EKS-RAN-00298

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00298

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	419.6	7.8E-126	192	478	287

Status

Unreviewed

Ensembl Protein

ENSRNOP00000007404

UniProt Accession

F1MA24;

Protein Name

Protein Synonyms/Alias

Activin receptor type-2A;

Gene Name

Acvr2a

Gene Synonyms/Alias

Acvr2a;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000005334	ENSRNOP00000007404	ENSRNOT00000007404

Organism

Rattus norvegicus

Functional Description

Protein Length

513

Protein Sequence
(FASTA)

MGAAAKLAFA VFLISCSSGA ILGRSETQEC LFFNANWERD RTNQTGVEPC YGDKDKRRHC 60

FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NEKFSYFPEM 120

EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 180

PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 240

MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 300

AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 360

GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 420

QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 480

QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL 513

Nucleotide Sequence
(FASTA)

ATGGGAGCTG CTGCAAAGTT GGCGTTCGCC GTCTTTCTTA TCTCTTGCTC TTCAGGTGCT 60

ATACTTGGCA GATCGGAAAC TCAGGAGTGT CTTTTCTTTA ATGCTAATTG GGAAAGAGAC 120

AGAACCAATC AGACTGGTGT TGAGCCTTGC TATGGTGATA AAGACAAACG ACGACATTGT 180

TTTGCTACCT GGAAGAATAT TTCTGGTTCC ATTGAAATAG TAAAGCAAGG TTGTTGGCTG 240

GATGATATCA ACTGCTATGA CAGGACTGAT TGTATAGAAA AAAAAGACAG CCCTGAAGTG 300

TACTTTTGTT GCTGTGAGGG CAATATGTGT AATGAAAAGT TCTCTTATTT TCCGGAGATG 360

GAAGTCACAC AGCCCACATC AAATCCTGTT ACCCCGAAAC CACCCTACTA CAACATCCTG 420

CTGTATTCCT TGGTACCACT TATGTTAATT GCGGGGATTG TCATTTGTGC GTTTTGGGTG 480

TACAGACATC ACAAGATGGC CTACCCTCCT GTACTTGTTC CTACTCAGGA CCCTGGACCA 540

CCTCCACCTT CCCCATTACT AGGGTTGAAG CCATTGCAGC TATTGGAAGT GAAAGCAAGG 600

GGAAGATTTG GTTGTGTCTG GAAAGCCCAG TTGCTCAATG AGTATGTGGC TGTCAAAATA 660

TTTCCGATAC AGGACAAACA GTCCTGGCAG AATGAATATG AAGTCTATAG TTTACCTGGT 720

ATGAAGCATG AAAACATACT ACAGTTCATT GGTGCAGAGA AAAGAGGCAC CAGTGTTGAT 780

GTGGACCTGT GGCTAATCAC GGCTTTTCAT GAAAAGGGCT CACTGTCAGA CTTTCTTAAG 840

GCTAATGTGG TCTCTTGGAA TGAACTTTGT CATATTGCAG AAACCATGGC TAGAGGATTG 900

GCATATTTAC ATGAGGATAT ACCTGGCTTA AAAGATGGCC ACAAGCCTGC AATATCTCAC 960

AGGGACATAA AAAGTAAAAA TGTGCTGTTG AAAAACAATC TGACAGCTTG CATTGCTGAC 1020

TTTGGGTTGG CCTTAAAGTT TGAGGCTGGC AAGTCTGCAG GTGACACCCA TGGCCAGGTT 1080

GGTACCCGGA GGTATATGGC TCCAGAGGTG TTAGAGGGTG CTATAAACTT CCAAAGGGAC 1140

GCATTTCTGA GGATAGATAT GTACGCCATG GGATTAGTCC TGTGGGAACT GGCTTCTCGT 1200

TGTACTGCTG CAGATGGACC TGTAGATGAG TACATGTTGC CATTTGAGGA GGAAATTGGC 1260

CAGCATCCAT CTCTTGAAGA TATGCAGGAA GTTGTTGTGC ATAAAAAAAA GAGGCCCGTT 1320

TTAAGAGATT ATTGGCAGAA ACACGCAGGA ATGGCAATGC TCTGTGAAAC GATAGAAGAA 1380

TGCTGGGATC ATGATGCAGA AGCCAGGTTA TCAGCTGGAT GTGTAGGTGA AAGAATTACT 1440

CAGATGCAAA GACTAACAAA TATAATTACT ACAGAGGACA TTGTAACAGT GGTCACAATG 1500

GTGACAAATG TTGACTTTCC TCCCAAAGAA TCTAGTCTAT GA 1542

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E e+y+++ ++henilqfi+

Q: 192   LQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIG  251

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++ ++l+l+t++hekgsLsd+Lk+++++++el+++a+++a+Gla+LHe+i+g k

Q: 252   AEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK  311

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kpai+HRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPE

Q: 312   DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE  369

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ +af r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee++g++Psle+m

Q: 370   VLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDM  428

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         +evvv+kk+rP +++ w+k++ +++l++++eecWd+d+eaRl+a +v +r

Q: 429   QEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGER  478

         ***********************************************987

Domain Sequence
(FASTA)

LQLLEVKARG RFGCVWKAQL LNEYVAVKIF PIQDKQSWQN EYEVYSLPGM KHENILQFIG 60

AEKRGTSVDV DLWLITAFHE KGSLSDFLKA NVVSWNELCH IAETMARGLA YLHEDIPGLK 120

DGHKPAISHR DIKSKNVLLK NNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAMG LVLWELASRC TAADGPVDEY MLPFEEEIGQ HPSLEDMQEV 240

VVHKKKRPVL RDYWQKHAGM AMLCETIEEC WDHDAEARLS AGCVGER 287

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005737	; C:cytoplasm
GO:0034673	; C:inhibin-betaglycan-ActRII complex
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0015026	; F:coreceptor activity
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0030509	; P:BMP signaling pathway
GO:0007368	; P:determination of left/right symmetry
GO:0048706	; P:embryonic skeletal system development
GO:0001702	; P:gastrulation with mouth forming second
GO:0007498	; P:mesoderm development
GO:0043084	; P:penile erection
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030510	; P:regulation of BMP signaling pathway
GO:0050999	; P:regulation of nitric-oxide synthase activity
GO:0060011	; P:Sertoli cell proliferation
GO:0023014	; P:signal transduction by phosphorylation
GO:0042713	; P:sperm ejaculation
GO:0007283	; P:spermatogenesis

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013