EKS-RAN-00340

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00340

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	323.1	1.7E-96	410	658	249

Status

Unreviewed

Ensembl Protein

ENSRNOP00000010471

UniProt Accession

D3ZQ51;

Protein Name

Protein Synonyms/Alias

Protein Pak6;

Gene Name

Pak6

Gene Synonyms/Alias

Pak6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000007925	ENSRNOP00000010471	ENSRNOT00000010471

Organism

Rattus norvegicus

Functional Description

Protein Length

681

Protein Sequence
(FASTA)

MFRKKKKKRP EISAPQNFQH RVHTSFDPKE GKFVGLPPQW QNILDTLRRP KPVVDPSRIT 60

RVQLQPMKTV VRGSSVPTEG YISGLLNDIQ KLSAISSNTL RGRSPTSRRR AQSLGLLGDD 120

QWAADPDMYL QSPQSERTDP HGVYLSCNGG TPAGHRQTPW PEPQSPQALP NGMAAKAQSL 180

GPAEFQGASQ RCLQLGACLQ SSPPGTSPPM ATGRRGVKVT KHSSEEARPQ SCLVGSAIGR 240

PGGEGSPSPK TQESSLKHRL FRSMFLSTPA TGSASSSKPV PLPQNKLNSA FRPPQKDSSS 300

NLVAKAQSLP SDQPTGTFSP LTTSDTSSPQ KSLRTAPATG PLPGRSSPAG SPRTRHAQIS 360

TSNLYLPQDP TVAKGALGGE DTGIVTHEQF KAALRMVVDQ GDPRLLLDSY VKIGEGSTGI 420

VCLAREKHSG RQVAVKMMDL RKQQRRELLF NEVVIMRDYQ HLNVVEMYKS YLVGEELWVL 480

MEFLQGGALT DIISQVRLNE EQIATVCEAV LQALAYLHAQ GVIHRDIKSD SILLTLDGRV 540

KLSDFGFCAQ ISKDVPKRKS LVGTPYWMAP EVISRSLYAT EVDIWSLGIM VIEMVDGEPP 600

YFSDSPVQAM KRLRDSPPPK LKNSYKVSPV LRDFLERMLV REPQERATAQ ELLDHPFLLQ 660

TGLPECLVPL IQLYRKQTST C 681

Nucleotide Sequence
(FASTA)

ATGTTCCGAA AGAAGAAGAA GAAACGCCCT GAGATATCAG CCCCACAGAA CTTCCAGCAC 60

CGTGTTCACA CCTCATTTGA CCCCAAGGAA GGCAAGTTCG TGGGCCTGCC CCCACAATGG 120

CAGAACATCC TGGATACTCT GAGGCGGCCC AAGCCTGTGG TGGATCCTTC TCGAATCACA 180

CGGGTGCAGT TGCAGCCCAT GAAGACGGTA GTACGGGGCA GCTCAGTGCC CACAGAGGGC 240

TACATCTCCG GGCTGCTCAA TGACATTCAG AAGTTGTCAG CTATCAGCTC CAACACTCTG 300

CGTGGACGCA GCCCCACCAG CCGGCGGCGG GCACAGTCCC TGGGGCTGCT AGGAGATGAT 360

CAGTGGGCGG CTGACCCGGA TATGTACCTC CAAAGTCCTC AGTCTGAGCG CACTGATCCC 420

CATGGCGTCT ACCTCAGCTG TAATGGGGGC ACACCAGCAG GTCACAGGCA AACGCCATGG 480

CCAGAACCAC AGAGCCCACA GGCCCTGCCC AATGGCATGG CTGCCAAGGC ACAGTCGCTG 540

GGCCCCGCTG AGTTCCAGGG TGCCTCCCAA CGCTGCCTGC AGCTGGGTGC CTGCCTACAG 600

AGTTCCCCAC CTGGTACCTC ACCCCCTATG GCCACAGGGA GGCGTGGGGT GAAGGTTACC 660

AAGCATAGCT CGGAAGAGGC TCGACCACAA TCTTGCCTGG TGGGCTCAGC CATTGGCAGA 720

CCAGGTGGAG AAGGCAGCCC CAGCCCTAAG ACCCAGGAAA GCAGCCTCAA GCACCGGCTC 780

TTCCGCAGCA TGTTCCTGTC CACTCCCGCC ACAGGCTCTG CAAGCAGCAG CAAGCCGGTC 840

CCTCTGCCAC AGAACAAGCT CAATTCTGCT TTCCGACCAC CACAAAAAGA TTCCTCTTCA 900

AACCTGGTAG CCAAGGCCCA GTCCTTGCCC TCAGATCAGC CCACGGGGAC CTTCAGTCCT 960

CTGACCACCT CAGATACCAG CAGTCCCCAG AAGTCCCTCC GCACAGCCCC AGCCACTGGT 1020

CCACTTCCAG GCCGGTCTTC TCCAGCAGGC TCCCCCCGCA CCCGGCATGC CCAGATCAGC 1080

ACCAGCAATC TATACCTGCC CCAGGACCCC ACAGTGGCCA AGGGGGCCCT GGGTGGCGAA 1140

GACACAGGCA TCGTAACACA TGAGCAGTTC AAAGCTGCGC TCAGGATGGT GGTGGACCAG 1200

GGTGACCCTC GGCTGCTGCT GGACAGCTAT GTGAAGATTG GGGAGGGCTC CACGGGCATT 1260

GTGTGTCTGG CCCGGGAGAA GCATTCAGGT CGCCAGGTAG CAGTCAAGAT GATGGACCTC 1320

AGAAAGCAGC AACGCAGGGA ACTGCTCTTT AATGAGGTGG TGATCATGCG TGACTACCAG 1380

CACCTCAATG TGGTGGAGAT GTACAAGAGT TACCTGGTAG GAGAGGAGCT GTGGGTGCTG 1440

ATGGAGTTCC TGCAGGGCGG GGCCCTCACA GACATCATCT CCCAAGTCAG ACTCAATGAG 1500

GAACAGATTG CTACTGTGTG TGAAGCTGTG CTTCAGGCCT TGGCTTACCT GCACGCCCAG 1560

GGTGTCATCC ACCGAGACAT CAAGAGTGAT TCCATCCTGC TGACCCTTGA TGGCAGGGTG 1620

AAGCTCTCAG ACTTTGGGTT CTGTGCTCAG ATCAGCAAAG ATGTCCCCAA GAGAAAGTCT 1680

CTCGTAGGAA CTCCATACTG GATGGCTCCT GAGGTGATCT CCAGATCCCT GTACGCTACT 1740

GAGGTGGATA TCTGGTCTCT GGGCATCATG GTGATTGAGA TGGTGGATGG AGAACCCCCT 1800

TACTTCAGCG ACTCCCCAGT GCAAGCCATG AAGAGGCTCC GGGACAGCCC CCCACCCAAG 1860

CTAAAGAACT CTTACAAGGT CTCTCCAGTG CTGCGAGACT TCCTGGAACG AATGCTGGTA 1920

CGGGAACCCC AAGAGAGAGC CACAGCCCAG GAGCTCCTGG ATCACCCCTT TCTGCTGCAG 1980

ACGGGGCTGC CCGAGTGTCT GGTGCCTCTG ATACAGCTCT ACCGCAAGCA GACCTCCACC 2040

TGCTGA 2046

Domain Profile

S: 4     leeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyle  63

         + +ig+G++g v+larek++g++va+k+++l+kq++ e+l++e+ ++++++h n+ve+++

Q: 410   YVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHLNVVEMYK  469

         679*********************************************************

S: 64    sflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrd  123

         s+l+ eelw++me+l+gG+l+d+++   + +l+Eeqia++++ vl+aL+ylH+++viHrd

Q: 470   SYLVGEELWVLMEFLQGGALTDIIS---QVRLNEEQIATVCEAVLQALAYLHAQGVIHRD  526

         *************************...99******************************

S: 124   ikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDi  183

         ik+++iLlt +g+VkLsdfg++aq++k++ krk++vgtpywmAPEvi+  ++ Y +++Di

Q: 527   IKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVIS--RSLYATEVDI  584

         ************************************************..9*********

S: 184   wslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpe  243

         wslGI++ie+++gepP+++ +p++a+ +  +++ppklk++ k+s+ +++f+e++l ++p+

Q: 585   WSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSYKVSPVLRDFLERMLVREPQ  644

         ************************************************************

S: 244   kRpsasellkhkFl  257

         +R++a+ell+h+Fl

Q: 645   ERATAQELLDHPFL  658

         *************7

Domain Sequence
(FASTA)

YVKIGEGSTG IVCLAREKHS GRQVAVKMMD LRKQQRRELL FNEVVIMRDY QHLNVVEMYK 60

SYLVGEELWV LMEFLQGGAL TDIISQVRLN EEQIATVCEA VLQALAYLHA QGVIHRDIKS 120

DSILLTLDGR VKLSDFGFCA QISKDVPKRK SLVGTPYWMA PEVISRSLYA TEVDIWSLGI 180

MVIEMVDGEP PYFSDSPVQA MKRLRDSPPP KLKNSYKVSP VLRDFLERML VREPQERATA 240

QELLDHPFL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013