EKS-RAN-00292

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00292

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	452.2	8.7E-136	195	482	288

Status

Unreviewed

Ensembl Protein

ENSRNOP00000056047

UniProt Accession

D3ZUY4;

Protein Name

Protein Synonyms/Alias

Activin receptor type-1C;

Gene Name

Acvr1c

Gene Synonyms/Alias

Acvr1c;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000004828	ENSRNOP00000056047	ENSRNOT00000059280

Organism

Rattus norvegicus

Functional Description

Protein Length

493

Protein Sequence
(FASTA)

MTPARRSALS LALLLVALAS DLAAGLKCVC LLCDSSNFTC QTEGACWASV MLTNGKEQVI 60

KSCVSLPELN AQVFCHSSNN VTKTECCFTD FCNNITLHLP TASPDAPRLG PTELTVVITV 120

PVCLLSIAAM LTIWACQDRQ CTYRKTKRHN VEEPLAEYSL VNAGKTLKDL IYDATASGSG 180

SGLPLLVQRT IARTIVLQEI VGKGRFGEVW HGRWCGEDVA VKIFSSRDER SWFREAEIYQ 240

TVMLRHENIL GFIAADNKDN GTWTQLWLVS EYHEQGSLYD YLNRNIVTVA GMVKLALSIA 300

SGLAHLHMEI VGTQGKPAIA HRDIKSKNIL VKKCDTCAIA DLGLAVKHDS IMNTIDIPQN 360

PKVGTKRYMA PEMLDDTMNV NIFESFKRAD IYSVGLVYWE IARRCSVGGL VEEYQLPYYD 420

MVPSDPSIEE MRKVVCDQKL RPNLPNQWQS CEALRVMGRI MRECWYANGA ARLTALRVKK 480

TISQLCVKED CKA 493

Nucleotide Sequence
(FASTA)

ATGACCCCAG CGCGCCGCTC CGCACTGAGC CTGGCCCTCC TGCTGGTGGC ACTGGCCTCC 60

GACCTTGCGG CAGGACTGAA GTGTGTGTGT CTTTTGTGTG ATTCCTCAAA CTTTACCTGC 120

CAAACCGAAG GAGCATGCTG GGCCTCTGTC ATGCTAACCA ACGGGAAAGA ACAGGTGATC 180

AAATCGTGCG TGTCCCTCCC GGAACTAAAT GCTCAGGTCT TCTGTCACAG TTCCAACAAC 240

GTGACCAAGA CCGAATGTTG CTTCACAGAC TTCTGCAACA ACATCACTCT GCACCTTCCC 300

ACAGCATCTC CAGATGCCCC TAGACTTGGC CCCACAGAGC TGACGGTTGT TATCACTGTA 360

CCTGTTTGCC TCCTGTCCAT CGCAGCCATG CTAACGATAT GGGCCTGCCA GGACCGCCAG 420

TGCACATACA GGAAGACCAA GAGACACAAT GTGGAGGAAC CACTGGCAGA GTACAGCCTT 480

GTCAATGCTG GAAAAACCCT CAAAGATCTG ATTTATGATG CCACTGCCTC GGGCTCAGGA 540

TCTGGCCTGC CTCTTTTGGT TCAAAGAACC ATCGCAAGGA CAATTGTACT TCAAGAAATC 600

GTAGGAAAAG GTCGGTTTGG GGAAGTGTGG CACGGAAGAT GGTGTGGAGA AGATGTGGCT 660

GTGAAAATAT TCTCCTCCAG AGATGAGAGA TCTTGGTTCC GTGAGGCAGA AATTTATCAG 720

ACGGTAATGC TGAGACATGA GAATATTCTC GGTTTCATCG CGGCCGACAA CAAAGATAAT 780

GGAACCTGGA CTCAGCTTTG GCTTGTGTCA GAGTATCACG AGCAGGGCTC CTTATATGAC 840

TATTTGAATA GAAACATAGT GACCGTGGCT GGAATGGTCA AGTTGGCGCT TTCAATAGCG 900

AGTGGTCTGG CTCACCTACA CATGGAGATC GTGGGCACTC AAGGTAAGCC TGCTATTGCT 960

CACCGAGATA TAAAGTCAAA GAATATCTTA GTCAAAAAGT GTGACACTTG TGCCATAGCT 1020

GACTTAGGGC TGGCTGTGAA ACATGATTCT ATCATGAACA CTATAGATAT ACCCCAGAAT 1080

CCTAAAGTGG GAACCAAGAG GTATATGGCT CCCGAAATGC TTGATGATAC AATGAACGTC 1140

AACATCTTTG AGTCCTTCAA GCGAGCTGAC ATCTATTCGG TGGGGCTGGT TTACTGGGAA 1200

ATAGCTCGAA GGTGTTCAGT TGGAGGACTT GTTGAAGAGT ACCAGTTGCC TTATTATGAC 1260

ATGGTGCCTT CAGATCCTTC CATAGAGGAA ATGAGGAAGG TCGTTTGTGA TCAGAAACTC 1320

CGACCAAATC TCCCAAACCA GTGGCAAAGC TGTGAGGCGC TCCGGGTCAT GGGAAGAATA 1380

ATGCGTGAGT GCTGGTATGC CAACGGGGCA GCTCGCCTGA CCGCCCTGCG CGTGAAGAAG 1440

ACCATTTCTC AGCTGTGTGT CAAGGAAGAC TGTAAGGCCT AA 1482

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e++gkGr+geVw++++ ge+vAvKifs++de+sw+rE+eiyqtv+lrhenil+fia

Q: 195   IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA  254

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv+eyhe+gsL+dyL+r++++v  +++lals+asGlahLH+eivgt+

Q: 255   ADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMVKLALSIASGLAHLHMEIVGTQ  314

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRD+kskNilvkk  tc+iaDlGLa+k+++  +++d+ +n +vGtkRYmaPE

Q: 315   G--KPAIAHRDIKSKNILVKKCDTCAIADLGLAVKHDSIMNTIDIPQNPKVGTKRYMAPE  372

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         +l++++n++ fe+fkraD+Ys+gLv+WE+a+Rc+  ++ veey+lp++++v+sdPs+eem

Q: 373   MLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSV-GGLVEEYQLPYYDMVPSDPSIEEM  431

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP++p++w+++eal+++ ++++ecW+a+++aRltalrvkk++

Q: 432   RKVVCDQKLRPNLPNQWQSCEALRVMGRIMRECWYANGAARLTALRVKKTI  482

         ************************************************986

Domain Sequence
(FASTA)

IVLQEIVGKG RFGEVWHGRW CGEDVAVKIF SSRDERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSEYHE QGSLYDYLNR NIVTVAGMVK LALSIASGLA HLHMEIVGTQ 120

GKPAIAHRDI KSKNILVKKC DTCAIADLGL AVKHDSIMNT IDIPQNPKVG TKRYMAPEML 180

DDTMNVNIFE SFKRADIYSV GLVYWEIARR CSVGGLVEEY QLPYYDMVPS DPSIEEMRKV 240

VCDQKLRPNL PNQWQSCEAL RVMGRIMREC WYANGAARLT ALRVKKTI 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0048179	; C:activin receptor complex
GO:0016361	; F:activin receptor activity, type I
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030154	; P:cell differentiation
GO:0019915	; P:lipid storage
GO:0008285	; P:negative regulation of cell proliferation
GO:0046676	; P:negative regulation of insulin secretion
GO:0038092	; P:nodal signaling pathway
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0002021	; P:response to dietary excess
GO:0009749	; P:response to glucose stimulus
GO:0032868	; P:response to insulin stimulus

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013