EKS-RAN-00383
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00383
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src434.61.3E-130260509250
StatusUnreviewed
Ensembl ProteinENSRNOP00000012432
UniProt AccessionF1LP43;
Protein Name
Protein Synonyms/Alias Tyrosine-protein kinase HCK;
Gene NameHck
Gene Synonyms/Alias Hck;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000009331ENSRNOP00000012432ENSRNOT00000012432
OrganismRattus norvegicus
Functional Description
Protein Length524
Protein Sequence
(FASTA)
LGGRSSCEDP GCPRGEGRVP RMGCVKSRFL REGSKASKIE PNANQKGPVY VPDPTSPKKL 60
GPNSINSLPP GVVEGSEDTI VVALYDYEAI HREDLSFQKG DQMVVLEESG EWWKARSLAT 120
KKEGYIPSNY VARVNSLETE EWFFKGISRK DAERHLLAPG NMLGSFMIRD SETTKGSYSL 180
SVRDFDPQHG DTVKHYKIRT LDSGGFYISP RSTFSSLQEL VVHYKKGKDG LCQKLSVPCV 240
SPKPQKPWEK DAWEIPRESL QMEKKLGAGQ FGEVWMATYN KHTKVAVKTM KPGSMSVEAF 300
LAEANLMKTL QHDKLVKLHA VVSQEPIFIV TEFMAKGSLL DFLKSEEGSK QPLPKLIDFS 360
AQISEGMAFI EQRNYIHRDL RAANILVSAS LVCKIADFGL ARIIEDNEYT AREGAKFPIK 420
WTAPEAINFG SFTIKSDVWS FGILLMEIVT YGRIPYPGMS NPEVIRALEH GYRMPRPDNC 480
PEELYSIMIR CWKNRPEERP TFEYIQSVLD DFYTATESQY QQQP 524
Nucleotide Sequence
(FASTA)
CTGGGGGGTC GTTCGAGCTG CGAGGATCCG GGCTGCCCGC GAGGCGAAGG GCGGGTGCCC 60
AGGATGGGAT GTGTGAAGTC CAGGTTCCTC CGAGAAGGAA GCAAGGCCTC AAAAATAGAG 120
CCAAATGCCA ACCAGAAAGG CCCTGTGTAT GTGCCGGATC CCACGTCCCC TAAGAAGCTG 180
GGACCGAACA GCATCAACAG CCTGCCCCCG GGGGTCGTGG AGGGCTCTGA GGACACCATT 240
GTGGTCGCAC TGTACGACTA TGAGGCCATT CACCGTGAAG ACCTCAGCTT CCAGAAGGGA 300
GACCAGATGG TGGTTCTGGA GGAGTCTGGG GAGTGGTGGA AGGCCCGTTC CCTGGCTACC 360
AAGAAAGAAG GCTATATCCC AAGCAATTAT GTAGCTCGAG TTAACTCTTT GGAGACTGAG 420
GAGTGGTTCT TCAAGGGTAT CAGCCGGAAG GATGCAGAGC GCCACCTGCT GGCTCCCGGG 480
AACATGCTGG GCTCCTTCAT GATCCGGGAC AGTGAGACCA CCAAAGGGAG CTACTCACTT 540
TCTGTTCGAG ACTTTGACCC CCAGCACGGA GACACGGTGA AGCATTATAA AATCCGGACA 600
CTGGACAGTG GAGGCTTCTA CATCTCTCCG AGGAGCACCT TCAGCAGCCT GCAGGAACTT 660
GTCGTCCACT ACAAGAAGGG GAAGGATGGG CTCTGCCAGA AGCTGTCAGT GCCCTGTGTG 720
TCTCCCAAAC CCCAGAAGCC ATGGGAGAAA GATGCCTGGG AGATTCCTCG AGAATCCCTC 780
CAGATGGAGA AGAAACTGGG AGCCGGGCAG TTTGGAGAAG TGTGGATGGC CACCTACAAC 840
AAGCACACCA AAGTGGCGGT GAAGACAATG AAGCCAGGGA GCATGTCTGT GGAGGCCTTC 900
CTGGCAGAGG CCAACCTGAT GAAGACGTTA CAGCATGATA AACTGGTGAA GCTGCACGCC 960
GTGGTCTCTC AGGAGCCCAT CTTTATTGTC ACCGAGTTCA TGGCCAAAGG AAGCCTGCTG 1020
GACTTTCTCA AGAGTGAAGA AGGCAGCAAG CAGCCACTGC CAAAACTCAT TGACTTCTCA 1080
GCCCAGATTT CAGAGGGCAT GGCTTTCATT GAGCAGAGGA ACTACATCCA CCGAGACCTC 1140
CGGGCTGCCA ACATCTTGGT TTCTGCATCA CTGGTGTGTA AGATCGCTGA CTTTGGACTG 1200
GCACGGATCA TCGAGGACAA TGAGTACACA GCTCGGGAAG GAGCCAAGTT CCCCATCAAG 1260
TGGACAGCTC CTGAAGCCAT CAACTTTGGC TCCTTCACCA TCAAGTCAGA TGTCTGGTCC 1320
TTTGGTATCC TGCTGATGGA AATCGTCACC TACGGCCGGA TCCCTTACCC AGGTATGTCA 1380
AACCCAGAGG TGATTCGAGC ACTAGAGCAT GGGTACCGTA TGCCTCGACC AGATAACTGC 1440
CCAGAGGAGC TCTACAGTAT CATGATCCGC TGCTGGAAGA ACCGTCCAGA GGAACGGCCC 1500
ACTTTCGAAT ACATCCAGAG CGTGCTGGAT GACTTCTACA CGGCCACTGA GAGCCAGTAT 1560
CAGCAGCAAC CTTGA 1575
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         l+++kklG+GqfGevw++++++++kvavkt+k+g++s eafl+ea+++k+l+h+klvkl+
Q: 260   LQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLH  319
         6899********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvs+ ePi+ivte+makGslldflk+eeg+k++lpkl+d++aq++eGma++e++n+ihr
Q: 320   AVVSQ-EPIFIVTEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHR  378
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+ slv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 379   DLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDV  438
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGill+eivt+G++PypGm+n ev++++e+gyr+prp++cpeely+++++cwk++pee
Q: 439   WSFGILLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPRPDNCPEELYSIMIRCWKNRPEE  498
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe++q+vl
Q: 499   RPTFEYIQSVL  509
         *******9976
Domain Sequence
(FASTA)
LQMEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FLAEANLMKT LQHDKLVKLH 60
AVVSQEPIFI VTEFMAKGSL LDFLKSEEGS KQPLPKLIDF SAQISEGMAF IEQRNYIHRD 120
LRAANILVSA SLVCKIADFG LARIIEDNEY TAREGAKFPI KWTAPEAINF GSFTIKSDVW 180
SFGILLMEIV TYGRIPYPGM SNPEVIRALE HGYRMPRPDN CPEELYSIMI RCWKNRPEER 240
PTFEYIQSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00343
EKS-ANC-00359
EKS-BOT-00369
EKS-CAJ-00373
EKS-CAF-00370
EKS-CAP-00404
EKS-DAR-00749
EKS-EQC-00360
EKS-FEC-00356
EKS-GAG-00313
EKS-GAA-00451
EKS-GOG-00360
EKS-HOS-00375
EKS-ICT-00350
EKS-LOA-00378
EKS-MAM-00369
EKS-MEG-00306
EKS-MOD-00358
EKS-MUM-00401
EKS-MUP-00363
EKS-MYL-00369
EKS-NOL-00337
EKS-OCP-00073
EKS-ORN-00478
EKS-ORC-00347
EKS-ORL-00440
EKS-OTG-00371
EKS-PAT-00354
EKS-PEM-00194
EKS-PTV-00094
EKS-SAH-00339
EKS-TAG-00442
EKS-TAR-00474
EKS-XIM-00467
Gene Ontology
GO:0005884; C:actin filament
GO:0005901; C:caveola
GO:0031234; C:extrinsic to internal side of plasma membrane
GO:0005925; C:focal adhesion
GO:0005764; C:lysosome
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0050830; P:defense response to Gram-positive bacterium
GO:0043066; P:negative regulation of apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0006909; P:phagocytosis
GO:2000251; P:positive regulation of actin cytoskeleton reorganization
GO:0008284; P:positive regulation of cell proliferation
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0050764; P:regulation of phagocytosis
GO:0071801; P:regulation of podosome assembly
GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013