EKS-RAN-00108

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00108

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	473.9	1.2E-142	369	619	251

Status

Unreviewed

Ensembl Protein

ENSRNOP00000009211

UniProt Accession

D4A7W7;

Protein Name

Protein Synonyms/Alias

IL2-inducible T-cell kinase (Predicted); Protein Itk;

Gene Name

Itk

Gene Synonyms/Alias

Itk; Itk_predicted; rCG_34547;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000006860	ENSRNOP00000009211	ENSRNOT00000009211

Organism

Rattus norvegicus

Functional Description

Protein Length

626

Protein Sequence
(FASTA)

MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT LKGSIELSRI 60

KCVEIVKSDI SIPCHYKYPF QTLTSFQVMH DNYLLYVFAP DCESRQRWVL TLKEETRNNN 120

SLVSKYHPNF WMDGRWRCCS QLEKLAVGCA PYDPTKNASK KPLPPTPEDN RRSFQEPEET 180

LVIALYDYQT NDPQELALRR DEEYYLLDSS EIHWWRVQDK NGHEGYAPSS YLVEKSPNSL 240

ETYEWYNKSI SRDKAEKLLL DTGKEGAFMV RDSRTPGTYT VSVFTKAIIS ENNPCIKHYH 300

IKETNDSPKR YYVAEKYVFD SIPLLIQYHQ YNGGGLVTRL RYPVCSWRQK APVTAGLRYG 360

KWVIQPSELT FVQEIGSGQF GLVHLGYWLN KDKVAIKTIQ EGAMSEEDFI EEAEVMMKLS 420

HPKLVQLYGV CLEQAPICLV FEFMEHGCLS DYLRSQRGLF AAETLLGMCL DVCEGMAYLE 480

KACVIHRDLA ARNCLVGENQ VIKVSDFGMT RFVLDDQYTS STGTKFPVKW ASPEVFSFSR 540

YSSKSDVWSF GVLMWEVFSE GKIPYENRSN SEVVEDISTG FRLYKPRLAS PHVYQVMNHC 600

WKEKPEDRPP FSRLLSQLAE IAECGL 626

Nucleotide Sequence
(FASTA)

ATGAACAACT TCATCCTCCT GGAAGAACAG CTGATCAAGA AGTCCCAACA GAAGAGAAGG 60

ACTTCTCCCT CGAATTTTAA AGTCCGTTTC TTCGTCTTAA CGAAAGCCAG CCTGGCATAC 120

TTCGAGGACC GCCACGGGAA GAAGCGCACG TTGAAGGGCT CCATCGAACT CTCCAGAATC 180

AAGTGCGTGG AGATTGTCAA GAGTGACATT AGCATCCCGT GCCACTATAA ATACCCTTTT 240

CAGACTCTTA CGTCCTTCCA GGTCATGCAC GACAACTACC TCCTGTACGT GTTTGCTCCA 300

GACTGCGAGA GCCGTCAGCG CTGGGTGCTC ACCCTTAAAG AAGAAACGAG GAATAACAAC 360

AGCCTAGTAT CCAAGTATCA CCCTAATTTC TGGATGGATG GGCGGTGGAG GTGCTGTTCC 420

CAGCTAGAGA AGCTTGCCGT AGGCTGTGCT CCCTACGACC CAACGAAGAA TGCTTCAAAG 480

AAGCCTCTTC CTCCTACTCC TGAAGACAAC AGGCGGTCAT TTCAGGAACC TGAAGAAACC 540

CTGGTCATTG CCTTGTACGA CTACCAAACC AACGATCCTC AGGAGCTCGC GCTGCGGCGT 600

GATGAAGAGT ACTACCTGCT GGACAGCTCC GAGATCCACT GGTGGCGGGT TCAAGACAAG 660

AATGGGCATG AAGGATATGC ACCCAGCAGT TACCTGGTGG AAAAGTCTCC AAATAGCCTT 720

GAAACCTACG AGTGGTACAA TAAAAGCATC AGCCGAGACA AAGCTGAAAA ACTTCTTTTG 780

GACACAGGTA AAGAAGGAGC ATTCATGGTC CGAGATTCCA GGACACCCGG GACATACACA 840

GTCTCTGTCT TCACCAAGGC CATCATAAGT GAGAACAACC CCTGTATAAA ACATTATCAC 900

ATCAAAGAAA CAAATGACAG CCCCAAGCGG TACTATGTGG CTGAGAAGTA TGTGTTTGAC 960

TCCATCCCTC TCCTCATCCA GTATCACCAA TACAATGGAG GAGGTTTGGT CACTCGACTC 1020

CGGTATCCAG TTTGCTCCTG GAGGCAGAAA GCCCCTGTCA CAGCAGGGCT AAGATATGGG 1080

AAGTGGGTGA TCCAGCCCTC GGAGCTAACT TTCGTGCAGG AGATTGGCAG CGGGCAGTTT 1140

GGACTGGTGC ATCTCGGCTA CTGGCTCAAC AAGGACAAGG TGGCCATCAA GACCATTCAG 1200

GAAGGGGCGA TGTCAGAAGA AGACTTTATC GAGGAGGCAG AAGTCATGAT GAAACTCTCT 1260

CACCCCAAGC TGGTGCAGCT CTATGGGGTG TGCTTGGAGC AAGCCCCCAT CTGCCTGGTG 1320

TTTGAGTTCA TGGAGCACGG CTGCCTATCG GATTACCTTC GAAGTCAGCG GGGTCTCTTT 1380

GCTGCAGAGA CCCTGCTGGG CATGTGCCTG GACGTGTGTG AGGGCATGGC CTACCTAGAA 1440

AAAGCGTGTG TCATCCACAG AGACCTGGCC GCCAGGAACT GTTTGGTGGG AGAAAACCAG 1500

GTCATCAAGG TGTCCGACTT CGGCATGACA AGGTTTGTCC TTGATGATCA ATATACCAGC 1560

TCCACGGGCA CCAAATTCCC AGTGAAGTGG GCATCCCCAG AAGTGTTCTC CTTCAGCCGC 1620

TACAGCAGCA AGTCAGATGT GTGGTCATTT GGTGTACTGA TGTGGGAAGT CTTCAGCGAA 1680

GGCAAAATCC CATATGAAAA CCGAAGCAAT TCAGAGGTCG TGGAAGACAT CAGCACTGGC 1740

TTTCGGTTAT ACAAGCCCCG CCTGGCCTCC CCTCATGTCT ACCAGGTCAT GAATCACTGC 1800

TGGAAAGAGA AACCGGAAGA CCGGCCACCC TTCTCCCGGC TGTTAAGCCA ACTGGCTGAA 1860

ATCGCAGAAT GTGGACTTTA G 1881

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+++e+gsgqfg+v+lg+w +k++vaik+i+egamseedfieea+vmmklshpklvqly

Q: 369   LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLY  428

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvcl+q+pi++v+e++e+gcl++ylr++++ +++e+ll mc dvcegm+yle++++ihrd

Q: 429   GVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAAETLLGMCLDVCEGMAYLEKACVIHRD  488

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+e++v+kvsdfg++r+vlddqy+ss+g+kfpvkw++pev+s+s+yssksdvw

Q: 489   LAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVW  548

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         +fgvlmwevfsegk+pye++snsevve++s+g+rly+p+las +vy+vm++cwkekpe+r

Q: 549   SFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASPHVYQVMNHCWKEKPEDR  608

         ************************************************************

S: 241   ptfkellsale  251

         p f++lls+l+

Q: 609   PPFSRLLSQLA  619

         ********996

Domain Sequence
(FASTA)

LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IQEGAMSEED FIEEAEVMMK LSHPKLVQLY 60

GVCLEQAPIC LVFEFMEHGC LSDYLRSQRG LFAAETLLGM CLDVCEGMAY LEKACVIHRD 120

LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW 180

SFGVLMWEVF SEGKIPYENR SNSEVVEDIS TGFRLYKPRL ASPHVYQVMN HCWKEKPEDR 240

PPFSRLLSQL A 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543	; F:phospholipid binding
GO:0007202	; P:activation of phospholipase C activity
GO:0002250	; P:adaptive immune response
GO:0032609	; P:interferon-gamma production
GO:0032633	; P:interleukin-4 production
GO:0035556	; P:intracellular signal transduction
GO:0001865	; P:NK T cell differentiation
GO:0050852	; P:T cell receptor signaling pathway

KEGG

rno:363577

;

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00402	; TECBTKDOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013