/threonine-protein kinase involved in regulationof lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo (By similarity).

Protein Length

980

Protein Sequence
(FASTA)

MAFANFRRIL RLSTFEKRKS REYEHVRRDL DPNDVWEILG ELGDGAFGKV YKAKNKETGA 60

LAAAKVIETK SEEELEDYIV EIEILATCDH PYIVKLLGAY YYDGKLWIMI EFCPGGAVDA 120

IMLELDRGLT EPQIQVVCRQ MLEALNFLHG KRIIHRDLKA GNVLMTLEGD IRLADFGVSA 180

KNLKTLQKRD SFIGTPYWMA PEVVLCETMK DAPYDYKADI WSLGITLIEM AQIEPPHHEL 240

NPMRVLLKIA KSDPPTLLTP SKWSTEFRDF LKIALDKNPE TRPSAAQLLQ HPFVSTVTSN 300

KALRELVAEA KAEVMEEIED GKEDGREDGR EDGEEEDGDE KDAVSAVPPP VNHTQDSSAN 360

GTQPSLNSDK LLQDSSTPLP PSQPQEPVNG PCNQPSGDGS PQNTSPADEV SKNDNGLKVP 420

VPLRKSRPLS VDARIQVTEE KQITDQAENP SSAASKPPKV NQSRPNSSAL ETLGVETLAN 480

GGLELPGSVT PNHSKRASDC SNLSTSESMD YGTSLSADLS LNKETGSLSL KGSKLHNKTL 540

KRTRRFVVDG VEVSITTSKI ISEDEKKDEE MRFLRRQELR ELRLLQKEEH RNQTQLSTKH 600

ELQLEQMHRR FEQEINAKKK FYDVELENLE RQQKQQVEKM EQDHSVRRRE EAKRIRLEQD 660

RDYARFQEQL KQMKKEVVKS SERLARNSRN SSSFQEQTEH PQAARRRDRD FVAKQKEDLE 720

LAMKKLTAEN RREICDKERD CLNKKQELLR DREAALWEME EHQLQERHQL VKQQLKDQYF 780

LQRHDLLRKH EKEREQMQRY NQRMMEQLKV RQQQEKARLP KIQRSDGKTR MAMYKKSLHI 840

NGAGSASEQR EKVKQFSQQE EKRQKAERLQ QQQKHENQMR DMVAQCESNM NELQQLQNEK 900

CHLLVEHETQ KLKALDESHN QSLKEWRDKL RPRKKALEED LNQKKREQEM FFRLSEEAET 960

RPTTPNRASK FFPYSSGDAS 980

Nucleotide Sequence
(FASTA)

ATGGCTTTCG CCAATTTTCG CCGCATCTTG CGGTTATCCA CCTTCGAGAA GAGAAAGTCC 60

CGTGAATACG AGCATGTCCG CAGGGACCTG GACCCCAACG ACGTATGGGA GATCCTGGGC 120

GAGCTGGGAG ACGGCGCCTT CGGCAAAGTC TACAAGGCCA AAAACAAGGA GACGGGCGCC 180

CTGGCAGCAG CCAAAGTCAT TGAGACTAAG AGCGAGGAGG AGCTGGAGGA CTACATCGTG 240

GAGATCGAGA TCCTCGCCAC CTGCGACCAC CCATATATCG TGAAGCTCCT GGGGGCCTAT 300

TACTATGACG GGAAACTATG GATCATGATT GAGTTCTGCC CTGGGGGAGC TGTGGATGCC 360

ATCATGCTAG AGCTGGATCG AGGCCTCACT GAGCCCCAGA TTCAGGTCGT TTGCCGCCAG 420

ATGTTGGAGG CTCTCAACTT CCTGCACGGC AAGAGAATCA TCCACCGCGA CCTGAAAGCT 480

GGCAACGTGC TTATGACCCT GGAGGGGGAC ATCAGGCTGG CTGATTTTGG AGTATCTGCC 540

AAGAATCTGA AAACTCTGCA AAAGCGAGAT TCCTTCATAG GAACGCCTTA CTGGATGGCC 600

CCTGAGGTGG TGCTGTGTGA AACCATGAAG GACGCCCCCT ATGACTACAA GGCTGACATC 660

TGGTCCCTGG GCATCACGCT GATCGAGATG GCGCAGATTG AGCCCCCACA CCATGAGCTC 720

AACCCCATGC GGGTCCTGCT CAAGATCGCC AAGTCGGACC CTCCCACCCT GCTCACACCC 780

TCCAAGTGGT CCACGGAGTT CCGAGACTTT CTGAAGATAG CCTTGGATAA GAACCCAGAA 840

ACCCGGCCCA GTGCTGCGCA GCTGCTGCAG CATCCCTTCG TCAGTACAGT CACCAGTAAT 900

AAGGCCCTTC GGGAGCTGGT GGCTGAGGCG AAGGCTGAGG TGATGGAGGA GATCGAGGAC 960

GGCAAGGAGG ACGGCAGGGA GGACGGCAGG GAGGATGGAG AAGAGGAGGA TGGAGACGAG 1020

AAGGATGCTG TGAGTGCTGT TCCGCCCCCA GTCAACCACA CTCAGGACTC CTCTGCCAAT 1080

GGAACTCAGC CAAGCCTCAA CTCTGACAAG CTTCTCCAGG ATTCTTCTAC CCCCCTGCCT 1140

CCCAGCCAGC CTCAGGAGCC TGTGAACGGG CCCTGTAACC AACCCTCAGG GGATGGATCC 1200

CCCCAGAACA CCAGCCCTGC AGATGAGGTC TCCAAGAATG ACAATGGCTT AAAGGTACCT 1260

GTTCCCCTCC GGAAGTCCCG GCCATTGTCC GTGGATGCCA GAATTCAGGT GACCGAAGAG 1320

AAACAAATCA CTGACCAGGC TGAGAACCCC AGTTCTGCAG CCAGCAAACC CCCGAAGGTC 1380

AACCAGAGCC GACCTAACAG CAGCGCCCTG GAGACTTTGG GTGTCGAGAC TCTGGCCAAT 1440

GGAGGCCTGG AGCTCCCTGG CTCTGTAACT CCAAACCATT CTAAGAGGGC GTCGGACTGT 1500

AGCAACCTGT CTACCTCAGA GAGCATGGAC TACGGCACCT CCTTGTCTGC TGACCTGTCA 1560

TTGAACAAAG AGACGGGCTC ATTGTCTCTC AAGGGCTCAA AACTGCACAA CAAGACCCTG 1620

AAGAGGACCC GCCGGTTTGT GGTGGACGGT GTGGAGGTGA GCATCACCAC CTCCAAGATC 1680

ATCAGCGAAG ACGAGAAGAA AGACGAGGAG ATGAGGTTTC TCAGGCGCCA GGAACTCCGA 1740

GAGCTTCGGC TCCTGCAGAA AGAAGAGCAT CGGAACCAGA CGCAGCTGAG CACCAAGCAC 1800

GAGCTGCAGC TGGAGCAGAT GCACAGACGA TTTGAACAAG AAATCAACGC CAAGAAGAAA 1860

TTCTATGACG TGGAGCTAGA GAACCTGGAG CGGCAGCAGA AGCAGCAGGT GGAGAAGATG 1920

GAGCAGGACC ACAGCGTGCG TCGCAGAGAG GAGGCCAAGC GGATCCGCCT GGAGCAGGAT 1980

CGAGACTACG CCAGGTTCCA AGAGCAGCTC AAGCAGATGA AGAAGGAGGT GGTGAAGTCC 2040

AGCGAGAGGT TGGCTAGAAA TAGTAGAAAT AGTTCTTCCT TCCAGGAACA GACTGAGCAT 2100

CCTCAGGCAG CTAGGAGGAG GGACCGAGAC TTTGTAGCCA AGCAGAAGGA AGACCTGGAG 2160

CTGGCCATGA AGAAGCTCAC GGCAGAAAAC AGGCGTGAGA TCTGTGACAA GGAACGTGAT 2220

TGCCTTAACA AGAAGCAGGA GCTCCTCCGA GACCGAGAGG CAGCCCTGTG GGAGATGGAG 2280

GAGCACCAGT TACAGGAGAG ACATCAGCTG GTGAAGCAGC AGCTTAAGGA CCAGTACTTC 2340

CTGCAGCGGC ATGACCTGCT GCGCAAGCAC GAGAAGGAGC GGGAGCAGAT GCAGCGCTAC 2400

AACCAGCGTA TGATGGAGCA GCTGAAGGTC AGACAGCAGC AGGAGAAGGC GCGGCTACCC 2460

AAGATCCAGA GGAGTGACGG CAAGACCCGC ATGGCCATGT ACAAGAAGAG CCTGCACATC 2520

AATGGTGCGG GCAGTGCCTC CGAGCAGCGG GAGAAGGTCA AGCAGTTCTC CCAGCAGGAA 2580

GAGAAGAGGC AGAAGGCGGA GAGGCTGCAG CAGCAGCAGA AACACGAGAA CCAGATGCGA 2640

GACATGGTGG CACAGTGCGA GAGCAACATG AACGAGCTGC AGCAGCTGCA GAATGAAAAG 2700

TGTCATCTGT TAGTGGAGCA TGAAACCCAG AAGCTGAAGG CCCTGGACGA GAGCCATAAC 2760

CAGAGCCTGA AGGAATGGCG AGACAAGCTT CGGCCACGCA AAAAGGCCCT GGAAGAGGAT 2820

TTGAACCAGA AGAAGCGGGA ACAGGAAATG TTCTTCAGAC TAAGTGAGGA GGCAGAGACC 2880

AGACCCACCA CACCCAACAG AGCCAGCAAG TTCTTCCCCT ACAGCTCTGG GGATGCTTCC 2940

TAA 2943

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +e+l e+g+Ga+gkvy+a++k+tg+l+a k+i+++++e+le+++ ei++l +++hp+iv+

Q: 36    WEILGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVK  95

         78999*******************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l++++++ +lw+++e++ gG+++ ++  el+++l+E qi++++r++l+aL++lH k++i

Q: 96    LLGAYYYDGKLWIMIEFCPGGAVDAIML-ELDRGLTEPQIQVVCRQMLEALNFLHGKRII  154

         ***************************9.9******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe...ekgY  177

         Hrd+ka+n+L+t eg+++L+dfgv+a+  kt +kr++++gtpywmAPEv+ +e   +  Y

Q: 155   HRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVLCEtmkDAPY  214

         ****************************************************9998999*

S: 178   dekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekc  237

         d+kaDiwslGIt+ie+a+ epP+++l+p+++llki+k++pp+l +++k+s+ef++f++ +

Q: 215   DYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSTEFRDFLKIA  274

         ************************************************************

S: 238   lqknpekRpsasellkhkFl  257

         l+knpe+Rpsa++ll+h+F+

Q: 275   LDKNPETRPSAAQLLQHPFV  294

         *******************7

Domain Sequence
(FASTA)

WEILGELGDG AFGKVYKAKN KETGALAAAK VIETKSEEEL EDYIVEIEIL ATCDHPYIVK 60

LLGAYYYDGK LWIMIEFCPG GAVDAIMLEL DRGLTEPQIQ VVCRQMLEAL NFLHGKRIIH 120

RDLKAGNVLM TLEGDIRLAD FGVSAKNLKT LQKRDSFIGT PYWMAPEVVL CETMKDAPYD 180

YKADIWSLGI TLIEMAQIEP PHHELNPMRV LLKIAKSDPP TLLTPSKWST EFRDFLKIAL 240

DKNPETRPSA AQLLQHPFV 259

Keyword

ATP-binding; Cell cycle; Cell membrane; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0042803	; F:protein homodimerization activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007049	; P:cell cycle
GO:0071593	; P:lymphocyte aggregation
GO:0046777	; P:protein autophosphorylation
GO:2000401	; P:regulation of lymphocyte migration

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR022165	; PKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF12474	; PKK; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013