EKS-RAN-00411
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00411
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl549.11.9E-165508773266
StatusUnreviewed
Ensembl ProteinENSRNOP00000007656
UniProt AccessionF1M7U7;
Protein Name
Protein Synonyms/Alias Tyrosine-protein kinase receptor TYRO3;
Gene NameTyro3
Gene Synonyms/Alias Tyro3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000005531ENSRNOP00000007656ENSRNOT00000007656
OrganismRattus norvegicus
Functional Description
Protein Length880
Protein Sequence
(FASTA)
MALRRSMGRP GLRPLLLAGL ASLLLPGSAA AGLKLMGAPV KMTVSQGQPV KLNCSVEGME 60
DPDIHWMKDG AVVQNASQVS ISISEQNWIG LLSLKSAERS DAGLYWCQVK DGEETKISQS 120
VWLTVEGVPF FTVEPKDLAV PPNVPFQLSC EAVGPPEPVT IFWWRGPTKV GGPASSPSVL 180
NVTGVTQRTE FSCEAHNIKG LATSRPAIIR LQAPPAAPFN ITVTTISSSN ASVAWVPGAD 240
GLALLHSCTV QVAHAPGEWE ALAVVVPVPP FTCLLRNLAP ATNYSLRVRC ANALGPSPYG 300
DWVPFQTKGL APARAPQNFH AIRTDSGLIL EWEEVIPEDP GEGPLGPYKL SWVQENGTQD 360
ELMVEGTTAN LTDWDPQKDL VLRVCASNAI GDGPWSQPLV VSSHDHAGRQ GPPHSRTSWV 420
PVVLGVLTAL ITAAALALIL LRKRRKETRF GQAFDSVMAR GEPAVHFRAA RSFNRERPER 480
IEATLDSLGI SDELKEKLED VLIPEQQFTL GRMLGKGEFG SVREAQLKQE DGSFVKVAVK 540
MLKADIIASS DIEEFLREAA CMKEFDHPHV AKLVGVSLRS RAKGRLPIPM VILPFMKHGD 600
LHAFLLASRI GENPFNLPLQ TLVRFMVDIA CGMEYLSSRN FIHRDLAARN CMLAEDMTVC 660
VADFGLSRKI YSGDYYRQGC ASKLPVKWLA LESLADNLYT VHSDVWAFGV TMWEIMTRGQ 720
TPYAGIENAE IYNYLIGGNR LKQPPECMEE VYDLMYQCWS ADPKQRPSFT CLRMELENIL 780
GHLSVLSTSQ DPLYINIERA GQPAENGSPE LPCGEQSSSE AGDGSGMGAI GGIPSDCRYI 840
FSPGGLAESP GQLEQQPESP LNENQRLLLL QQGLLPHSSC 880
Nucleotide Sequence
(FASTA)
ATGGCGCTGA GGCGGAGCAT GGGGCGGCCG GGGCTCCGGC CGCTGCTGCT GGCGGGGCTG 60
GCCTCTCTGC TGCTCCCTGG GTCCGCGGCC GCAGGCCTGA AGCTCATGGG AGCCCCAGTG 120
AAGATGACAG TGTCTCAGGG GCAGCCAGTG AAGCTTAACT GCAGTGTGGA AGGGATGGAG 180
GACCCTGACA TACACTGGAT GAAGGATGGC GCTGTGGTCC AGAATGCAAG CCAGGTGTCC 240
ATCTCAATAA GCGAACAGAA CTGGATTGGC TTACTCAGCC TAAAGTCAGC GGAGCGGTCT 300
GATGCCGGCC TGTACTGGTG CCAGGTGAAG GATGGGGAGG AAACCAAGAT CTCTCAGTCA 360
GTATGGCTCA CTGTTGAAGG TGTGCCATTC TTCACGGTGG AACCAAAAGA TCTGGCGGTG 420
CCACCCAATG TCCCTTTTCA ACTGTCTTGT GAGGCTGTGG GTCCACCAGA ACCCGTAACC 480
ATTTTCTGGT GGAGAGGACC CACTAAGGTT GGGGGACCTG CTTCCTCTCC CTCTGTTTTA 540
AATGTAACAG GAGTGACCCA GCGCACAGAG TTTTCTTGTG AAGCTCATAA CATAAAAGGC 600
CTGGCCACTT CCCGACCAGC CATTATTCGC CTTCAAGCAC CGCCTGCAGC TCCTTTCAAC 660
ATCACAGTAA CAACGATCTC CAGCAGCAAC GCTAGTGTGG CCTGGGTGCC GGGTGCTGAT 720
GGCTTAGCTC TGCTGCACTC CTGTACTGTA CAGGTGGCAC ATGCCCCAGG AGAATGGGAG 780
GCCCTTGCTG TCGTGGTTCC CGTGCCACCC TTTACTTGCT TGCTTCGGAA CTTGGCCCCT 840
GCCACCAACT ACAGCCTTAG GGTTCGCTGT GCCAACGCCT TGGGCCCTTC TCCCTATGGC 900
GACTGGGTGC CCTTTCAGAC AAAGGGCCTA GCGCCAGCCA GAGCCCCTCA GAATTTCCAC 960
GCCATTCGTA CTGACTCAGG CCTTATCCTG GAATGGGAAG AAGTGATTCC TGAGGACCCT 1020
GGGGAAGGCC CCCTGGGACC TTATAAGCTG TCCTGGGTCC AAGAAAATGG AACCCAGGAT 1080
GAGCTGATGG TGGAAGGAAC TACGGCCAAT CTGACTGACT GGGATCCCCA GAAGGACCTG 1140
GTTTTGCGTG TGTGTGCCTC CAATGCAATT GGTGATGGGC CCTGGAGTCA ACCACTGGTG 1200
GTGTCTTCTC ATGACCATGC AGGGAGGCAG GGCCCTCCTC ACAGCCGTAC ATCCTGGGTG 1260
CCTGTGGTCC TGGGTGTGCT CACCGCCCTG ATCACAGCTG CTGCCTTGGC CCTCATCCTG 1320
CTTCGGAAGA GACGCAAGGA GACGCGGTTC GGGCAAGCCT TTGACAGTGT CATGGCCCGA 1380
GGGGAGCCAG CTGTACACTT CCGGGCAGCC CGGTCTTTCA ATCGAGAAAG GCCTGAACGC 1440
ATTGAAGCTA CATTGGATAG CCTGGGCATC AGCGATGAAT TGAAGGAGAA GCTGGAGGAC 1500
GTCCTCATCC CAGAGCAGCA GTTCACCCTC GGCCGGATGT TGGGCAAAGG AGAGTTTGGA 1560
TCAGTGCGGG AAGCCCAGCT GAAGCAGGAA GATGGCTCCT TTGTGAAAGT GGCAGTGAAG 1620
ATGCTGAAAG CTGACATCAT TGCCTCAAGC GACATAGAAG AGTTCCTGAG AGAAGCAGCT 1680
TGCATGAAGG AGTTTGACCA TCCACACGTG GCCAAGCTTG TTGGAGTGAG CCTCCGGAGC 1740
AGGGCTAAAG GTCGTCTCCC CATTCCCATG GTCATCCTGC CCTTCATGAA GCACGGAGAC 1800
TTGCATGCCT TTCTGCTCGC CTCCCGAATT GGGGAGAACC CTTTTAACCT GCCCCTCCAG 1860
ACCCTCGTCC GGTTCATGGT GGACATTGCC TGTGGCATGG AGTACCTGAG CTCCCGGAAC 1920
TTCATCCACC GAGACCTAGC AGCTCGGAAT TGCATGCTGG CAGAGGACAT GACAGTGTGT 1980
GTGGCTGACT TTGGACTCTC CCGGAAAATT TATAGCGGGG ACTATTATCG TCAGGGCTGT 2040
GCCTCCAAAC TGCCTGTCAA GTGGCTGGCC CTGGAGAGCT TGGCTGACAA CTTGTATACT 2100
GTACACAGCG ATGTGTGGGC CTTCGGGGTG ACCATGTGGG AGATCATGAC TCGTGGGCAG 2160
ACGCCATATG CTGGCATCGA AAATGCTGAG ATTTACAACT ACCTCATCGG CGGGAACCGC 2220
CTGAAGCAGC CTCCGGAGTG CATGGAGGAA GTGTATGATC TCATGTACCA GTGCTGGAGT 2280
GCCGACCCAA AGCAGCGCCC AAGCTTCACA TGCCTGCGAA TGGAACTGGA GAACATTCTG 2340
GGCCACCTAT CTGTTCTGTC CACCAGCCAG GACCCCTTGT ACATCAACAT TGAGAGAGCT 2400
GGGCAGCCTG CTGAGAATGG CAGTCCCGAG CTGCCCTGTG GAGAGCAGTC TAGCAGCGAG 2460
GCGGGGGATG GCAGTGGCAT GGGGGCAATA GGTGGCATCC CCAGTGACTG TCGGTACATC 2520
TTCAGCCCTG GAGGGTTGGC CGAGTCACCA GGGCAGCTGG AGCAGCAGCC AGAAAGCCCC 2580
CTCAACGAGA ACCAGAGGCT TTTGTTGTTG CAGCAAGGGC TACTGCCTCA CAGTAGCTGT 2640
TAA 2643
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         ++lg++lg+gefgsv+e+qlkqedgs++kvavk+lk+diia+s+ieefl+eaacmkefdh
Q: 508   FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDH  567
         68**********************************************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         p+v++lvgvsl+s++kgrlp+p+vilpfmk+gdlhafll+sr+genp++lplqtlv+fmv
Q: 568   PHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMV  627
         ************************************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         dia+gmeylssrnfihrdlaarncmlaedmtvcvadfgls+kiysgdyyrqg+++klpvk
Q: 628   DIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVK  687
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         w+a+eslad++yt++sdvwafgvtmwei+trgqtpyag+enaeiy+yl++gnrlkqp++c
Q: 688   WLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPEC  747
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlr  266
         ++e+ydlmy+cw+adpk+rpsf+ lr
Q: 748   MEEVYDLMYQCWSADPKQRPSFTCLR  773
         ***********************998
Domain Sequence
(FASTA)
FTLGRMLGKG EFGSVREAQL KQEDGSFVKV AVKMLKADII ASSDIEEFLR EAACMKEFDH 60
PHVAKLVGVS LRSRAKGRLP IPMVILPFMK HGDLHAFLLA SRIGENPFNL PLQTLVRFMV 120
DIACGMEYLS SRNFIHRDLA ARNCMLAEDM TVCVADFGLS RKIYSGDYYR QGCASKLPVK 180
WLALESLADN LYTVHSDVWA FGVTMWEIMT RGQTPYAGIE NAEIYNYLIG GNRLKQPPEC 240
MEEVYDLMYQ CWSADPKQRP SFTCLR 266
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00372
EKS-ANC-00384
EKS-BOT-00399
EKS-CAJ-00404
EKS-CAF-00400
EKS-CAP-00424
EKS-DAR-00777
EKS-EQC-00387
EKS-FEC-00382
EKS-GAG-00338
EKS-GAA-00488
EKS-GOG-00387
EKS-HOS-00403
EKS-ICT-00375
EKS-LOA-00403
EKS-MAM-00399
EKS-MEG-00329
EKS-MOD-00385
EKS-MUM-00432
EKS-MUP-00390
EKS-MYL-00393
EKS-NOL-00364
EKS-ORN-00511
EKS-ORA-00344
EKS-ORC-00374
EKS-ORL-00465
EKS-OTG-00402
EKS-PAT-00375
EKS-PES-00355
EKS-POA-00391
EKS-PTV-00110
EKS-SAH-00365
EKS-SUS-00346
EKS-TAG-00471
EKS-TAR-00502
EKS-TAS-00046
EKS-XET-00511
EKS-XIM-00503
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043277; P:apoptotic cell clearance
GO:0021885; P:forebrain cell migration
GO:0001779; P:natural killer cell differentiation
GO:0050728; P:negative regulation of inflammatory response
GO:0045824; P:negative regulation of innate immune response
GO:0051250; P:negative regulation of lymphocyte activation
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0034122; P:negative regulation of toll-like receptor signaling pathway
GO:0070050; P:neuron homeostasis
GO:0042698; P:ovulation cycle
GO:0070527; P:platelet aggregation
GO:0046777; P:protein autophosphorylation
GO:0043491; P:protein kinase B signaling cascade
GO:0032940; P:secretion by cell
GO:0007283; P:spermatogenesis
GO:0034446; P:substrate adhesion-dependent cell spreading
GO:0060068; P:vagina development
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 2.
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013