EKS-RAN-00351
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00351
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20262.16.6E-7825296272
StatusUnreviewed
Ensembl ProteinENSRNOP00000053882
UniProt AccessionF1LZB6;
Protein Name
Protein Synonyms/Alias
Gene NameNrk
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000008880ENSRNOP00000053882ENSRNOT00000057049
OrganismRattus norvegicus
Functional Description
Protein Length1454
Protein Sequence
(FASTA)
MAGPGSWRDK EVTDLGHLPD PTGIFSLEKT IGLGTYGRIY LGLHEKTGSF VAIKVMNARK 60
TPLPEIGKRV RVNKYRKSVG WRYSDEEEDL RTELNLLRKY SFHKNIVTFY GAFFKLNPPG 120
HQHQLWMVME LCAAGSVTDV VRMTRNQSLK EDWIAYICRE ILQGLAHLHA HQVIHRDIKG 180
QNVLLTQDAE VKIVDFGVSA QVSRTNGRRN SFIGTPYWMA PEVIHCDEDP RRSYDYRVTL 240
CNLQPLEALF VILREAAPTV KSSGWSRKFQ NFMENCMIKN FLFRPTSGNM LHHPFVHDIK 300
NERRVVESLT KHLTGIIQKR ERKGIPLAFE GEEAVNEQYI TRRFRGPSCT PELLRVPTSS 360
RCRPLRVLHG EPPQPRWLPD EEQPEDQELQ QLQEAARMFM PLHSQDKTLK PLQKQAQLPQ 420
HLHVAPQVLM PVQVEATVAT PLAKKIRAPP QLSKAAWGLT SPPSQDNKAS SPEVQAPIPR 480
EQQAQNDALE TEQPEDLDQV PEEFQGQDRA AEEQRQGQAA EQEQRQNGVP EQHPEENREP 540
EQAEVQEEAV EPPQAEVEEK DPEVIQVHAR VFLPLQSQNH HVFLPLHLDT QLLIPVGEQN 600
EEAPRAQAWD LEASRAAGAV QALVEGLSRD LLRAPNAFTS KPLGPLQILL ESLCTNGFYT 660
EPEAVQKKKS RVSSLKKAIV KRLTPKRFRA KALWRRQDFE CSDVESSRRR RQRRWEEIFN 720
QHEEQLREVE NDRDDDDSSD NDEVFHSIQA EVQIEPYAPN RTGNEVQERS APMPCNRNRT 780
HRVKFSPSVC EQALLEEAQQ PMDIRPRNSL NPRNFQAESE SSSEEDSPVT RRKSQSSPPY 840
STIDQRLLID IHVPDGFKVG KISPPVYLTN EWVGCNPLSE VFWDDWVNPT PATRRHEEDG 900
DYVELYDADA NGDGRASNYA YEENYASGHD DMNHQANGYR GHGNRHYSDG SFRNRGDSRG 960
AAFNGPRASY CRGGILKNAG NDGRDLRRGA FRAYGDNEAS NYHGAASGAS AAFGSQEGHE 1020
GHMGGRRGNR YREVNGSSGE NGACGFHRDG AGLDQQHVFP DFENEQEQSD AGTETSDSIA 1080
LEITSFSLDG EQNNDRAEPT LGFPLRRSSS RGSASDTDIM SDSYNKPIIH AYEREFSHEI 1140
FCGSLWGVNL LLGTKSHLYL MDRSGKAEII KLVKRRPFRQ IQVVEQLNLL ITISGRKNRL 1200
RVYHLTWLRN KILNNDPESK KRQKAMLKRE KACKSLDKLI GCEHFSILHH EETTYIAIAL 1260
KSSIHLYAWA PKSFNESTAI KVFPTHDLKP VTVDLAVGSE KTLKIFFSSA NGYHIIDAES 1320
EVMSDVTLPS NNVILLPDSL GVGVMLSFND ETAPEEANEQ LLKKILDVWK DIPSSAAFEC 1380
TQRITGWDQK AVEVRSLQAT ILENELKRRS IKKLRFLCSR GDKLFFASLL NNEHSLVYYV 1440
SIAKLEALQR RYAV 1454
Nucleotide Sequence
(FASTA)
ATGGCAGGAC CTGGGAGTTG GAGGGACAAG GAGGTGACAG ATCTCGGCCA CTTGCCGGAT 60
CCAACTGGAA TATTCTCACT AGAGAAGACC ATTGGTCTCG GTACTTATGG AAGAATCTAT 120
TTGGGACTCC ATGAAAAGAC GGGTTCTTTC GTGGCTATTA AAGTAATGAA TGCCCGGAAG 180
ACTCCTTTGC CTGAAATAGG AAAGCGGGTG AGAGTGAACA AATACCGAAA GTCTGTCGGA 240
TGGAGATACA GCGATGAAGA AGAGGATCTT CGGACTGAAC TCAACCTGCT GAGGAAGTAC 300
TCTTTCCACA AAAACATTGT GACCTTCTAT GGTGCGTTCT TCAAGCTGAA TCCTCCTGGC 360
CATCAGCACC AACTTTGGAT GGTAATGGAG CTCTGTGCAG CAGGCTCTGT CACTGATGTA 420
GTGAGGATGA CAAGAAATCA GAGTTTAAAA GAAGACTGGA TCGCTTACAT CTGTCGAGAA 480
ATCCTTCAGG GCTTAGCTCA CCTTCATGCG CACCAAGTAA TCCACCGGGA CATCAAAGGT 540
CAGAATGTGC TACTGACCCA GGATGCTGAA GTCAAGATAG TGGATTTTGG AGTGAGTGCC 600
CAAGTGAGCA GAACAAATGG ACGGAGAAAT AGCTTCATTG GTACACCGTA CTGGATGGCC 660
CCCGAGGTGA TTCATTGTGA TGAGGACCCA AGACGTTCCT ATGATTACAG AGTGACTCTG 720
TGTAACCTTC AGCCCCTGGA AGCCCTTTTT GTTATTCTAC GGGAAGCTGC TCCCACAGTC 780
AAATCCAGTG GATGGTCCCG TAAGTTCCAG AATTTCATGG AAAATTGCAT GATAAAAAAT 840
TTCCTATTTC GTCCTACATC TGGAAACATG CTTCATCACC CATTTGTCCA CGATATAAAA 900
AATGAACGAC GTGTTGTGGA GTCATTGACC AAGCACCTTA CTGGGATCAT CCAAAAGAGA 960
GAGAGAAAAG GAATACCTCT GGCCTTCGAA GGAGAAGAAG CTGTTAACGA ACAATACATC 1020
ACAAGGAGAT TCAGAGGACC TTCTTGCACT CCTGAACTTC TGAGAGTGCC AACCAGCAGC 1080
CGATGCAGAC CACTCAGAGT CCTGCATGGA GAGCCTCCTC AGCCAAGGTG GTTACCTGAT 1140
GAAGAACAGC CAGAGGACCA AGAGCTTCAG CAACTGCAGG AGGCAGCCAG GATGTTCATG 1200
CCTCTACATT CTCAGGACAA AACACTTAAG CCTTTACAAA AGCAGGCTCA GTTACCACAG 1260
CATCTACATG TGGCCCCTCA AGTGCTGATG CCAGTACAGG TTGAAGCAAC AGTAGCTACG 1320
CCTCTAGCTA AAAAGATTCG GGCACCTCCC CAACTAAGCA AAGCAGCTTG GGGACTCACG 1380
TCACCACCTA GTCAGGATAA CAAAGCTAGT TCTCCTGAGG TACAGGCCCC CATACCCAGA 1440
GAACAGCAGG CCCAGAATGA TGCCTTAGAA ACGGAACAGC CTGAAGATTT GGACCAGGTG 1500
CCAGAAGAAT TTCAGGGGCA AGACAGGGCA GCTGAGGAGC AAAGGCAGGG CCAGGCCGCT 1560
GAACAAGAGC AGAGGCAGAA TGGAGTCCCT GAGCAGCATC CAGAGGAGAA TAGGGAACCT 1620
GAACAAGCTG AGGTGCAGGA AGAGGCTGTT GAGCCTCCAC AAGCTGAGGT TGAGGAGAAG 1680
GATCCTGAGG TAATACAAGT ACATGCCCGG GTGTTCCTGC CTTTACAGTC CCAGAACCAT 1740
CATGTGTTCT TGCCTCTTCA TCTGGACACA CAGCTGCTAA TTCCAGTAGG GGAACAAAAT 1800
GAAGAGGCAC CTCGGGCACA GGCCTGGGAT CTGGAGGCCT CAAGGGCAGC TGGTGCAGTA 1860
CAAGCACTGG TAGAGGGACT ATCAAGAGAC TTGCTTCGAG CACCAAACGC ATTTACCTCA 1920
AAACCACTTG GTCCACTGCA AATCTTGTTG GAAAGTTTGT GCACCAACGG GTTTTACACT 1980
GAACCTGAAG CAGTACAGAA GAAAAAGTCA AGAGTTTCTA GCCTGAAGAA AGCAATAGTA 2040
AAAAGACTAA CACCCAAGAG GTTCAGGGCA AAGGCATTAT GGAGACGTCA AGATTTTGAA 2100
TGCTCAGATG TAGAAAGCAG CAGGAGACGG CGCCAGCGTA GATGGGAGGA AATCTTTAAT 2160
CAGCATGAAG AGCAACTGAG GGAAGTTGAA AATGATAGAG ACGATGATGA CTCATCAGAC 2220
AATGATGAAG TGTTTCATTC AATTCAGGCT GAAGTCCAAA TAGAACCATA CGCTCCAAAT 2280
CGTACAGGAA ATGAGGTCCA AGAGAGATCT GCTCCTATGC CTTGCAACCG GAATCGTACA 2340
CATCGTGTGA AATTTTCTCC AAGTGTCTGT GAGCAGGCTC TTTTGGAAGA AGCTCAGCAG 2400
CCGATGGACA TCAGACCGAG GAACTCCCTA AATCCTCGGA ATTTTCAAGC AGAATCAGAG 2460
TCATCTTCTG AGGAGGACAG CCCTGTGACT AGGAGGAAGT CCCAGTCATC GCCGCCTTAT 2520
TCTACTATTG ATCAGAGGTT ACTGATTGAT ATCCATGTTC CAGATGGATT TAAAGTGGGA 2580
AAAATATCAC CCCCTGTGTA CTTGACAAAC GAATGGGTAG GCTGTAACCC ACTCTCTGAA 2640
GTCTTCTGGG ATGATTGGGT AAACCCTACA CCTGCCACTA GGCGACATGA AGAAGATGGT 2700
GATTATGTTG AACTCTATGA TGCTGATGCT AATGGTGATG GACGAGCTTC AAATTATGCT 2760
TATGAAGAAA ACTATGCCAG TGGCCATGAT GACATGAATC ATCAGGCAAA TGGCTATAGA 2820
GGCCATGGTA ACCGTCACTA CAGTGATGGG TCTTTTCGAA ACAGAGGTGA TAGTCGTGGT 2880
GCTGCTTTCA ATGGGCCAAG GGCAAGTTAT TGCAGAGGGG GAATCTTGAA GAATGCTGGT 2940
AATGATGGCC GTGATCTAAG GCGAGGGGCT TTCAGAGCCT ATGGAGACAA TGAAGCCAGC 3000
AATTACCATG GAGCTGCCAG TGGAGCAAGC GCAGCCTTTG GAAGCCAGGA AGGACATGAA 3060
GGCCACATGG GCGGTCGACG AGGTAACAGA TACAGGGAAG TCAATGGAAG CAGCGGAGAG 3120
AATGGCGCAT GTGGATTCCA TAGAGATGGG GCAGGACTGG ATCAACAACA TGTATTCCCA 3180
GATTTTGAAA ATGAACAAGA GCAATCAGAT GCTGGAACTG AGACGTCAGA TTCAATTGCC 3240
CTGGAGATCA CATCCTTTTC CCTTGATGGT GAGCAAAACA ATGATAGAGC AGAACCAACA 3300
TTGGGTTTTC CTCTCAGACG CTCATCTTCC AGAGGTTCTG CTTCGGATAC TGACATTATG 3360
AGTGACTCAT ATAACAAACC AATAATCCAT GCGTATGAAA GGGAATTCTC GCATGAAATC 3420
TTCTGTGGTT CTCTGTGGGG AGTCAATTTG TTGCTGGGCA CCAAATCTCA TCTGTATCTG 3480
ATGGACAGAA GTGGAAAGGC AGAAATCATT AAACTTGTAA AACGAAGACC ATTCCGCCAG 3540
ATTCAAGTCG TGGAGCAGCT CAATTTGCTG ATTACCATCT CTGGCCGCAA GAACAGACTT 3600
CGCGTGTATC ATCTGACTTG GCTGAGGAAC AAGATTCTGA ATAATGATCC AGAAAGTAAG 3660
AAAAGGCAGA AAGCAATGCT GAAGAGAGAG AAAGCCTGCA AATCTCTGGA TAAGTTGATT 3720
GGCTGTGAAC ACTTCAGTAT CCTTCATCAT GAAGAAACAA CATACATTGC AATTGCTTTG 3780
AAATCATCAA TTCACCTGTA TGCGTGGGCA CCAAAATCCT TCAATGAAAG CACTGCCATT 3840
AAAGTGTTTC CAACTCATGA TCTTAAGCCA GTGACAGTTG ACCTGGCTGT TGGTTCTGAG 3900
AAAACACTGA AGATTTTCTT CAGCTCAGCT AATGGATACC ACATCATCGA TGCAGAATCT 3960
GAAGTTATGT CTGATGTGAC CTTGCCAAGT AATAATGTCA TCCTTTTACC TGATTCCTTG 4020
GGAGTTGGAG TGATGCTGTC CTTCAATGAT GAAACTGCCC CTGAGGAAGC AAATGAACAG 4080
CTTCTCAAGA AGATCCTGGA CGTGTGGAAA GACATACCGT CTTCTGCGGC TTTTGAGTGT 4140
ACACAGAGAA TCACTGGATG GGACCAAAAG GCTGTTGAAG TGCGCTCTCT GCAGGCAACT 4200
ATTCTTGAGA ATGAGCTGAA GCGCCGCTCA ATCAAGAAGC TGAGATTTCT GTGTTCTCGT 4260
GGGGACAAGC TGTTCTTTGC TTCTCTACTG AACAATGAGC ACAGCCTGGT TTACTATGTG 4320
AGCATTGCAA AACTTGAAGC GCTCCAAAGA AGATATGCTG TTTAA 4365
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekq.......................  37
         ++l ++ig G++g++yl+ ++ktg++vaik++n++k+                       
Q: 25    FSLEKTIGLGTYGRIYLGLHEKTGSFVAIKVMNARKTplpeigkrvrvnkyrksvgwrys  84
         78899*******************************************************
S: 38    ekleelqkeisvlkklkh.pniveylesflk......eeelwlvmeylagGslsdlvkee  90
         +++e+l++e+++l+k++  +niv+++++f+k      +++lw+vme++a+Gs++d+v+++
Q: 85    DEEEDLRTELNLLRKYSFhKNIVTFYGAFFKlnppghQHQLWMVMELCAAGSVTDVVRMT  144
         ****************966*****************************************
S: 91    lkselkEeqiayilrevlkaLeylHskkviHrdikakniLlteegeVkLsdfgvaaqlek  150
         ++++lkE++iayi+re+l++L++lH+++viHrdik++n+Llt+++eVk++dfgv+aq+++
Q: 145   RNQSLKEDWIAYICREILQGLAHLHAHQVIHRDIKGQNVLLTQDAEVKIVDFGVSAQVSR  204
         ************************************************************
S: 151   trkkrktvvgtpywmAPEviaqe...ekgYdekaDiwslGItaielaegepPfkdleplk  207
         t+ +r++++gtpywmAPEvi+++   +++Yd+++                  +++l+pl+
Q: 205   TNGRRNSFIGTPYWMAPEVIHCDedpRRSYDYRVT-----------------LCNLQPLE  247
         **********************9999999999963.................57899***
S: 208   allkilkneppklkskkkfskefkefvekclqknpekRpsasellkhkFl  257
         al+ il++ +p++ks+  +s++f++f+e+c+ kn+ +Rp++ ++l+h+F+
Q: 248   ALFVILREAAPTVKSS-GWSRKFQNFMENCMIKNFLFRPTSGNMLHHPFV  296
         *************888.********************************7
Domain Sequence
(FASTA)
FSLEKTIGLG TYGRIYLGLH EKTGSFVAIK VMNARKTPLP EIGKRVRVNK YRKSVGWRYS 60
DEEEDLRTEL NLLRKYSFHK NIVTFYGAFF KLNPPGHQHQ LWMVMELCAA GSVTDVVRMT 120
RNQSLKEDWI AYICREILQG LAHLHAHQVI HRDIKGQNVL LTQDAEVKIV DFGVSAQVSR 180
TNGRRNSFIG TPYWMAPEVI HCDEDPRRSY DYRVTLCNLQ PLEALFVILR EAAPTVKSSG 240
WSRKFQNFME NCMIKNFLFR PTSGNMLHHP FV 272
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sus scrofa"; ?>Tarsius syrichta"; ?>
EKS-AIM-00306
EKS-CAJ-00328
EKS-CAF-00336
EKS-CAP-00368
EKS-EQC-00328
EKS-FEC-00318
EKS-GOG-00318
EKS-HOS-00330
EKS-ICT-00310
EKS-LOA-00340
EKS-MAM-00323
EKS-MUM-00355
EKS-MUP-00314
EKS-MYL-00326
EKS-NOL-00295
EKS-ORC-00312
EKS-OTG-00334
EKS-PAT-00305
EKS-POA-00312
EKS-SUS-00289
EKS-TAS-00031
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
GO:0007256; P:activation of JNKK activity
GO:0008285; P:negative regulation of cell proliferation
GO:0007567; P:parturition
GO:0060721; P:regulation of spongiotrophoblast cell proliferation
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
Prosites
PS50219; CNH; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013