EKS-RAN-00404
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00404
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11349.81.5E-104651907257
StatusUnreviewed
Ensembl ProteinENSRNOP00000012463
UniProt AccessionD3ZFL3;
Protein Name
Protein Synonyms/Alias Mitogen-activated protein kinase kinase kinase 6 (Predicted); Protein Map3k6;
Gene NameMap3k6
Gene Synonyms/Alias Map3k6; Map3k6_predicted; rCG_31587;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000008936ENSRNOP00000012463ENSRNOT00000012463
OrganismRattus norvegicus
Functional Description
Protein Length1292
Protein Sequence
(FASTA)
MAGPCPGAGV LERAGSCWQD PLAEALSRGR SSPAVAGRGC ARSRPLSVVY VLTREPGPGV 60
EPGSGTEAEP LPLRCLREAC AQLQSTRPPP QLRSLPFATL ALGDTAALDS FYNADVVVLE 120
VSNSLAQPSL FYHLGVRESF SMTNNVLLCS QAELPDLQAL REDVFQKNSD CVGSYTLIPY 180
VVTATGRVLC GDAGLLRGIA DGLVQAGVGT EALLTPLVGR LVRLLEATPT DSCGYFRETI 240
RQDIRKARER FSGQQLRQEL ARLQRRLDSV ELLSPDIIMN LLLSYRDVQD YSAIIELVET 300
LQALPTCDVA EQHNVCFHYT FALNRRNRPG DREKALAVLL PLVKHEGPVA PDLYCMCGRI 360
YKDMFFSSSF QSTGHLEQAY HWYRKAFDVE PSLHSGINAA VLLIAAGKHF DDSEELQLIG 420
MKLGCLLARK GCVEKMQYYW DVGFYLGAQI LANDPIQVVL AAEQLYKLNA PIWYLVSVME 480
TFLLYQHFRP TPEPSGGPVL RAHFWLHFLL QSCQPFKATP PQEDQCLVLV LEINKVLLPA 540
RLEIQGADPM SAVTLSLLEP ETQDDPSSWT FPVTSICGIS ASKLDQRCCF LYALPPAQDV 600
QLCFPSVERC RWFCSQIQVL VMNPDSSAPT EEAEGTREVL EFDYEYSETG ERLVLGKGTY 660
GVVYAGRDRH TRVRIAIKEI PERDSRFSQP LHEEIALHKR LRHKNIVRYL GSASQGGYLK 720
IFMEEVPGGS LSSLLRSVWG PLKDNESTIS FYTRQILQGL SYLHENRIVH RDIKGDNVLI 780
NTFSGLLKIS DFGTSKRLAG ITPCTETFTG TLQYMAPEII DQGPRGYGKA ADIWSLGCTV 840
IEMATGWPPF HELGSPQAAM FQVGMYKVHP PVPSSLSAEA QAFLLRTFEP DPRLRASAQE 900
LLGDPFLQPG KRSRSPGSPR HTPRPSGTPS STSSPSADSA TQSQTFPRPQ APSQHPPSPP 960
KRCLSYGDTS QLRVPEESAA EEPASPEESS GLSLLHQESK RRAMLAAVLE QEVPILAENL 1020
LDQEQDSRLS RNHVELLLRC LGAQIHTPNR RQLAQELRAL QAQLRAQSLS PALLKGPLFA 1080
FPDAVKQILR RRQIRPHWMF VLDSLLSRAV RAALAVLDAE AEKKAVSPKS EEWSQGESQQ 1140
KPLESQPPLQ SQLPPEQEPP SLMIQLGLLR AETDRLRDIL AEKERECQAL VQQALHRVHA 1200
ETRTYALASE TPATLPKDQK LVQWLQDLSV DPTTIQTLLS HSFTLQTLLT CATQDDLVYT 1260
RIRGGMVCRI WRAILAQRAG ATSVTPGPRD AE 1292
Nucleotide Sequence
(FASTA)
ATGGCGGGGC CGTGTCCCGG GGCCGGGGTT CTAGAACGGG CGGGCAGCTG CTGGCAGGAC 60
CCTCTGGCGG AGGCGCTGAG CCGGGGCCGC TCGTCTCCTG CGGTCGCCGG TCGGGGCTGC 120
GCGCGGAGCC GGCCTCTCAG TGTGGTCTAC GTGTTGACCC GCGAGCCTGG ACCCGGGGTG 180
GAGCCCGGGT CGGGAACCGA GGCAGAGCCG CTGCCGCTGC GATGCCTGCG CGAGGCCTGT 240
GCTCAGCTCC AGAGCACGCG GCCACCCCCG CAACTGCGCA GCCTGCCCTT TGCGACGCTG 300
GCGCTAGGCG ACACCGCTGC GCTAGACTCC TTCTACAACG CGGACGTAGT GGTGCTGGAG 360
GTGAGCAACT CCCTGGCACA GCCTTCCTTG TTCTACCACC TCGGCGTGCG TGAGAGCTTC 420
AGCATGACCA ACAATGTGCT CCTCTGTTCC CAGGCAGAGC TCCCTGACCT GCAGGCCCTT 480
CGTGAGGATG TTTTCCAGAA GAACTCGGAT TGCGTTGGCA GCTACACACT GATTCCTTAT 540
GTTGTGACAG CCACTGGCCG GGTCTTATGT GGCGATGCAG GCCTCCTGAG GGGCATAGCC 600
GATGGGCTAG TACAGGCTGG GGTGGGCACT GAGGCCCTCC TCACGCCCCT GGTGGGCCGG 660
CTTGTCCGTC TCTTGGAGGC CACACCCACA GACTCTTGCG GCTACTTCCG GGAGACCATT 720
CGTCAAGATA TCCGGAAGGC ACGGGAGCGG TTCAGCGGGC AGCAGCTGAG GCAGGAGCTG 780
GCTCGCCTGC AGCGGAGGCT GGACAGCGTA GAGCTGTTGA GCCCCGACAT CATCATGAAT 840
CTGCTTCTGT CATACCGCGA CGTCCAGGAC TACTCCGCCA TCATTGAGCT GGTGGAGACG 900
CTGCAGGCTT TGCCCACCTG TGATGTGGCC GAACAGCACA ATGTCTGCTT CCACTACACG 960
TTTGCCCTCA ACAGGAGGAA CAGGCCTGGG GACCGTGAGA AGGCCCTGGC TGTCCTTCTG 1020
CCATTGGTGA AGCATGAAGG CCCCGTGGCT CCAGACCTGT ACTGCATGTG TGGTCGTATC 1080
TACAAGGACA TGTTCTTCAG CTCCAGCTTC CAAAGTACTG GGCACCTGGA GCAGGCCTAT 1140
CACTGGTACC GCAAGGCATT TGATGTGGAG CCCAGCCTAC ACTCGGGCAT CAATGCAGCT 1200
GTGCTGCTCA TTGCAGCTGG GAAACACTTT GACGACTCTG AGGAGCTCCA GCTGATAGGC 1260
ATGAAGCTGG GCTGCCTGTT AGCCCGCAAA GGCTGTGTGG AGAAGATGCA GTATTACTGG 1320
GACGTGGGGT TCTACCTGGG AGCCCAGATT CTTGCCAACG ACCCCATCCA GGTGGTGCTG 1380
GCTGCAGAAC AACTATACAA GCTCAATGCC CCCATATGGT ACTTGGTGTC AGTGATGGAG 1440
ACCTTCTTAC TGTACCAGCA TTTCAGACCC ACACCAGAGC CCTCGGGAGG ACCCGTGCTG 1500
CGAGCTCACT TTTGGCTCCA TTTCTTGCTA CAATCCTGCC AGCCTTTCAA GGCGACCCCT 1560
CCTCAGGAGG ACCAGTGCCT GGTACTGGTG CTGGAGATAA ACAAGGTTCT GCTGCCTGCC 1620
AGACTTGAGA TTCAGGGAGC CGACCCCATG AGCGCAGTGA CCCTAAGCTT GCTGGAGCCA 1680
GAGACTCAGG ATGATCCTTC CAGCTGGACC TTCCCAGTCA CCTCCATCTG TGGGATCAGC 1740
GCCTCCAAGC TGGACCAGCG CTGCTGCTTC CTGTACGCAC TTCCTCCGGC CCAGGACGTC 1800
CAGCTGTGCT TTCCCAGCGT AGAGCGCTGC CGGTGGTTCT GTAGCCAAAT TCAGGTCTTG 1860
GTGATGAATC CAGATTCCTC GGCGCCCACT GAGGAGGCAG AAGGCACAAG GGAGGTGCTG 1920
GAGTTTGATT ATGAATATTC GGAGACGGGT GAGCGGCTGG TGCTGGGCAA AGGCACGTAC 1980
GGGGTGGTGT ATGCTGGCCG CGACAGGCAC ACGAGGGTAC GAATCGCCAT CAAAGAGATC 2040
CCAGAGAGAG ATAGCAGATT CTCTCAGCCT CTGCACGAGG AGATCGCTCT CCACAAACGC 2100
CTTCGCCACA AGAATATAGT GCGCTATTTG GGCTCAGCCA GCCAGGGCGG CTACCTCAAG 2160
ATCTTCATGG AGGAAGTGCC TGGAGGCAGC CTGTCCTCCT TGCTTAGGTC AGTGTGGGGA 2220
CCCCTAAAGG ACAACGAGAG TACTATTAGC TTCTACACGC GTCAGATCCT GCAAGGACTT 2280
AGCTACCTGC ATGAGAACCG CATTGTTCAC CGAGACATCA AGGGGGACAA TGTACTGATC 2340
AACACCTTCA GTGGGCTGCT CAAGATTTCT GACTTTGGCA CCTCCAAGCG GCTGGCAGGC 2400
ATCACACCCT GCACGGAGAC TTTCACAGGG ACCCTGCAGT ATATGGCCCC AGAAATCATT 2460
GACCAGGGCC CACGAGGATA TGGAAAGGCG GCTGACATCT GGTCTCTGGG CTGCACTGTG 2520
ATTGAGATGG CCACAGGTTG GCCGCCCTTT CACGAACTAG GGAGCCCGCA GGCTGCCATG 2580
TTTCAGGTGG GCATGTACAA GGTACATCCA CCAGTGCCAA GTTCCCTGTC AGCTGAGGCC 2640
CAAGCCTTCC TCCTCCGAAC TTTTGAGCCA GATCCCCGCC TCCGAGCCAG TGCCCAAGAG 2700
CTGTTGGGAG ACCCCTTCCT GCAACCAGGG AAGAGGAGCC GCAGCCCTGG CTCTCCTCGG 2760
CACACTCCCC GGCCCTCAGG CACCCCTTCC AGTACTTCCA GTCCTTCAGC TGACTCAGCC 2820
ACACAGTCTC AGACATTCCC AAGGCCCCAG GCACCCTCTC AGCACCCACC CAGCCCTCCG 2880
AAGCGCTGCC TTAGTTATGG GGACACCAGT CAGCTCCGTG TGCCCGAGGA ATCCGCTGCC 2940
GAGGAACCCG CGTCCCCAGA AGAGAGTTCA GGCCTGAGCC TGCTGCACCA GGAGAGCAAG 3000
CGCCGAGCCA TGCTGGCTGC AGTGCTGGAA CAGGAGGTGC CCATACTAGC AGAGAATCTC 3060
CTGGATCAGG AACAGGATTC TCGACTCAGC AGGAATCATG TGGAACTTCT GCTTCGGTGC 3120
CTCGGGGCAC AAATCCATAC TCCTAACCGC CGGCAGCTGG CCCAGGAGCT GCGGGCCCTG 3180
CAAGCTCAAC TGCGGGCCCA GAGCCTGAGC CCTGCGCTTT TGAAGGGGCC GCTCTTCGCC 3240
TTTCCAGACG CGGTGAAGCA GATCCTCCGC AGACGCCAGA TCCGCCCACA CTGGATGTTC 3300
GTGTTGGACT CGCTGCTCAG CCGGGCAGTC CGGGCGGCGC TGGCCGTACT GGACGCGGAG 3360
GCAGAGAAGA AAGCGGTCTC ACCGAAGTCA GAGGAGTGGA GTCAAGGGGA GTCCCAGCAG 3420
AAACCGCTGG AGAGCCAGCC GCCGCTGCAG AGTCAGCTCC CACCAGAGCA GGAACCTCCA 3480
TCCCTGATGA TACAGCTGGG TCTCTTGCGA GCTGAGACTG ACAGGCTTCG GGACATTCTG 3540
GCTGAGAAGG AACGTGAGTG CCAGGCCCTC GTGCAACAGG CCCTGCATCG GGTGCACGCA 3600
GAGACCAGGA CGTATGCCCT GGCTTCAGAG ACCCCGGCCA CTCTCCCAAA GGACCAGAAA 3660
CTGGTGCAGT GGCTACAGGA CCTGAGTGTA GATCCAACCA CTATCCAAAC GCTCCTGAGC 3720
CATAGCTTTA CCCTTCAAAC CCTGCTCACC TGTGCCACTC AGGATGACCT CGTCTACACC 3780
AGAATCAGGG GAGGGATGGT ATGCAGAATT TGGAGAGCCA TCTTGGCACA GCGAGCAGGA 3840
GCCACGTCGG TCACCCCTGG ACCCCGGGAT GCTGAGTGA 3879
Domain Profile
S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62
         +r v+gkG++g vya++d +t+ ++a+Ke+   pe++s+   +++l+eEi+l+k+l+H+n
Q: 651   ERLVLGKGTYGVVYAGRDRHTRVRIAIKEI---PERDSR--FSQPLHEEIALHKRLRHKN  705
         5779**************************...888775..9******************
S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119
         iv+y+G++++ ++lkif+E v+gGslssll+  +g+l+  es+i++yt+qil+gl+yLHe
Q: 706   IVRYLGSASQGGYLKIFMEEVPGGSLSSLLRsVWGPLKdnESTISFYTRQILQGLSYLHE  765
         *******************************99****9999*******************
S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178
         ++ivHRDiKg+N+l+++ sg++k+sDFG+skrla ++++   +e++tGtl+ymaPE+i++
Q: 766   NRIVHRDIKGDNVLINTfSGLLKISDFGTSKRLAGITPC---TETFTGTLQYMAPEIIDQ  822
         *****************9*********************...8*****************
S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238
         + +gyg++aDiWslgc+viem+tg +Pf+el++++a+mf+vg+ k++P++p++ls+e+++
Q: 823   GPRGYGKAADIWSLGCTVIEMATGWPPFHELGSPQAAMFQVGMYKVHPPVPSSLSAEAQA  882
         ************************************************************
S: 239   flekcleldpkkrpsaeeLLkhefl  263
         fl +++e dp+ r+sa+eLL ++fl
Q: 883   FLLRTFEPDPRLRASAQELLGDPFL  907
         **********************996
Domain Sequence
(FASTA)
ERLVLGKGTY GVVYAGRDRH TRVRIAIKEI PERDSRFSQP LHEEIALHKR LRHKNIVRYL 60
GSASQGGYLK IFMEEVPGGS LSSLLRSVWG PLKDNESTIS FYTRQILQGL SYLHENRIVH 120
RDIKGDNVLI NTFSGLLKIS DFGTSKRLAG ITPCTETFTG TLQYMAPEII DQGPRGYGKA 180
ADIWSLGCTV IEMATGWPPF HELGSPQAAM FQVGMYKVHP PVPSSLSAEA QAFLLRTFEP 240
DPRLRASAQE LLGDPFL 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>
EKS-AIM-00364
EKS-ANC-00380
EKS-BOT-00391
EKS-CAJ-00392
EKS-CAF-00391
EKS-CAP-00420
EKS-EQC-00382
EKS-FEC-00381
EKS-GAA-00477
EKS-HOS-00398
EKS-ICT-00368
EKS-LOA-00400
EKS-MAM-00388
EKS-MAE-00046
EKS-MIM-00057
EKS-MOD-00378
EKS-MUM-00422
EKS-MUP-00384
EKS-MYL-00387
EKS-ORC-00368
EKS-OTG-00392
EKS-PAT-00368
EKS-POA-00382
EKS-SUS-00342
EKS-TUT-00109
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004709; F:MAP kinase kinase kinase activity
KEGG
rno:313022;
InterPros
IPR025136; DUF4071.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR013761; SAM/pointed.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF13281; DUF4071; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013