EKS-RAN-00157

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00157

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	497.7	8.5E-150	422	679	258

Status

Unreviewed

Ensembl Protein

ENSRNOP00000008938

UniProt Accession

D3Z8E0;

Protein Name

Protein Synonyms/Alias

Protein Rps6ka3;

Gene Name

Rps6ka3

Gene Synonyms/Alias

Rps6ka3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000006632	ENSRNOP00000008938	ENSRNOT00000008938

Organism

Rattus norvegicus

Functional Description

Protein Length

740

Protein Sequence
(FASTA)

MPLAQLADPW QKMAVESPSD SAENGQQIMD EPMGEEEINP QTEEGSIKEI AITHHVKEGH 60

EKADPSQFEL LKVLGQGSFG KVFLVKKISG SDARQLYAMK VLKKATLKVR DRVRTKMERD 120

ILVEVNHPFI VKLHYAFQTE GKLYLILDFL RGGDLFTRLS KEVMFTEEDV KFYLAELALA 180

LDHLHSLGII YRDLKPENIL LDEEGHIKLT DFGLSKESID HEKKAYSFCG TVEYMAPEVV 240

NRRGHTQSAD WWSFGVLMFE MLTGTLPFQG KDRKETMTMI LKAKLGMPQF LSPEAQSLLR 300

MLFKRNPANR LGAGPDGVEE IKRHSFFSTI DWNKLYRREI HPPFKPATGR PEDTFYFDPE 360

FTAKTPKDSP GIPPSANAHQ LFRGFSFVAI TSDDESQAMQ TVGVHSIVQQ LHRNSIQFTD 420

GYEVKEDIGV GSYSVCKRCI HKATNMEFAV KIIDKSKRDP TEEIEILLRY GQHPNIITLK 480

DVYDDGKYVY VVTELMKGGE LLDKILRQKF FSEREASAVL FTITKTVEYL HTQGVVHRDL 540

KPSNILYVDE SGNPESIRIC DFGFAKQLRA ENGLLMTPCY TANFVAPEVL KRQGYDAACD 600

IWSLGVLLYT MLTGYTPFAN GPDDTPEEIL ARIGSGKFSL SGGYWNSVSD TAKDLVSKML 660

HVDPHQRLTA ALVLRHPWIV HWDQLPQYQL NRQDAPHLVK GAMAATYSAL NRNQSPVLEP 720

VGRSTLAQRR GIKKITSTAL 740

Nucleotide Sequence
(FASTA)

ATGCCGCTGG CGCAGCTGGC GGACCCGTGG CAGAAGATGG CTGTGGAGAG CCCTTCCGAC 60

AGCGCTGAGA ATGGACAGCA AATTATGGAT GAACCTATGG GAGAGGAGGA GATTAATCCA 120

CAAACTGAAG AAGGCAGTAT CAAAGAAATT GCAATCACAC ATCATGTGAA GGAAGGACAT 180

GAAAAGGCAG ATCCTTCCCA GTTTGAGCTT TTAAAAGTAT TAGGGCAGGG ATCTTTTGGA 240

AAGGTTTTCT TAGTTAAAAA AATCTCAGGC TCTGATGCTA GACAACTTTA TGCCATGAAG 300

GTATTAAAGA AGGCCACACT GAAAGTTCGA GACCGTGTTC GGACAAAAAT GGAACGTGAT 360

ATCTTGGTAG AAGTCAATCA TCCTTTCATT GTCAAATTGC ATTATGCTTT TCAAACTGAA 420

GGGAAGTTGT ATCTTATTTT GGATTTTCTC AGGGGAGGAG ATTTGTTTAC ACGCTTATCC 480

AAAGAGGTGA TGTTCACAGA GGAAGATGTC AAATTCTACT TGGCTGAACT TGCACTTGCT 540

TTAGACCATC TGCATAGCCT GGGAATAATC TATAGAGACT TAAAACCAGA AAACATACTT 600

CTTGATGAAG AAGGTCACAT CAAGTTAACT GATTTTGGCT TAAGTAAGGA ATCTATTGAC 660

CACGAGAAGA AGGCATATTC CTTTTGTGGC ACTGTGGAAT ACATGGCTCC AGAAGTAGTT 720

AATCGTAGAG GTCATACTCA AAGTGCTGAC TGGTGGTCTT TTGGTGTGTT GATGTTTGAA 780

ATGCTCACTG GTACACTACC TTTCCAAGGA AAAGATCGTA AAGAAACAAT GACTATGATT 840

CTTAAAGCCA AACTCGGGAT GCCACAGTTT CTGAGTCCTG AAGCCCAGAG TCTTTTACGA 900

ATGCTTTTCA AACGGAATCC TGCAAACAGA TTAGGTGCCG GACCAGATGG AGTTGAAGAA 960

ATTAAAAGAC ATTCATTTTT CTCAACAATA GACTGGAATA AACTATACAG AAGAGAGATT 1020

CACCCACCTT TTAAGCCTGC AACTGGCAGA CCTGAAGATA CATTTTATTT TGATCCTGAG 1080

TTTACTGCAA AAACTCCCAA AGATTCACCT GGCATTCCAC CTAGTGCTAA CGCACATCAG 1140

CTTTTTCGGG GGTTTAGTTT TGTTGCTATT ACCTCAGATG ACGAAAGCCA AGCTATGCAG 1200

ACAGTTGGTG TGCATTCAAT TGTTCAGCAA TTACACAGGA ACAGTATTCA GTTTACTGAT 1260

GGATATGAAG TAAAAGAGGA TATTGGTGTT GGCTCATACT CCGTTTGTAA GAGATGTATA 1320

CATAAAGCCA CAAACATGGA GTTTGCCGTG AAGATTATTG ATAAAAGCAA GAGAGACCCA 1380

ACAGAAGAAA TTGAAATTCT TCTTCGTTAC GGACAGCATC CAAACATCAT TACCCTAAAA 1440

GATGTGTATG ATGATGGAAA ATACGTATAC GTAGTAACAG AACTTATGAA AGGAGGTGAA 1500

TTGCTGGATA AAATTCTTAG ACAGAAGTTT TTCTCAGAGC GAGAGGCCAG TGCTGTCCTG 1560

TTTACTATAA CCAAAACTGT TGAGTATCTT CACACACAAG GGGTGGTTCA CAGAGACTTA 1620

AAACCTAGCA ACATTCTTTA TGTGGATGAG TCTGGTAATC CAGAATCTAT TCGAATTTGT 1680

GACTTTGGCT TTGCAAAACA ACTGAGAGCA GAAAATGGTC TTCTTATGAC TCCTTGCTAT 1740

ACTGCAAATT TTGTTGCACC AGAGGTTTTA AAACGACAAG GTTATGATGC TGCCTGTGAT 1800

ATATGGAGTC TTGGTGTCCT CCTTTATACA ATGCTTACTG GTTACACTCC ATTTGCAAAT 1860

GGTCCTGATG ATACTCCAGA GGAAATACTG GCACGAATAG GTAGTGGAAA ATTCTCACTC 1920

AGTGGTGGTT ACTGGAATTC TGTTTCAGAC ACAGCAAAGG ACCTGGTGTC AAAGATGCTT 1980

CATGTAGATC CTCATCAGAG ACTGACTGCT GCTCTTGTGC TCAGACATCC TTGGATTGTC 2040

CACTGGGACC AACTGCCACA ATACCAACTA AACAGACAGG ATGCACCGCA TCTCGTAAAG 2100

GGTGCCATGG CAGCTACATA CTCTGCTTTA AACCGCAATC AGTCTCCAGT TTTGGAACCG 2160

GTAGGCCGTT CTACTCTTGC TCAGCGGAGA GGTATTAAAA AAATCACCTC AACAGCCCTG 2220

TGA 2223

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         yevked+GvGsysvckrc+hkatn+efavkiidkskrd++eeieillry+qhpni+tlkd

Q: 422   YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKD  481

         789*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyddgkyvy+v+el+kGGelld+i+++kffsereasa+l+t++k+veylh+qGvvhrdlk

Q: 482   VYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHTQGVVHRDLK  541

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvdes+n+esi+i+dfGfak++raengll+tpcyt+nfvapevlkrqGyd+acd+

Q: 542   PSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI  601

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslGvllytml+Gy+pfangp+dt+eeila+i++GkfslsG++w+svs++akdlvsk+l+

Q: 602   WSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLH  661

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++ +l+h+w+

Q: 662   VDPHQRLTAALVLRHPWI  679

         *****************8

Domain Sequence
(FASTA)

YEVKEDIGVG SYSVCKRCIH KATNMEFAVK IIDKSKRDPT EEIEILLRYG QHPNIITLKD 60

VYDDGKYVYV VTELMKGGEL LDKILRQKFF SEREASAVLF TITKTVEYLH TQGVVHRDLK 120

PSNILYVDES GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDI 180

WSLGVLLYTM LTGYTPFANG PDDTPEEILA RIGSGKFSLS GGYWNSVSDT AKDLVSKMLH 240

VDPHQRLTAA LVLRHPWI 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0043027	; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0032496	; P:response to lipopolysaccharide
GO:0002224	; P:toll-like receptor signaling pathway

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013