EKS-RAN-00353
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00353
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PEK409.78.0E-1235851069485
StatusReviewed
Ensembl ProteinENSRNOP00000008451
UniProt AccessionQ9Z1Z1;
Protein NameEukaryotic translation initiation factor 2-alpha kinase 3
Protein Synonyms/Alias PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase;
Gene NameEif2ak3
Gene Synonyms/Alias Eif2ak3; Pek, Perk;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000006069ENSRNOP00000008451ENSRNOT00000008451
OrganismRattus norvegicus
Functional DescriptionPhosphorylates the alpha subunit of eukaryotictranslation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity).
Protein Length1108
Protein Sequence
(FASTA)
MERATQPRPR ALLLLFLLLG CAAGISAVAR ARSLLAPTSD TAFGLGAAAA PTSAARVPAV 60
ATAEVTVEDA EALPAASGEQ ESRATESDDD VELRPRGRSL VIISTLDGRI AALDAENHGK 120
KQWDLDVGSG SLVSSSLSKP EVFGNKMIIP SLDGDLFQWD RDRESMEAVP FTVESLLESS 180
YKFGDDVVLV GGKSLTTYGL SAYSGKLRYI CSALGCRRWD SDEMEEEEDI LLLQRTQKTV 240
RAVGPRSGSE KWNFSVGHFE LRYIPDMETR AGFIESTFKL GGNKEDSKII SDVEEQDVDT 300
VIKVSVADWK VMAFSKKGGR LEWEYQFCTP IASAWLVRDG KVIPISLFDD TSYTANEEVL 360
EDEEDIVEAA RGATENSVYL GMYRGQLYLQ SSVRVSEKFP TRPKALESVN GESAIIPLPT 420
IKWKPLIHSP SRTPVLVGSD EFDKCLSNDK YSHEEYSNGA LSILQYPYDN GYYLPYYKRE 480
RNKRSTQITV RFLDSPHYSK NIRKKDPILL LHWWKEIFGT ILLCIVATTF IVRRLFHPQP 540
HRQRKESETQ CQTESKYDSV SADNSDNSWN DIKHSGYVSR YLTDFEPIQC MGRGGFGVVF 600
EAKNKVDDCN YAIKRIRLPN RELAREKVMR EVKALAKLEH PGIVRYFNAW LETPPEKWQE 660
EMDEIWLKDE STDWPLSSPS PMDAPSVKIR QMDPFSTKEQ IEVIAPSPER SRSFSVGISC 720
GRTSSSESQF SPLEFSGTDC GDNSDSEDAA HNLQDSCLTD CDMEDGTVDG DDEGHSFELC 780
PSEASPYTRS REGTSSSIVF EDSGCDNASS KEDPRMNRLH NGHHYVNKLT EFKHSSSRSS 840
SEATLSTSPT RPTTLSLDFT RNTVDRLQPS SPKVYLYIQM QLCRKENLKD WMNRRCSMED 900
REHRVCLHIF LQIAEAVQFL HSKGLMHRDL KPSNIFFTMD DVVKVGDFGL VTAMDQDEEE 960
QTVLTPMPAY ATHTGQVGTK LYMSPEQIHG NNYSHKVDIF SLGLILFELL YPFSTQMERV 1020
RTLTDVRNLK FPPLFTQKYP QEHMMVQDML SPSPMERPEA TDIIENAVFE NLEFPGKTVL 1080
RQRSRSLSSS GTKHSRQPSS TFSPLPGN 1108
Nucleotide Sequence
(FASTA)
ATGGAGCGCG CCACCCAGCC CCGACCGCGC GCGCTGCTGC TGCTGTTCCT GCTGCTGGGC 60
TGCGCGGCGG GGATCTCAGC GGTCGCGCGC GCCCGCAGCT TGCTTGCTCC CACATCGGAT 120
ACGGCATTTG GCTTGGGGGC AGCAGCCGCC CCTACTTCAG CCGCGCGGGT GCCTGCGGTG 180
GCTACGGCCG AAGTGACCGT GGAAGACGCC GAGGCATTGC CCGCTGCCTC CGGCGAACAG 240
GAGTCACGCG CGACCGAGTC CGATGACGAC GTGGAACTGC GGCCTCGCGG CAGGTCCTTA 300
GTAATCATCA GCACTTTAGA TGGACGAATT GCCGCACTGG ATGCCGAGAA TCATGGGAAA 360
AAGCAGTGGG ATTTGGACGT GGGATCTGGT TCCTTGGTTT CATCTAGCCT TAGCAAGCCA 420
GAGGTGTTTG GGAACAAGAT GATCATTCCT TCCCTGGACG GAGACCTCTT CCAGTGGGAC 480
CGAGACCGAG AGAGCATGGA GGCCGTCCCT TTCACTGTGG AGTCCCTTCT CGAATCTTCA 540
TACAAGTTTG GAGATGATGT TGTTCTGGTT GGAGGAAAGT CTCTGACCAC ATACGGGCTC 600
AGTGCATATA GTGGAAAGCT GAGGTATATC TGTTCTGCCT TGGGATGTCG CCGATGGGAT 660
AGTGATGAAA TGGAAGAAGA GGAAGACATC TTGCTTCTGC AACGCACGCA GAAGACTGTG 720
CGAGCTGTCG GGCCTCGAAG CGGCAGTGAG AAGTGGAATT TCAGTGTTGG CCACTTTGAA 780
CTTCGGTATA TTCCAGACAT GGAAACTAGA GCCGGATTCA TTGAAAGCAC CTTTAAACTG 840
GGTGGAAACA AAGAAGACTC TAAAATCATT TCAGATGTGG AAGAACAAGA TGTGGACACA 900
GTGATAAAAG TTTCCGTTGC TGATTGGAAG GTCATGGCGT TTAGTAAGAA GGGAGGCCGC 960
CTAGAATGGG AGTACCAGTT TTGTACTCCC ATTGCGTCTG CCTGGCTGGT GAGGGATGGT 1020
AAAGTCATCC CCATCAGTCT GTTTGATGAC ACAAGTTACA CAGCCAATGA GGAAGTTTTG 1080
GAAGATGAAG AAGACATTGT AGAGGCTGCT CGGGGAGCCA CAGAGAACAG CGTGTACTTA 1140
GGGATGTACA GAGGCCAGCT GTACCTGCAA TCATCCGTCA GGGTCTCGGA AAAGTTCCCT 1200
ACAAGGCCGA AGGCCTTGGA GTCTGTAAAT GGAGAAAGTG CCATTATTCC TCTGCCGACG 1260
ATCAAATGGA AGCCCTTAAT CCATTCTCCG TCTAGGACTC CTGTCTTGGT TGGGTCTGAT 1320
GAATTTGACA AGTGTCTAAG TAATGATAAA TATTCCCATG AAGAATACAG TAATGGTGCG 1380
CTTTCAATCC TACAGTATCC ATATGACAAC GGTTACTATC TGCCTTATTA CAAGAGAGAA 1440
AGGAATAAGC GGAGCACGCA GATCACGGTC AGGTTCCTGG ACAGCCCGCA CTACAGCAAG 1500
AACATCCGCA AGAAGGACCC CATCCTCCTC CTGCACTGGT GGAAGGAAAT ATTTGGAACG 1560
ATCTTGCTTT GCATTGTGGC CACGACCTTT ATCGTGCGCA GGCTTTTCCA TCCTCAGCCC 1620
CACAGGCAAC GGAAGGAGTC TGAAACTCAG TGCCAAACTG AAAGTAAATA CGACTCTGTG 1680
AGTGCTGATA ACAGCGACAA CAGCTGGAAC GACATTAAAC ACTCAGGATA CGTGTCCCGA 1740
TACCTAACAG ATTTTGAGCC AATTCAGTGC ATGGGTCGAG GCGGCTTTGG CGTTGTCTTT 1800
GAAGCTAAGA ACAAAGTAGA TGACTGCAAT TACGCCATCA AGAGGATCCG TCTCCCAAAC 1860
AGGGAGCTGG CACGGGAGAA GGTAATGCGG GAAGTCAAAG CCTTGGCTAA GCTGGAGCAC 1920
CCAGGCATCG TGAGGTATTT CAATGCGTGG CTGGAAACAC CACCAGAGAA GTGGCAAGAG 1980
GAGATGGATG AAATCTGGCT GAAGGACGAA AGCACAGACT GGCCACTCAG CTCCCCTAGC 2040
CCAATGGATG CCCCATCTGT TAAGATCCGG CAGATGGATC CTTTCTCTAC AAAAGAACAG 2100
ATTGAAGTCA TAGCTCCTTC TCCTGAAAGA AGTCGGTCTT TCTCAGTGGG CATTTCCTGT 2160
GGCCGGACAA GCTCATCTGA GAGCCAGTTC TCTCCCCTGG AGTTCTCAGG GACAGACTGT 2220
GGAGACAACA GTGACTCAGA GGACGCAGCC CACAACCTCC AGGACAGCTG CCTGACAGAT 2280
TGCGACATGG AAGATGGTAC AGTGGACGGC GATGATGAGG GACACTCCTT TGAACTTTGT 2340
CCTTCTGAAG CTTCTCCCTA TACCAGGTCA AGGGAGGGAA CGTCCTCTTC CATAGTGTTT 2400
GAAGACTCTG GCTGTGATAA TGCGTCCAGT AAGGAGGACC CCAGAATGAA TCGGCTGCAT 2460
AATGGCCACC ATTACGTTAA TAAGCTAACT GAGTTCAAGC ACTCCAGCAG CAGGTCTTCT 2520
TCCGAAGCCA CCTTGTCTAC CTCTCCTACC AGGCCAACCA CCCTAAGTTT AGATTTCACC 2580
AGGAACACGG TGGACCGGCT CCAGCCCAGC TCCCCCAAGG TGTACCTGTA CATCCAGATG 2640
CAGCTGTGCA GGAAGGAGAA CCTTAAAGAC TGGATGAACC GGCGCTGCAG CATGGAGGAC 2700
AGGGAGCACA GAGTGTGCCT GCACATCTTT CTGCAGATCG CAGAGGCAGT GCAGTTTCTG 2760
CACAGCAAGG GACTCATGCA CAGGGACCTC AAGCCTTCCA ACATATTCTT CACAATGGAT 2820
GATGTGGTCA AAGTTGGGGA CTTTGGGCTA GTGACTGCAA TGGACCAGGA TGAAGAAGAG 2880
CAGACAGTAC TGACTCCAAT GCCAGCCTAT GCTACACACA CGGGACAAGT CGGGACCAAG 2940
CTGTACATGA GCCCAGAACA GATTCATGGA AACAACTACT CCCATAAAGT GGACATCTTC 3000
TCTTTAGGCT TGATTCTGTT TGAACTCCTT TACCCATTCA GCACTCAGAT GGAACGAGTT 3060
AGGACTTTAA CTGATGTAAG AAATCTCAAG TTTCCACCAC TGTTCACTCA GAAATATCCC 3120
CAAGAGCATA TGATGGTTCA AGACATGCTT TCTCCATCCC CCATGGAGCG GCCTGAAGCC 3180
ACAGACATCA TTGAAAATGC TGTGTTTGAG AACTTGGAGT TTCCTGGGAA AACGGTTCTG 3240
AGACAGCGGT CCCGCTCCTT GAGTTCATCC GGAACTAAAC ATTCCAGACA GCCCAGCAGC 3300
ACATTCAGCC CACTGCCTGG CAACTAG 3327
Domain Profile
S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60
         fe i+++G+GgfgvV++aknk+d+++yaikri+l++++ ++ekv+revkaLaklehp+iv
Q: 585   FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIV  644
         799*********************************************************
S: 61    rYfaawleekeesl..............................................  74
         rYf+awle+++e++                                              
Q: 645   RYFNAWLETPPEKWqeemdeiwlkdestdwplsspspmdapsvkirqmdpfstkeqievi  704
         ************************************************************
S: 75    ............................................................  74
                                                                     
Q: 705   apspersrsfsvgiscgrtsssesqfsplefsgtdcgdnsdsedaahnlqdscltdcdme  764
         ************************************************************
S: 75    ..td.sseveaeaeleesesseesdtk.................................  98
           t  ++++ +++el++se+s++++++                                 
Q: 765   dgTVdGDDEGHSFELCPSEASPYTRSRegtsssivfedsgcdnasskedprmnrlhnghh  824
         *966699*****************************************************
S: 99    ..................................................llyiqmelce  108
                                                           +lyiqm+lc+
Q: 825   yvnkltefkhsssrssseatlstsptrpttlsldftrntvdrlqpsspkvYLYIQMQLCR  884
         ************************************************************
S: 109   ketLkdwiderkllesrselvm.rlfkqllegleylHskgliHrdLkpsniFldsddqvK  167
         ke+Lkdw+++r+++e+r++ v+ ++f q++e++++lHskgl+HrdLkpsniF+++dd vK
Q: 885   KENLKDWMNRRCSMEDREHRVClHIFLQIAEAVQFLHSKGLMHRDLKPSNIFFTMDDVVK  944
         ************************************************************
S: 168   igDFgLatalaealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGl  227
         +gDFgL+ta++++++e+++ ++++++a+htgqvgtklymsPeq+++++Y++kvDifsLGl
Q: 945   VGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQIHGNNYSHKVDIFSLGL  1004
         ************************************************************
S: 228   ilfeLlypfstemervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasell  287
         ilfeLlypfst+merv+tlt++r++k+p  f++k+p+e++++q++ls +p+eRp+a++++
Q: 1005  ILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPQEHMMVQDMLSPSPMERPEATDII  1064
         ************************************************************
S: 288   ksell  292
         +++++
Q: 1065  ENAVF  1069
         *9875
Domain Sequence
(FASTA)
FEPIQCMGRG GFGVVFEAKN KVDDCNYAIK RIRLPNRELA REKVMREVKA LAKLEHPGIV 60
RYFNAWLETP PEKWQEEMDE IWLKDESTDW PLSSPSPMDA PSVKIRQMDP FSTKEQIEVI 120
APSPERSRSF SVGISCGRTS SSESQFSPLE FSGTDCGDNS DSEDAAHNLQ DSCLTDCDME 180
DGTVDGDDEG HSFELCPSEA SPYTRSREGT SSSIVFEDSG CDNASSKEDP RMNRLHNGHH 240
YVNKLTEFKH SSSRSSSEAT LSTSPTRPTT LSLDFTRNTV DRLQPSSPKV YLYIQMQLCR 300
KENLKDWMNR RCSMEDREHR VCLHIFLQIA EAVQFLHSKG LMHRDLKPSN IFFTMDDVVK 360
VGDFGLVTAM DQDEEEQTVL TPMPAYATHT GQVGTKLYMS PEQIHGNNYS HKVDIFSLGL 420
ILFELLYPFS TQMERVRTLT DVRNLKFPPL FTQKYPQEHM MVQDMLSPSP MERPEATDII 480
ENAVF 485
KeywordADP-ribosylation; ATP-binding; Complete proteome; Endoplasmic reticulum; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Signal; Stress response; Transferase; Translation regulation; Transmembrane; Transmembrane helix; Unfolded protein response.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00317
EKS-ANC-00330
EKS-BOT-00338
EKS-CAE-00275
EKS-CAJ-00347
EKS-CAF-00346
EKS-CAP-00372
EKS-CII-00189
EKS-CIS-00091
EKS-DAR-00702
EKS-DRM-00166
EKS-EQC-00330
EKS-FEC-00329
EKS-GAG-00285
EKS-GAA-00421
EKS-GOG-00335
EKS-HOS-00345
EKS-ICT-00322
EKS-LAC-00353
EKS-LOA-00350
EKS-MAM-00344
EKS-MEG-00279
EKS-MOD-00334
EKS-MUM-00373
EKS-MUP-00333
EKS-MYL-00337
EKS-NOL-00309
EKS-ORN-00442
EKS-ORA-00297
EKS-ORC-00317
EKS-ORL-00409
EKS-OTG-00343
EKS-PAT-00321
EKS-PES-00298
EKS-PEM-00179
EKS-POA-00331
EKS-PTV-00079
EKS-SAH-00317
EKS-SUS-00302
EKS-TAG-00414
EKS-TAR-00445
EKS-TEN-00441
EKS-VIP-00041
EKS-XET-00434
EKS-XIM-00430
Gene Ontology
GO:0005623; C:cell
GO:0005789; C:endoplasmic reticulum membrane
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0030282; P:bone mineralization
GO:0019722; P:calcium-mediated signaling
GO:0002063; P:chondrocyte development
GO:0031018; P:endocrine pancreas development
GO:0007029; P:endoplasmic reticulum organization
GO:0030968; P:endoplasmic reticulum unfolded protein response
GO:0006983; P:ER overload response
GO:0045444; P:fat cell differentiation
GO:0030073; P:insulin secretion
GO:0048009; P:insulin-like growth factor receptor signaling pathway
GO:0007595; P:lactation
GO:0031642; P:negative regulation of myelination
GO:0032057; P:negative regulation of translational initiation in response to stress
GO:0001503; P:ossification
GO:0032092; P:positive regulation of protein binding
GO:0009967; P:positive regulation of signal transduction
GO:0046777; P:protein autophosphorylation
GO:0051260; P:protein homooligomerization
GO:0019217; P:regulation of fatty acid metabolic process
GO:0032933; P:SREBP signaling pathway
GO:0006412; P:translation
GO:0006926; P:virus-infected cell apoptotic process
KEGG
rno:29702;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR011047; Quinonprotein_ADH-like.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013