EKS-RAN-00042

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00042

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/VRK	436.5	3.9E-131	37	303	267

Status

Unreviewed

Ensembl Protein

ENSRNOP00000029546

UniProt Accession

D4AEH5;

Protein Name

Protein Synonyms/Alias

Protein Vrk1;

Gene Name

Vrk1

Gene Synonyms/Alias

Vrk1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000005274	ENSRNOP00000029546	ENSRNOT00000036035

Organism

Rattus norvegicus

Functional Description

Protein Length

414

Protein Sequence
(FASTA)

MPRVKAAQAG RQGPAKRRLA EQFAAGEIIT DMSKKEWKLG LPIGQGGFGC IYLADTNSSK 60

PVGSDAPCVV KVEPSDNGPL FTELKFYQRA AKPEQIQKWI HTHKLKYLGV PKYWGSGLHD 120

KNGKSYRFMI MDRFGSDLQK IYEANAKRFS RKTVLQLSLR ILDILEYIHE HEYVHGDIKA 180

SNLLLSYKNP DQVYLVDYGL AYRYCPDGVH KEYKEDPKRC HDGTLEFTSI DAHNGVAPSR 240

RGDLEILGYC MIQWLSGCLP WEDNLKDPNY VRQSKIRYRD NVAALMEKCF PERNKPGEIA 300

KYMETVKLLD YTEKPLYQNL RDILLQGLKA IGSKDDGKLD FSAVENGSVN TKPASKKRKK 360

GAVEEESSVC AVEESPVCAV EESPVCAVED MECADTQAQE AIQTRSRTRK KAQQ 414

Nucleotide Sequence
(FASTA)

ATGCCTCGTG TAAAAGCAGC TCAGGCTGGA AGACAGGGAC CTGCAAAGAG GCGCCTCGCA 60

GAGCAGTTTG CCGCTGGAGA GATCATAACC GACATGTCTA AAAAGGAATG GAAACTAGGC 120

TTGCCTATTG GCCAAGGAGG CTTTGGCTGC ATCTATCTGG CGGACACAAA TTCTTCCAAA 180

CCGGTCGGCA GTGATGCGCC CTGTGTTGTG AAAGTGGAAC CCAGTGACAA TGGACCTCTT 240

TTCACTGAAT TAAAGTTCTA CCAGAGGGCT GCTAAACCAG AGCAAATTCA GAAATGGATT 300

CATACACATA AATTGAAGTA TCTTGGTGTT CCTAAGTATT GGGGATCTGG TCTACATGAT 360

AAAAATGGAA AAAGTTACAG GTTTATGATA ATGGACCGCT TTGGGAGTGA CCTTCAGAAA 420

ATATATGAAG CAAATGCCAA AAGGTTTTCT CGGAAAACTG TCTTGCAGCT AAGCTTAAGA 480

ATTCTGGATA TCCTGGAGTA CATCCACGAG CACGAGTATG TGCATGGGGA CATCAAGGCC 540

TCCAACCTCC TTCTGAGTTA CAAGAACCCT GACCAGGTGT ATTTGGTTGA CTATGGACTT 600

GCTTATCGGT ACTGCCCAGA TGGAGTTCAT AAAGAGTACA AGGAAGATCC CAAAAGGTGC 660

CACGACGGCA CACTGGAGTT CACCAGCATC GATGCTCACA ATGGCGTGGC CCCATCTCGA 720

CGTGGTGATT TGGAAATACT TGGTTACTGC ATGATCCAGT GGCTCAGCGG CTGTCTTCCT 780

TGGGAGGATA ACTTGAAAGA CCCCAACTAC GTCAGACAGT CCAAAATTAG ATACAGAGAC 840

AATGTCGCAG CTTTGATGGA GAAATGCTTT CCTGAGAGGA ATAAGCCAGG TGAGATCGCT 900

AAGTACATGG AGACTGTGAA ACTACTGGAC TACACTGAAA AGCCGCTTTA CCAAAACCTA 960

CGTGACATCC TTCTGCAAGG ACTAAAAGCT ATAGGAAGTA AGGATGACGG CAAACTGGAT 1020

TTTAGTGCTG TGGAGAACGG AAGTGTGAAC ACAAAACCAG CTTCAAAGAA GCGGAAGAAA 1080

GGCGCTGTGG AAGAAGAAAG CTCAGTGTGC GCTGTGGAAG AAAGCCCAGT GTGCGCTGTG 1140

GAAGAAAGCC CAGTGTGCGC CGTGGAAGAC ATGGAGTGCG CAGACACACA GGCGCAAGAG 1200

GCCATACAGA CTCGTTCACG AACCAGAAAG AAAGCCCAGC AATAA 1245

Domain Profile

S: 1     wklgkkigkggfGeiyla..ltckkeekdaklvvkvepkenGpLfvelkfyqraakkeqi  58

         wklg +ig+ggfG+iyla  +++k +++da +vvkvep++nGpLf+elkfyqraak+eqi

Q: 37    WKLGLPIGQGGFGCIYLAdtNSSKPVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQI  96

         9*****************98899999**********************************

S: 59    kkwkkkkklkllgiPtliasGlhefegekyRflvlprlgrdLqklleqngkrlsektvlq  118

         +kw++++klk+lg+P++++sGlh+++g++yRf++++r+g+dLqk++e+n+kr+s+ktvlq

Q: 97    QKWIHTHKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQ  156

         ************************************************************

S: 119   lavrlldvleylHeneYvHgdikAanllleeeeasqvyLvdyGlayrycpegkhkeyked  178

         l++r+ld+ley+He+eYvHgdikA+nlll++++++qvyLvdyGlayrycp+g+hkeyked

Q: 157   LSLRILDILEYIHEHEYVHGDIKASNLLLSYKNPDQVYLVDYGLAYRYCPDGVHKEYKED  216

         ************************************************************

S: 179   krraHdGtleftslDaHkGvapsrRsDleiLgYcllkWltgkLPWeallkdpekvqkake  238

         ++r+HdGtlefts+DaH+GvapsrR+DleiLgYc+++Wl+g+LPWe++lkdp++v+++k

Q: 217   PKRCHDGTLEFTSIDAHNGVAPSRRGDLEILGYCMIQWLSGCLPWEDNLKDPNYVRQSKI  276

         ************************************************************

S: 239   kfldelpellkkllkkkssseelakyl  265

         ++ d++++l++k+++++++++e+aky+

Q: 277   RYRDNVAALMEKCFPERNKPGEIAKYM  303

         **************************8

Domain Sequence
(FASTA)

WKLGLPIGQG GFGCIYLADT NSSKPVGSDA PCVVKVEPSD NGPLFTELKF YQRAAKPEQI 60

QKWIHTHKLK YLGVPKYWGS GLHDKNGKSY RFMIMDRFGS DLQKIYEANA KRFSRKTVLQ 120

LSLRILDILE YIHEHEYVHG DIKASNLLLS YKNPDQVYLV DYGLAYRYCP DGVHKEYKED 180

PKRCHDGTLE FTSIDAHNGV APSRRGDLEI LGYCMIQWLS GCLPWEDNLK DPNYVRQSKI 240

RYRDNVAALM EKCFPERNKP GEIAKYM 267

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005795	; C:Golgi stack
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0090166	; P:Golgi disassembly
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013