EKS-RAN-00317

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00317

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	535.0	4.2E-161	684	953	270

Status

Unreviewed

Ensembl Protein

ENSRNOP00000011630

UniProt Accession

F1LRZ0;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

Alk

Gene Synonyms/Alias

Alk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000008683	ENSRNOP00000011630	ENSRNOT00000011630

Organism

Rattus norvegicus

Functional Description

Protein Length

1181

Protein Sequence
(FASTA)

MALQSSFTCW NGTVLQLGQA CDFHQNCAQG EDEGQLCSKL PAGFYCNFED GFCGWTQSPL 60

SPRVPRWQVK TLKDTHSQGH QGHALLLSTT DDPTSESATV TSATFPAPMK SSPCEASLRM 120

SWLIRGVLKG NVSLVLVENK TGKEQSRTVW HVATNEGLSL WQWTVLSLLD VTDRFWLQIV 180

TWWGPGSRAT VAFDNISISL DCYLTISGEE KMSLNAVPKS RNLFEKNPNK EPKPWANISG 240

PTPIFDPTVH WLFTTCGASG PHGPTQAQCN NAYQNSNLSV VVGSEGPLRG IQIWKVPATD 300

TYSISGYGAA GGKGGKNTMM RSHGVSVLGI FNLEKDDTLY ILVGQQGEDA CPRANQLIQK 360

VCVGENNVIE EEIRVNRSVH EWAGGGGGGG GATYVFKMKD GVPVPLIIAA GGGGRAYGAK 420

TETFHPERLE NNSSVLGLNG NSGAAGGGGG WNDNTSLLWA GKSLLEGAAG GHSCPQAMKK 480

WGWETRGGFG GGGGGCSSGG GGGGYIGGNA ASNNDPEMDG EDGVSFISPL GILYTPALKV 540

MEGHGEVNIK HYLNCSHCEV DECHMDPESH KVICFCDHGT VLADDGVSCI VSPTPEPHLP 600

LSLILSVVTS ALVAALVLAF SGIMIVYRRK HQELQAMQME LQSPEYKLSK LRTSTIMTDY 660

NPNYCFAGKT SSISDLKEVP RKNITLIRGL GHGAFGEVYE GQVSGMPNDP SPLQVAVKTL 720

PEVCSEQDEL DFLMEALIIS KFNHQNIVRC IGVSLQALPR FILLELMAGG DLKSFLRETR 780

PRPNQPTSLA MLDLLHVARD IACGCQYLEE NHFIHRDIAA RNCLLTCPGA GRIAKIGDFG 840

MARDIYRASY YRKGGCAMLP VKWMPPEAFM EGIFTSKTDT WSFGVLLWEI FSLGYMPYPS 900

KSNQEVLEFV TSGGRMDPPK NCPGPVYRIM TQCWQHQPED RPNFAIILER IEYCTQDPDV 960

INTALPIEYG PVVEEEEKVP MRPKDPEGMP PLLVSPQSAK HEEASSAPQP SALAAPGPLV 1020

KKPSGAGAGA GAGPVPRGAA DRGHVNMAFS QPNPPPELHK GPGSRNKPTS LWNPTYGSWF 1080

TEKPAKKTHP PPGAEPQARA GAAEGGWTGP GAGPRRAEAA LLLEPSALSA TMKEVPLFRL 1140

RHFPCGNVNY GYQQQGLPLE ATAAPGDTVL KSKTKVTQPG P 1181

Nucleotide Sequence
(FASTA)

ATGGCCTTGC AGAGTTCCTT CACTTGTTGG AACGGGACAG TCCTCCAGCT CGGGCAAGCC 60

TGTGACTTCC ACCAGAACTG TGCCCAAGGA GAAGATGAGG GTCAGCTATG CAGTAAACTT 120

CCTGCTGGGT TTTACTGTAA CTTCGAGGAT GGCTTCTGTG GCTGGACCCA AAGTCCACTC 180

TCACCCCGTG TGCCCCGATG GCAAGTGAAG ACCCTGAAAG ATACCCATTC CCAGGGCCAC 240

CAAGGCCATG CCCTGTTGCT CAGCACCACT GACGACCCCA CTTCAGAAAG TGCAACAGTG 300

ACCAGTGCTA CATTCCCCGC ACCAATGAAG AGCTCTCCTT GTGAGGCAAG TCTCCGGATG 360

TCCTGGCTCA TCCGTGGGGT TCTGAAAGGA AATGTATCTT TGGTGCTGGT GGAGAACAAA 420

ACTGGAAAGG AGCAAAGCCG GACCGTCTGG CATGTTGCCA CCAATGAAGG CCTAAGCCTG 480

TGGCAGTGGA CAGTGTTGTC GCTCCTCGAT GTGACTGACA GGTTCTGGCT GCAAATAGTC 540

ACATGGTGGG GCCCAGGATC CAGGGCAACC GTGGCATTTG ACAACATTTC CATCAGCCTC 600

GACTGCTACC TCACCATCAG TGGGGAGGAG AAAATGTCCC TGAATGCAGT ACCCAAATCC 660

AGAAATCTGT TTGAGAAAAA CCCAAACAAG GAGCCAAAAC CCTGGGCAAA CATATCAGGA 720

CCAACTCCCA TCTTCGACCC TACAGTTCAC TGGCTGTTCA CCACATGTGG GGCCAGTGGC 780

CCTCATGGCC CCACACAGGC ACAGTGCAAC AACGCCTACC AGAACTCCAA CCTGAGCGTG 840

GTGGTGGGAA GTGAAGGGCC CTTGAGGGGC ATCCAGATTT GGAAAGTGCC AGCTACTGAC 900

ACCTACAGTA TCTCAGGCTA TGGAGCAGCT GGCGGAAAAG GTGGGAAGAA CACCATGATG 960

CGGTCCCATG GCGTGTCTGT CCTGGGCATC TTCAATCTGG AGAAAGATGA CACGCTCTAC 1020

ATCCTTGTCG GTCAACAAGG GGAAGATGCC TGTCCCAGGG CAAACCAACT AATCCAGAAA 1080

GTATGTGTCG GCGAGAACAA TGTGATAGAA GAAGAGATCC GAGTGAACAG AAGCGTTCAC 1140

GAGTGGGCAG GAGGAGGAGG AGGTGGGGGT GGAGCCACCT ACGTGTTTAA GATGAAAGAC 1200

GGCGTGCCCG TGCCCCTGAT TATTGCGGCC GGCGGTGGTG GCAGGGCCTA TGGGGCCAAG 1260

ACAGAAACGT TCCACCCAGA GAGACTGGAG AATAACTCCT CAGTTCTAGG GCTGAACGGC 1320

AATTCCGGAG CCGCAGGTGG TGGAGGCGGC TGGAATGATA ACACTTCCTT GCTCTGGGCC 1380

GGAAAGTCTT TGTTGGAGGG CGCCGCCGGA GGACATTCCT GCCCCCAGGC CATGAAGAAG 1440

TGGGGGTGGG AGACAAGAGG GGGTTTCGGA GGGGGTGGAG GGGGGTGCTC CTCAGGTGGA 1500

GGAGGCGGAG GATATATAGG TGGCAACGCA GCATCAAACA ATGACCCCGA AATGGATGGG 1560

GAAGATGGGG TTTCCTTCAT CAGTCCATTG GGTATCCTGT ATACCCCGGC CTTAAAAGTG 1620

ATGGAGGGCC ATGGGGAAGT GAATATCAAG CACTATCTAA ACTGCAGCCA CTGTGAGGTA 1680

GACGAATGTC ACATGGACCC CGAGAGCCAC AAAGTCATCT GCTTCTGTGA CCATGGGACC 1740

GTGCTGGCTG ACGATGGTGT CTCCTGCATT GTGTCGCCCA CCCCGGAACC CCACCTGCCG 1800

CTCTCATTGA TCCTCTCCGT CGTGACCTCT GCCCTGGTGG CCGCTCTCGT TCTGGCATTC 1860

TCCGGCATCA TGATTGTGTA CCGCCGGAAG CACCAGGAGT TGCAAGCTAT GCAGATGGAG 1920

CTGCAGAGCC CTGAGTATAA GCTGAGCAAG CTACGGACCT CGACCATCAT GACAGACTAC 1980

AACCCCAACT ACTGCTTTGC TGGCAAGACT TCATCCATCA GTGACCTGAA GGAGGTGCCT 2040

CGGAAAAACA TCACCCTCAT CCGGGGCCTA GGCCATGGCG CATTTGGGGA GGTGTATGAA 2100

GGCCAGGTAT CTGGAATGCC CAATGACCCA AGCCCTCTAC AAGTGGCTGT AAAGACGCTG 2160

CCGGAAGTGT GTTCAGAGCA AGATGAGCTG GACTTCCTCA TGGAAGCTCT GATCATCAGT 2220

AAATTCAACC ACCAGAACAT TGTCCGCTGC ATCGGGGTGA GTCTGCAAGC CCTGCCCCGC 2280

TTCATCCTGC TGGAGCTCAT GGCTGGTGGA GACCTCAAGT CCTTCCTCAG GGAGACACGT 2340

CCTCGCCCGA ACCAGCCCAC CTCCCTGGCC ATGTTGGATC TTCTGCACGT AGCTCGGGAC 2400

ATTGCCTGTG GCTGTCAGTA CCTGGAGGAA AATCACTTTA TCCACCGCGA TATTGCTGCT 2460

AGAAACTGTC TGCTGACCTG TCCGGGAGCT GGGAGGATAG CGAAGATCGG AGACTTCGGG 2520

ATGGCCCGAG ATATCTACAG GGCCAGCTAC TACAGAAAGG GAGGCTGTGC CATGCTGCCA 2580

GTGAAGTGGA TGCCCCCGGA GGCCTTCATG GAAGGAATAT TTACTTCTAA AACAGATACA 2640

TGGTCTTTTG GAGTGTTGCT GTGGGAAATA TTTTCTCTTG GATATATGCC ATACCCCAGC 2700

AAGAGCAACC AGGAAGTTCT GGAGTTTGTC ACCAGTGGAG GACGGATGGA CCCACCTAAG 2760

AACTGCCCCG GACCTGTATA CCGGATAATG ACTCAGTGCT GGCAGCATCA GCCTGAGGAC 2820

AGACCCAACT TTGCCATCAT TCTGGAGAGG ATCGAATACT GCACCCAGGA CCCCGATGTC 2880

ATCAATACAG CTCTGCCCAT CGAATATGGC CCCGTAGTAG AGGAGGAGGA GAAAGTGCCC 2940

ATGCGCCCCA AAGACCCTGA GGGGATGCCT CCTCTGCTGG TGTCTCCCCA GTCTGCGAAG 3000

CACGAGGAGG CGTCCTCAGC CCCCCAACCC TCAGCCCTGG CAGCGCCAGG CCCGCTGGTG 3060

AAGAAGCCCT CGGGTGCAGG CGCGGGAGCG GGTGCCGGTC CGGTGCCCCG AGGTGCAGCC 3120

GATCGGGGCC ACGTGAACAT GGCGTTCTCT CAGCCCAACC CTCCCCCAGA GCTGCACAAA 3180

GGCCCGGGCT CCAGAAACAA GCCGACCAGC CTGTGGAACC CCACCTACGG CTCGTGGTTC 3240

ACCGAGAAGC CAGCCAAAAA GACCCATCCC CCACCGGGCG CGGAGCCGCA GGCCCGGGCA 3300

GGAGCGGCGG AGGGTGGCTG GACCGGGCCG GGTGCGGGGC CCCGCAGAGC CGAGGCTGCG 3360

CTGCTGCTCG AGCCGTCGGC GCTCAGCGCC ACCATGAAGG AGGTGCCCCT GTTCAGGCTG 3420

CGCCACTTCC CCTGCGGCAA CGTCAACTAT GGTTACCAGC AACAGGGTCT CCCCTTGGAA 3480

GCCACTGCTG CCCCGGGGGA CACCGTGCTG AAAAGCAAGA CTAAGGTCAC CCAGCCAGGG 3540

CCCTGA 3546

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         i+l+r+lG+GafGevyeg+vsg+p+d+s+l+vavktlpe++seqdeldfl+ealiiskfn

Q: 684   ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFN  743

         799*********************************************************

S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120

         h+nivr+iGvsl++lpr+illel+aGGdlksflre+rp+p+q++slam dll+va+d+a+

Q: 744   HQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPNQPTSLAMLDLLHVARDIAC  803

         ************************************************************

S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180

         Gc+yleen+fihrdiaarn+ll+++G++r+aki+dfGmardiyra+yyrkgg+a+lpvkw

Q: 804   GCQYLEENHFIHRDIAARNCLLTCPGAGRIAKIGDFGMARDIYRASYYRKGGCAMLPVKW  863

         ************************************************************

S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240

         mppeaf+eGiftsktd+wsfGvllwe+fslG++pyp+ksnqevle+v++Ggr+d+pk++p

Q: 864   MPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCP  923

         ************************************************************

S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270

         g+vyrimt+cw+h+pedrp+f++iler+++

Q: 924   GPVYRIMTQCWQHQPEDRPNFAIILERIEY  953

         ***************************986

Domain Sequence
(FASTA)

ITLIRGLGHG AFGEVYEGQV SGMPNDPSPL QVAVKTLPEV CSEQDELDFL MEALIISKFN 60

HQNIVRCIGV SLQALPRFIL LELMAGGDLK SFLRETRPRP NQPTSLAMLD LLHVARDIAC 120

GCQYLEENHF IHRDIAARNC LLTCPGAGRI AKIGDFGMAR DIYRASYYRK GGCAMLPVKW 180

MPPEAFMEGI FTSKTDTWSF GVLLWEIFSL GYMPYPSKSN QEVLEFVTSG GRMDPPKNCP 240

GPVYRIMTQC WQHQPEDRPN FAIILERIEY 270

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0048666	; P:neuron development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR026830	; ALK.
IPR008985	; ConA-like_lec_gl_sf.
IPR011009	; Kinase-like_dom.
IPR002172	; LDrepeatLR_classA_rpt.
IPR000998	; MAM_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00629	; MAM; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00192	; LDLa; 1.
SM00219	; TyrKc; 1.

Prosites

PS50060	; MAM_2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013