EKS-RAN-00059
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00059
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/CDK385.31.9E-115121402282
StatusReviewed
Ensembl ProteinENSRNOP00000010976
UniProt AccessionO35832;
Protein NameCyclin-dependent kinase 18
Protein Synonyms/Alias Cell division protein kinase 18; PCTAIRE-motif protein kinase 3; Serine/threonine-protein kinase PCTAIRE-3;
Gene NameCdk18
Gene Synonyms/Alias Cdk18; Pctk3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000008137ENSRNOP00000010976ENSRNOT00000010976
OrganismRattus norvegicus
Functional DescriptionMay play a role in signal transduction cascades interminally differentiated cells.
Protein Length451
Protein Sequence
(FASTA)
MNKMKNFKRR LSLSVPRPET IEESLTEFTE QFNQLHTQRN EDGRDEPGQL SPGVQYQQRQ 60
NQRRFSMEDL NKRLSLPMDI RLPQEFLQKL QLENPGLPKP LTRMSRRASL SDIGFGKLET 120
YVKLDKLGEG TYATVFKGRS KLTENLVALK EIRLEHEEGA PCTAIREVSL LKDLKHANIV 180
TLHDLIHTDR SLTLVFEYLD SDLKQYLDHC GNLMNMHNVK IFMFQLLRGL AYCHRRKILH 240
RDLKPQNLLI NERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID 300
MWGVGCILYE MATGKPLFPG STVKEELHLI FRLLGTPTEE SWPGVTSISE FRAYNFPRYL 360
PQPLLSHAPR LDTEGINLLT SLLLYESKSR MSAEAALSHP YFQSLGERVH QLDDTASIFS 420
LKEIQLQKDP GYRGLAFQHP GRGKSRRQSI F 451
Nucleotide Sequence
(FASTA)
ATGAACAAGA TGAAGAACTT CAAACGAAGG CTTTCCCTGT CAGTGCCCCG CCCAGAGACC 60
ATTGAGGAGT CATTGACCGA GTTCACCGAG CAGTTCAACC AGCTCCACAC TCAGAGGAAT 120
GAGGACGGCA GGGACGAACC TGGGCAGCTG TCTCCGGGCG TGCAGTATCA GCAACGGCAG 180
AACCAGCGCC GATTCTCCAT GGAGGACCTC AACAAGAGGC TCTCTCTGCC CATGGATATC 240
CGCCTGCCCC AGGAATTCCT GCAGAAGCTA CAGCTGGAGA ACCCAGGGCT GCCCAAACCA 300
CTCACCCGAA TGTCCCGCCG TGCCTCCCTG TCAGATATCG GCTTCGGGAA ACTGGAAACA 360
TACGTGAAAC TGGACAAACT GGGGGAGGGC ACCTATGCCA CCGTCTTCAA GGGACGCAGC 420
AAGTTGACAG AGAACCTCGT GGCCCTGAAG GAGATCCGGT TGGAACATGA GGAAGGGGCA 480
CCCTGCACTG CTATTCGAGA GGTGTCTCTG CTGAAGGACC TGAAACATGC CAATATTGTG 540
ACCCTGCATG ACCTCATTCA CACAGATCGG TCCCTCACCC TGGTGTTTGA GTACCTGGAC 600
AGTGACCTGA AACAGTACCT AGACCACTGC GGGAACCTCA TGAACATGCA CAACGTCAAG 660
ATTTTTATGT TCCAGCTGCT CCGGGGTCTG GCCTATTGCC ACCGCCGCAA GATCCTACAC 720
CGGGACCTGA AGCCCCAGAA CCTGCTCATC AATGAGAGGG GGGAACTGAA ACTGGCTGAC 780
TTTGGCCTGG CCCGGGCCAA ATCAGTGCCT ACAAAGACCT ACTCCAATGA GGTGGTGACC 840
CTCTGGTACA GGCCCCCAGA CGTGCTGCTG GGATCCACGG AGTACTCCAC CCCCATCGAC 900
ATGTGGGGCG TGGGCTGCAT CCTCTATGAG ATGGCCACCG GCAAGCCCCT CTTCCCAGGC 960
TCCACTGTCA AGGAGGAGTT GCACCTCATC TTCCGTCTCC TGGGGACACC TACAGAAGAG 1020
TCGTGGCCAG GTGTGACATC CATCTCCGAG TTTCGAGCCT ACAACTTCCC CCGGTACCTA 1080
CCGCAACCGC TGCTCAGCCA CGCTCCCAGG TTGGATACTG AAGGCATCAA CCTCCTGACC 1140
AGCCTCCTCC TGTATGAATC CAAGAGTCGC ATGTCAGCAG AGGCGGCCCT AAGTCACCCC 1200
TACTTCCAGT CTCTCGGGGA ACGAGTACAC CAGCTCGATG ACACTGCCTC CATCTTCTCC 1260
CTGAAGGAGA TCCAGCTCCA AAAGGACCCA GGCTATCGTG GCCTTGCCTT CCAGCACCCA 1320
GGGCGAGGGA AGAGCCGGCG ACAGAGCATC TTCTGA 1356
Domain Profile
S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60
         y kl+k+geGty++v+k+++k t+++vAlK+irle+e eg p+ta+rE+sllk+lkh+ni
Q: 121   YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANI  179
         7899********************************9.9*********************
S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120
         v+L+++++ ++++l+Lvfe+l++dLk++l+++ +  +++++vk +++qll+glay+H++k
Q: 180   VTLHDLIH-TDRSLTLVFEYLDSDLKQYLDHCGN-LMNMHNVKIFMFQLLRGLAYCHRRK  237
         ********.99***********************.*************************
S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180
         ilHRDlKpqNlLi+++g+lklaDfGlara s+p+kty++evvTlwYr+P++Llg++eYst
Q: 238   ILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYST  297
         ************************************************************
S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksfp  239
          +D+W+vgcil e++t kplf+g++ +++l+ if+llgtp+e++wp+v++++e++ ++fp
Q: 298   PIDMWGVGCILYEMATGKPLFPGSTVKEELHLIFRLLGTPTEESWPGVTSISEFRaYNFP  357
         *******************************************************99***
S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284
         ++ ++ l ++ ++l++++++ll++ll ++ k+R+sa++al+h+yf
Q: 358   RYLPQPLLSHAPRLDTEGINLLTSLLLYESKSRMSAEAALSHPYF  402
         ********************************************9
Domain Sequence
(FASTA)
YVKLDKLGEG TYATVFKGRS KLTENLVALK EIRLEHEEGA PCTAIREVSL LKDLKHANIV 60
TLHDLIHTDR SLTLVFEYLD SDLKQYLDHC GNLMNMHNVK IFMFQLLRGL AYCHRRKILH 120
RDLKPQNLLI NERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID 180
MWGVGCILYE MATGKPLFPG STVKEELHLI FRLLGTPTEE SWPGVTSISE FRAYNFPRYL 240
PQPLLSHAPR LDTEGINLLT SLLLYESKSR MSAEAALSHP YF 282
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00057
EKS-ANC-00052
EKS-BOT-00062
EKS-CAJ-00068
EKS-CAF-00074
EKS-CAP-00059
EKS-DAR-00076
EKS-EQC-00061
EKS-FEC-00059
EKS-GAG-00048
EKS-GAA-00078
EKS-GOG-00060
EKS-HOS-00062
EKS-ICT-00058
EKS-LAC-00062
EKS-MAM-00070
EKS-MIM-00031
EKS-MOD-00068
EKS-MUM-00061
EKS-MUP-00064
EKS-MYL-00083
EKS-NOL-00070
EKS-OCP-00041
EKS-ORN-00082
EKS-ORC-00066
EKS-ORL-00074
EKS-OTG-00065
EKS-PES-00054
EKS-POA-00058
EKS-PTV-00054
EKS-SAH-00054
EKS-TAR-00083
EKS-TEN-00082
EKS-XIM-00080
Gene Ontology
GO:0005524; F:ATP binding
GO:0004693; F:cyclin-dependent protein kinase activity
GO:0007049; P:cell cycle
KEGG
rno:289019;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013