EKS-RAN-00314

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00314

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	498.6	4.3E-150	713	970	258

Status

Unreviewed

Ensembl Protein

ENSRNOP00000006087

UniProt Accession

G3V6K6;

Protein Name

Protein Synonyms/Alias

Epidermal growth factor receptor, isoform CRA_b; Protein Egfr;

Gene Name

Egfr

Gene Synonyms/Alias

Egfr; rCG_23316;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000004332	ENSRNOP00000006087	ENSRNOT00000006087

Organism

Rattus norvegicus

Functional Description

Protein Length

1209

Protein Sequence
(FASTA)

MRPSGTARTK LLLLLAALCA AGGALEEKKV CQGTSNRLTQ LGTFEDHFLS LQRMFNNCEV 60

VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN ALYENTYALA 120

VLSNYGTNKT GLRELPMRNL QEILIGAVRF SNNPILCNME TIQWRDIVQD VFLSNMSMDV 180

QRHLTGCPKC DPSCPNGSCW GRGEENCQKL TKIICAQQCS RRCRGRSPSD CCHNQCAAGC 240

TGPRESDCLV CHRFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV 300

VTDHGSCVRA CGPDYYEVEE DGVSKCKKCD GPCRKVCNGI GIGEFKDTLS INATNIKHFK 360

YCTAISGDLH ILPVAFKGDS FTRTPPLDPR ELEILKTVKE ITGFLLIQAW PENWTDLHAF 420

ENLEIIRGRT KQHGQFSLAV VGLNITSLGL RSLKEISDGD VIISGNRNLC YANTINWKKL 480

FGTPNQKTKI MNNRAEKDCK ATNHVCNPLC SSEGCWGPEP TDCVSCQNVS RGRECVDKCN 540

ILEGEPREFV ENSECIQCHP ECLPQTMNIT CTGRGPDNCI KCAHYVDGPH CVKTCPSGIM 600

GENNTLVWKF ADANNVCHLC HANCTYGCAG PGLKGCQQPE GPKIPSIATG IVGGLLFIVV 660

VALGIGLFMR RRHIVRKRTL RRLLQERELV EPLTPSGEAP NQAHLRILKE TEFKKIKVLG 720

SGAFGTVYKG LWIPEGEKVK IPVAIKELRE ATSPKANKEI LDEAYVMASV DNPHVCRLLG 780

ICLTSTVQLI TQLMPYGCLL DYVREHKDNI GSQYLLNWCV QIAKGMNYLE DRRLVHRDLA 840

ARNVLVKTPQ HVKITDFGLA KLLGAEEKEY HAEGGKVPIK WMALESILHR IYTHQSDVWS 900

YGVTVWELMT FGSKPYDGIP ASEISSILEK GERLPQPPIC TIDVYMIMVK CWMIDADSRP 960

KFRELILEFS KMARDPQRYL VIQGDERMHL PSPTDSNFYR ALMEEEDMED VVDADEYLIP 1020

QQGFFNSPST SRTPLLSSLS ANSNSSAVAC INRNGSCRVK EDAFLQRYSS DPTSVLTEDN 1080

IDDTFLPVPE YINQSVPKRP AGSVQNPVYH NQPLHPAPGR DLHYQNPHSN AVSNPEYLNT 1140

AQPTCLSSGF DSSALWIQKG SHQMSLDNPD YQQDFFPKEA KPNGIFKGPT AENAEYLRVA 1200

PPSSEFIGA 1209

Nucleotide Sequence
(FASTA)

ATGCGACCCT CAGGGACTGC GAGAACCAAG CTACTGCTGC TGCTGGCTGC GCTCTGCGCC 60

GCAGGTGGGG CGCTGGAGGA AAAGAAAGTT TGCCAAGGCA CAAGTAACAG GCTCACCCAA 120

CTAGGCACCT TTGAAGACCA CTTTCTGAGC CTCCAGAGGA TGTTCAACAA CTGTGAAGTG 180

GTCCTTGGAA ACTTGGAAAT CACCTATGTG CAAAGGAATT ATGACCTTTC CTTCTTAAAG 240

ACCATTCAGG AGGTGGCTGG CTATGTTCTC ATTGCCCTGA ACACCGTGGA GAGAATCCCT 300

TTGGAGAACC TGCAGATCAT CAGGGGAAAT GCTCTCTACG AAAACACCTA CGCCTTAGCC 360

GTCCTGTCCA ACTATGGAAC CAACAAAACT GGGCTTAGGG AACTGCCCAT GCGGAACTTA 420

CAGGAAATTC TGATCGGTGC TGTGCGATTT AGCAACAACC CCATCCTCTG CAATATGGAG 480

ACCATCCAGT GGAGGGACAT CGTCCAAGAT GTCTTTCTGA GCAACATGTC AATGGACGTA 540

CAGCGCCACC TGACCGGCTG CCCGAAATGT GATCCGAGCT GTCCCAATGG AAGCTGCTGG 600

GGAAGAGGAG AGGAGAACTG CCAGAAATTG ACCAAAATCA TCTGCGCCCA GCAATGTTCC 660

CGGCGTTGTC GTGGCAGGTC CCCTAGCGAC TGCTGCCACA ACCAGTGTGC CGCAGGGTGT 720

ACAGGGCCCA GAGAGAGTGA CTGTCTGGTC TGCCACAGGT TCCGAGATGA AGCCACGTGC 780

AAAGACACCT GCCCACCACT CATGCTGTAC AACCCCACCA CGTACCAGAT GGATGTCAAC 840

CCTGAGGGGA AGTACAGCTT TGGTGCCACC TGTGTGAAGA AATGCCCCAG AAACTACGTG 900

GTGACAGATC ACGGCTCGTG TGTCCGGGCC TGTGGGCCAG ACTACTATGA AGTAGAAGAA 960

GATGGAGTCA GCAAGTGTAA AAAATGTGAT GGGCCCTGCC GCAAAGTTTG CAATGGCATA 1020

GGCATTGGTG AATTTAAAGA CACACTCTCC ATAAATGCTA CAAACATCAA ACACTTCAAG 1080

TACTGCACTG CCATCAGTGG GGACCTCCAC ATCCTGCCAG TGGCCTTTAA GGGGGATTCT 1140

TTCACCCGCA CTCCTCCTCT AGACCCACGG GAACTAGAAA TTCTCAAAAC TGTGAAGGAA 1200

ATAACAGGGT TTTTGCTGAT TCAGGCTTGG CCTGAAAACT GGACTGACCT CCATGCTTTT 1260

GAGAACCTAG AAATAATTCG TGGCAGAACA AAGCAACATG GTCAGTTTTC TCTGGCGGTT 1320

GTCGGCCTGA ACATAACATC GCTGGGGTTG CGTTCCCTCA AGGAGATCAG TGATGGGGAT 1380

GTGATTATTT CTGGGAACCG AAATTTGTGC TACGCAAACA CTATAAACTG GAAAAAACTC 1440

TTCGGGACGC CCAATCAAAA GACCAAAATC ATGAACAACA GAGCTGAAAA GGACTGCAAG 1500

GCCACGAACC ACGTCTGTAA TCCTTTATGC TCCTCGGAAG GCTGCTGGGG CCCTGAGCCC 1560

ACGGACTGTG TCTCCTGCCA GAATGTGAGC AGAGGCAGGG AGTGCGTGGA CAAGTGCAAC 1620

ATCCTGGAGG GGGAACCGAG GGAGTTTGTG GAAAATTCTG AATGCATCCA GTGCCATCCA 1680

GAATGTCTGC CCCAGACCAT GAACATCACC TGTACAGGCC GGGGGCCAGA CAACTGCATC 1740

AAGTGTGCCC ACTATGTTGA TGGTCCCCAC TGTGTCAAGA CCTGCCCTTC GGGCATCATG 1800

GGGGAGAACA ACACCCTGGT CTGGAAGTTT GCAGATGCCA ATAACGTCTG CCACCTCTGC 1860

CATGCAAACT GTACCTATGG ATGTGCTGGG CCAGGCCTTA AAGGATGTCA ACAACCAGAA 1920

GGGCCAAAGA TCCCATCCAT CGCCACTGGG ATTGTGGGTG GCCTCCTCTT CATAGTAGTG 1980

GTGGCCCTTG GGATCGGCCT CTTCATGCGA AGGCGTCACA TTGTCCGAAA ACGTACACTA 2040

CGCCGCCTGC TTCAAGAGAG AGAGCTCGTG GAACCTCTCA CACCCAGCGG AGAAGCTCCG 2100

AACCAAGCCC ACTTGAGGAT ATTAAAGGAA ACAGAATTCA AAAAGATCAA AGTTCTGGGT 2160

TCAGGAGCAT TTGGCACAGT GTATAAGGGT CTCTGGATCC CAGAAGGCGA GAAAGTGAAA 2220

ATCCCTGTGG CCATCAAGGA GTTAAGAGAA GCCACATCTC CCAAAGCCAA CAAGGAAATC 2280

CTTGATGAAG CCTACGTGAT GGCCAGTGTG GACAACCCTC ATGTATGCCG CCTCCTGGGC 2340

ATCTGTCTGA CCTCCACTGT CCAGCTCATT ACACAACTCA TGCCCTATGG TTGCCTCCTG 2400

GACTATGTCC GAGAACATAA GGACAACATT GGCTCCCAGT ACCTACTCAA CTGGTGTGTG 2460

CAGATTGCAA AGGGCATGAA CTACCTGGAA GACCGGCGTT TGGTACACCG TGACTTGGCA 2520

GCCAGGAATG TACTGGTAAA GACACCACAG CATGTCAAGA TCACAGATTT TGGACTGGCC 2580

AAACTGCTTG GTGCTGAGGA GAAAGAATAC CATGCAGAGG GGGGCAAAGT GCCTATCAAG 2640

TGGATGGCTT TGGAATCAAT TTTACACCGA ATTTATACAC ACCAAAGCGA CGTCTGGAGC 2700

TATGGAGTCA CCGTGTGGGA ACTGATGACC TTTGGGTCCA AGCCTTATGA TGGGATCCCT 2760

GCAAGTGAGA TCTCATCCAT CCTAGAGAAA GGAGAGCGCC TTCCACAGCC ACCTATCTGC 2820

ACCATCGACG TCTACATGAT CATGGTCAAG TGCTGGATGA TAGATGCTGA TAGCCGCCCA 2880

AAGTTCCGAG AGTTGATTCT CGAATTCTCC AAAATGGCCA GAGACCCACA GCGCTACCTT 2940

GTTATCCAGG GGGATGAAAG GATGCATTTG CCGAGCCCTA CAGACTCCAA CTTTTACCGA 3000

GCCCTGATGG AGGAGGAGGA CATGGAAGAC GTAGTTGATG CTGATGAATA CCTCATCCCA 3060

CAGCAAGGCT TCTTCAACAG CCCATCCACG TCACGGACTC CACTCTTGAG CTCTCTGAGT 3120

GCAAATAGCA ACAGTTCCGC TGTGGCTTGC ATTAATAGAA ATGGGAGCTG CCGTGTCAAA 3180

GAAGACGCCT TCTTGCAACG GTATAGCTCC GATCCCACCA GCGTCCTGAC AGAGGACAAC 3240

ATAGATGACA CATTCCTTCC CGTGCCTGAA TATATAAACC AATCTGTTCC CAAGAGGCCG 3300

GCTGGCTCTG TGCAGAACCC AGTCTATCAC AATCAGCCCC TGCATCCAGC TCCTGGAAGA 3360

GACCTGCATT ATCAAAATCC CCATAGCAAT GCGGTGAGCA ACCCTGAGTA TCTCAACACT 3420

GCCCAGCCGA CCTGCCTCAG TAGTGGGTTT GACAGCTCTG CCCTCTGGAT CCAGAAAGGC 3480

AGCCACCAAA TGAGCCTGGA CAACCCTGAC TACCAGCAGG ACTTCTTTCC CAAAGAAGCC 3540

AAGCCGAATG GCATCTTTAA GGGCCCCACA GCTGAAAATG CAGAGTACCT GCGGGTGGCA 3600

CCGCCAAGCA GTGAGTTTAT TGGAGCATGA 3630

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         +kk+kvlGsGafGtvykG+wipege+vkipvaik+l+e+t++kanke+ldea+v+as+d+

Q: 713   FKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN  772

         59**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++++rllg+cl+st+ql+tql+p+Gclldyvrehkd++Gsq+llnwcvqiakGm+yle++

Q: 773   PHVCRLLGICLTSTVQLITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDR  832

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvk+p+hvkitdfGlakll a+eke++aeggkvpikw+alesil+r+y

Q: 833   RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIY  892

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfG+kpydgipa+ei+++lekGerl+qppictidvym++vkcw

Q: 893   THQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCW  952

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mida+srpkf+el+ efs

Q: 953   MIDADSRPKFRELILEFS  970

         ***************996

Domain Sequence
(FASTA)

FKKIKVLGSG AFGTVYKGLW IPEGEKVKIP VAIKELREAT SPKANKEILD EAYVMASVDN 60

PHVCRLLGIC LTSTVQLITQ LMPYGCLLDY VREHKDNIGS QYLLNWCVQI AKGMNYLEDR 120

RLVHRDLAAR NVLVKTPQHV KITDFGLAKL LGAEEKEYHA EGGKVPIKWM ALESILHRIY 180

THQSDVWSYG VTVWELMTFG SKPYDGIPAS EISSILEKGE RLPQPPICTI DVYMIMVKCW 240

MIDADSRPKF RELILEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 4.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013