EKS-RAN-00245

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00245

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	331.9	2.7E-99	56	307	252

Status

Unreviewed

Ensembl Protein

ENSRNOP00000010636

UniProt Accession

D3ZQN8;

Protein Name

Protein Synonyms/Alias

NUAK family, SNF1-like kinase, 1; Protein Nuak1;

Gene Name

Nuak1

Gene Synonyms/Alias

Nuak1; rCG_49052;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000008061	ENSRNOP00000010636	ENSRNOT00000010636

Organism

Rattus norvegicus

Functional Description

Protein Length

661

Protein Sequence
(FASTA)

MEGAAVSAAG DGPAVETGLP GSPREVVAGA TAAPVEPRKP HGVKRHHHKH NLKHRYELQE 60

TLGKGTYGKV KRATERFSGR VVAIKSIRKD KIKDELDMVH IRREIEIMSS LNHPHIISIY 120

EVFENKDKIV IIMEYASKGE LYDYISERRR LSERETRHFF RQIVSAVHYC HKNGVVHRDL 180

KLENILLDDN CNIKIADFGL SNLYQKDKFL QTFCGSPLYA SPEIVNGRPY RGPEVDSWAL 240

GVLLYTLIYG TMPFDGFDHK NLIRQISSGE YREPTQPSDA RGLIRWMLMV NPDRRATIED 300

IANHWWVNWG YKSSVCDCDA LPDSESPLLA RIIDWHHRST GLQAEADAKM KAKPGASEVV 360

LERQRSLKKS KKENDFPQSG QDSLPESPSK LSSKRPKGIL KKRSNSEHRS HSTGFIEGIV 420

GPALPSPFKM EQDLCRTAIP LPGSPEAQGS SGKLSLKQSA TMPKKGILKK TQQRESGYYS 480

SPERSESSEL LDSNNVIISS GLSSPPPDPA RGTSHSLSCR RKGILKHSSR YSDGATDPAL 540

TGPEIPTLES LSPPGVPSDG ISRSYSRPSS IISDDSVLSS DSFDLLDLQE NRPARQRIRS 600

CVSAENFLQL QDFETPHNRP RPQYLKRYRN RLADSSFSLL ADMDDVTQVY KKALEICSKL 660

N 661

Nucleotide Sequence
(FASTA)

ATGGAAGGGG CGGCAGTGTC CGCGGCAGGG GATGGCCCTG CTGTGGAGAC GGGTTTGCCC 60

GGCTCTCCGC GGGAGGTAGT GGCCGGGGCG ACTGCTGCTC CAGTGGAACC CAGGAAGCCG 120

CACGGGGTGA AGCGACATCA CCACAAACAC AACTTGAAGC ATCGCTATGA GCTGCAAGAG 180

ACCCTGGGCA AAGGTACCTA CGGCAAAGTC AAGAGAGCCA CGGAGAGGTT TTCAGGCCGA 240

GTGGTTGCTA TAAAATCCAT CCGTAAGGAC AAAATCAAGG ATGAGCTAGA CATGGTTCAC 300

ATCAGACGAG AGATTGAGAT TATGTCATCC CTCAACCATC CTCATATCAT CAGTATTTAT 360

GAAGTGTTTG AGAACAAAGA TAAGATTGTG ATCATCATGG AATATGCCAG CAAAGGAGAG 420

CTGTATGACT ACATCAGTGA GCGGAGACGC CTCAGCGAGA GGGAGACCAG GCACTTCTTC 480

CGGCAGATCG TGTCTGCCGT GCATTACTGT CACAAGAATG GCGTGGTCCA TCGGGACTTG 540

AAGCTGGAGA ACATACTGCT TGATGACAAC TGTAATATTA AGATCGCTGA CTTTGGGCTT 600

TCCAACCTGT ACCAGAAGGA CAAGTTCTTG CAAACATTTT GTGGGAGCCC ACTCTATGCA 660

TCACCCGAGA TTGTCAATGG CAGGCCTTAC CGGGGGCCAG AGGTGGACAG CTGGGCCCTG 720

GGCGTCTTGC TTTACACTCT CATTTATGGA ACAATGCCCT TCGATGGCTT TGATCACAAA 780

AACCTCATCC GACAGATCAG CAGTGGAGAG TACCGGGAGC CCACACAACC CTCAGATGCT 840

CGGGGACTCA TCCGGTGGAT GCTGATGGTG AATCCTGACC GCCGGGCCAC CATCGAGGAC 900

ATCGCCAACC ACTGGTGGGT GAACTGGGGC TACAAGAGCA GCGTCTGTGA CTGCGATGCC 960

CTTCCCGACT CCGAGTCTCC GCTCTTGGCT CGGATCATTG ATTGGCATCA CCGCTCCACC 1020

GGGCTGCAGG CTGAGGCTGA CGCCAAGATG AAGGCCAAGC CCGGGGCCTC GGAGGTTGTG 1080

TTGGAGCGGC AACGGTCACT GAAGAAGTCC AAGAAAGAGA ACGACTTTCC CCAGTCTGGC 1140

CAGGACTCAT TGCCTGAAAG CCCATCCAAG CTGAGTTCCA AGAGGCCCAA GGGCATCCTG 1200

AAGAAGCGGA GCAACAGTGA ACATCGCTCC CACAGCACTG GCTTCATCGA AGGCATCGTG 1260

GGCCCCGCCT TACCATCCCC TTTCAAAATG GAGCAAGACT TGTGCCGGAC TGCCATCCCC 1320

CTCCCCGGCT CCCCCGAGGC GCAGGGAAGC TCAGGGAAGC TCAGCCTCAA ACAGTCTGCC 1380

ACCATGCCCA AGAAAGGCAT CTTGAAAAAG ACCCAGCAGA GAGAATCTGG TTACTACTCG 1440

TCCCCAGAGC GCAGCGAGTC CTCAGAGCTG CTGGACAGTA ACAATGTGAT CATCAGCAGT 1500

GGCCTCTCCT CCCCTCCCCC AGACCCAGCC AGGGGAACGT CCCACAGCCT GTCCTGCCGG 1560

AGGAAGGGCA TCTTGAAACA CAGCAGCAGG TACTCGGATG GTGCCACAGA CCCTGCCCTC 1620

ACCGGCCCCG AAATACCCAC ACTGGAATCC TTGTCGCCTC CCGGTGTCCC CTCCGATGGC 1680

ATCTCTCGGA GCTACAGTCG CCCGTCCAGT ATCATCAGTG ACGACAGCGT CCTGTCCAGC 1740

GACTCTTTCG ACTTGTTAGA TCTCCAGGAG AATCGGCCGG CCCGCCAGCG CATCCGCAGC 1800

TGCGTCTCTG CGGAAAACTT CCTCCAGCTT CAGGACTTTG AGACTCCCCA CAACCGGCCC 1860

CGGCCCCAGT ACCTGAAGCG GTACCGGAAC CGGCTGGCAG ACAGTAGCTT CTCCCTTCTT 1920

GCTGATATGG ACGACGTGAC TCAGGTGTAT AAGAAGGCTC TGGAGATCTG CAGCAAGCTC 1980

AACTAG 1986

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl.seeslekikrEieilkklkhpn  59

         y+l++tlG+g++gkVk a+++  ++ va+K i+k+k+ +e  + +i+rEiei+++l+hp+

Q: 56    YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIkDELDMVHIRREIEIMSSLNHPH  115

         99**********************************94455677****************

S: 60    iikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

         ii+++ev+e+k+k+++++eyas+geL+dyi+e++rl+e+e+r++f+q+vsav+Y+h++g+

Q: 116   IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV  175

         ************************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eN+lld++ nikiaDFGl+nl++++k l+tfcGsp Ya+Pe+++g++Y+gp+v

Q: 176   VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV  235

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         D W+lGv+Ly+l++g++Pfd+ + k+l ++i++g+++ p++  ++++ L+r +L+v+p++

Q: 236   DSWALGVLLYTLIYGTMPFDGFDHKNLIRQISSGEYREPTQ-PSDARGLIRWMLMVNPDR  294

         ***************************************99.7789**************

S: 240   Ratieeilkhewl  252

         Ratie+i +h w+

Q: 295   RATIEDIANHWWV  307

         ************6

Domain Sequence
(FASTA)

YELQETLGKG TYGKVKRATE RFSGRVVAIK SIRKDKIKDE LDMVHIRREI EIMSSLNHPH 60

IISIYEVFEN KDKIVIIMEY ASKGELYDYI SERRRLSERE TRHFFRQIVS AVHYCHKNGV 120

VHRDLKLENI LLDDNCNIKI ADFGLSNLYQ KDKFLQTFCG SPLYASPEIV NGRPYRGPEV 180

DSWALGVLLY TLIYGTMPFD GFDHKNLIRQ ISSGEYREPT QPSDARGLIR WMLMVNPDRR 240

ATIEDIANHW WV 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030155	; P:regulation of cell adhesion
GO:2000772	; P:regulation of cellular senescence
GO:0035507	; P:regulation of myosin-light-chain-phosphatase activity

KEGG

rno:299694

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013