EKS-RAN-00156

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00156

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	623.6	4.7E-188	440	719	280

Status

Unreviewed

Ensembl Protein

ENSRNOP00000062555

UniProt Accession

F1LPP2;

Protein Name

Protein Synonyms/Alias

Protein Tlk2;

Gene Name

Tlk2

Gene Synonyms/Alias

Tlk2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000006285	ENSRNOP00000062555	ENSRNOT00000066484

Organism

Rattus norvegicus

Functional Description

Protein Length

750

Protein Sequence
(FASTA)

MMEELHSLDP RRQELLEARF TGVGVSKGPL NSESSNQSLC SVGSLSDKEV ETPEKKQNDQ 60

RNRKRKAEPY ETSQGKGTPR GHKISDYFEF AGGSGPGTSP GRSVPPVARS SPQHSLSNPL 120

PRRVEQPLYG LDGSTAKEAS EEQSALPTLM SVMLAKPRLD TEQLAPRGAG LCFTFVSAQQ 180

NSPSSTGSGN TEHSCSSQKQ ISIQHRQTQS DLTIEKISAL ENSKNSDLEK KEGRIDDLLR 240

ANCDLRRQID EQQKMLEKYK ERLNRCVTMS KKLLIEKSKQ EKMACRDKSM QDRLRLGHFT 300

TVRHGASFTE QWTDGYAFQN LIKQQERINS QREEIERQRK MLAKRKPPAM GQAPPATNEQ 360

KQRKSKTNGA ENETLTLAEY HEQEEIFKLR LGHLKKEEAE IQAELERLER VRNLHIRELK 420

RIHNEDNSQF KDHPTLNDRY LLLHLLGRGG FSEVYKAFDL TEQRYVAVKI HQLNKNWRDE 480

KKENYHKHAC REYRIHKELD HPRIVKLYDY FSLDTDSFCT VLEYCEGNDL DFYLKQHKLM 540

SEKEARSIIM QIVNALKYLN EIKPPIIHYD LKPGNILLVN GTACGEIKIT DFGLSKIMDD 600

DSYNSVDGME LTSQGAGTYW YLPPECFVVG KEPPKISNKV DVWSVGVIFY QCLYGRKPFG 660

HNQSQQDILQ ENTILKATEV QFPPKPVVTP EAKAFIRRCL AYRKEDRIDV QQLACDPYLL 720

PHIRKSVSTS SPAGAAIAST SGASNNSSSN 750

Nucleotide Sequence
(FASTA)

ATGATGGAAG AACTGCACAG CCTGGACCCA CGGAGGCAGG AGTTACTGGA GGCCAGGTTC 60

ACTGGGGTTG GCGTAAGTAA GGGGCCACTC AACAGTGAGT CTTCCAACCA GAGTTTGTGC 120

AGTGTGGGGT CCTTGAGTGA TAAAGAAGTA GAGACTCCTG AGAAAAAGCA GAATGACCAG 180

CGAAATCGGA AAAGAAAAGC TGAACCATAT GAAACTAGCC AAGGGAAAGG CACTCCTAGG 240

GGACATAAAA TTAGTGATTA CTTTGAGTTT GCTGGGGGAA GCGGGCCAGG AACCAGCCCT 300

GGCAGAAGTG TTCCACCAGT TGCACGATCC TCACCGCAAC ATTCCTTATC CAATCCCTTA 360

CCGCGTCGAG TAGAACAGCC TCTCTATGGT TTAGATGGCA GTACTGCAAA GGAGGCCTCA 420

GAAGAGCAGT CTGCCCTGCC AACCCTCATG TCAGTGATGT TAGCAAAACC TCGACTTGAC 480

ACAGAGCAGT TAGCGCCAAG GGGAGCTGGC CTCTGCTTCA CTTTCGTCTC TGCTCAACAA 540

AACAGCCCTT CGTCCACGGG GTCTGGCAAT ACAGAACATT CTTGCAGCTC CCAGAAACAG 600

ATCTCCATCC AGCACAGGCA GACCCAGTCT GACCTCACAA TAGAAAAAAT ATCTGCACTA 660

GAAAACAGTA AGAACTCTGA CTTAGAGAAG AAGGAAGGAA GAATAGATGA TTTATTAAGA 720

GCCAACTGTG ATTTGAGACG ACAGATAGAT GAACAGCAAA AGATGCTAGA GAAATACAAG 780

GAACGATTAA ATAGATGTGT CACCATGAGC AAGAAGCTCC TTATAGAAAA GTCAAAACAA 840

GAGAAGATGG CATGCAGGGA CAAGAGCATG CAGGACCGAT TGCGATTAGG TCACTTTACA 900

ACTGTCCGGC ATGGAGCCTC TTTTACTGAA CAGTGGACAG ATGGTTATGC TTTCCAAAAC 960

CTCATCAAGC AACAGGAAAG GATAAATTCA CAGAGAGAAG AGATAGAAAG GCAACGGAAA 1020

ATGTTAGCAA AACGGAAACC CCCTGCCATG GGTCAGGCCC CTCCCGCAAC CAATGAGCAG 1080

AAACAACGGA AAAGCAAGAC CAATGGAGCT GAAAATGAAA CGTTAACCTT AGCTGAATAC 1140

CATGAACAAG AAGAAATCTT CAAACTTAGA TTAGGTCATC TTAAGAAAGA GGAAGCAGAA 1200

ATCCAGGCAG AACTGGAAAG GCTAGAAAGG GTTAGGAATC TACACATCAG GGAATTAAAA 1260

AGGATACATA ATGAAGATAA TTCACAGTTT AAAGACCACC CAACACTAAA TGACAGATAT 1320

TTGTTGTTAC ATCTTTTGGG TAGAGGAGGT TTCAGTGAAG TTTACAAGGC GTTTGATCTA 1380

ACGGAGCAAA GATATGTAGC TGTGAAAATT CACCAGTTAA ATAAAAACTG GAGAGATGAG 1440

AAAAAGGAGA ATTACCACAA GCATGCGTGT AGGGAATACC GGATTCACAA AGAACTGGAT 1500

CACCCCAGAA TAGTGAAGCT GTATGATTAC TTTTCACTGG ACACTGACTC GTTTTGTACA 1560

GTATTAGAAT ACTGTGAAGG AAATGATCTG GACTTCTACC TAAAGCAGCA CAAATTAATG 1620

TCGGAGAAAG AAGCCCGATC CATTATTATG CAGATTGTGA ATGCTTTAAA GTACTTAAAT 1680

GAAATAAAAC CTCCCATCAT ACACTATGAC CTCAAACCAG GTAATATCCT TTTAGTAAAT 1740

GGTACAGCGT GTGGAGAGAT AAAAATTACA GATTTTGGTC TTTCCAAGAT CATGGATGAC 1800

GATAGCTACA ATTCAGTGGA CGGCATGGAG CTAACGTCAC AAGGTGCTGG TACTTATTGG 1860

TATTTGCCAC CAGAGTGTTT TGTGGTTGGG AAAGAGCCAC CAAAGATCTC AAATAAAGTC 1920

GATGTCTGGT CAGTGGGTGT GATCTTCTAC CAGTGTCTGT ATGGGAGGAA GCCTTTTGGT 1980

CATAACCAGT CCCAGCAAGA TATTCTACAA GAGAATACTA TTCTTAAAGC TACTGAAGTA 2040

CAGTTCCCGC CCAAGCCAGT AGTAACACCT GAAGCAAAGG CGTTTATCAG GCGATGTTTG 2100

GCCTATCGAA AGGAAGACCG CATTGATGTG CAGCAGCTGG CCTGTGACCC CTACTTGTTG 2160

CCTCACATCC GAAAGTCAGT CTCCACAAGT AGTCCTGCAG GAGCTGCCAT TGCATCAACC 2220

TCGGGGGCAT CCAATAACAG TTCTTCGAAT TGA 2253

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqryvavkihqlnk+w+dekkeny+kha+reyrihkel

Q: 440   YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL  499

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtdsfctvley+egndldfylkqhkl+sekearsiimqiv+alkyl

Q: 500   DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL  559

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy+s+dg+eltsqgagty

Q: 560   NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY  619

         ************************************************************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvifyqclyg+kpfghnqsqqdil+entilkate

Q: 620   WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE  679

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvv++eakafirrclayrkedridvqqla+d+yl

Q: 680   VQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL  719

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LTEQRYVAVK IHQLNKNWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDSFC TVLEYCEGND LDFYLKQHKL MSEKEARSII MQIVNALKYL 120

NEIKPPIIHY DLKPGNILLV NGTACGEIKI TDFGLSKIMD DDSYNSVDGM ELTSQGAGTY 180

WYLPPECFVV GKEPPKISNK VDVWSVGVIF YQCLYGRKPF GHNQSQQDIL QENTILKATE 240

VQFPPKPVVT PEAKAFIRRC LAYRKEDRID VQQLACDPYL 280

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005882	; C:intermediate filament
GO:0005634	; C:nucleus
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

rno:303592

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013