EKS-RAN-00334

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00334

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	344.9	3.8E-103	20	277	258

Status

Unreviewed

Ensembl Protein

ENSRNOP00000006705

UniProt Accession

D3ZHL6;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

Map4k5

Gene Synonyms/Alias

Map4k5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000004923	ENSRNOP00000006705	ENSRNOT00000006705

Organism

Rattus norvegicus

Functional Description

Protein Length

846

Protein Sequence
(FASTA)

MEAPLRPAAD ILRRNPQHDY ELVQRVGSGT YGDVYKARNV HTGELAAVKI IKLEPGDDFS 60

LIQQEIFMVK ECKHCNIVAY FGSYLSREKL WICMEYCGGG SLQDIYHVTG PLSELQIAYV 120

CRETLQGLAY LHTKGKMHRD IKGANILLTD HGDVKLADFG VAAKITATIA KRKSFIGTPY 180

WMAPEVAAVE KNGGYNQLCD IWAVGITAIE LGELQPPMFD LHPMRALFLM SKSNFQPPKL 240

KDKTKWSSTF HNFVKIALTK NPKKRPTAER LLTHTFVGQS GLSRALAVEL LDKVNNPDNH 300

AHYSEGDDDD FEPHAIIRHT IRSTNRNSRA ERTASEINFD KLQFEPPLRK ETEARDEMGL 360

SSEPNFILHW NPFVDGANTG RSTSKRAIPP PLPPKPRINS YPEESLPDEE KSSTVKRCPD 420

PETRAPQVLR RQSSPSCVPI AETSSVGNGN GISKLISENT EGSAQAPQLP RKKDKRDFPK 480

PTINGLPPTP KVLMGACFSK VFDGCPLKIN CATSWIHPDT KDQYIIFGTE DGIYTLNLNE 540

LHEATMEQLF PRKCTWLYVI NNTLMSLSAG KTFQLYSHNL IALFEQAKKP GLAAHIQTHR 600

FPDRILPRKF ALTTKIPDTK GCHKCCIVRN PYTGHKYLCG ALQSGIVLLQ WYEPMQKFML 660

IKHFDFPLPS PLNVFEMLVI PEQEYPMVCV AISKGTESNQ VVQFETINLN SASSWFTEIG 720

AGSQQLDSIH VTQLERDTVL VCLDKFVKIV NLQGKLKPSK KLASELSFDF RIESVVCLQD 780

SVLAFWKHGM QGKSFKSDEV TQEISDETRV FRLLGSDRVV VLESRPTENP TAHSNLYILA 840

GHENSY 846

Nucleotide Sequence
(FASTA)

ATGGAGGCCC CTCTGAGGCC TGCCGCCGAC ATCCTGAGAC GGAACCCGCA GCACGACTAC 60

GAACTGGTGC AGAGGGTCGG CAGCGGCACC TACGGGGACG TGTACAAGGC CAGAAATGTA 120

CATACAGGAG AATTAGCTGC AGTAAAAATC ATCAAATTGG AGCCTGGTGA TGATTTTTCT 180

TTGATTCAAC AAGAAATATT TATGGTTAAA GAATGTAAAC ATTGCAACAT CGTAGCCTAC 240

TTTGGGAGCT ATCTCAGTAG GGAAAAGCTG TGGATCTGCA TGGAGTACTG CGGTGGCGGC 300

TCACTTCAAG ACATCTATCA CGTTACTGGA CCACTATCTG AACTGCAAAT AGCCTACGTC 360

TGCAGAGAGA CCTTACAGGG TCTTGCTTAT TTGCATACTA AAGGCAAAAT GCATAGAGAT 420

ATCAAAGGTG CAAATATCTT ATTAACAGAC CATGGTGATG TAAAGTTAGC TGATTTTGGT 480

GTGGCTGCAA AGATCACAGC TACCATTGCA AAGAGGAAGT CCTTCATCGG CACCCCTTAC 540

TGGATGGCTC CAGAGGTGGC AGCGGTGGAA AAGAATGGCG GCTACAACCA GCTCTGTGAT 600

ATCTGGGCAG TCGGGATAAC AGCCATCGAG CTTGGAGAAC TTCAGCCGCC TATGTTTGAC 660

CTTCATCCAA TGAGGGCTCT CTTCTTAATG TCAAAAAGTA ATTTCCAGCC TCCAAAGCTA 720

AAGGACAAAA CTAAATGGTC ATCGACATTC CATAATTTTG TCAAAATAGC ACTAACTAAA 780

AACCCCAAGA AAAGACCAAC TGCTGAAAGG CTTCTGACTC ACACTTTTGT TGGGCAGTCA 840

GGTCTGTCTC GGGCCCTCGC GGTTGAACTG TTGGACAAGG TGAACAATCC AGACAACCAT 900

GCTCACTACA GTGAGGGTGA CGATGATGAC TTTGAGCCTC ACGCAATCAT TCGTCATACC 960

ATTAGATCAA CAAACAGGAA TTCCAGAGCT GAACGGACAG CTTCAGAAAT AAACTTTGAC 1020

AAATTACAGT TTGAACCTCC TCTAAGAAAA GAAACAGAAG CCCGGGATGA AATGGGATTA 1080

TCTTCAGAAC CAAACTTTAT ATTACATTGG AATCCTTTTG TCGATGGTGC AAATACAGGC 1140

AGATCAACGT CTAAGCGAGC CATACCGCCT CCGCTACCTC CCAAGCCAAG GATAAACAGT 1200

TACCCTGAAG AAAGCCTCCC AGATGAAGAA AAATCCTCAA CCGTCAAACG TTGCCCTGAT 1260

CCGGAGACCA GAGCACCTCA GGTCCTCAGA AGACAGAGTA GCCCAAGCTG TGTTCCTATA 1320

GCGGAGACAT CCTCTGTAGG AAACGGCAAT GGAATTTCAA AACTGATCAG TGAGAACACG 1380

GAGGGATCAG CACAGGCTCC ACAGTTACCT CGGAAAAAGG ACAAGCGGGA CTTCCCTAAA 1440

CCAACCATCA ATGGCCTTCC CCCAACCCCA AAAGTGCTGA TGGGAGCATG CTTTTCAAAA 1500

GTATTTGATG GCTGCCCTTT GAAAATTAAT TGTGCAACAT CCTGGATACA CCCTGATACA 1560

AAAGACCAGT ACATTATTTT TGGGACTGAA GATGGTATTT ACACATTGAA TCTCAATGAG 1620

CTACATGAAG CAACTATGGA ACAGTTATTT CCACGGAAAT GCACATGGCT CTACGTCATC 1680

AATAATACAC TGATGTCATT GTCAGCAGGA AAAACCTTTC AGCTCTACTC TCACAACCTT 1740

ATCGCTTTGT TTGAACAAGC CAAAAAGCCA GGGTTAGCCG CCCACATCCA GACTCACAGG 1800

TTTCCTGACC GCATTCTGCC AAGAAAATTT GCCTTAACAA CAAAGATTCC TGATACAAAA 1860

GGATGCCACA AATGCTGTAT AGTTAGAAAC CCTTACACGG GACATAAATA CCTCTGCGGA 1920

GCCTTGCAAT CTGGAATCGT TCTGCTTCAG TGGTATGAAC CGATGCAGAA GTTCATGTTG 1980

ATAAAGCATT TTGACTTTCC TTTGCCAAGT CCACTGAATG TGTTTGAAAT GCTGGTGATA 2040

CCAGAGCAGG AGTACCCCAT GGTTTGTGTG GCCATCAGCA AAGGGACAGA GTCAAACCAA 2100

GTAGTTCAGT TTGAGACAAT CAACTTGAAC TCTGCATCGT CCTGGTTTAC AGAAATTGGT 2160

GCAGGCAGCC AGCAGCTGGA CTCCATTCAC GTGACGCAGC TGGAGAGAGA CACTGTTCTG 2220

GTGTGTTTGG ACAAATTTGT AAAAATTGTA AATCTACAAG GAAAGCTGAA ACCCAGTAAG 2280

AAGCTGGCGT CTGAGCTCAG TTTTGACTTC CGCATTGAGT CCGTGGTGTG CCTTCAAGAC 2340

AGCGTGTTGG CTTTCTGGAA ACACGGGATG CAGGGTAAAA GCTTCAAATC CGACGAGGTT 2400

ACCCAGGAAA TTTCGGATGA AACAAGAGTT TTCCGCCTGC TAGGATCAGA CAGGGTCGTT 2460

GTTTTGGAAA GTAGGCCGAC AGAAAACCCT ACAGCTCACA GCAATCTCTA CATCCTGGCT 2520

GGACATGAAA ACAGTTACTA A 2541

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         yel++++g+G++g+vy+ar+++tgel+a+k+i+le  ++ +++q+ei ++k++kh niv+

Q: 20    YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVA  79

         99**********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s+l +e+lw++mey+ gGsl+d+++  ++ +l+E qiay++re+l++L+ylH+k+++

Q: 80    YFGSYLSREKLWICMEYCGGGSLQDIYH--VTGPLSELQIAYVCRETLQGLAYLHTKGKM  137

         ****************************..******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179

         Hrdik++niLlt++g+VkL+dfgvaa++++t +krk+++gtpywmAPEv a+e + gY++

Q: 138   HRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEkNGGYNQ  197

         ****************************************************98889***

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237

          +Diw++GItaiel e +pP++dl+p++al++++k++  ppklk+k+k+s++f++fv+ +

Q: 198   LCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNfqPPKLKDKTKWSSTFHNFVKIA  257

         ********************************9999988*********************

S: 238   lqknpekRpsasellkhkFl  257

         l+knp+kRp+a++ll+h+F+

Q: 258   LTKNPKKRPTAERLLTHTFV  277

         *******************7

Domain Sequence
(FASTA)

YELVQRVGSG TYGDVYKARN VHTGELAAVK IIKLEPGDDF SLIQQEIFMV KECKHCNIVA 60

YFGSYLSREK LWICMEYCGG GSLQDIYHVT GPLSELQIAY VCRETLQGLA YLHTKGKMHR 120

DIKGANILLT DHGDVKLADF GVAAKITATI AKRKSFIGTP YWMAPEVAAV EKNGGYNQLC 180

DIWAVGITAI ELGELQPPMF DLHPMRALFL MSKSNFQPPK LKDKTKWSST FHNFVKIALT 240

KNPKKRPTAE RLLTHTFV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0006950	; P:response to stress

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013