EKS-RAN-00203

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00203

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	483.6	1.8E-145	4	286	283

Status

Reviewed

Ensembl Protein

ENSRNOP00000055819

UniProt Accession

Q9JM01; Q9JM02;

Protein Name

Cyclin-dependent kinase-like 3

Protein Synonyms/Alias

Serine/threonine protein kinase NKIATRE;

Gene Name

Cdkl3

Gene Synonyms/Alias

Cdkl3; Nkiatre;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000005097	ENSRNOP00000055819	ENSRNOT00000059040

Organism

Rattus norvegicus

Functional Description

Protein Length

593

Protein Sequence
(FASTA)

MEMYETLGKV GEGSYGTVMK CKHKDTGRIV AIKIFYEKPE KSVNKIATRE IKFLKQFRHE 60

NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK RLRKYLFQIL RAIEYLHNNN 120

IIHRDIKPEN ILVSQSGITK LCDFGFARTL AAPGDVYTDY VATRWYRAPE LVLKDTTYGK 180

PVDIWALGCM IIEMATGNPY LPSSSDLDLL HKIVLKVGNL TPHLHNIFSK SPIFAGVVLP 240

QVQHPKNARK KYPKLNGLLA DIVHACLQID PAERISSTDL LHHDYFTRDG FIEKFIPELR 300

AKLLQEAKVN SFIKPKENFK ENEPVRDEKK PVFTNPLLYG NPTLYGKEVD RDKRAKELKV 360

RVIKAKGGKG DVPDLKKTES EGEHRQQGTA EDTHPTSLDR KPSVSELTNP VHPSANSDTV 420

KEDPHSGGCM IMPPINLTSS NLLAANPSSN LSHPNSRLTE RTKKRRTSSQ TIGQTLSNSR 480

QEDTGPTQVQ TEKGAFNERT GQNDQIASGN KRKLNFSKCD RKEFHFPELP FTIQAKEMKG 540

MEVKQIKVLK RESKKTDSPK IPTLLSMDSN QEKQEVFNIF PGWCKRGNLN WPS 593

Nucleotide Sequence
(FASTA)

ATGGAGATGT ATGAAACCCT TGGAAAAGTA GGAGAGGGAA GTTATGGAAC GGTCATGAAA 60

TGCAAGCATA AGGATACTGG GCGGATAGTG GCCATTAAGA TATTCTATGA GAAACCAGAA 120

AAATCTGTCA ACAAAATTGC AACGAGAGAA ATAAAGTTTC TAAAGCAATT TCGTCATGAA 180

AACCTGGTCA ATCTGATTGA AGTTTTTAGA CAAAAAAAGA AAATCCATTT GGTATTTGAG 240

TTTATTGACC ACACGGTCTT AGATGAGTTA CAGCATTATT GTCACGGATT AGAGAGTAAG 300

CGACTAAGAA AGTACCTGTT CCAGATCCTC CGAGCGATCG AGTATCTGCA CAACAACAAC 360

ATTATCCACC GAGATATAAA GCCTGAGAAT ATTTTAGTCT CCCAGTCAGG AATTACAAAG 420

CTCTGCGATT TTGGGTTTGC GCGGACACTA GCAGCTCCTG GAGACGTTTA CACAGACTAC 480

GTGGCCACCC GCTGGTACAG AGCTCCAGAG CTGGTGTTGA AAGACACCAC CTATGGAAAA 540

CCAGTGGATA TCTGGGCTTT GGGCTGTATG ATCATTGAAA TGGCCACTGG CAATCCCTAC 600

CTTCCTAGCA GTTCCGATTT GGATTTGCTC CACAAGATTG TTTTAAAAGT AGGCAACCTG 660

ACCCCGCACC TGCACAATAT TTTTTCCAAG AGTCCCATCT TTGCTGGGGT GGTTCTTCCT 720

CAAGTTCAAC ATCCCAAAAA CGCAAGAAAG AAATACCCAA AGCTCAACGG ATTGCTGGCA 780

GATATAGTTC ATGCTTGTTT ACAAATTGAT CCTGCTGAGA GGATATCATC CACCGATCTT 840

TTGCATCACG ATTACTTTAC TAGAGATGGA TTTATTGAGA AATTTATACC AGAGCTGAGA 900

GCTAAGTTAT TACAGGAAGC AAAGGTTAAT TCATTTATAA AGCCAAAAGA GAATTTTAAG 960

GAAAATGAAC CTGTGAGAGA TGAGAAAAAA CCAGTTTTTA CCAACCCTCT GCTCTATGGA 1020

AACCCAACAC TTTATGGAAA GGAAGTGGAC AGAGACAAAA GGGCCAAGGA GCTCAAAGTC 1080

AGAGTCATTA AGGCCAAAGG GGGAAAAGGA GACGTCCCAG ACCTGAAGAA GACAGAGAGT 1140

GAAGGTGAAC ACCGCCAGCA GGGCACAGCT GAGGACACAC ACCCCACATC ACTGGACAGG 1200

AAGCCTTCTG TCTCGGAACT AACAAACCCT GTCCATCCCA GTGCGAATTC TGACACTGTC 1260

AAAGAAGACC CACACTCTGG GGGCTGTATG ATAATGCCAC CTATCAACCT GACAAGCAGT 1320

AATTTGTTGG CCGCAAATCC CAGTTCAAAC CTCTCCCACC CCAATTCACG GTTAACTGAA 1380

AGAACAAAAA AGAGACGCAC CTCTTCACAA ACTATTGGAC AAACTTTGTC TAATAGCAGA 1440

CAAGAGGACA CAGGTCCCAC ACAAGTCCAA ACAGAGAAAG GTGCATTTAA TGAGCGAACA 1500

GGTCAGAATG ACCAAATAGC AAGTGGAAAC AAAAGAAAAC TGAATTTTTC CAAATGCGAC 1560

AGGAAAGAAT TCCATTTCCC TGAGCTGCCG TTCACAATAC AGGCGAAGGA GATGAAAGGG 1620

ATGGAGGTTA AACAGATAAA AGTGCTGAAG AGAGAATCAA AGAAAACGGA TTCACCTAAA 1680

ATACCAACTT TACTTAGTAT GGACTCAAAT CAAGAAAAAC AAGAGGTTTT CAACATCTTT 1740

CCTGGCTGGT GCAAGAGAGG CAACCTCAAC TGGCCATCCT GA 1782

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         ye+lgkvGeGsyG+v+kc++kdtg+ivaik f+e+++ k+v+kia+reik+lkq++henl

Q: 4     YETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPE-KSVNKIATREIKFLKQFRHENL  62

         9***********************************9.9*********************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnl+evfr+kkk++lvfe++d+tvldel++y++G+e+++++k+l+qil+aie++h+nnii

Q: 63    VNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIEYLHNNNII  122

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrdikpenil+s+sg++klcdfGfar+laapgdvytdyvatrwyrapel+++dt+yGk+v

Q: 123   HRDIKPENILVSQSGITKLCDFGFARTLAAPGDVYTDYVATRWYRAPELVLKDTTYGKPV  182

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         d+wa+Gc+++e++tG+p++p++sd+d l+ki+ ++G+l+p+ ++ifsk+++faGv+lp+v

Q: 183   DIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLTPHLHNIFSKSPIFAGVVLPQV  242

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         +++++++kkypkln +l+d++++cl++dpaer+s+++ll+h+yf

Q: 243   QHPKNARKKYPKLNGLLADIVHACLQIDPAERISSTDLLHHDYF  286

         *******************************************9

Domain Sequence
(FASTA)

YETLGKVGEG SYGTVMKCKH KDTGRIVAIK IFYEKPEKSV NKIATREIKF LKQFRHENLV 60

NLIEVFRQKK KIHLVFEFID HTVLDELQHY CHGLESKRLR KYLFQILRAI EYLHNNNIIH 120

RDIKPENILV SQSGITKLCD FGFARTLAAP GDVYTDYVAT RWYRAPELVL KDTTYGKPVD 180

IWALGCMIIE MATGNPYLPS SSDLDLLHKI VLKVGNLTPH LHNIFSKSPI FAGVVLPQVQ 240

HPKNARKKYP KLNGLLADIV HACLQIDPAE RISSTDLLHH DYF 283

Keyword

Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0007049	; P:cell cycle

KEGG

rno:60396

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013