EKS-RAN-00192

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00192

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/RCK	513.7	1.6E-154	4	284	281

Status

Unreviewed

Ensembl Protein

ENSRNOP00000012257

UniProt Accession

G3V760;

Protein Name

Protein Synonyms/Alias

Intestinal cell kinase, isoform CRA_a; Serine/threonine-protein kinase ICK;

Gene Name

Ick

Gene Synonyms/Alias

Ick;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000008691	ENSRNOP00000012257	ENSRNOT00000012257

Organism

Rattus norvegicus

Functional Description

Protein Length

630

Protein Sequence
(FASTA)

MNRYTTIKQL GDGTYGSVLL GRSIESGELI AIKKMKRKFY SWEECMNLRE VKSLKKLNHA 60

NIVKLKEVIR ENDHLYFIFE YMKENLYQLI KERNKLFPES AIRNIMYQIL QGLAFIHKHG 120

FFHRDLKPEN LLCMGPELVK IADFGLAREI RSRPPYTDYV STRWYRAPEV LLRSTNYSSP 180

IDVWAVGCIM AEVYTLRPLF PGASEIDTIF KICQVLGTPK KTDWPEGYQL SSAMNFIWPQ 240

CIPNNLKTLI PNASSEAIQL LRDLLQWDPK KRPTASQALR YPYFQIGHPL GISTQDSGKP 300

QKDVQDKTGP PPYVKPAPPA QAPTKAHTLI SSRPNQASQP HQHFVYPYKG EASRTEQLSH 360

VQEGQPNPPF FPSLHNKNLP PKILAGLEQK SGDMKPKSRR RWGLISRSTK GSDDWADLAD 420

LDFSSSLTRI DVKNKKRQSD DPLCFESVLD LKPSEPVGTG TSVSTQASSQ RRDTPTLQST 480

AKQHYLKHSR YLPGINIRNG VLPNPGKDFL PSSSWSSSGL SGKSSGTVSV VSKITSGKIG 540

SGSTSSGGLT GSYIPSFLKK EVGSVMQRVQ LAPLAAPSPG YSSLKAVRPH PGRPFFHTQP 600

RSTPGLIPRP PAVQPVHGRI DWSSKYPSRR 630

Nucleotide Sequence
(FASTA)

ATGAATAGAT ACACAACGAT CAAACAGCTT GGGGATGGGA CCTATGGTTC TGTCCTGCTG 60

GGGAGAAGCA TTGAATCTGG AGAACTAATT GCCATTAAAA AAATGAAAAG AAAGTTTTAC 120

TCCTGGGAAG AATGCATGAA CCTTCGGGAG GTTAAGTCTT TAAAGAAGCT CAACCATGCC 180

AATATAGTGA AGTTAAAAGA GGTTATCAGG GAGAACGACC ATCTCTATTT CATCTTCGAG 240

TACATGAAGG AAAACCTTTA CCAGCTCATT AAAGAAAGAA ATAAGTTGTT TCCAGAGTCT 300

GCAATAAGGA ATATAATGTA TCAGATATTG CAAGGACTGG CGTTCATTCA CAAACATGGT 360

TTCTTCCACC GGGACTTAAA GCCTGAGAAC CTCCTCTGCA TGGGACCAGA ACTTGTGAAA 420

ATCGCGGACT TCGGATTGGC CCGAGAAATC CGATCAAGAC CTCCATACAC AGACTATGTG 480

TCTACTAGAT GGTATAGGGC TCCAGAAGTA CTCCTGAGAT CTACCAACTA CAGCTCCCCC 540

ATTGATGTCT GGGCCGTGGG CTGCATCATG GCAGAGGTGT ACACCCTCCG GCCTCTTTTC 600

CCTGGGGCCA GTGAAATTGA CACGATTTTC AAAATTTGCC AAGTGTTGGG AACACCGAAG 660

AAGACTGACT GGCCTGAAGG CTACCAGCTG TCAAGTGCTA TGAATTTCAT CTGGCCCCAG 720

TGCATACCCA ATAACTTAAA GACACTAATT CCAAATGCTA GCAGCGAAGC AATTCAGCTC 780

CTGAGAGACT TGCTTCAGTG GGATCCCAAG AAACGACCAA CTGCTAGTCA GGCACTTCGA 840

TACCCTTACT TCCAGATCGG ACACCCACTG GGCATCAGCA CACAGGACTC GGGAAAGCCA 900

CAGAAAGATG TCCAAGACAA GACAGGCCCA CCTCCTTACG TCAAGCCAGC CCCTCCTGCC 960

CAGGCCCCAA CCAAGGCGCA TACACTGATT TCTTCACGAC CAAACCAAGC CAGTCAACCC 1020

CATCAGCATT TTGTATATCC CTACAAGGGC GAAGCCTCTA GGACAGAGCA GCTGAGCCAC 1080

GTGCAGGAGG GCCAGCCAAA CCCACCATTC TTCCCGTCCC TCCACAACAA GAATCTCCCG 1140

CCAAAAATCC TAGCTGGCCT GGAACAGAAA AGCGGTGACA TGAAACCAAA GAGCAGGAGA 1200

AGATGGGGTC TCATTTCCAG GTCAACCAAG GGTTCTGATG ATTGGGCCGA CTTGGCTGAC 1260

TTAGATTTCA GTTCCTCTCT CACCAGAATA GATGTCAAAA ACAAGAAGAG ACAGAGTGAC 1320

GACCCCCTCT GCTTTGAAAG TGTTTTGGAC CTGAAGCCAT CTGAGCCGGT GGGTACAGGA 1380

ACTAGTGTCT CCACCCAGGC TTCCTCCCAG AGGAGAGACA CGCCGACCCT GCAGTCCACA 1440

GCAAAGCAGC ACTACTTGAA GCACTCTCGC TACCTGCCTG GAATAAATAT AAGAAATGGC 1500

GTGCTCCCAA ATCCAGGCAA GGACTTTCTT CCATCAAGTT CATGGTCCAG TTCTGGTTTG 1560

TCTGGAAAAT CTTCAGGAAC GGTATCAGTA GTGAGCAAAA TAACTTCAGG CAAAATTGGC 1620

TCCGGCTCCA CGAGCTCTGG TGGACTGACT GGAAGCTACA TCCCTTCCTT TCTGAAGAAG 1680

GAAGTCGGCT CTGTCATGCA GAGGGTCCAG CTGGCGCCTC TCGCAGCCCC TTCCCCCGGC 1740

TACTCTTCCC TCAAGGCCGT GAGACCTCAC CCAGGGAGGC CATTCTTTCA CACCCAGCCT 1800

AGGAGCACGC CTGGCTTGAT TCCACGACCT CCAGCTGTGC AGCCTGTGCA CGGCAGGATA 1860

GACTGGTCTT CCAAGTACCC ATCTCGGCGG TGA 1893

Domain Profile

S: 1     yklikklGdGtfgevllakslktgelvaikkmkrkfesleevtnlrevkslkklnahdni  60

         y++ik+lGdGt+g+vll++s+++gel+aikkmkrkf+s+ee++nlrevkslkkln h+ni

Q: 4     YTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLN-HANI  62

         99*****************************************************.****

S: 61    iklkeviidrendslylvlelmeenlyqlikdrrkllsesklksilyqilkglafihkhg  120

         +klkevi  rend+ly+++e+m+enlyqlik+r+kl++es++++i+yqil+glafihkhg

Q: 63    VKLKEVI--RENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHG  120

         *******..***************************************************

S: 121   ffhrdlkPenilikgselvkladfGlarevrsknPytdyvstrwyraPevllrsgvyssp  180

         ffhrdlkPen+l++g+elvk+adfGlare+rs++PytdyvstrwyraPevllrs++yssp

Q: 121   FFHRDLKPENLLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSP  180

         ************************************************************

S: 181   ldlwavGcvlaevavlrplfPGaseidqifkilevlGtPkkkewdeayklasalnlkfpq  240

         +d+wavGc++aev++lrplfPGaseid+ifki++vlGtPkk++w+e+y+l+sa+n+ +pq

Q: 181   IDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFIWPQ  240

         ************************************************************

S: 241   vegsslktlvsnaskealellkdllaydPderataqqalkypyf  284

         +++++lktl++nas+ea++ll+dll++dP++r+ta+qal+ypyf

Q: 241   CIPNNLKTLIPNASSEAIQLLRDLLQWDPKKRPTASQALRYPYF  284

         *******************************************9

Domain Sequence
(FASTA)

YTTIKQLGDG TYGSVLLGRS IESGELIAIK KMKRKFYSWE ECMNLREVKS LKKLNHANIV 60

KLKEVIREND HLYFIFEYMK ENLYQLIKER NKLFPESAIR NIMYQILQGL AFIHKHGFFH 120

RDLKPENLLC MGPELVKIAD FGLAREIRSR PPYTDYVSTR WYRAPEVLLR STNYSSPIDV 180

WAVGCIMAEV YTLRPLFPGA SEIDTIFKIC QVLGTPKKTD WPEGYQLSSA MNFIWPQCIP 240

NNLKTLIPNA SSEAIQLLRD LLQWDPKKRP TASQALRYPY F 281

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013