EKS-RAN-00281

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00281

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	465.5	1.2E-139	183	496	314

Status

Reviewed

Ensembl Protein

ENSRNOP00000006502

UniProt Accession

Q4V8A3;

Protein Name

Dual specificity tyrosine-phosphorylation-regulated kinase 3

Protein Synonyms/Alias

Gene Name

Dyrk3

Gene Synonyms/Alias

Dyrk3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000004870	ENSRNOP00000006502	ENSRNOT00000006502

Organism

Rattus norvegicus

Functional Description

Negative regulator of EPO-dependent erythropoiesis, mayplace an upper limit on red cell production during stress erythropoiesis. Inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. May act by regulating CREB/CRE signaling (By similarity).

Protein Length

561

Protein Sequence
(FASTA)

RLGDGVYDTF MMIDETKCPP YTNTLCNPSE APVSRRLNIT TEPFTRGHTQ HFVSGGVMKV 60

EQLFQEFGSR RTSTLQSDGV SNSEKSSPAS QGKSSDSLGT VKCSLSSRPS KVLPLTPEQA 120

LKQYKHHLTA YEKLEIISYP EIYFVGPNAK KRQGVIGGPN NGGYDDADGA YIHVPRDHLA 180

YRYEVLKIIG KGSFGQVARV YDHKLRQYVA LKMVRNEKRF HRQAAEEIRI LEHLKKQDKT 240

GSMNVIHMLE SFTFRNHVCM AFELLSIDLY ELIKKNKFQG FSVQLVRKFA QSILQSLDAL 300

HKNKIIHCDL KPENILLKHH GRSATKVIDF GSSCFEYQKL YTYIQSRFYR APEIILGCRY 360

STPIDIWSFG CILAELLTGQ PLFPGEDEGD QLACMMELLG MPPQKLLEQS KRAKYFINSK 420

GLPRYCSVTT QTDGRVVLLG GRSRRGKKRG PPGSKDWAAA LKGCDDYLFI EFLKRCLQWD 480

PSARLTPAQA LRHPWISKSA PRPLTTDKVS GKRVVNPTNA FQGLGSKLPP VVGIASKLKA 540

NLMSETSGSI PLCSVLPKLI S 561

Nucleotide Sequence
(FASTA)

AGGTTGGGGG ATGGTGTCTA TGATACCTTC ATGATGATAG ATGAAACCAA GTGCCCACCC 60

TATACAAACA CACTTTGCAA TCCCTCTGAA GCACCTGTCT CCAGAAGGCT AAATATTACC 120

ACTGAGCCAT TCACGAGAGG CCACACTCAG CACTTCGTGA GTGGGGGTGT GATGAAGGTG 180

GAGCAACTGT TTCAAGAATT TGGCAGCAGA AGAACCAGTA CTCTCCAGTC CGATGGCGTC 240

AGCAACTCCG AAAAGTCCTC TCCTGCTTCT CAGGGGAAGA GTTCAGACAG CCTGGGTACA 300

GTGAAGTGCA GCCTCTCATC CAGACCATCT AAGGTGCTCC CGCTGACTCC TGAGCAAGCT 360

CTGAAGCAGT ACAAGCACCA CCTCACCGCC TACGAGAAGC TGGAGATCAT CAGCTACCCA 420

GAAATCTACT TCGTGGGCCC GAATGCCAAG AAGCGGCAAG GAGTTATTGG TGGTCCCAAT 480

AACGGGGGGT ACGACGATGC GGACGGGGCC TATATCCACG TGCCTCGAGA CCATCTGGCT 540

TACCGCTATG AGGTGCTGAA AATTATTGGC AAGGGGAGTT TTGGACAGGT AGCCCGGGTC 600

TACGATCACA AACTCCGACA GTACGTGGCC CTGAAAATGG TGCGCAACGA GAAGCGCTTT 660

CACCGCCAGG CAGCCGAGGA GATCCGGATT CTGGAGCATC TTAAAAAGCA AGACAAAACT 720

GGGAGCATGA ATGTCATCCA CATGTTAGAA AGCTTCACCT TCCGGAACCA CGTGTGCATG 780

GCCTTTGAGT TGCTAAGCAT AGACCTGTAC GAGCTCATTA AAAAAAACAA GTTTCAGGGC 840

TTCAGCGTCC AGTTGGTCCG GAAGTTCGCC CAGTCCATCC TGCAGTCCTT GGACGCCCTT 900

CACAAAAATA AGATCATTCA CTGTGATCTG AAGCCTGAGA ACATTCTCCT GAAGCATCAC 960

GGACGGAGCG CGACCAAGGT CATTGACTTC GGGTCCAGCT GTTTTGAGTA TCAGAAACTT 1020

TACACGTACA TCCAGTCCCG TTTCTACAGA GCCCCGGAAA TCATCTTGGG GTGCCGCTAC 1080

AGCACGCCAA TTGACATATG GAGTTTTGGT TGCATCCTCG CAGAACTTTT GACAGGACAG 1140

CCCCTGTTCC CAGGAGAGGA TGAAGGAGAC CAGTTGGCCT GCATGATGGA GTTGCTAGGA 1200

ATGCCACCAC AGAAACTTCT GGAGCAATCC AAACGTGCCA AGTACTTTAT TAACTCCAAA 1260

GGCTTGCCTC GATACTGCTC CGTAACTACC CAGACGGACG GGAGGGTTGT GCTTCTCGGG 1320

GGCCGCTCAC GCAGGGGTAA AAAGCGAGGC CCACCAGGCA GCAAAGACTG GGCAGCCGCG 1380

CTGAAGGGGT GCGATGACTA CTTGTTCATA GAGTTTCTGA AAAGGTGCCT TCAGTGGGAC 1440

CCCTCTGCCC GCCTCACCCC AGCTCAAGCA TTAAGACATC CTTGGATTAG CAAGTCTGCA 1500

CCCAGGCCCC TCACCACGGA CAAGGTGTCA GGGAAACGGG TAGTTAATCC TACAAATGCT 1560

TTCCAGGGAC TGGGCTCCAA GCTGCCTCCA GTCGTTGGAA TCGCCAGTAA GCTTAAAGCT 1620

AACCTAATGT CGGAAACCAG TGGTAGTATA CCTCTGTGCA GTGTATTGCC AAAGCTGATC 1680

AGCTAA 1686

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl++igkGsfgqV++++d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+ +

Q: 183   YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS  242

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le+f+frnh+c+ fells++Lyel+kknkf+g+s++lvrk+aq+il++L++L++

Q: 243   MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK  302

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         +kiiH+DlKPeNill++++rs+ kviDFGss+++ qk +ytyiqsrfYraPEiilg++y+

Q: 303   NKIIHCDLKPENILLKHHGRSATKVIDFGSSCFEYQK-LYTYIQSRFYRAPEIILGCRYS  361

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iD+WS+Gc+laEl+tG+pLfpGe+e dqla+++e+lg+pp+klle++k+ak+f+++k+

Q: 362   TPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPQKLLEQSKRAKYFINSKG  421

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

          p+y+ +t+++d +++l  ++++++kkr +p+sk+++ alk ++d+lf+++lkr+l++dp

Q: 422   LPRYCSVTTQTDGRVVLLGGRSRRGKKRGPPGSKDWAAALKGCDDYLFIEFLKRCLQWDP  481

         ************************************************************

S: 301   akRitpkealkhpfv  315

         ++R+tp++al+hp++

Q: 482   SARLTPAQALRHPWI  496

         **************7

Domain Sequence
(FASTA)

YEVLKIIGKG SFGQVARVYD HKLRQYVALK MVRNEKRFHR QAAEEIRILE HLKKQDKTGS 60

MNVIHMLESF TFRNHVCMAF ELLSIDLYEL IKKNKFQGFS VQLVRKFAQS ILQSLDALHK 120

NKIIHCDLKP ENILLKHHGR SATKVIDFGS SCFEYQKLYT YIQSRFYRAP EIILGCRYST 180

PIDIWSFGCI LAELLTGQPL FPGEDEGDQL ACMMELLGMP PQKLLEQSKR AKYFINSKGL 240

PRYCSVTTQT DGRVVLLGGR SRRGKKRGPP GSKDWAAALK GCDDYLFIEF LKRCLQWDPS 300

ARLTPAQALR HPWI 314

Keyword

ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004712	; F:protein serine/threonine/tyrosine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0030218	; P:erythrocyte differentiation

KEGG

rno:304775

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013