EKS-RAN-00234

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00234

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	398.3	1.8E-119	1	240	240

Status

Unreviewed

Ensembl Protein

ENSRNOP00000057786

UniProt Accession

F1M9C0;

Protein Name

Protein Synonyms/Alias

Protein Mapkapk2;

Gene Name

Mapkapk2

Gene Synonyms/Alias

Mapkapk2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000004726	ENSRNOP00000057786	ENSRNOT00000061070

Organism

Rattus norvegicus

Functional Description

Protein Length

315

Protein Sequence
(FASTA)

TQKMLALQML QDCPKARREV ELHWRASQCP HIVHIVDVYE NLYAGRKCLL IVMECLDGGE 60

LFSRIQDRGD QAFTEREASE IMKSIGEAIQ YLHSINIAHR DVKPENLLYT SKRPNAILKL 120

TDFGFAKETT SHNSLTTPCY TPYYVAPEVL GPEKYDKSCD MWSLGVIMYI LLCGYPPFYS 180

NHGLAISPGM KTRIRMGQYE FPNPEWSEVS EEVKMLIRNL LKTEPTQRMT ITEFMNHPWI 240

MQSTKVPQTP LHTSRVLKED KERWEDVKEE MTSALATMRV DYEQVKIKKI EDASNPLLLK 300

RRKKARAVED AALAH 315

Nucleotide Sequence
(FASTA)

ACTCAGAAGA TGTTGGCCTT GCAGATGCTG CAGGACTGTC CCAAGGCACG CAGAGAGGTG 60

GAGCTGCACT GGAGGGCCTC CCAGTGCCCA CACATCGTGC ACATCGTGGA CGTCTATGAG 120

AACCTGTATG CCGGGAGGAA GTGCTTGCTG ATTGTCATGG AGTGTCTCGA TGGTGGAGAG 180

CTCTTTAGTC GGATCCAGGA CCGAGGAGAC CAGGCATTCA CAGAAAGAGA GGCATCAGAG 240

ATCATGAAGA GCATCGGGGA GGCCATCCAG TACCTGCACT CTATCAACAT CGCTCACCGG 300

GACGTCAAGC CCGAGAACCT CTTATACACT TCCAAAAGAC CCAATGCCAT CCTGAAACTC 360

ACTGATTTTG GCTTTGCCAA GGAAACCACC AGTCACAACT CTTTGACCAC TCCGTGTTAT 420

ACACCGTACT ATGTGGCTCC GGAAGTACTG GGCCCAGAGA AGTATGACAA GTCCTGTGAC 480

ATGTGGTCCT TGGGTGTCAT CATGTATATT TTGCTGTGTG GGTATCCCCC CTTCTATTCC 540

AACCACGGCC TTGCCATCTC TCCGGGCATG AAGACTCGCA TTCGAATGGG CCAGTATGAA 600

TTTCCTAACC CAGAATGGTC AGAAGTATCA GAAGAAGTGA AGATGCTTAT TCGGAATCTG 660

CTGAAAACAG AGCCCACCCA GAGAATGACC ATCACAGAAT TCATGAACCA CCCGTGGATC 720

ATGCAATCTA CGAAGGTCCC TCAGACTCCA CTGCACACCA GCCGCGTCCT GAAGGAGGAC 780

AAGGAACGAT GGGAGGATGT CAAGGAGGAG ATGACCAGTG CCTTGGCCAC GATGCGTGTC 840

GACTATGAGC AGGTCAAGAT AAAGAAGATA GAGGACGCAT CCAACCCTCT GCTTCTCAAG 900

AGGAGGAAGA AAGCTCGCGC CGTGGAAGAC GCGGCCCTTG CCCACTGA 948

Domain Profile

S: 23    tgekyalkilkdrkkvrrevelhvqasghknivelidvfensfedekrlllvlekleGGe  82

         t++  al++l+d++k+rrevelh++as++++iv+++dv+en ++++k+ll+v+e+l+GGe

Q: 1     TQKMLALQMLQDCPKARREVELHWRASQCPHIVHIVDVYENLYAGRKCLLIVMECLDGGE  60

         68899*******************************************************

S: 83    llsriqer..kaftekeasevvkdiasalkflhskniahrDlkpenlLyeskeknapvkl  140

         l+sriq+r  +afte+ease++k+i++a+++lhs niahrD+kpenlLy+sk+ na++kl

Q: 61    LFSRIQDRgdQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKL  120

         *********9**************************************************

S: 141   cDfglaketeeeeelktpcltaeyvaPevleaekeeallydksCDlWslGvilyillcGy  200

         +Dfg+aket+++++l+tpc+t++yvaPevl++ek     ydksCD+WslGvi+yillcGy

Q: 121   TDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEK-----YDKSCDMWSLGVIMYILLCGY  175

         **********************************.....*********************

S: 201   pPfyskkgraiskklkeriqegkyefPeeeWsevseeakdlirklLkrdpkerltieevl  260

         pPfys++g ais+++k+ri++g+yefP++eWsevsee+k+lir+lLk++p++r+ti+e++

Q: 176   PPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFM  235

         ************************************************************

S: 261   nhpwv  265

         nhpw+

Q: 236   NHPWI  240

         ****8

Domain Sequence
(FASTA)

TQKMLALQML QDCPKARREV ELHWRASQCP HIVHIVDVYE NLYAGRKCLL IVMECLDGGE 60

LFSRIQDRGD QAFTEREASE IMKSIGEAIQ YLHSINIAHR DVKPENLLYT SKRPNAILKL 120

TDFGFAKETT SHNSLTTPCY TPYYVAPEVL GPEKYDKSCD MWSLGVIMYI LLCGYPPFYS 180

NHGLAISPGM KTRIRMGQYE FPNPEWSEVS EEVKMLIRNL LKTEPTQRMT ITEFMNHPWI 240

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0070935	; P:3'-UTR-mediated mRNA stabilization
GO:0035924	; P:cellular response to vascular endothelial growth factor stimulus
GO:0031572	; P:G2/M transition DNA damage checkpoint
GO:0006954	; P:inflammatory response
GO:0048839	; P:inner ear development
GO:0044351	; P:macropinocytosis
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0032675	; P:regulation of interleukin-6 production
GO:0032680	; P:regulation of tumor necrosis factor production
GO:0032496	; P:response to lipopolysaccharide
GO:0002224	; P:toll-like receptor signaling pathway
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013