EKS-RAN-00120

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00120

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	482.5	3.7E-145	1079	1339	261

Status

Unreviewed

Ensembl Protein

ENSRNOP00000009662

UniProt Accession

Q2IBC7;

Protein Name

Protein Synonyms/Alias

Hepatocyte growth factor receptor; Met proto-oncogene; RCG27969;

Gene Name

Met

Gene Synonyms/Alias

Met; Capza2, Cav, Cav2, Cftr, LOC500040, ST7, Wnt2; rCG_27969;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000007079	ENSRNOP00000009662	ENSRNOT00000009662

Organism

Rattus norvegicus

Functional Description

Protein Length

1382

Protein Sequence
(FASTA)

MKAPTALAPG ILLLLLTLAQ RSHGECKEAL VKSEMNVNMK YQLPNFTAET PIHNVVLHGH 60

HIYLGATNYI YVLDDKDLQK VSEFKTGPVV EHPDCFPCQD CSSKANVSGG VWKDNVNMAL 120

LVDTYYDDQL ISCGSVNRGT CQRHVLPPDN AADIQSEVHC MFSPLAEEES GQCPDCVVSA 180

LGAKVLLSEK DRFINFFVGN TINSSYPPDY SLHSISVRRL KETQDGFKFL TDQSYIDVLP 240

EFRDSYPIKY IHAFESNHFI YFLTVQKETL DAQTFHTRII RFCSVDSGLH SYMEMPLECI 300

LTEKRRKRST REEVFNILQA AYVSKPGANL AKQIGASPYD DILYGVFAQS KPDSAEPMNR 360

SAVCAFPIKY VNDFFNKIVN KNNVRCLQHF YGPNHEHCFN RTLLRNSSGC EVRSDEYRTE 420

FTTALQRVDL FMGRLNHVLL TSISTFIKGD LTIANLGTSE GRFMQVVLSR TAHFTPHVNF 480

LLDSYPVSPE VIVEHPSNQN GYTLVVTGKK ITKIPLNGLG CGHFQSCSQC LSAPYFIQCG 540

WCHNRCVHSN ECPSGTWTQE ICLPAVYKVF PTSAPLEGGT MLTICGWDFG FKKNNKFDLR 600

KTKVLLGNES CTLTLSESTT NTLKCTVGPA MSEHFNVSVI VSNSRETTQY SAFSYVDPVI 660

TSISPRYGPH AGGTLLTLTG KYLNSGNSRH ISIGGKTCTL KSVSDSILEC YTPGHTVSAE 720

FPVKLKIDLA DRVTSSFSYR EDPVVSEIHP TKSFISGGST ITGIGKNLNS VSTPKLVIEV 780

HDVGVNYTVA CQHRSSSEII CCTTPSLQQL DLQLPLKTKA FFLLDGILSK HFDLTYVHDP 840

MFKPFEKPVM ISMGNENVVE IKGDDIDPEA VKGEVLKVGN KSCENLHWHS EALLCTVPSD 900

LLKLNGGELN IEWKQAVSST VLGKVIVQPD QNFAGLIIGA VSISVVVLLV SGLFLWLRKR 960

KHKDLGSELV RYDARVHTPH LDRLVSARSV SPTTEMVSNE SVDYRATFPE DQFPNSSQNG 1020

ACRQVQYPLT DLSPILTSGD SDISSPLLQN TVHIDLSALN PELVQAVQHV VIGPSSLIVH 1080

FNEVIGRGHF GCVYHGTLLD SDGKKIHCAV KSLNRITDIE EVSQFLTEGI IMKDFSHPNV 1140

LSLLGICLRS EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMKYLASKK 1200

FVHRDLAARN CMLDEKFTVK VADFGLARDM YDKEYYSVHN KTGAKLPVKW MALESLQTQK 1260

FTTKSDVWSF GVLLWELMTR GAPPYPDVNT FDITIYLLQG RRLLQPEYCP DALYEVMLKC 1320

WHPKAEMRPS FSELVSRISS IFSTFIGEHY VHVNATYVNV KCVAPYPSLL PSQDNIDGEA 1380

NT 1382

Nucleotide Sequence
(FASTA)

ATGAAGGCTC CCACCGCGCT GGCACCTGGC ATTCTGCTGC TGCTGCTGAC CTTGGCGCAG 60

AGGAGCCATG GGGAGTGCAA GGAGGCCCTA GTGAAGTCTG AGATGAACGT GAACATGAAG 120

TACCAGCTTC CCAACTTCAC CGCAGAAACC CCCATCCACA ATGTCGTCCT CCATGGGCAC 180

CATATTTATC TCGGAGCCAC AAACTACATT TATGTTTTAG ATGACAAAGA CCTTCAGAAG 240

GTATCTGAGT TCAAGACCGG GCCCGTGGTG GAACACCCAG ATTGTTTTCC TTGTCAGGAC 300

TGCAGCAGCA AAGCCAATGT GTCAGGAGGT GTTTGGAAAG ACAACGTCAA CATGGCGCTG 360

CTTGTTGACA CTTACTATGA CGACCAGCTC ATCAGCTGTG GCAGCGTCAA CAGAGGGACC 420

TGCCAAAGGC ATGTCCTTCC TCCTGACAAT GCTGCCGACA TTCAGTCCGA GGTTCACTGC 480

ATGTTCTCCC CACTTGCGGA GGAAGAGTCA GGCCAGTGTC CCGACTGTGT AGTGAGTGCC 540

CTGGGAGCCA AAGTCCTCCT GTCTGAAAAG GACCGGTTCA TCAATTTCTT CGTGGGGAAT 600

ACGATAAACT CTTCCTACCC TCCCGATTAT TCATTGCATT CAATATCGGT GAGGCGGCTG 660

AAGGAAACCC AGGACGGTTT TAAGTTTTTG ACAGACCAGT CCTACATTGA TGTCCTGCCA 720

GAATTCCGAG ATTCCTACCC CATCAAGTAC ATACATGCCT TCGAAAGCAA CCATTTTATC 780

TACTTTCTGA CTGTCCAGAA GGAAACCCTA GATGCTCAGA CTTTCCATAC AAGAATAATC 840

AGGTTCTGTT CTGTAGACTC TGGGTTGCAC TCCTACATGG AAATGCCTCT GGAGTGCATT 900

CTGACGGAAA AAAGAAGAAA GAGATCCACA AGGGAAGAAG TGTTTAATAT CCTCCAAGCC 960

GCATATGTCA GTAAACCGGG GGCCAATCTT GCTAAGCAAA TAGGGGCCAG CCCGTATGAT 1020

GACATTCTCT ACGGGGTGTT TGCACAAAGC AAGCCAGATT CTGCTGAGCC CATGAACCGA 1080

TCAGCGGTCT GTGCATTCCC CATCAAATAT GTCAATGACT TCTTCAACAA GATTGTCAAC 1140

AAAAACAACG TACGGTGTCT CCAGCATTTT TATGGACCCA ACCACGAGCA CTGTTTCAAT 1200

AGGACCCTGC TGAGAAATTC ATCGGGCTGC GAAGTGCGCA GTGACGAGTA CCGGACGGAG 1260

TTTACCACGG CGCTGCAGCG TGTGGATTTA TTCATGGGCC GGCTCAACCA TGTACTCTTG 1320

ACGTCTATCT CTACCTTCAT CAAAGGTGAC CTCACCATTG CTAATCTAGG GACATCAGAA 1380

GGTCGCTTCA TGCAGGTGGT GCTCTCTCGC ACAGCACATT TCACCCCCCA TGTGAATTTC 1440

CTCCTGGATT CCTATCCTGT GTCTCCGGAA GTTATTGTCG AACATCCATC AAATCAAAAT 1500

GGCTATACCT TGGTGGTCAC AGGGAAGAAG ATCACCAAGA TTCCACTGAA TGGCCTAGGC 1560

TGTGGGCATT TCCAGTCCTG CAGTCAGTGT CTCTCTGCCC CCTACTTTAT ACAGTGTGGC 1620

TGGTGCCACA ATCGGTGTGT GCATTCCAAT GAATGCCCCA GCGGTACATG GACTCAAGAG 1680

ATCTGTCTGC CAGCAGTTTA TAAGGTTTTC CCCACTAGTG CACCCCTCGA AGGAGGAACA 1740

ATGCTGACCA TATGTGGCTG GGACTTTGGA TTCAAGAAGA ATAATAAATT TGATTTAAGG 1800

AAAACCAAAG TTCTGCTTGG CAACGAGAGC TGTACCTTGA CCTTAAGCGA GAGCACGACA 1860

AATACGTTGA AATGCACAGT TGGCCCCGCG ATGAGTGAGC ACTTCAATGT GTCTGTGATC 1920

GTCTCAAACA GTCGAGAGAC AACACAGTAC AGTGCGTTTT CCTATGTGGA TCCTGTAATA 1980

ACAAGTATTT CTCCAAGGTA TGGTCCTCAT GCCGGAGGCA CCTTACTCAC TTTGACTGGA 2040

AAATACCTCA ACAGCGGCAA TTCTAGACAC ATTTCAATCG GAGGGAAAAC ATGTACTTTA 2100

AAAAGTGTAT CAGATAGCAT TCTCGAATGC TACACCCCAG GCCACACCGT CTCTGCCGAG 2160

TTTCCCGTGA AATTGAAAAT CGACCTGGCT GACCGAGTGA CAAGCAGCTT CAGTTACCGG 2220

GAAGACCCGG TTGTCTCTGA AATCCACCCG ACCAAATCTT TTATCAGTGG TGGAAGCACA 2280

ATAACGGGGA TTGGAAAGAA CCTGAATTCA GTTAGCACCC CAAAGCTGGT AATAGAAGTG 2340

CATGACGTGG GCGTGAACTA CACCGTGGCG TGCCAACATC GCTCGAGTTC AGAGATCATC 2400

TGCTGCACCA CTCCTTCCCT GCAACAGCTG GACCTGCAAC TCCCCCTGAA GACCAAAGCC 2460

TTCTTCCTGC TGGACGGGAT CCTTTCCAAA CACTTTGATC TCACTTATGT ACATGATCCT 2520

ATGTTTAAGC CTTTTGAAAA GCCAGTAATG ATCTCCATGG GCAATGAGAA TGTAGTGGAA 2580

ATTAAGGGAG ACGATATTGA CCCTGAAGCA GTTAAAGGTG AAGTGTTAAA AGTCGGGAAT 2640

AAGAGCTGTG AGAATCTCCA CTGGCATTCT GAAGCTTTGT TGTGTACGGT CCCCAGTGAC 2700

CTGCTGAAGC TGAACGGCGG CGAGCTAAAT ATAGAGTGGA AGCAAGCAGT CTCTTCAACT 2760

GTCCTTGGAA AAGTGATCGT TCAACCGGAT CAGAATTTTG CAGGATTGAT CATTGGTGCG 2820

GTCTCAATAT CAGTGGTAGT TTTGTTAGTA TCCGGGCTCT TCCTGTGGCT GAGAAAGAGA 2880

AAGCATAAAG ATCTGGGCAG TGAATTAGTT CGCTATGACG CAAGAGTACA CACTCCTCAT 2940

TTGGATAGGC TTGTAAGTGC CCGAAGTGTA AGCCCAACTA CAGAGATGGT CTCAAATGAG 3000

TCTGTAGACT ACAGAGCTAC TTTTCCAGAA GACCAGTTTC CCAACTCCTC TCAGAATGGA 3060

GCCTGCAGAC AAGTGCAGTA TCCTCTGACA GATCTGTCCC CCATCCTGAC GAGTGGAGAC 3120

TCTGATATAT CCAGCCCATT ACTACAAAAC ACTGTTCACA TTGACCTCAG CGCTCTAAAT 3180

CCAGAGCTGG TCCAAGCGGT GCAGCACGTA GTGATTGGAC CCAGTAGCCT GATTGTGCAT 3240

TTCAATGAAG TCATAGGAAG AGGGCATTTT GGCTGTGTCT ATCATGGGAC TTTGTTGGAC 3300

AGTGACGGAA AGAAAATTCA CTGTGCTGTG AAATCCTTGA ACAGAATCAC AGATATAGAA 3360

GAAGTCTCCC AGTTTCTGAC TGAGGGAATC ATCATGAAAG ATTTCAGCCA CCCCAATGTT 3420

CTCTCACTCT TGGGAATCTG CCTGCGGAGT GAAGGGTCCC CTCTGGTGGT TCTGCCCTAT 3480

ATGAAGCACG GAGATCTTCG CAATTTCATT CGAAATGAGA CTCATAACCC AACTGTGAAA 3540

GATCTTATAG GATTCGGTCT TCAAGTAGCC AAGGGCATGA AATATCTTGC CAGCAAAAAG 3600

TTTGTCCACA GAGACTTAGC TGCAAGAAAC TGCATGTTGG ATGAAAAATT CACTGTCAAG 3660

GTTGCTGATT TCGGTCTTGC CAGAGACATG TACGACAAAG AGTATTATAG CGTCCACAAC 3720

AAAACGGGTG CGAAACTACC GGTGAAGTGG ATGGCTTTAG AGAGTCTGCA GACGCAAAAG 3780

TTCACCACCA AGTCAGACGT GTGGTCCTTC GGTGTGCTTC TCTGGGAGCT CATGACGAGA 3840

GGAGCCCCTC CTTATCCTGA CGTGAACACA TTTGATATCA CTATATACCT GTTGCAAGGC 3900

AGAAGACTCT TGCAACCAGA GTACTGTCCA GACGCCTTGT ATGAAGTGAT GCTAAAATGC 3960

TGGCACCCCA AAGCAGAAAT GCGCCCATCG TTTTCTGAAC TGGTCTCCAG GATATCCTCA 4020

ATCTTCTCCA CTTTCATTGG CGAGCACTAT GTCCATGTGA ACGCTACTTA TGTGAATGTA 4080

AAATGTGTTG CTCCATATCC TTCTCTGTTG CCATCCCAAG ACAACATTGA CGGCGAAGCG 4140

AACACATGA 4149

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+++eviG+GhfG+vy+g+l+ds++kki++avksl+ritdie+v++fl+eg++mk+++hp

Q: 1079  VHFNEVIGRGHFGCVYHGTLLDSDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHP  1138

         799*********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas

Q: 1139  NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS  1198

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+ldek+tvkvadfGlard++dke+y+v+++++a+lpvkw+aleslqt

Q: 1199  KKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQT  1258

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k fttksdvwsfGvllwel+trga+py++v++fd+t+yl +grrl +peycpd+ly+vm

Q: 1259  QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDALYEVM  1317

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         lkcw++k+++rp+fs+lvs+is

Q: 1318  LKCWHPKAEMRPSFSELVSRIS  1339

         ********************98

Domain Sequence
(FASTA)

VHFNEVIGRG HFGCVYHGTL LDSDGKKIHC AVKSLNRITD IEEVSQFLTE GIIMKDFSHP 60

NVLSLLGICL RSEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMKYLAS 120

KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DMYDKEYYSV HNKTGAKLPV KWMALESLQT 180

QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NTFDITIYLL QGRRLLQPEY CPDALYEVML 240

KCWHPKAEMR PSFSELVSRI S 261

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0009925	; C:basal plasma membrane
GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005008	; F:hepatocyte growth factor-activated receptor activity
GO:0000187	; P:activation of MAPK activity
GO:0030534	; P:adult behavior
GO:0007420	; P:brain development
GO:0048754	; P:branching morphogenesis of a tube
GO:0042593	; P:glucose homeostasis
GO:0001889	; P:liver development
GO:0014812	; P:muscle cell migration
GO:0051450	; P:myoblast proliferation
GO:0014902	; P:myotube differentiation
GO:0001890	; P:placenta development
GO:0010828	; P:positive regulation of glucose transport
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 4.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013