EPS-RAN-00024

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-RAN-00024

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	240.1	4.2E-71	94	344	251

Status

Unreviewed

Ensembl Protein

ENSRNOP00000009202

UniProt Accession

D4A7X5;

Protein Name

Protein Synonyms/Alias

Protein Ppm1k; Protein phosphatase 1K (PP2C domain containing) (Predicted);

Gene Name

Ppm1k

Gene Synonyms/Alias

Ppm1k; Ppm1k_predicted; rCG_52320;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000006893	ENSRNOP00000009202	ENSRNOT00000009202

Organism

Rattus norvegicus

Functional Description

Protein Length

372

Protein Sequence
(FASTA)

MLSTAFITLV RSGRNQVKKR VLLSSILLQD HRQMTPACYC SISEPRCSRF DPDGSGQPAT 60

WDNFGIWDNR IDEPILLPPS IKYGKPIPKI SLENVGCASL IGKRKENEDR FGFAQLTEEV 120

LYFAVYDGHG GPAAADFCHT HMEKCVTDLL PREKDLETVL TLAFLEIDKA FSSYAHLSAD 180

ASLLTSGTTA TVALLRDGVE LVVASVGDSR ALLCRKGKPM KLTTDHTPER KDEKERIKKC 240

GGFVAWNSLG QPHVNGRLAM TRSIGDLDLK ASGVIAEPET TRIKLYHADD SFLVLTTDGI 300

NFMVNSQEIC DFVNQCHDPK EAAHAVTEQA IQYGTEDNST AVVVPFGAWG KYKNSEITFS 360

FSRSFASSGR WA 372

Nucleotide Sequence
(FASTA)

ATGTTATCAA CGGCCTTCAT TACTTTGGTG AGAAGTGGTA GGAACCAGGT GAAGAAGAGA 60

GTGTTGTTAA GCTCCATCCT CCTGCAGGAC CACAGACAGA TGACTCCTGC CTGCTACTGC 120

TCCATTTCGG AGCCCAGGTG TTCTCGGTTT GATCCGGACG GAAGTGGGCA GCCAGCCACT 180

TGGGACAATT TTGGGATCTG GGATAACCGC ATTGATGAGC CAATTCTGTT GCCACCTAGC 240

ATCAAGTATG GCAAGCCAAT TCCCAAAATT AGCCTGGAGA ACGTGGGCTG TGCCTCCCTC 300

ATTGGCAAAC GAAAAGAAAA CGAAGATCGA TTTGGGTTCG CACAGTTGAC AGAAGAGGTG 360

CTATACTTTG CAGTCTATGA TGGGCATGGA GGCCCTGCAG CTGCTGACTT CTGTCACACA 420

CACATGGAAA AATGTGTTAC GGATTTGCTT CCTCGGGAGA AAGACTTGGA AACTGTCCTG 480

ACCTTGGCCT TTCTAGAAAT AGATAAAGCC TTTTCAAGTT ATGCCCACCT GTCTGCTGAT 540

GCAAGCCTCC TGACCTCTGG GACTACTGCA ACAGTAGCCC TGTTGAGAGA TGGTGTTGAA 600

CTGGTGGTAG CCAGTGTTGG AGACAGCCGG GCTCTTTTGT GTAGAAAAGG CAAACCCATG 660

AAGCTGACCA CTGACCATAC CCCAGAGAGA AAAGATGAGA AAGAAAGGAT CAAGAAATGC 720

GGTGGGTTTG TAGCTTGGAA TAGCCTGGGA CAGCCCCATG TAAATGGCAG ACTTGCGATG 780

ACAAGGAGTA TTGGAGATTT GGATCTTAAA GCCAGTGGTG TAATAGCAGA ACCTGAGACA 840

ACCAGGATTA AGCTCTACCA CGCTGACGAC AGTTTCCTGG TCCTCACCAC CGACGGGATT 900

AACTTCATGG TGAATAGTCA AGAGATCTGC GACTTTGTCA ACCAGTGCCA CGATCCTAAA 960

GAAGCAGCTC ATGCTGTGAC TGAGCAGGCA ATTCAGTACG GTACTGAAGA CAACAGCACT 1020

GCCGTAGTAG TGCCCTTTGG TGCCTGGGGA AAATACAAGA ACTCTGAGAT AACCTTCTCA 1080

TTCAGCAGAA GCTTTGCCTC CAGCGGGCGA TGGGCCTGA 1119

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         +vg++s+ g+r+e ed++    +f++ +e+   + +f+vyDGhgg  +a+fc++++++++

Q: 94    NVGCASLIGKRKENEDRF----GFAQLTEE---VLYFAVYDGHGGPAAADFCHTHMEKCV  146

         5899**************....67887666...78*************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidk....sGstavvalikds.k  116

         +  l     +e++++++l+ aFl++d+++   ++++l+ d+    sG+ta+val++d  +

Q: 147   TDLLP----REKDLETVLTLAFLEIDKAF--SSYAHLSADAslltSGTTATVALLRDGvE  200

         ***87....********************..55555566656699************99*

S: 117   lyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkd.ga.RvlGvLav  174

         l+va vGdSra+Lcr+gk+++l++dH+p+r+dE+eRi++ gg v+ ++ g+ +v+G La+

Q: 201   LVVASVGDSRALLCRKGKPMKLTTDHTPERKDEKERIKKCGGFVAWNSlGQpHVNGRLAM  260

         ********************************************98889999********

S: 175   sRalGdlylk.pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvlekk  232

         +R++Gdl+lk + v++ePe+t ++l + d+ fl+L +DG+  +v+++e++++v+++++

Q: 261   TRSIGDLDLKaSGVIAEPETTRIKLYHADDsFLVLTTDGINFMVNSQEICDFVNQCHD--  318

         **********556************999999***************************..

S: 233   eaeqeaakkLvklalargskdnvsaivv  260

           ++eaa+ ++++a+++g++dn +a+vv

Q: 319   --PKEAAHAVTEQAIQYGTEDNSTAVVV  344

         ..***********************997

Domain Sequence
(FASTA)

NVGCASLIGK RKENEDRFGF AQLTEEVLYF AVYDGHGGPA AADFCHTHME KCVTDLLPRE 60

KDLETVLTLA FLEIDKAFSS YAHLSADASL LTSGTTATVA LLRDGVELVV ASVGDSRALL 120

CRKGKPMKLT TDHTPERKDE KERIKKCGGF VAWNSLGQPH VNGRLAMTRS IGDLDLKASG 180

VIAEPETTRI KLYHADDSFL VLTTDGINFM VNSQEICDFV NQCHDPKEAA HAVTEQAIQY 240

GTEDNSTAVV V 251

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

rno:312381

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013