| Tag | Content |
|---|
| EKPD ID | EKS-RAN-00040 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CAMK/Trbl | 418.7 | 8.9E-126 | 68 | 310 | 243 |
|
| Status | Reviewed |
| Ensembl Protein | ENSRNOP00000009840 |
| UniProt Accession | Q9WTQ6; Q5BKD1; |
| Protein Name | Tribbles homolog 3 |
| Protein Synonyms/Alias | TRB-3; Neuronal cell death-inducible putative kinase; |
| Gene Name | Trib3 |
| Gene Synonyms/Alias | Trib3; Nipk; |
| Ensembl Information | |
| Organism | Rattus norvegicus |
| Functional Description | Disrupts insulin signaling by binding directly to Aktkinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress (By similarity). |
| Protein Length | 349 |
Protein Sequence
(FASTA) | | MRATSLAASA DVPCRKKPLE FDDNIDVECP VLKRVRDEPE PGPTPSLPPA SDLSPAVAPA 60 | | TRLGPYILLE REQGNCTYRA LHCPTGTEYT CKVYPASEAQ AVLAPYARLP THQHVARPTE 120 | | VLLGSQLLYT FFTKTHGDLH SLVRSRRGIP EPEAAALFRQ MASAVAHCHK HGLILRDLKL 180 | | RRFVFSNCER TKLVLENLED ACVMTGPDDS LWDKHACPAY VGPEILSSRP SYSGRAADVW 240 | | SLGVALFTML AGRYPFQDSE PALLFGKIRR GTFALPEGLS ASARCLIRCL LRREPSERLV 300 | | ALGILLHPWL REDCSQVSPP RSDRREMDQV VPDGPQLEEA EEGEVGLYG 349 |
|
Nucleotide Sequence
(FASTA) | | ATGCGAGCCA CATCTCTGGC TGCTTCTGCC GATGTTCCCT GCAGGAAGAA ACCGTTGGAG 60 | | TTTGATGACA ACATTGATGT CGAGTGTCCA GTCTTAAAAC GAGTGAGAGA TGAGCCTGAG 120 | | CCTGGACCAA CCCCCAGCCT ACCTCCCGCC TCAGACTTGT CACCTGCTGT GGCCCCTGCA 180 | | ACCCGGCTGG GGCCCTATAT CCTTTTGGAA CGAGAGCAAG GCAACTGCAC CTATCGGGCC 240 | | CTGCACTGCC CCACAGGCAC AGAGTACACC TGCAAGGTGT ATCCCGCCAG CGAGGCCCAG 300 | | GCGGTGCTGG CACCGTATGC AAGACTGCCT ACCCACCAGC ACGTGGCCCG TCCCACAGAG 360 | | GTCCTGCTGG GCTCTCAGCT CCTATACACC TTTTTCACGA AGACCCATGG GGACTTGCAC 420 | | AGTCTGGTGC GCAGCCGCCG CGGTATCCCC GAGCCCGAGG CTGCCGCGCT TTTCCGACAG 480 | | ATGGCTAGTG CGGTGGCACA CTGCCACAAG CACGGGCTCA TCTTGCGCGA CCTCAAGTTG 540 | | CGTCGATTTG TCTTCAGCAA CTGTGAGAGG ACGAAGTTGG TGCTGGAGAA CCTGGAGGAT 600 | | GCCTGTGTGA TGACTGGACC AGACGACTCT CTGTGGGACA AGCACGCGTG CCCTGCCTAT 660 | | GTGGGACCAG AGATACTCAG CTCCCGGCCA TCCTACTCCG GCAGAGCGGC TGATGTCTGG 720 | | AGCCTGGGCG TGGCGCTCTT CACCATGCTG GCTGGCCGAT ACCCGTTCCA GGACTCTGAA 780 | | CCAGCCCTGC TCTTTGGCAA GATCCGTAGA GGGACCTTTG CCCTGCCTGA GGGCCTATCA 840 | | GCCTCTGCTC GATGCCTCAT CCGCTGTCTC CTCCGCAGGG AGCCTTCAGA GCGACTTGTG 900 | | GCCCTGGGAA TCCTGCTACA TCCCTGGTTG AGGGAGGATT GCAGCCAAGT CTCTCCTCCA 960 | | CGGTCTGACC GAAGGGAGAT GGACCAGGTT GTCCCAGATG GGCCACAGCT GGAGGAGGCA 1020 | | GAGGAAGGGG AGGTGGGGCT GTATGGCTAG 1050 |
|
| Domain Profile | S: 1 lleleegekvyraldiftGeellckvfeieelqevlrpyiqlsahseiaritevllgeek 60 | lle+e+g+++yral+++tG+e++ckv++++e+q+vl+py++l++h+++ar+tevllg++ | Q: 68 LLEREQGNCTYRALHCPTGTEYTCKVYPASEAQAVLAPYARLPTHQHVARPTEVLLGSQL 127 | 799********************************************************* |
| S: 61 ayvlfeksygdlhsyvrsakrlreeeaaalfkqiasavahchksglvlrdlklrkfvfsd 120 | +y +f+k++gdlhs+vrs++ ++e eaaalf+q+asavahchk+gl+lrdlklr+fvfs+ | Q: 128 LYTFFTKTHGDLHSLVRSRRGIPEPEAAALFRQMASAVAHCHKHGLILRDLKLRRFVFSN 187 | ************************************************************ |
| S: 121 eertklklesledslilkGeddslsdkhgcPayvsPeilstrgsysGkaadvwslGvily 180 | +ertkl+le+led+++++G ddsl+dkh+cPayv+Peils+r sysG+aadvwslGv+l+ | Q: 188 CERTKLVLENLEDACVMTGPDDSLWDKHACPAYVGPEILSSRPSYSGRAADVWSLGVALF 247 | ************************************************************ |
| S: 181 tllvGryPfhdsepsalfskirrGqfaiPetlskkarclirsllrkepserltaseillh 240 | t+l+GryPf+dsep+ lf+kirrG+fa+Pe+ls++arclir+llr+epserl+a +illh | Q: 248 TMLAGRYPFQDSEPALLFGKIRRGTFALPEGLSASARCLIRCLLRREPSERLVALGILLH 307 | ************************************************************ |
| S: 241 Pwl 243 | Pwl | Q: 308 PWL 310 | **8 |
|
Domain Sequence
(FASTA) | | LLEREQGNCT YRALHCPTGT EYTCKVYPAS EAQAVLAPYA RLPTHQHVAR PTEVLLGSQL 60 | | LYTFFTKTHG DLHSLVRSRR GIPEPEAAAL FRQMASAVAH CHKHGLILRD LKLRRFVFSN 120 | | CERTKLVLEN LEDACVMTGP DDSLWDKHAC PAYVGPEILS SRPSYSGRAA DVWSLGVALF 180 | | TMLAGRYPFQ DSEPALLFGK IRRGTFALPE GLSASARCLI RCLLRREPSE RLVALGILLH 240 | | PWL 243 |
|
| Keyword | Apoptosis; Complete proteome; Nucleus; Protein kinase inhibitor; Reference proteome; Transcription; Transcription regulation. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | | GO:0005634 | ; C:nucleus | | GO:0005524 | ; F:ATP binding | | GO:0019901 | ; F:protein kinase binding | | GO:0004860 | ; F:protein kinase inhibitor activity | | GO:0003714 | ; F:transcription corepressor activity | | GO:0016772 | ; F:transferase activity, transferring phosphorus-containing groups | | GO:0055106 | ; F:ubiquitin-protein ligase regulator activity | | GO:0032869 | ; P:cellular response to insulin stimulus | | GO:0070059 | ; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | | GO:0045599 | ; P:negative regulation of fat cell differentiation | | GO:0045717 | ; P:negative regulation of fatty acid biosynthetic process | | GO:0006469 | ; P:negative regulation of protein kinase activity | | GO:0045892 | ; P:negative regulation of transcription, DNA-dependent | | GO:0032092 | ; P:positive regulation of protein binding | | GO:0051443 | ; P:positive regulation of ubiquitin-protein ligase activity | | GO:0006468 | ; P:protein phosphorylation | | GO:0010827 | ; P:regulation of glucose transport | | GO:0043405 | ; P:regulation of MAP kinase activity | | GO:0006351 | ; P:transcription, DNA-dependent |
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| KEGG | |
| InterPros | |
| Pfam | |
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| Prints | |
| Created Date | 20-Feb-2013 |