EKS-RAN-00154
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00154
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/RSK252.28.0E-7548233186
StatusUnreviewed
Ensembl ProteinENSRNOP00000063163
UniProt AccessionD4ABM6;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRps6ka5
Gene Synonyms/Alias Rps6ka5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000004362ENSRNOP00000063163ENSRNOT00000064716
OrganismRattus norvegicus
Functional Description
Protein Length518
Protein Sequence
(FASTA)
MEGEGGGSGG AGTSGDSGDG GEQLLTVKHE LRTANLTGHA EKVGIENFEL LKVLGTGAYG 60
KVFLVRKISG HDAGKLYAMK VLKKATIVQK AKTTEHTRTE RQVLEHIRQS PFLVTLHYAF 120
QTETKLHLIL DYINGGELFT HLSQRERFTE HEVQIYVGEI VLALEHLHKL GIIYRDIKLE 180
NILLDSNGHV VLTDFGLSKE FVADEAERAY SFCGTIEYMA PDIVRGGDSG HDKGMSSVAK 240
DLLQRLLMKD PKKRLGCGPR DAEEIKEHLF FEKINWDDLA AKKVPAPFKP VIRDELDVSN 300
FAEEFTEMDP TYSPAALPQS SERLFQGYSF VAPSILFKRN AAVIDPLQFH MGVDRPGVTN 360
VARSAMMKDS PFYQHYDLDL KDKPLGEGSF SICRKCVHKK TNQAFAVKII SKRMEANTQK 420
EITALKLCEG HPNVVKLHEV FHDQLHTFLV MELLNGGELF ERIKKKKHFS ETEASYIMRK 480
LVSAVSHMHD VGVVHRDLKP ETVFHREISR SPVISMRI 518
Nucleotide Sequence
(FASTA)
ATGGAGGGGG AGGGCGGCGG CAGCGGCGGC GCGGGCACCA GCGGGGACAG TGGCGACGGC 60
GGCGAGCAGC TCCTTACTGT CAAGCATGAG CTGCGGACCG CCAACTTAAC AGGACATGCA 120
GAGAAGGTGG GAATTGAAAA TTTTGAGCTG CTGAAGGTCC TAGGAACTGG AGCTTATGGG 180
AAAGTATTTC TAGTTCGTAA AATAAGCGGC CATGATGCTG GAAAGCTGTA TGCCATGAAA 240
GTTTTAAAAA AAGCAACAAT CGTTCAGAAG GCTAAAACTA CGGAGCATAC GAGGACAGAA 300
CGGCAGGTTC TGGAGCACAT TAGACAGTCG CCATTTCTGG TGACGTTGCA CTATGCTTTC 360
CAGACAGAGA CCAAGCTTCA TCTCATCTTA GATTATATAA ATGGTGGAGA ACTTTTTACT 420
CATCTTTCTC AAAGAGAGCG TTTCACAGAG CACGAAGTGC AGATCTATGT TGGAGAGATC 480
GTGCTTGCCC TGGAACACCT GCACAAGTTG GGGATTATAT ACCGTGACAT TAAGCTGGAA 540
AATATTCTAC TTGATTCTAA TGGCCATGTG GTGCTGACAG ATTTTGGTCT GAGTAAGGAG 600
TTTGTGGCTG ATGAAGCCGA AAGAGCGTAT TCTTTCTGTG GGACTATTGA GTACATGGCG 660
CCAGATATTG TCAGAGGGGG CGATTCCGGA CATGACAAGG GAATGAGCTC AGTAGCTAAA 720
GACCTCCTTC AGCGTCTTTT GATGAAAGAT CCCAAGAAGC GATTGGGATG TGGCCCACGG 780
GATGCAGAAG AAATCAAAGA ACATCTCTTC TTTGAGAAGA TAAATTGGGA TGACTTAGCT 840
GCCAAAAAAG TGCCTGCGCC CTTTAAACCA GTGATCCGGG ACGAGTTAGA CGTGAGTAAC 900
TTTGCTGAAG AGTTCACTGA GATGGACCCC ACCTACTCTC CTGCAGCTCT GCCCCAGAGC 960
TCTGAGCGAC TGTTCCAGGG CTACTCCTTC GTTGCTCCTT CCATCCTCTT CAAGCGTAAC 1020
GCGGCGGTCA TAGATCCCCT TCAGTTCCAT ATGGGAGTAG ACCGCCCTGG AGTGACAAAC 1080
GTTGCCAGGA GCGCAATGAT GAAGGACTCA CCATTCTACC AACACTATGA CCTAGATCTG 1140
AAGGACAAAC CTTTGGGAGA AGGAAGTTTT TCAATCTGTC GGAAGTGTGT ACACAAAAAA 1200
ACTAACCAAG CCTTTGCCGT CAAAATAATC AGCAAAAGGA TGGAAGCCAA TACTCAGAAA 1260
GAAATAACAG CTCTGAAACT CTGCGAAGGC CACCCCAATG TTGTGAAGCT GCATGAAGTT 1320
TTTCATGACC AGCTTCATAC ATTTCTTGTG ATGGAGCTTC TGAATGGGGG AGAGCTGTTT 1380
GAGCGCATCA AGAAAAAGAA GCACTTCAGC GAGACTGAGG CCAGCTACAT TATGCGGAAG 1440
CTTGTGTCGG CTGTGAGCCA CATGCACGAT GTTGGAGTGG TGCACAGAGA CCTGAAGCCG 1500
GAGACAGTGT TCCATAGAGA GATCAGCAGA TCTCCCGTCA TTTCCATGAG AATCTAA 1557
Domain Profile
S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58
         fellkvlg+Gaygkvflvrk++++d+gklya+Kvlkka++v+  k++e+t++er++Le++
Q: 48    FELLKVLGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATIVQkaKTTEHTRTERQVLEHI  107
         89***************************************988999*************
S: 59    eh.pfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleyl  117
         ++ pf+v+lh+afq+e+kl+l+l++++GgeL+++l+++++f+e+e++ ++ e+vlale+l
Q: 108   RQsPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHL  167
         ************************************************************
S: 118   HskgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevl..k  175
         H+ g++yrD+k+eNilld++ghv+ltDfgl+ke +a++ e+aysfcgT+ey+aP+++   
Q: 168   HKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADEAERAYSFCGTIEYMAPDIVrgG  227
         *********************************************************555
S: 176   rkgyde  181
         ++g+d+
Q: 228   DSGHDK  233
         678876
Domain Sequence
(FASTA)
FELLKVLGTG AYGKVFLVRK ISGHDAGKLY AMKVLKKATI VQKAKTTEHT RTERQVLEHI 60
RQSPFLVTLH YAFQTETKLH LILDYINGGE LFTHLSQRER FTEHEVQIYV GEIVLALEHL 120
HKLGIIYRDI KLENILLDSN GHVVLTDFGL SKEFVADEAE RAYSFCGTIE YMAPDIVRGG 180
DSGHDK 186
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Mus musculus"; ?>Pelodiscus sinensis"; ?>
EKS-AIM-00149
EKS-ANC-00151
EKS-MUM-00161
EKS-PES-00139
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043990; P:histone H2A-S1 phosphorylation
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013