EKS-RAN-00316

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00316

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	457.8	1.2E-137	707	963	257

Status

Unreviewed

Ensembl Protein

ENSRNOP00000006796

UniProt Accession

G3V6N1;

Protein Name

Protein Synonyms/Alias

Receptor tyrosine-protein kinase erbB-3; V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (Avian), isoform CRA_a;

Gene Name

Erbb3

Gene Synonyms/Alias

Erbb3; rCG_42497;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000004964	ENSRNOP00000006796	ENSRNOT00000006796

Organism

Rattus norvegicus

Functional Description

Protein Length

1339

Protein Sequence
(FASTA)

MRATGTLQVL CFLLSLARGS EMGNSQAVCP GTLNGLSVTG DADNQYQTLY KLYEKCEVVM 60

GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSVLPLP NLRVVRGTQV YDGKFAIFVM 120

LNYNTNSSHA LRQLKFTQLT EILSGGVYIE KNDKLCHMDT IDWRDIVRVR GAEIVVKNNG 180

ANCPPCHEVC KGRCWGPGPD DCQILTKTIC APQCNGRCFG PNPNQCCHDE CAGGCSGPQD 240

TDCFACRRFN DSGACVPRCP EPLVYNKLTF QLEPNPHTKY QYGGVCVASC PHNFVVDQTF 300

CVRACPPDKM EVDKHGLKMC EPCGGLCPKA CEGTGSGSRY QTVDSSNIDG FVNCTKILGN 360

LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ SWPPHMHNFS VFSNLTTIGG 420

RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS AGRVYISANQ QLCYHHSLNW TRLLRGPSEE 480

RLDIKYNRPL GECLAEGKVC DPLCSSGGCW GPGPGQCLSC RNYSREGVCV THCNFLQGEP 540

REFVHEAQCF SCHPECLPME GTSTCNGSGS DACARCAHFR DGPHCVNSCP HGILGAKGPI 600

YKYPDAQNEC RPCHENCTQG CNGPELQDCL GQAEVLMSKP HLVIAVTVGL AVILMILGGS 660

FLYWRGRRIQ NKRAMRRYLE RGESIEPLDP SEKANKVLAR IFKETELRKL KVLGSGVFGT 720

VHKGIWIPEG ESIKIPVCIK VIEDKSGRQS FQAVTDHMLA VGSLDHAHIV RLLGLCPGSS 780

LQLVTQYLPL GSLLDHVKQH RETLGPQLLL NWGVQIAKGM YYLEEHSMVH RDLALRNVML 840

KSPSQVQVAD FGVADLLPPD DKQLLHSEAK TPIKWMALES IHFGKYTHQS DVWSYGVTVW 900

ELMTFGAEPY AGLRLAEIPD LLEKGERLAQ PQICTIDVYM VMVKCWMIDE NIRPTFKELA 960

NEFTRMARDP PRYLVIKRAS GPGTPPAAEP SVLTTKELQE AELEPELDLD LDLEAEEEGL 1020

ATSLGSALSL PTGTLTRPRG SQSLLSPSSG YMPMNQSSLG EACLDSAVLG GREQFSRPIS 1080

LHPIPRGRPA SESSEGHVTG SEAELQEKVS VCRSRSRSRS PRPRGDSAYH SQRHSLLTPV 1140

TPLSPPGLEE EDGNGYVMPD THLRGASSSR EGTLSSVGLS SVLGTEEEDE DEEYEYMNRK 1200

RRGSPPRPPR PGSLEELGYE YMDVGSDLSA SLGSTQSCPL HPMAIVPSAG TTPDEDYEYM 1260

NRRRGAGGAG GDYAAMGACP AAEQGYEEMR AFQGPGHHAP HVRYARLKTL RSLEATDSAF 1320

DNPDYWHSRL FPKANAQRT 1339

Nucleotide Sequence
(FASTA)

ATGAGGGCGA CTGGGACTCT GCAGGTGCTG TGCTTCCTTC TCAGCCTGGC CCGGGGTTCC 60

GAGATGGGCA ACTCTCAGGC AGTGTGTCCT GGGACTCTGA ACGGACTGAG TGTGACCGGA 120

GATGCAGACA ACCAGTACCA GACGCTGTAC AAACTGTATG AAAAGTGTGA GGTGGTCATG 180

GGTAACCTGG AGATTGTGCT CACAGGACAC AATGCTGACC TTTCCTTCCT GCAATGGATC 240

CGAGAAGTGA CAGGCTACGT CCTCGTGGCC ATGAATGAAT TCTCTGTGCT TCCCTTGCCT 300

AACCTCCGAG TGGTCCGGGG AACCCAGGTC TACGATGGGA AGTTCGCCAT CTTTGTTATG 360

TTGAACTACA ACACCAACTC CAGCCATGCT CTGCGCCAGC TCAAGTTCAC TCAGCTAACA 420

GAGATTCTGT CAGGGGGCGT TTACATTGAA AAGAATGACA AACTTTGCCA CATGGATACA 480

ATTGACTGGA GAGACATCGT GAGGGTTCGA GGCGCTGAGA TAGTGGTGAA GAACAATGGT 540

GCGAACTGTC CACCCTGTCA CGAGGTCTGC AAGGGACGGT GCTGGGGTCC TGGACCGGAC 600

GACTGCCAGA TATTGACCAA GACGATCTGT GCCCCTCAGT GTAACGGTCG CTGCTTCGGG 660

CCCAACCCTA ACCAGTGCTG TCACGATGAG TGTGCTGGGG GCTGCTCTGG ACCTCAGGAC 720

ACAGATTGCT TTGCCTGCCG ACGCTTCAAT GACAGTGGGG CCTGTGTGCC CCGGTGTCCA 780

GAGCCTCTTG TGTACAACAA GCTAACGTTT CAGCTTGAAC CCAACCCCCA TACCAAGTAT 840

CAGTATGGAG GAGTCTGCGT TGCCAGTTGT CCCCATAACT TTGTGGTGGA CCAGACGTTT 900

TGTGTCAGGG CTTGTCCTCC TGACAAGATG GAAGTAGATA AGCACGGACT GAAGATGTGT 960

GAGCCTTGCG GAGGGCTGTG CCCCAAAGCC TGTGAGGGGA CAGGCTCTGG AAGCCGCTAC 1020

CAGACTGTGG ACTCAAGCAA CATTGATGGG TTCGTGAACT GTACCAAGAT CCTGGGCAAT 1080

CTGGACTTCC TCATCACCGG CCTCAACGGT GACCCCTGGC ATAAGATACC CGCACTGGAC 1140

CCGGAAAAGC TCAATGTTTT CAGAACAGTC CGGGAGATCA CAGGTTACCT AAACATCCAG 1200

TCCTGGCCCC CTCACATGCA CAACTTCAGT GTTTTTTCCA ATCTGACAAC CATCGGGGGC 1260

AGAAGCCTCT ACAACCGGGG CTTCTCCTTG TTGATCATGA AGAACTTGAA TGTCACATCC 1320

CTGGGTTTCC GGTCCCTGAA GGAAATCAGT GCTGGGCGTG TCTACATAAG TGCCAATCAG 1380

CAGCTTTGCT ACCACCACTC TCTGAACTGG ACCAGACTGC TTCGGGGGCC CTCGGAAGAG 1440

AGACTTGACA TCAAGTACAA CCGGCCTCTG GGAGAATGCT TGGCAGAGGG CAAAGTGTGT 1500

GATCCACTGT GTTCCTCTGG GGGATGCTGG GGCCCAGGCC CTGGTCAGTG CTTGTCTTGT 1560

CGAAACTACA GCCGGGAAGG TGTCTGTGTG ACTCACTGCA ACTTCCTGCA AGGGGAACCC 1620

CGGGAGTTTG TTCATGAGGC TCAATGCTTC TCCTGCCATC CAGAATGCCT ACCCATGGAG 1680

GGCACCAGCA CATGCAATGG CTCGGGCTCT GACGCTTGTG CACGATGTGC TCATTTTCGT 1740

GACGGGCCCC ACTGTGTGAA CAGCTGCCCC CATGGAATCC TAGGTGCCAA AGGTCCAATC 1800

TACAAGTATC CAGATGCTCA GAATGAGTGT CGGCCCTGCC ATGAGAACTG CACCCAAGGG 1860

TGTAACGGAC CAGAACTACA AGACTGTTTA GGCCAAGCAG AGGTGTTGAT GAGCAAACCT 1920

CATCTGGTAA TAGCGGTGAC GGTGGGACTG GCCGTGATCC TCATGATTCT GGGAGGCTCT 1980

TTTCTGTATT GGCGTGGACG CAGGATTCAG AACAAAAGGG CTATGAGACG CTACTTGGAG 2040

CGGGGTGAGA GCATCGAGCC TCTGGACCCA AGCGAGAAGG CAAACAAAGT CTTGGCTAGA 2100

ATCTTCAAAG AGACAGAGCT GAGGAAACTT AAAGTGCTTG GCTCTGGCGT CTTTGGAACT 2160

GTCCACAAGG GGATTTGGAT TCCTGAGGGT GAATCCATCA AGATTCCAGT CTGCATTAAA 2220

GTCATCGAGG ACAAGAGTGG GCGCCAAAGT TTTCAAGCTG TGACTGACCA TATGCTGGCC 2280

GTTGGCAGCC TGGACCATGC CCACATTGTA CGGCTGCTAG GACTGTGCCC AGGGTCATCT 2340

CTGCAGCTTG TTACTCAGTA CTTGCCCCTG GGCTCCCTCC TTGATCATGT GAAACAGCAC 2400

CGTGAGACAT TGGGACCACA GCTGCTGCTC AACTGGGGAG TACAAATTGC CAAGGGCATG 2460

TATTACCTCG AGGAACATAG CATGGTGCAC AGGGACCTTG CGCTCCGGAA CGTGATGCTC 2520

AAGTCACCAA GTCAGGTCCA GGTGGCAGAT TTTGGTGTGG CTGACTTGTT GCCACCAGAT 2580

GACAAGCAGT TGCTACATAG TGAGGCCAAG ACTCCAATTA AGTGGATGGC CCTTGAGAGT 2640

ATCCACTTTG GGAAATACAC ACACCAGAGT GATGTCTGGA GTTATGGTGT AACAGTTTGG 2700

GAGTTGATGA CCTTCGGGGC AGAGCCCTAT GCAGGGTTAC GACTGGCTGA AATACCAGAC 2760

CTGCTAGAGA AGGGAGAGCG GTTAGCACAG CCCCAGATCT GCACCATTGA CGTCTACATG 2820

GTCATGGTCA AGTGCTGGAT GATTGATGAG AATATTCGCC CAACCTTTAA AGAACTAGCC 2880

AATGAGTTTA CCAGGATGGC CCGTGACCCA CCAAGGTATC TGGTCATCAA GAGAGCGAGT 2940

GGGCCTGGAA CACCTCCTGC GGCAGAACCC TCTGTTCTGA CCACCAAAGA GTTGCAGGAG 3000

GCAGAGCTGG AGCCAGAACT GGACCTAGAC CTAGACTTGG AGGCAGAGGA GGAGGGCCTG 3060

GCCACCTCCC TGGGTTCTGC TCTCAGCTTG CCTACGGGAA CGCTCACCCG GCCACGTGGG 3120

AGCCAGAGCC TTTTAAGTCC CTCATCTGGG TACATGCCCA TGAACCAGAG CAGTCTCGGA 3180

GAGGCTTGTC TGGATTCTGC GGTTTTGGGG GGTCGTGAAC AGTTCTCCCG TCCCATCTCT 3240

CTGCACCCAA TTCCACGGGG GCGTCCAGCA TCAGAGTCAT CAGAGGGCCA CGTGACAGGC 3300

TCTGAGGCTG AACTCCAAGA GAAAGTGTCA GTGTGTAGGA GCCGAAGCCG GAGTCGGAGC 3360

CCGCGGCCTC GTGGGGACAG TGCCTACCAT TCGCAGCGAC ACAGCCTGCT TACTCCTGTG 3420

ACCCCGCTCT CCCCACCAGG GTTAGAGGAG GAGGACGGCA ATGGCTACGT CATGCCAGAT 3480

ACACACCTCA GAGGTGCGTC CTCCTCCCGG GAAGGCACCC TCTCGTCGGT AGGTCTCAGT 3540

TCTGTGTTGG GTACTGAGGA GGAAGATGAA GATGAGGAGT ATGAATACAT GAACCGGAAG 3600

AGAAGGGGTA GCCCTCCTCG GCCCCCCAGG CCTGGCTCCC TGGAAGAACT GGGTTACGAG 3660

TACATGGATG TGGGTTCAGA CCTCAGTGCT TCTCTGGGCA GTACACAGAG CTGCCCGCTC 3720

CATCCCATGG CCATCGTGCC CTCTGCTGGC ACAACTCCAG ATGAAGACTA TGAGTACATG 3780

AACCGGAGGC GTGGTGCGGG TGGCGCCGGA GGGGACTATG CAGCTATGGG GGCCTGCCCA 3840

GCAGCTGAGC AAGGGTACGA GGAGATGCGA GCTTTCCAGG GGCCTGGACA TCACGCCCCC 3900

CATGTTCGTT ATGCCCGCCT CAAAACTCTG CGTAGTTTAG AAGCCACCGA CTCTGCCTTC 3960

GACAACCCCG ATTACTGGCA CAGCAGGCTT TTCCCCAAGG CTAATGCCCA GAGAACGTAA 4020

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+klkvlGsG+fGtv+kGiwipege++kipv+ikv+e+k+g++++++++d++l+++sldh

Q: 707   LRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDH  766

         69**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         a++vrllglc  s+lqlvtq+lplG+lld+v++h+++lG+q llnw+vqiakGm+ylee+

Q: 767   AHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVKQHRETLGPQLLLNWGVQIAKGMYYLEEH  826

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         ++vhrdla rnv++ksp++v+++dfG+a+ll  d+k+l ++++k+pikw+alesi++ ky

Q: 827   SMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKY  886

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfGa+py+g++++eipdllekGerlaqp+ictidvymv+vkcw

Q: 887   THQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCW  946

         ************************************************************

S: 241   midaesrpkfkelaeef  257

         mid+++rp+fkela+ef

Q: 947   MIDENIRPTFKELANEF  963

         ****************9

Domain Sequence
(FASTA)

LRKLKVLGSG VFGTVHKGIW IPEGESIKIP VCIKVIEDKS GRQSFQAVTD HMLAVGSLDH 60

AHIVRLLGLC PGSSLQLVTQ YLPLGSLLDH VKQHRETLGP QLLLNWGVQI AKGMYYLEEH 120

SMVHRDLALR NVMLKSPSQV QVADFGVADL LPPDDKQLLH SEAKTPIKWM ALESIHFGKY 180

THQSDVWSYG VTVWELMTFG AEPYAGLRLA EIPDLLEKGE RLAQPQICTI DVYMVMVKCW 240

MIDENIRPTF KELANEF 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 5.
SM00219	; TyrKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013