EKS-RAN-00482
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00482
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK364.54.5E-10915305291
StatusReviewed
Ensembl ProteinENSRNOP00000012460
UniProt AccessionQ9Z2A6;
Protein NameMitogen-activated protein kinase 15
Protein Synonyms/Alias MAP kinase 15; MAPK 15; Extracellular signal-regulated kinase 7; ERK-7;
Gene NameMapk15
Gene Synonyms/Alias Mapk15; Erk7;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000009336ENSRNOP00000012460ENSRNOT00000012461
OrganismRattus norvegicus
Functional DescriptionConstitutively active kinase which may function as anegative regulator of cell growth. In vitro, phosphorylates FOS.
Protein Length547
Protein Sequence
(FASTA)
MCAAEVDRHV SQRYLIKRRL GKGAYGIVWK AMDRRTGEVV AIKKIFDAFR DQTDAQRTFR 60
EIMLLREFGG HPNIIRLLDV IPAKNDRDIY LVFESMDTDL NAVIQKGRLL EDIHKRCIFY 120
QLLRATKFIH SGRVIHRDQK PANVLLDAAC RVKLCDFGLA RSLSDFPEGP GGQALTEYVA 180
TRWYRAPEVL LSSRWYTPGV DMWSLGCILG EMLRGQPLFP GTSTFHQLEL ILETIPLPSM 240
EELQGLGSDY SALILQNLGS RPRQTLDALL PPDTPPEALD LLKRLLAFAP DKRLSAEQAL 300
QHPYVQRFHC PDREWTRGSD VRLPVHEGDQ LSAPEYRNRL YQMILERRRN SRSPREEDLG 360
VVASRAELRA SQRQSLKPGV LPQVLAETPA RKRGPKPQNG HGHDPEHVEV RRQSSDPLYQ 420
LPPPGSGERP PGATGEPPSA PSGVKTHVRA VAPSLTSQAA AQAANQPLIR SDPARGGGPR 480
AVGARRVPSR LPREAPEPRP GRRMFGISVS QGAQGAARAA LGGYSQAYGT VCRSALGRLP 540
LLPGPRA 547
Nucleotide Sequence
(FASTA)
ATGTGTGCTG CCGAGGTGGA CCGTCATGTA TCCCAGAGAT ACCTGATCAA GCGGAGGCTT 60
GGGAAGGGGG CCTACGGCAT TGTATGGAAG GCCATGGACC GGAGGACTGG TGAGGTAGTG 120
GCCATCAAGA AAATCTTTGA TGCCTTTAGG GACCAGACAG ATGCTCAGAG GACCTTCCGT 180
GAAATCATGC TTCTCCGGGA GTTTGGGGGC CATCCCAACA TCATCCGCCT GCTTGATGTA 240
ATCCCAGCAA AGAATGACAG GGATATTTAC CTGGTGTTTG AGTCCATGGA CACCGACCTG 300
AACGCGGTCA TCCAGAAGGG CAGACTGTTG GAGGACATCC ACAAACGTTG CATCTTTTAC 360
CAGCTCCTGA GAGCCACCAA GTTTATCCAT TCAGGGCGCG TCATTCACCG GGACCAGAAG 420
CCAGCCAACG TTCTATTGGA TGCTGCTTGC CGGGTGAAAC TATGTGACTT TGGCCTGGCA 480
CGCTCCCTCA GTGACTTCCC TGAAGGGCCT GGGGGCCAGG CCCTGACAGA ATATGTGGCC 540
ACACGCTGGT ACCGAGCTCC AGAGGTGCTT CTGTCTTCCC GATGGTATAC CCCTGGGGTG 600
GACATGTGGA GCCTGGGCTG CATACTGGGA GAGATGCTTC GAGGGCAGCC ACTGTTTCCG 660
GGTACATCTA CTTTCCACCA GCTGGAGCTG ATCCTGGAGA CCATTCCATT GCCCTCCATG 720
GAGGAGCTCC AGGGCCTTGG ATCAGACTAC AGTGCTTTGA TTCTGCAGAA TCTTGGATCC 780
AGGCCACGGC AGACGCTGGA CGCCCTCCTG CCGCCAGACA CCCCCCCAGA AGCCCTGGAC 840
CTCCTCAAGC GACTCTTGGC ATTTGCTCCG GACAAACGGC TTAGTGCAGA GCAGGCTCTT 900
CAACACCCTT ACGTGCAGAG ATTCCATTGC CCCGACCGCG AGTGGACACG GGGGTCCGAT 960
GTGCGGCTCC CGGTACACGA AGGAGACCAG CTCTCTGCAC CAGAGTATCG CAACCGCCTG 1020
TACCAGATGA TCCTGGAGCG GAGACGGAAC AGCCGCAGCC CTCGAGAGGA AGACTTGGGG 1080
GTTGTGGCCT CGCGGGCAGA GCTCAGGGCT TCCCAGAGGC AATCGCTCAA GCCCGGAGTC 1140
CTCCCCCAGG TCTTGGCGGA GACGCCTGCG CGGAAACGCG GACCCAAACC TCAGAATGGC 1200
CATGGTCACG ATCCCGAGCA TGTGGAAGTT CGCAGGCAGA GTTCAGACCC CCTGTACCAA 1260
CTTCCGCCGC CAGGCAGCGG GGAAAGGCCC CCAGGGGCCA CAGGGGAGCC ACCCTCCGCA 1320
CCCTCAGGGG TGAAGACTCA CGTTAGGGCG GTGGCGCCCT CCCTGACTTC ACAGGCCGCG 1380
GCTCAGGCGG CCAATCAGCC TCTGATCCGC AGTGATCCGG CCCGGGGCGG TGGGCCAAGG 1440
GCTGTCGGCG CGCGACGGGT CCCTTCCCGC CTGCCCCGGG AGGCCCCGGA ACCCCGACCC 1500
GGCCGAAGGA TGTTTGGCAT CTCGGTCTCG CAGGGGGCCC AGGGTGCAGC CAGAGCTGCT 1560
CTTGGCGGCT ACTCCCAGGC CTACGGGACC GTGTGCCGCT CCGCGCTGGG CCGCCTGCCT 1620
CTGCTCCCCG GACCGCGTGC GTGA 1644
Domain Profile
S: 2     eslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkel.kheNi  60
           +++lg+Gayg+v++a+d+rt+e vaikk++++f+++t+a+rt+RE++ll+e+  h+Ni
Q: 15    LIKRRLGKGAYGIVWKAMDRRTGEVVAIKKIFDAFRDQTDAQRTFREIMLLREFgGHPNI  74
         56789*************************************************99****
S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylH  119
         i+lldv+ +++     +d+Ylv+e m+tdL++vi++   l+d h ++++yq+lr++k++H
Q: 75    IRLLDVIPAKN----DRDIYLVFESMDTDLNAVIQKGrLLEDIHKRCIFYQLLRATKFIH  130
         *******9888....9********************9788999*****************
S: 120   sanviHrDlKPsNllvnedcelkildFGlarsadkekekk....lteyvatrwYraPeil  175
         s +viHrD+KP+N+l+++ c++k++dFGlars ++  e      lteyvatrwYraPe+l
Q: 131   SGRVIHRDQKPANVLLDAACRVKLCDFGLARSLSDFPEGPggqaLTEYVATRWYRAPEVL  190
         ********************************999888778889****************
S: 176   lslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiesee  235
         ls++ yt  vD+Ws+GCIl+E+l+g+plfpg+++++qle+ile+++ ps e l+ + s+ 
Q: 191   LSSRWYTPGVDMWSLGCILGEMLRGQPLFPGTSTFHQLELILETIPLPSMEELQGLGSDY  250
         ************************************************************
S: 236   arnyikslpkkkkkdfeelfpk.aseealdLleklLvldpdkRisveeaLehpYl  289
          + ++++l +++++++++l+p  + +ealdLl++lL ++pdkR+s+e+aL+hpY+
Q: 251   SALILQNLGSRPRQTLDALLPPdTPPEALDLLKRLLAFAPDKRLSAEQALQHPYV  305
         *******************9875889****************************7
Domain Sequence
(FASTA)
LIKRRLGKGA YGIVWKAMDR RTGEVVAIKK IFDAFRDQTD AQRTFREIML LREFGGHPNI 60
IRLLDVIPAK NDRDIYLVFE SMDTDLNAVI QKGRLLEDIH KRCIFYQLLR ATKFIHSGRV 120
IHRDQKPANV LLDAACRVKL CDFGLARSLS DFPEGPGGQA LTEYVATRWY RAPEVLLSSR 180
WYTPGVDMWS LGCILGEMLR GQPLFPGTST FHQLELILET IPLPSMEELQ GLGSDYSALI 240
LQNLGSRPRQ TLDALLPPDT PPEALDLLKR LLAFAPDKRL SAEQALQHPY V 291
KeywordATP-binding; Complete proteome; Direct protein sequencing; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Ubl conjugation.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00438
EKS-ANC-00459
EKS-BOT-00470
EKS-CAE-00391
EKS-CAJ-00479
EKS-CAF-00469
EKS-CAP-00501
EKS-CII-00263
EKS-CIS-00223
EKS-DAR-00878
EKS-DRM-00226
EKS-FEC-00447
EKS-GAM-00273
EKS-GAG-00390
EKS-GAA-00570
EKS-GOG-00458
EKS-HOS-00476
EKS-ICT-00445
EKS-LAC-00483
EKS-MAM-00465
EKS-MEG-00383
EKS-MOD-00462
EKS-MUM-00501
EKS-NOL-00430
EKS-ORN-00593
EKS-ORA-00409
EKS-ORC-00444
EKS-ORL-00538
EKS-OTG-00476
EKS-PES-00415
EKS-PEM-00257
EKS-POA-00456
EKS-SAH-00438
EKS-TAR-00583
EKS-TEN-00589
EKS-TUT-00174
EKS-XET-00617
EKS-XIM-00585
Gene Ontology
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004707; F:MAP kinase activity
GO:0008156; P:negative regulation of DNA replication
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0045732; P:positive regulation of protein catabolic process
GO:0001934; P:positive regulation of protein phosphorylation
GO:0031398; P:positive regulation of protein ubiquitination
GO:0046777; P:protein autophosphorylation
GO:0032355; P:response to estradiol stimulus
KEGG
rno:286997;
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; FALSE_NEG.
Prints
Created Date20-Feb-2013