EPS-RAN-00147

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-RAN-00147

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/Myotubularins	534.2	2.3E-160	152	572	421

Status

Reviewed

Ensembl Protein

ENSRNOP00000054309

UniProt Accession

Q5PQT2;

Protein Name

Myotubularin-related protein 3

Protein Synonyms/Alias

Gene Name

Mtmr3

Gene Synonyms/Alias

Mtmr3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000007120	ENSRNOP00000054309	ENSRNOT00000057501

Organism

Rattus norvegicus

Functional Description

Phosphatase that acts on lipids with a phosphoinositolheadgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity).

Protein Length

1194

Protein Sequence
(FASTA)

MRHSLECIQA NQIFPRKQLI REDENLQVPF LELHGESTEY VGRAEDAIIA LSNYRLHIKF 60

KESLVNVPLQ LIESVECRDI FQLHLTCKDC KVIRCQFPTF EQCQDWLKRL NNAIRPPGKI 120

EDLFSFAYHA WCMEVYASEK EQHGDLCRPG EHVTSRFKNE VERMGFDMNN AWRISNINEK 180

YKLCGSYPQE LIVPAWITDK ELESVAGFRS WKRIPAVIYR HQSNGAVIAR CGQPEVSWWG 240

WRNADDEHLV QSVAKACASD SQSSVGKVST RNSCRGFPNA GDLSDVEFDA SLSNASGTES 300

LALQPQKLLI LDARSYAAAV ANRAKGGGCE CPEYYPNCEV VFMGMANIHS IRRSFQSLRL 360

LCTQMPDPGN WLSALESTKW LHHLSVLLKS ALLVVHAVDR DQRPVLVHCS DGWDRTPQIV 420

ALAKLLLDPY YRTVEGFQVL VEMEWLDFGH KFADRCGHGE NSDDLNERCP VFLQWLDCVH 480

QLQRQFPCSF EFNEAFLVKL VQHTYSCLFG TFLCNNAKER GEKQTQERTC SVWSLLRAGN 540

KAFKNLLYSS QSEAVLYPVC HVRNLMLWSA VYLPCPSPST PTDDSCAPYP APGTSPDEPP 600

LSRLPKTRSF DNLTTTCDNM VPLASRRSSD PSLNEKWQEH GRSLELSSFA GSGEEVPAID 660

SLRRPSRLLG GAELSVAAGV AEGQMENILQ EATKEESGVE EPTHREHTEV PEVKEEAPLA 720

KESRTAAQGS GVLYQEPQLD DATLRSHLGP SLSSFSQGIP EHREVGHSVL SSSLPASLRG 780

EDSQEVPVEQ PQVENIAEDR ENVVPAVPVD VKIGLGTSES SPLLPSQVPF ETRGPHMNNS 840

VHMLLEDKVK SESGPQLHHR PCLASSGRFS GKDMLPIAPE PRSAERPQWD SVLHRTSSPG 900

NTLSLMMQAP CALPLDKCRQ RIVCNGALET ENKASEQPAG FDTLQKYPTP NGHCANGETG 960

RSKDSLSHQL SATSYSSAHS CSRNLHHKWL NSHSGRPSTT NSPEQPSRSH LDDDGMPVYT 1020

DTIQQRLRQI ESGHQQEVET LKKQVQELKS RLESQYLTSS LRFNGDFGDE VTSIPDSESN 1080

LDQNCLSRCS TEIFSEASWE QVDKQDTEMT RWLPDHLAAH CYACDSAFWL ASRKHHCRNC 1140

GNVFCSSCCN QKVPVPSQQL FEPSRVCKSC YSSLHPTSSS IDLELDKPIA ATSN 1194

Nucleotide Sequence
(FASTA)

ATGCGGCATA GCCTTGAGTG CATCCAGGCC AATCAGATCT TTCCCAGGAA GCAGCTGATT 60

CGGGAGGATG AAAATCTTCA GGTTCCTTTC CTTGAACTCC ATGGAGAGAG CACAGAGTAT 120

GTGGGCCGTG CTGAGGATGC CATCATTGCC CTCTCTAATT ACAGACTTCA CATCAAGTTT 180

AAGGAGTCTC TTGTGAATGT TCCATTACAG CTTATAGAAA GCGTTGAATG CCGTGATATA 240

TTTCAGCTTC ACTTGACATG CAAAGACTGC AAAGTTATCA GGTGTCAGTT CCCAACCTTT 300

GAGCAGTGTC AAGATTGGCT TAAGAGATTA AACAATGCAA TCCGACCACC TGGAAAAATA 360

GAAGATCTCT TCTCATTTGC ATACCATGCT TGGTGCATGG AGGTCTATGC CAGTGAAAAA 420

GAGCAGCATG GAGACCTGTG CAGACCAGGG GAACATGTAA CGTCAAGGTT TAAGAATGAA 480

GTGGAGCGGA TGGGTTTTGA TATGAACAAT GCCTGGAGGA TTTCCAACAT CAATGAGAAA 540

TACAAATTAT GTGGTAGTTA TCCACAAGAG CTCATAGTAC CTGCCTGGAT CACTGACAAA 600

GAACTAGAAA GCGTGGCAGG CTTCAGATCC TGGAAGCGCA TCCCCGCCGT CATCTACAGG 660

CACCAGAGCA ATGGAGCCGT CATTGCCCGC TGCGGACAGC CCGAGGTTAG CTGGTGGGGC 720

TGGCGGAATG CTGATGATGA ACATCTGGTG CAGTCAGTGG CCAAGGCTTG TGCTTCTGAC 780

TCTCAGTCAA GTGTTGGCAA GGTTTCCACT CGGAACAGTT GTCGGGGCTT TCCCAATGCA 840

GGGGATCTTT CTGATGTGGA GTTCGATGCC TCTCTGTCAA ATGCTTCAGG AACAGAAAGT 900

TTAGCTCTCC AGCCACAGAA GCTTTTGATC TTGGACGCAC GCTCCTATGC AGCAGCTGTG 960

GCAAATCGAG CCAAAGGAGG GGGCTGTGAG TGTCCAGAGT ATTATCCAAA CTGTGAAGTT 1020

GTGTTTATGG GAATGGCAAA CATACATTCT ATCCGGAGGA GTTTCCAGTC TCTGCGACTG 1080

CTGTGCACAC AGATGCCAGA TCCTGGAAAT TGGCTTTCTG CTCTTGAAAG TACGAAGTGG 1140

CTCCACCACC TGTCTGTGCT TCTGAAGTCG GCACTTCTCG TGGTGCATGC TGTGGACCGA 1200

GATCAGCGAC CAGTGCTGGT GCACTGCTCA GATGGCTGGG ATCGCACTCC CCAAATCGTG 1260

GCCCTGGCTA AGCTTCTGCT GGACCCTTAT TACCGAACCG TAGAGGGTTT CCAAGTCCTT 1320

GTGGAGATGG AATGGCTGGA TTTTGGCCAT AAGTTTGCTG ATCGGTGTGG TCATGGGGAG 1380

AACTCAGATG ACCTGAATGA GCGTTGCCCA GTGTTTCTCC AATGGCTTGA CTGTGTTCAT 1440

CAACTCCAGA GGCAATTTCC TTGCTCTTTT GAGTTCAACG AAGCATTCCT TGTGAAGCTG 1500

GTTCAGCACA CCTATTCCTG TCTCTTTGGG ACATTCCTGT GCAACAACGC CAAGGAGAGG 1560

GGGGAGAAGC AGACTCAGGA ACGGACATGC TCGGTGTGGT CGCTTCTGCG GGCCGGCAAC 1620

AAGGCCTTCA AAAACCTGCT ATATTCATCC CAGTCAGAAG CCGTGCTGTA CCCTGTGTGC 1680

CATGTGCGGA ATCTGATGCT GTGGAGTGCA GTGTACCTTC CCTGCCCGTC CCCATCCACC 1740

CCCACAGACG ACAGCTGTGC ACCATACCCA GCCCCAGGCA CCAGCCCTGA TGAGCCTCCA 1800

CTGAGCCGGC TACCCAAGAC TAGATCATTT GACAATCTGA CCACAACCTG TGACAACATG 1860

GTGCCGCTGG CCAGCCGGCG CAGCAGTGAC CCCAGCCTGA ATGAGAAGTG GCAGGAGCAC 1920

GGGCGCTCGC TGGAGTTGAG CAGCTTTGCT GGCTCTGGGG AAGAGGTGCC TGCCATAGAC 1980

AGCCTGCGCA GGCCCAGCAG GCTGCTCGGA GGAGCCGAGC TATCTGTGGC AGCTGGTGTG 2040

GCTGAAGGGC AGATGGAGAA TATTTTGCAA GAGGCCACCA AAGAGGAGAG TGGGGTAGAA 2100

GAGCCCACCC ACAGGGAGCA CACTGAGGTG CCAGAGGTCA AAGAGGAGGC ACCCCTAGCA 2160

AAAGAGAGTA GGACGGCAGC TCAGGGCTCA GGTGTACTTT ACCAAGAACC ACAGCTGGAT 2220

GATGCTACTC TAAGGAGCCA TTTAGGCCCC AGCCTGTCTT CGTTCTCCCA GGGTATTCCT 2280

GAGCATCGGG AGGTGGGGCA CAGTGTTCTC TCTAGTTCAC TCCCAGCTTC TCTCAGGGGA 2340

GAGGACTCCC AGGAGGTCCC TGTAGAACAG CCTCAAGTAG AGAACATTGC AGAGGACAGG 2400

GAGAATGTAG TCCCTGCTGT CCCAGTAGAT GTAAAAATTG GCCTTGGTAC CTCAGAGTCT 2460

AGTCCTCTGC TGCCTTCCCA AGTCCCATTC GAGACAAGAG GACCACACAT GAACAACTCC 2520

GTGCACATGT TATTAGAAGA TAAGGTGAAG TCCGAGAGTG GGCCCCAGCT CCATCACAGA 2580

CCCTGCCTGG CAAGCAGTGG TAGATTCAGT GGCAAGGACA TGCTTCCTAT AGCACCAGAG 2640

CCCAGGTCTG CTGAGAGGCC CCAGTGGGAC TCTGTGCTAC ACAGGACTTC TTCCCCTGGC 2700

AACACCCTCA GCCTGATGAT GCAGGCTCCT TGTGCCTTGC CATTAGACAA ATGTAGACAG 2760

AGAATTGTGT GCAACGGTGC CCTAGAGACT GAAAACAAGG CCTCAGAACA GCCTGCAGGG 2820

TTTGACACCC TTCAGAAGTA CCCCACACCC AATGGGCATT GTGCCAATGG GGAGACTGGG 2880

AGGAGTAAGG ACTCACTGAG CCACCAGCTG TCTGCCACAA GCTATAGCTC TGCTCACTCG 2940

TGCTCAAGGA ACTTGCACCA CAAGTGGCTG AATAGCCACT CGGGGAGGCC ATCCACTACC 3000

AACAGCCCTG AGCAGCCTTC CCGCAGCCAC CTGGATGATG ACGGCATGCC TGTGTACACA 3060

GACACGATCC AACAGCGCCT GCGACAGATA GAGTCTGGTC ACCAGCAGGA AGTGGAGACC 3120

TTGAAGAAAC AAGTCCAGGA ACTGAAGAGT CGCCTGGAGA GCCAGTACCT GACCAGCTCT 3180

CTGCGCTTCA ATGGGGACTT TGGAGATGAA GTGACTTCAA TCCCCGACTC GGAAAGCAAT 3240

CTGGATCAGA ACTGTTTGTC TCGCTGCAGC ACAGAGATTT TCTCTGAAGC CAGCTGGGAG 3300

CAGGTGGATA AACAGGACAC AGAGATGACC CGTTGGCTAC CTGACCACTT GGCTGCCCAC 3360

TGCTATGCCT GTGACAGTGC CTTCTGGCTT GCCAGTAGGA AGCACCACTG CAGGAATTGT 3420

GGGAACGTAT TCTGCTCCAG TTGTTGTAAC CAGAAGGTTC CAGTTCCCAG CCAGCAGCTC 3480

TTTGAACCCA GTCGAGTGTG CAAGTCTTGC TATAGCAGCC TCCATCCCAC AAGCTCCAGC 3540

ATTGACCTTG AACTGGATAA GCCTATTGCT GCCACTTCAA ACTGA 3585

Domain Profile

S: 2     etlkdleeelkrlgla.nekwrissvNeeykvcesyPallvVPksvqdeelkrvskffsk  60

         ++++++++e++r+g++ n++wris++Ne+yk+c syP++l+VP++++d+el++v+ f+s+

Q: 152   HVTSRFKNEVERMGFDmNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVAGFRSW  211

         678999**********9*******************************************

S: 61    kriPvlswshkengaallrssqplssledrrskedekllqailkava.............  107

         kriP ++++h++nga+++r++qp++s++++r+++de+l+q+++ka+a

Q: 212   KRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACAsdsqssvgkvstr  271

         ************************************************************

S: 108   ................................grskllivdtrkalaavankakgkgves  135

                                         + +klli+d+r+++aavan+akg+g+e+

Q: 272   nscrgfpnagdlsdvefdaslsnasgteslalQPQKLLILDARSYAAAVANRAKGGGCEC  331

         ************************************************************

S: 136   e.aysnielvfvelenihevrasfkklkelclpdsvseekwlsaLesseWLehikallkk  194

           +y+n+e+vf++++nih++r+sf++l+ lc++ ++++ +wlsaLes++WL+h+++llk+

Q: 332   PeYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQ-MPDPGNWLSALESTKWLHHLSVLLKS  390

         99******************************8.**************************

S: 195   avevaelvesekasvlvheedgwDltaqvtsLvqllldpyyRtleGfqvLvekeWlsfGh  254

         a++v+++v++++++vlvh++dgwD+t+q+++L++llldpyyRt+eGfqvLve+eWl+fGh

Q: 391   ALLVVHAVDRDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTVEGFQVLVEMEWLDFGH  450

         ************************************************************

S: 255   kFsdRlghleasekea.esPvflqFldcvwqlleQfPaaFEFneafLlvlldhlysslfg  313

         kF+dR+gh e+s++ + ++Pvflq+ldcv+ql++QfP++FEFneafL++l++h+ys+lfg

Q: 451   KFADRCGHGENSDDLNeRCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFG  510

         *************9998*******************************************

S: 314   tFLlnsekervkqsgekklkektlsvWdllqreskrkklfkNplYseeskevllPvvsvs  373

         tFL+n+ ker    gek+++e+t+svW+ll+  + +k+ fkN lYs++s++vl+Pv++v+

Q: 511   TFLCNNAKER----GEKQTQERTCSVWSLLR--AGNKA-FKNLLYSSQSEAVLYPVCHVR  563

         **********....*****************..77777.*********************

S: 374   elklWkavy  382

         +l+lW+avy

Q: 564   NLMLWSAVY  572

         ******998

Domain Sequence
(FASTA)

HVTSRFKNEV ERMGFDMNNA WRISNINEKY KLCGSYPQEL IVPAWITDKE LESVAGFRSW 60

KRIPAVIYRH QSNGAVIARC GQPEVSWWGW RNADDEHLVQ SVAKACASDS QSSVGKVSTR 120

NSCRGFPNAG DLSDVEFDAS LSNASGTESL ALQPQKLLIL DARSYAAAVA NRAKGGGCEC 180

PEYYPNCEVV FMGMANIHSI RRSFQSLRLL CTQMPDPGNW LSALESTKWL HHLSVLLKSA 240

LLVVHAVDRD QRPVLVHCSD GWDRTPQIVA LAKLLLDPYY RTVEGFQVLV EMEWLDFGHK 300

FADRCGHGEN SDDLNERCPV FLQWLDCVHQ LQRQFPCSFE FNEAFLVKLV QHTYSCLFGT 360

FLCNNAKERG EKQTQERTCS VWSLLRAGNK AFKNLLYSSQ SEAVLYPVCH VRNLMLWSAV 420

Y 421

Keyword

Coiled coil; Complete proteome; Cytoplasm; Hydrolase; Membrane; Metal-binding; Phosphoprotein; Protein phosphatase; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004438	; F:phosphatidylinositol-3-phosphatase activity
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0004725	; F:protein tyrosine phosphatase activity
GO:0046856	; P:phosphatidylinositol dephosphorylation

KEGG

rno:305482

;

InterPros

IPR010569	; Myotub-related.
IPR017906	; Myotubularin_phosphatase_dom.
IPR016130	; Tyr_Pase_AS.
IPR000306	; Znf_FYVE.
IPR017455	; Znf_FYVE-rel.
IPR011011	; Znf_FYVE_PHD.
IPR013083	; Znf_RING/FYVE/PHD.

Pfam

PF01363	; FYVE; 1.
PF06602	; Myotub-related; 1.

SMARTs

SM00064

; FYVE; 1.

Prosites

PS51339	; PPASE_MYOTUBULARIN; 1.
PS00383	; TYR_PHOSPHATASE_1; 1.
PS50056	; TYR_PHOSPHATASE_2; FALSE_NEG.
PS50178	; ZF_FYVE; 1.

Prints

Created Date

20-Feb-2013