EKS-RAN-00224

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00224

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	387.0	5.5E-116	53	314	262

Status

Unreviewed

Ensembl Protein

ENSRNOP00000006217

UniProt Accession

Q925D6;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase 6; Mitogen-activated protein kinase kinase 6, isoform CRA_a; Protein Map2k6;

Gene Name

Map2k6

Gene Synonyms/Alias

Map2k6; Mkk6; rCG_34806;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000004437	ENSRNOP00000006217	ENSRNOT00000006217

Organism

Rattus norvegicus

Functional Description

Protein Length

334

Protein Sequence
(FASTA)

MSQSKGKKRN PGLKIPREAF EQPQTSSTPP RDLDSKACIS IGNQNFEVKA DDLEPIVELG 60

RGAYGVVEKM RHVPSGQIMA VKRIRATVNS QEQKRLLMDL DVSMRTVDCP FTVTFYGALF 120

REGDVWICME LMDTSLDKFY KQVIDKGQTI PEDILGKIAV SIVKALEHLH SKLSVIHRDV 180

KPSNVLINTL GQVKMCDFGI SGYLVDSVAK TIDAGCKPYM APERINPELN QKGYSVKSDI 240

WSLGITMIEL AILRFPYDSW GTPFQQLKQV VEEPSPQLPA DKFSADFVDF TSQCLKKNSK 300

ERPTYPELMQ HPFFTVHEAK AADVASFVKL ILGD 334

Nucleotide Sequence
(FASTA)

ATGTCTCAGT CGAAAGGCAA GAAGCGAAAC CCCGGCCTTA AGATTCCAAG GGAAGCGTTT 60

GAACAACCTC AGACCAGTTC CACGCCGCCT CGGGATTTAG ACTCCAAGGC TTGCATTTCT 120

ATTGGAAACC AGAACTTTGA GGTGAAGGCC GATGACTTGG AGCCTATAGT GGAGCTGGGA 180

CGAGGTGCGT ACGGGGTGGT GGAGAAGATG CGTCACGTGC CCAGCGGGCA GATCATGGCG 240

GTGAAGCGGA TACGGGCCAC AGTTAATAGC CAGGAGCAGA AACGGCTACT GATGGATCTG 300

GATGTTTCTA TGAGGACAGT GGACTGTCCG TTTACCGTGA CCTTCTATGG TGCACTCTTC 360

CGGGAGGGCG ATGTGTGGAT CTGCATGGAG CTCATGGATA CGTCACTAGA TAAATTCTAC 420

AAACAAGTTA TTGATAAAGG CCAAACAATT CCAGAAGATA TCTTAGGGAA GATAGCAGTT 480

TCTATTGTAA AAGCATTAGA ACATTTACAC AGTAAGCTCT CTGTTATCCA TCGAGATGTC 540

AAGCCTTCAA ATGTGCTCAT TAACACGCTG GGCCAAGTGA AGATGTGTGA CTTTGGAATC 600

AGCGGCTACC TGGTAGACTC TGTTGCGAAA ACGATCGATG CCGGTTGCAA ACCATACATG 660

GCTCCTGAAC GAATAAATCC AGAGCTCAAC CAGAAGGGGT ACAGTGTGAA GTCTGACATT 720

TGGAGTCTGG GCATCACCAT GATTGAGCTG GCCATCCTCC GGTTTCCCTA TGATTCTTGG 780

GGAACGCCCT TCCAGCAGCT AAAACAGGTG GTAGAAGAGC CGTCTCCACA ACTCCCAGCG 840

GACAAGTTCT CTGCTGACTT CGTTGACTTT ACCTCACAGT GCTTGAAGAA AAATTCCAAA 900

GAACGGCCCA CGTATCCAGA GCTTATGCAA CATCCATTTT TCACCGTCCA TGAAGCCAAA 960

GCAGCAGATG TGGCGTCTTT CGTAAAACTG ATACTCGGGG ACTAA 1005

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         le + elG+G++gvVek++h +sg+i+avK+ir++++++eqk++l++l+v +++ ++p++

Q: 53    LEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFT  112

         567899******************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylke  120

         v+fyGa+++egdv+icmelmd tsldk++k+v++k ++ipe++lgkiav++vkale+l++

Q: 113   VTFYGALFREGDVWICMELMD-TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHS  171

         *********************.**************************************

S: 121   klkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg...k  176

         kl++iHRDvKPsN+L+n+ G+vK+CDFG+sg+lvds+Ak++ +G+k+YmaPEri++   +

Q: 172   KLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIdAGCKPYMAPERINPelnQ  231

         ********************************************************9999

S: 177   kkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpeeefseefqefv  236

         k Ysvksd+WslG+t++ela+ r+py+++ +++++lk++v+e++p+lp+++fs +f++f

Q: 232   KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSADFVDFT  291

         9***********************************************************

S: 237   skClkkdekeRpklkellkhafi  259

         s+Clkk++keRp++ el++h+f+

Q: 292   SQCLKKNSKERPTYPELMQHPFF  314

         *********************96

Domain Sequence
(FASTA)

LEPIVELGRG AYGVVEKMRH VPSGQIMAVK RIRATVNSQE QKRLLMDLDV SMRTVDCPFT 60

VTFYGALFRE GDVWICMELM DTSLDKFYKQ VIDKGQTIPE DILGKIAVSI VKALEHLHSK 120

LSVIHRDVKP SNVLINTLGQ VKMCDFGISG YLVDSVAKTI DAGCKPYMAP ERINPELNQK 180

GYSVKSDIWS LGITMIELAI LRFPYDSWGT PFQQLKQVVE EPSPQLPADK FSADFVDFTS 240

QCLKKNSKER PTYPELMQHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0006915	; P:apoptotic process
GO:0060048	; P:cardiac muscle contraction
GO:0000165	; P:MAPK cascade
GO:0043065	; P:positive regulation of apoptotic process
GO:0042493	; P:response to drug

KEGG

rno:114495

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013