EKS-RAN-00294

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00294

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	451.2	1.9E-135	208	495	288

Status

Reviewed

Ensembl Protein

ENSRNOP00000006963

UniProt Accession

P80201;

Protein Name

Activin receptor type-1

Protein Synonyms/Alias

Activin receptor type I; ACTR-I; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I;

Gene Name

Acvr1

Gene Synonyms/Alias

Acvr1; Acvrlk2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000005033	ENSRNOP00000006963	ENSRNOT00000006963

Organism

Rattus norvegicus

Functional Description

On ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).

Protein Length

509

Protein Sequence
(FASTA)

MVDGAMILSV LMMMALPSPS MEDEEPKVNP KLYMCVCEGL SCGNEDHCEG QQCFSSLSVN 60

DGFRVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNVTARLPTK GKSFPGSQNF 120

HLEVGLIILS VVFAVCLFAC ILGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL 180

AELLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR 240

DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 300

DTVSCLRIVL SIASGLAHLH IEIFGTQGKS AIAHRDLKSK NILVKKNGQC CIADLGLAVM 360

HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS 420

NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ 480

NPSARLTALR IKKTLTKIDN SLDKLKTDC 509

Nucleotide Sequence
(FASTA)

ATGGTCGATG GAGCAATGAT CCTTTCTGTG CTAATGATGA TGGCTCTCCC TTCCCCGAGT 60

ATGGAAGATG AGGAGCCCAA GGTCAACCCG AAGCTTTACA TGTGTGTGTG TGAGGGCCTC 120

TCCTGCGGGA ACGAGGACCA CTGTGAGGGC CAGCAGTGTT TTTCCTCCCT GAGCGTCAAT 180

GATGGCTTCC GCGTCTACCA GAAGGGCTGC TTTCAGGTCT ATGAGCAGGG GAAGATGACG 240

TGTAAGACCC CGCCGTCGCC TGGCCAGGCT GTGGAGTGCT GCCAAGGGGA CTGGTGCAAC 300

AGGAACGTCA CGGCCCGGCT GCCCACTAAA GGGAAATCCT TCCCTGGATC GCAGAACTTC 360

CACCTGGAAG TTGGCCTTAT CATCCTCTCC GTGGTGTTTG CGGTATGCCT TTTCGCTTGC 420

ATCCTTGGCG TTGCTCTCAG GAAGTTTAAA AGGCGCAATC AAGAGCGCCT GAACCCCAGA 480

GACGTGGAGT ATGGTACTAT CGAAGGGCTC ATCACCACCA ACGTCGGAGA TAGCACTCTA 540

GCGGAATTAC TAGATCACTC GTGTACATCA GGAAGTGGCT CCGGTCTTCC TTTTCTGGTA 600

CAGAGAACTG TGGCTCGACA GATAACCCTG TTGGAGTGTG TCGGGAAGGG CCGGTATGGA 660

GAAGTGTGGA GGGGCAGCTG GCAAGGCGAA AATGTTGCTG TGAAGATCTT CTCCTCCCGT 720

GATGAGAAGT CGTGGTTCAG GGAGACAGAA TTGTACAACA CGGTGATGCT GAGGCATGAG 780

AATATCTTAG GTTTCATTGC TTCAGACATG ACCTCTAGAC ACTCCAGTAC CCAGCTGTGG 840

CTCATTACAC ATTACCACGA AATGGGATCG TTGTATGACT ACCTTCAGCT CACCACTCTG 900

GACACGGTTA GCTGCCTTCG GATCGTGTTG TCCATAGCCA GCGGCCTTGC ACACTTGCAC 960

ATAGAGATAT TTGGGACCCA GGGGAAGTCT GCCATCGCCC ACCGAGATCT AAAGAGCAAA 1020

AACATCCTCG TGAAGAAGAA CGGACAGTGC TGCATAGCAG ATTTGGGCCT GGCAGTCATG 1080

CATTCCCAGA GCACGAATCA GCTTGATGTG GGAAACAACC CCCGTGTGGG GACCAAGCGC 1140

TACATGGCCC CTGAAGTGCT TGATGAAACC ATCCAAGTGG ATTGCTTTGA TTCTTATAAG 1200

AGGGTCGATA TTTGGGCCTT TGGCCTCGTT CTGTGGGAAG TGGCCAGGAG GATGGTGAGC 1260

AATGGTATAG TGGAAGATTA CAAGCCACCA TTCTATGATG TTGTTCCCAA TGACCCAAGT 1320

TTTGAAGATA TGAGGAAAGT TGTCTGTGTG GATCAACAGA GGCCAAACAT ACCTAACAGA 1380

TGGTTCTCAG ACCCGACATT AACTTCTCTG GCGAAGCTGA TGAAAGAATG CTGGTACCAG 1440

AACCCATCCG CCAGACTCAC AGCTCTACGT ATCAAAAAGA CTTTGACCAA AATTGATAAC 1500

TCCCTAGACA AATTAAAAAC TGACTGTTGA 1530

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++lle++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+e+y+tv+lrhenil+fia

Q: 208   ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIA  267

         789*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+++++s+t+l+l+t+yhe+gsL+dyL+ +tld+ ++lr++ls+asGlahLH ei+gt+

Q: 268   SDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQ  327

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  K aiaHRDlkskNilvkk+++cciaDlGLa+++++++++ld+ +n +vGtkRYmaPE

Q: 328   G--KSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE  385

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++++++f+++kr+D++++gLvlWEva+R+ + +++ve+yk+pf++vv++dPs+e+m

Q: 386   VLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS-NGIVEDYKPPFYDVVPNDPSFEDM  444

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++++rP+ip++w ++++l++l+kl++ecW+++p+aRltalr+kk+l

Q: 445   RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL  495

         *************************************************97

Domain Sequence
(FASTA)

ITLLECVGKG RYGEVWRGSW QGENVAVKIF SSRDEKSWFR ETELYNTVML RHENILGFIA 60

SDMTSRHSST QLWLITHYHE MGSLYDYLQL TTLDTVSCLR IVLSIASGLA HLHIEIFGTQ 120

GKSAIAHRDL KSKNILVKKN GQCCIADLGL AVMHSQSTNQ LDVGNNPRVG TKRYMAPEVL 180

DETIQVDCFD SYKRVDIWAF GLVLWEVARR MVSNGIVEDY KPPFYDVVPN DPSFEDMRKV 240

VCVDQQRPNI PNRWFSDPTL TSLAKLMKEC WYQNPSARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0048179	; C:activin receptor complex
GO:0045177	; C:apical part of cell
GO:0016361	; F:activin receptor activity, type I
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0046332	; F:SMAD binding
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0002526	; P:acute inflammatory response
GO:0003289	; P:atrial septum primum morphogenesis
GO:0030509	; P:BMP signaling pathway
GO:0060923	; P:cardiac muscle cell fate commitment
GO:0071385	; P:cellular response to glucocorticoid stimulus
GO:0007368	; P:determination of left/right symmetry
GO:0003143	; P:embryonic heart tube morphogenesis
GO:0003197	; P:endocardial cushion development
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0001702	; P:gastrulation with mouth forming second
GO:0007281	; P:germ cell development
GO:0001701	; P:in utero embryonic development
GO:0001707	; P:mesoderm formation
GO:0003183	; P:mitral valve morphogenesis
GO:0032926	; P:negative regulation of activin receptor signaling pathway
GO:0043066	; P:negative regulation of apoptotic process
GO:0001755	; P:neural crest cell migration
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0001569	; P:patterning of blood vessels
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0060037	; P:pharyngeal system development
GO:0030501	; P:positive regulation of bone mineralization
GO:2000017	; P:positive regulation of determination of dorsal identity
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0048641	; P:regulation of skeletal muscle tissue development
GO:0051145	; P:smooth muscle cell differentiation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0001655	; P:urogenital system development

KEGG

rno:79558

;

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013