EKS-RAN-00315
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00315
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR496.12.5E-149724981258
StatusUnreviewed
Ensembl ProteinENSRNOP00000040591
UniProt AccessionQ8K3F9;
Protein Name
Protein Synonyms/Alias Neu protooncoprotein; Receptor tyrosine-protein kinase erbB-2;
Gene NameErbb2
Gene Synonyms/Alias Erbb2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000006450ENSRNOP00000040591ENSRNOT00000049070
ENSRNOG00000006450ENSRNOP00000009116ENSRNOT00000009114
OrganismRattus norvegicus
Functional Description
Protein Length1259
Protein Sequence
(FASTA)
MIIMELAAWC RWGFLLALLP PGIAGTQVCT GTDMKLRLPA SPETHLDMLR HLYQGCQVVQ 60
GNLELTYVPA NASLSFLQDI QEVQGYMLIA HNQVKRVPLQ RLRIVRGTQL FEDKYALAVL 120
DNRDPQDNVA ASTPGRTPEG LRELQLRSLT EILKGGVLIR GNPQLCYQDM VLWKDVFRKN 180
NQLAPVDIDT NRSRACPPCA PACKDNHCWG ESPEDCQILT GTICTSGCAR CKGRLPTDCC 240
HEQCAAGCTG PKHSDCLACL HFNHSGICEL HCPALVTYNT DTFESMHNPE GRYTFGASCV 300
TTCPYNYLST EVGSCTLVCP PNNQEVTAED GTQRCEKCSK PCARVCYGLG MEHLRGARAI 360
TSDNVQEFDG CKKIFGSLAF LPESFDGDPS SGIAPLRPEQ LQVFETLEEI TGYLYISAWP 420
DSLRDLSVFQ NLRIIRGRIL HDGAYSLTLQ GLGIHSLGLR SLRELGSGLA LIHRNAHLCF 480
VHTVPWDQLF RNPHQALLHS GNRPEEDCGL EGLVCNSLCA HGHCWGPGPT QCVNCSHFLR 540
GQECVEECRV WKGLPREYVS DKRCLPCHPE CQPQNSSETC FGSEADQCAA CAHYKDSSSC 600
VARCPSGVKP DLSYMPIWKY PDEEGICQPC PINCTHSCVD LDERGCPAEQ RASPVTFIIA 660
TVVGVLLFLI LVVVVGILIK RRRQKIRKYT MRRLLQETEL VEPLTPSGAM PNQAQMRILK 720
ETELRKVKVL GSGAFGTVYK GIWIPDGENV KIPVAIKVLR ENTSPKANKE ILDEAYVMAG 780
VGSPYVSRLL GICLTSTVQL VTQLMPYGCL LDHVREHRGR LGSQDLLNWC VQIAKGMSYL 840
EDVRLVHRDL AARNVLVKSP NHVKITDFGL ARLLDIDETE YHADGGKVPI KWMALESILR 900
RRFTHQSDVW SYGVTVWELM TFGAKPYDGI PAREIPDLLE KGERLPQPPI CTIDVYMIMV 960
KCWMIDSECR PRFRELVSEF SRMARDPQRF VVIQNEDLGP SSPMDSTFYR SLLEDDDMGD 1020
LVDAEEYLVP QQGFFSPDPT PGTGSTAHRR HRSSSTRSGG GELTLGLEPS EEGPPRSPLA 1080
PSEGAGSDVF DGDLAMGVTK GLQSLSPHDL SPLQRYSEDP TLPLPPETDG YVAPLACSPQ 1140
PEYVNQSEVQ PQPPLTPEGP LPPVRPAGAT LERPKTLSPG KNGVVKDVFA FGGAVENPEY 1200
LVPREGTASP PHPSPAFSPA FDNLYYWDQN SSEQGPPPSN FEGTPTAENP EYLGLDVPV 1259
Nucleotide Sequence
(FASTA)
ATGATCATCA TGGAGCTGGC GGCCTGGTGC CGCTGGGGGT TCCTCCTCGC CCTCCTGCCC 60
CCCGGAATCG CGGGCACCCA AGTGTGTACC GGCACAGACA TGAAGTTGCG GCTCCCTGCC 120
AGTCCTGAGA CCCACCTGGA CATGCTCCGC CACCTGTACC AGGGCTGTCA GGTAGTGCAG 180
GGCAACTTGG AGCTTACCTA CGTGCCTGCC AATGCCAGCC TCTCATTCCT GCAGGACATC 240
CAGGAAGTTC AGGGTTACAT GCTCATCGCT CACAACCAGG TGAAGCGCGT CCCACTGCAA 300
AGGCTGCGCA TCGTGAGAGG GACCCAGCTC TTTGAGGACA AGTATGCCCT GGCTGTGCTA 360
GACAACCGAG ATCCTCAGGA CAATGTCGCC GCCTCCACCC CAGGCAGAAC CCCAGAGGGG 420
CTGCGGGAGC TGCAGCTTCG AAGTCTCACA GAGATCCTGA AGGGAGGAGT TTTGATCCGT 480
GGGAACCCTC AGCTCTGCTA CCAGGACATG GTTTTGTGGA AGGACGTCTT CCGCAAGAAT 540
AACCAACTGG CTCCTGTCGA TATAGACACC AATCGTTCCC GGGCCTGTCC ACCTTGTGCC 600
CCCGCCTGCA AAGACAATCA CTGTTGGGGT GAGAGTCCGG AAGACTGTCA GATCTTGACT 660
GGCACCATCT GTACCAGTGG TTGTGCCCGG TGCAAGGGCC GGCTGCCCAC TGACTGCTGC 720
CATGAGCAGT GTGCCGCAGG CTGCACGGGC CCCAAGCATT CTGACTGCCT GGCCTGCCTC 780
CACTTCAATC ATAGTGGTAT CTGTGAGCTG CACTGCCCAG CCCTCGTCAC CTACAACACA 840
GACACCTTTG AGTCCATGCA CAACCCTGAG GGTCGCTACA CCTTTGGTGC CAGCTGCGTG 900
ACCACCTGCC CCTACAACTA CCTGTCTACG GAAGTGGGAT CCTGCACTCT GGTGTGTCCC 960
CCGAATAACC AAGAGGTCAC AGCTGAGGAC GGAACACAGC GTTGTGAGAA ATGCAGCAAG 1020
CCCTGTGCTC GAGTGTGCTA TGGTCTGGGC ATGGAGCACC TTCGAGGGGC GAGGGCCATC 1080
ACCAGTGACA ATGTCCAGGA GTTTGATGGC TGCAAGAAGA TCTTTGGGAG CCTGGCATTT 1140
TTGCCGGAGA GCTTTGATGG GGACCCCTCC TCCGGCATTG CTCCGCTGAG GCCTGAGCAG 1200
CTCCAAGTGT TCGAAACCCT GGAGGAGATC ACAGGTTACC TGTACATCTC AGCATGGCCA 1260
GACAGTCTCC GTGACCTCAG TGTCTTCCAG AACCTTCGAA TCATTCGGGG ACGGATTCTC 1320
CACGATGGCG CGTACTCATT GACACTGCAA GGCCTGGGGA TCCACTCGCT GGGGCTGCGC 1380
TCACTGCGGG AGCTGGGCAG TGGATTGGCT CTGATTCACC GCAACGCCCA TCTCTGCTTT 1440
GTACACACTG TACCTTGGGA CCAGCTCTTC CGGAACCCAC ATCAGGCCCT GCTCCACAGT 1500
GGGAACCGGC CGGAAGAGGA TTGTGGTCTC GAGGGCTTGG TCTGTAACTC ACTGTGTGCC 1560
CACGGGCACT GCTGGGGGCC AGGGCCCACC CAGTGTGTCA ACTGCAGTCA TTTCCTTCGG 1620
GGCCAGGAGT GTGTGGAGGA GTGCCGAGTA TGGAAGGGGC TCCCCCGGGA GTATGTGAGT 1680
GACAAGCGCT GTCTGCCGTG TCACCCCGAG TGTCAGCCTC AAAACAGCTC AGAGACCTGC 1740
TTTGGATCGG AGGCTGATCA GTGTGCAGCC TGCGCCCACT ACAAGGACTC GTCCTCCTGT 1800
GTGGCTCGCT GCCCCAGTGG TGTGAAACCG GACCTCTCCT ACATGCCCAT CTGGAAGTAC 1860
CCGGATGAGG AGGGCATATG CCAGCCGTGC CCCATCAACT GCACCCACTC CTGTGTGGAT 1920
CTGGATGAAC GAGGCTGCCC AGCAGAGCAG AGAGCCAGCC CGGTGACATT CATCATTGCA 1980
ACTGTAGTGG GCGTCCTGCT GTTCCTGATC TTAGTGGTGG TCGTTGGAAT CCTAATCAAA 2040
CGAAGGAGAC AGAAGATCCG GAAGTATACG ATGCGTAGGC TGCTGCAGGA AACTGAGTTA 2100
GTGGAGCCGC TGACGCCCAG CGGAGCAATG CCCAACCAGG CTCAGATGCG GATCCTAAAA 2160
GAGACGGAGC TAAGGAAGGT GAAGGTGCTT GGATCAGGAG CTTTTGGCAC TGTCTACAAG 2220
GGCATCTGGA TCCCAGATGG GGAGAATGTG AAAATCCCCG TGGCTATCAA GGTGTTGAGA 2280
GAAAACACAT CTCCTAAAGC CAACAAAGAA ATTCTAGATG AAGCGTATGT GATGGCTGGT 2340
GTGGGTTCTC CGTATGTGTC CCGCCTCCTG GGCATCTGCC TGACATCCAC AGTACAGCTG 2400
GTGACACAGC TTATGCCCTA CGGCTGCCTT CTGGACCATG TCCGAGAACA CCGAGGTCGC 2460
CTAGGCTCCC AGGACCTGCT CAACTGGTGT GTTCAGATTG CCAAGGGGAT GAGCTACCTG 2520
GAGGACGTGC GGCTTGTACA CAGGGACCTG GCTGCCCGGA ATGTGCTAGT CAAGAGTCCC 2580
AACCACGTCA AGATTACAGA TTTCGGGCTG GCTCGGCTGC TGGACATTGA TGAGACAGAG 2640
TACCATGCAG ATGGGGGCAA GGTGCCCATC AAATGGATGG CATTGGAATC TATTCTCAGA 2700
CGCCGGTTCA CCCATCAGAG TGATGTGTGG AGCTATGGAG TGACTGTGTG GGAGCTGATG 2760
ACTTTTGGGG CCAAACCTTA CGATGGAATC CCAGCCCGGG AGATCCCTGA TTTGCTGGAG 2820
AAGGGAGAAC GCCTACCTCA GCCTCCAATC TGCACCATTG ATGTCTACAT GATTATGGTC 2880
AAATGTTGGA TGATTGACTC TGAATGTCGC CCGAGATTCC GGGAGTTGGT GTCAGAATTT 2940
TCACGTATGG CGAGGGACCC CCAGCGTTTT GTGGTCATCC AGAACGAGGA CTTGGGCCCA 3000
TCCAGCCCCA TGGACAGTAC CTTCTACCGT TCACTGCTGG AAGATGATGA CATGGGTGAC 3060
CTGGTAGACG CTGAAGAGTA TCTGGTGCCC CAGCAGGGAT TCTTCTCCCC GGACCCTACC 3120
CCAGGCACTG GGAGCACAGC CCATAGAAGG CACCGCAGCT CGTCCACCAG GAGTGGAGGT 3180
GGTGAGCTGA CACTGGGCCT GGAGCCCTCG GAAGAAGGGC CCCCCAGATC TCCACTGGCT 3240
CCCTCGGAAG GGGCTGGCTC CGATGTGTTT GATGGTGACC TGGCAATGGG GGTAACCAAA 3300
GGGCTGCAGA GCCTCTCTCC ACATGACCTC AGCCCTCTAC AGCGGTACAG CGAGGACCCC 3360
ACATTACCTC TGCCCCCCGA GACTGATGGC TATGTTGCTC CCCTGGCCTG CAGCCCCCAG 3420
CCCGAGTATG TGAACCAATC AGAGGTTCAG CCTCAGCCTC CTTTAACCCC AGAGGGTCCT 3480
CTGCCTCCTG TCCGGCCTGC TGGTGCTACT CTAGAAAGAC CCAAGACTCT CTCTCCTGGG 3540
AAGAATGGGG TTGTCAAAGA CGTTTTTGCC TTCGGGGGTG CTGTGGAGAA CCCTGAATAC 3600
TTAGTACCGA GAGAAGGCAC TGCCTCTCCG CCCCACCCTT CTCCTGCCTT CAGCCCAGCC 3660
TTTGACAACC TCTATTACTG GGACCAGAAC TCATCGGAGC AGGGGCCTCC ACCAAGTAAC 3720
TTTGAAGGGA CCCCCACTGC AGAGAACCCT GAGTACCTAG GCCTGGATGT ACCTGTATGA 3780
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         l+k+kvlGsGafGtvykGiwip+genvkipvaikvl+e+t++kanke+ldea+v+a + +
Q: 724   LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGS  783
         69**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+qlvtql+p+Gclld+vreh+++lGsq+llnwcvqiakGmsyle+ 
Q: 784   PYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDV  843
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesil+r++
Q: 844   RLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRF  903
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfGakpydgipa+eipdllekGerl+qppictidvym++vkcw
Q: 904   THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCW  963
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mid+e+rp+f+el++efs
Q: 964   MIDSECRPRFRELVSEFS  981
         ****************96
Domain Sequence
(FASTA)
LRKVKVLGSG AFGTVYKGIW IPDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 60
PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VREHRGRLGS QDLLNWCVQI AKGMSYLEDV 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF 180
THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI DVYMIMVKCW 240
MIDSECRPRF RELVSEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00280
EKS-ANC-00289
EKS-BOT-00298
EKS-CAJ-00305
EKS-CAF-00305
EKS-CAP-00334
EKS-DAR-00646
EKS-EQC-00290
EKS-FEC-00284
EKS-GAA-00370
EKS-GOG-00296
EKS-HOS-00305
EKS-ICT-00281
EKS-LAC-00310
EKS-LOA-00309
EKS-MAM-00302
EKS-MOD-00293
EKS-MUM-00330
EKS-MUP-00296
EKS-MYL-00300
EKS-NOL-00275
EKS-ORN-00389
EKS-ORC-00281
EKS-ORL-00360
EKS-OTG-00303
EKS-PAT-00284
EKS-SAH-00280
EKS-SUS-00262
EKS-TAR-00391
EKS-TEN-00386
EKS-XET-00372
EKS-XIM-00379
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0016323; C:basolateral plasma membrane
GO:0010008; C:endosome membrane
GO:0016021; C:integral to membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007507; P:heart development
GO:0008045; P:motor neuron axon guidance
GO:0042552; P:myelination
GO:0033088; P:negative regulation of immature T cell proliferation in thymus
GO:0007528; P:neuromuscular junction development
GO:0007422; P:peripheral nervous system development
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0045785; P:positive regulation of cell adhesion
GO:0030307; P:positive regulation of cell growth
GO:0050679; P:positive regulation of epithelial cell proliferation
GO:0043406; P:positive regulation of MAP kinase activity
GO:0032321; P:positive regulation of Rho GTPase activity
GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter
GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter
GO:0045727; P:positive regulation of translation
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0032886; P:regulation of microtubule-based process
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0042060; P:wound healing
KEGG
rno:24337;
InterPros
IPR021157; Cyt_c1_TM_anchor_C.
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 4.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013