EKS-RAN-00183

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00183

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ryk	488.4	6.3E-147	254	520	267

Status

Unreviewed

Ensembl Protein

ENSRNOP00000063141

UniProt Accession

F1LQR5;

Protein Name

Protein Synonyms/Alias

Protein Ryk;

Gene Name

Ryk

Gene Synonyms/Alias

Ryk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000008593	ENSRNOP00000063141	ENSRNOT00000067203

Organism

Rattus norvegicus

Functional Description

Protein Length

531

Protein Sequence
(FASTA)

LDAELYYVRN DLISHYALSF NLLVPSETNF LHFTWHAKSK VEYKLGFQVD NFVAMGMPQV 60

NISAQGEVPR TLSVFRVELS CTGKVDSEVM ILMQLNLTVN SSKNFTVLNF KRRKMCYKKL 120

EEVKTSALDK NTSRTIYDPV HAAPTTSTRV FYISVGVCCA VIFLVAIILA VLHLHSMKRI 180

ELDDSISASS SSQGLSQPST QTTQYLRADT PNNATPVTSK SYPTLRIEKN DLRSVTLLEA 240

KAKVKDIAIS RERVTLKDVL QEGTFGRIFH GILVDEKDPN KEKQTFVKTV KDQASEVQVT 300

MMLTESCKLR GLHHRNLLPI THVCIEEGEK PMVISPYMNW GNLKLFLRQC KLVEANNPQA 360

ISQQDLVHMA IQIACGMSYL ARREVIHKDL AARNCVIDDT LQVKITDNAL SRDLFPMDYH 420

CLGDNENRPV RWMALESLVN NEFSSASDVW AFGVTLWELM TLGQTPYVDI DPFEMAAYLK 480

DGYRIAQPIN CPDELFAVMA CCWALDPEER PKFQQLVQCL TEFHAALGAY V 531

Nucleotide Sequence
(FASTA)

CTTGATGCAG AACTTTACTA TGTGAGAAAT GACCTCATCA GTCACTACGC TCTGTCCTTT 60

AACCTGCTAG TGCCCAGTGA GACAAACTTC CTGCACTTCA CTTGGCATGC AAAGTCCAAG 120

GTTGAATATA AGCTGGGATT CCAAGTAGAC AACTTTGTGG CCATGGGCAT GCCCCAGGTC 180

AATATTTCTG CTCAAGGGGA GGTCCCACGC ACTTTATCAG TGTTTCGGGT CGAGCTTTCG 240

TGTACCGGCA AAGTAGACTC GGAAGTCATG ATACTAATGC AGCTCAATCT GACAGTGAAT 300

TCTTCAAAAA ATTTTACAGT TTTAAATTTT AAACGAAGGA AAATGTGCTA CAAAAAACTT 360

GAAGAAGTAA AAACTTCAGC CTTGGACAAA AACACTAGCA GAACTATTTA TGATCCTGTA 420

CACGCAGCTC CAACTACTTC CACACGTGTG TTTTACATCA GTGTGGGGGT TTGTTGTGCA 480

GTAATATTTC TTGTAGCAAT AATATTAGCA GTTTTGCACC TTCATAGTAT GAAAAGGATT 540

GAACTGGATG ACAGCATCAG CGCCAGCAGC AGTTCACAGG GGCTGTCTCA GCCGTCCACC 600

CAGACGACCC AGTATCTGAG AGCTGACACA CCCAACAATG CAACTCCTGT CACCAGTAAG 660

AGTTACCCTA CCTTGCGGAT AGAGAAGAAC GACTTGCGAA GTGTCACTCT TTTGGAAGCC 720

AAAGCCAAGG TGAAGGATAT TGCAATATCC AGGGAAAGGG TCACACTGAA AGATGTACTT 780

CAAGAAGGTA CTTTTGGGCG TATTTTCCAT GGGATTTTAG TAGATGAAAA AGATCCAAAT 840

AAAGAAAAAC AAACATTCGT AAAAACAGTT AAAGACCAAG CTTCTGAAGT TCAGGTGACC 900

ATGATGCTTA CTGAGAGCTG CAAGCTGCGA GGTCTGCACC ACAGAAACCT CCTTCCTATT 960

ACTCATGTGT GCATAGAAGA AGGAGAAAAG CCTATGGTGA TATCGCCATA TATGAACTGG 1020

GGGAATCTTA AATTATTTCT ACGGCAGTGC AAATTAGTAG AAGCCAATAA TCCACAGGCA 1080

ATTTCCCAAC AAGATCTGGT ACATATGGCT ATTCAGATTG CCTGCGGAAT GAGCTACCTG 1140

GCCAGAAGGG AAGTGATTCA TAAAGACCTG GCTGCTAGGA ACTGCGTCAT CGACGACACT 1200

CTTCAAGTAA AAATCACAGA CAATGCCCTT TCCAGAGACC TGTTTCCGAT GGACTACCAC 1260

TGTCTGGGGG ACAACGAGAA CAGGCCAGTG AGATGGATGG CTCTGGAAAG CCTGGTCAAC 1320

AATGAGTTCT CTAGTGCTAG TGACGTGTGG GCCTTTGGAG TGACACTGTG GGAGCTCATG 1380

ACTCTGGGCC AGACGCCCTA CGTGGACATC GACCCCTTTG AGATGGCCGC TTACCTGAAA 1440

GATGGTTACC GAATAGCCCA GCCAATCAAC TGCCCTGACG AACTGTTTGC TGTGATGGCC 1500

TGTTGCTGGG CCTTGGACCC AGAGGAGCGG CCTAAGTTTC AGCAGCTGGT CCAGTGCCTC 1560

ACAGAGTTCC ATGCTGCCCT GGGCGCCTAC GTCTGA 1596

Domain Profile

S: 1     lrlkellqeGtfGriyrGkledekdtnkekavlvktvkdqaseiqvalllqealllygvs  60

         ++lk++lqeGtfGri++G+l dekd+nkek+++vktvkdqase+qv+++l+e+++l+g++

Q: 254   VTLKDVLQEGTFGRIFHGILVDEKDPNKEKQTFVKTVKDQASEVQVTMMLTESCKLRGLH  313

         5799********************************************************

S: 61    hrnilsvllvsieeaekPlvvypalnkgnlkkflricklkdkekaqalstkqlvelaiqi  120

         hrn+l++++v+iee ekP+v+ p++n+gnlk flr+ckl++++++qa+s+++lv++aiqi

Q: 314   HRNLLPITHVCIEEGEKPMVISPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQI  373

         ************************************************************

S: 121   asalaylhkrevvhkdiaarncviddelqvkltdsalsrdlfPadydclGdnenrPlkWl  180

         a++++yl++rev+hkd+aarncvidd+lqvk+td+alsrdlfP+dy+clGdnenrP++W+

Q: 374   ACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWM  433

         ************************************************************

S: 181   slealqkeeyssasdvWalGvllWelvtlgksPyaeidpfeleaylkdGyrlaqPvncPd  240

         +le+l+++e+ssasdvWa+Gv+lWel+tlg++Py++idpfe++aylkdGyr+aqP+ncPd

Q: 434   ALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPD  493

         ************************************************************

S: 241   elftvmaccWallpeerPsfeqlvscl  267

         elf+vmaccWal+peerP+f+qlv+cl

Q: 494   ELFAVMACCWALDPEERPKFQQLVQCL  520

         **************************8

Domain Sequence
(FASTA)

VTLKDVLQEG TFGRIFHGIL VDEKDPNKEK QTFVKTVKDQ ASEVQVTMML TESCKLRGLH 60

HRNLLPITHV CIEEGEKPMV ISPYMNWGNL KLFLRQCKLV EANNPQAISQ QDLVHMAIQI 120

ACGMSYLARR EVIHKDLAAR NCVIDDTLQV KITDNALSRD LFPMDYHCLG DNENRPVRWM 180

ALESLVNNEF SSASDVWAFG VTLWELMTLG QTPYVDIDPF EMAAYLKDGY RIAQPINCPD 240

ELFAVMACCW ALDPEERPKF QQLVQCL 267

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0042813	; F:Wnt-activated receptor activity
GO:0071679	; P:commissural neuron axon guidance
GO:0022038	; P:corpus callosum development
GO:0050919	; P:negative chemotaxis
GO:0048843	; P:negative regulation of axon extension involved in axon guidance
GO:0043410	; P:positive regulation of MAPK cascade
GO:0048705	; P:skeletal system morphogenesis
GO:0016055	; P:Wnt receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR003306	; WIF.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF02019	; WIF; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50814	; WIF; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013